Hub : Genes

S100A16

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0390	0.0210	1.9e-02	0.043	0.009	0.017	0.014	0.029	5.8e-06	0.02200	3.2e-03	0.0061	1.7e-04
2	GTEx	Artery Aorta	0.0950	0.0400	7.6e-03	0.017	NA	0.001	NA	0.013	3.9e-02	NA	2.9e-01	NA	6.3e-02
3	GTEx	Brain Cerebellar Hemisphere	0.3530	0.0930	1.6e-05	0.292	NA	0.268	NA	0.295	3.4e-08	NA	1.4e-07	NA	2.7e-08
4	GTEx	Brain Cerebellum	0.2110	0.0700	1.1e-04	0.353	NA	0.309	NA	0.324	2.8e-11	NA	8.0e-10	NA	2.6e-10
5	GTEx	Cells Transformed fibroblasts	0.1170	0.0370	3.1e-05	0.067	NA	0.068	NA	0.068	1.0e-05	NA	8.7e-06	NA	8.0e-06
6	GTEx	Muscle Skeletal	0.0451	0.0214	9.9e-03	0.048	NA	0.048	NA	0.045	1.7e-05	NA	1.5e-05	NA	3.1e-05
7	GTEx	Nerve Tibial	0.0906	0.0293	3.4e-05	0.081	NA	0.065	NA	0.093	2.2e-06	NA	2.3e-05	NA	4.2e-07
8	GTEx	Skin Not Sun Exposed Suprapubic	0.1330	0.0600	9.5e-03	0.107	NA	0.089	NA	0.098	1.8e-06	NA	1.4e-05	NA	5.0e-06
9	TCGA	Bladder Urothelial Carcinoma	0.0270	0.0170	1.6e-03	0.018	0.026	0.017	NA	0.021	1.1e-02	0.00260	1.4e-02	NA	6.1e-03
10	TCGA	Breast Invasive Carcinoma	0.0141	0.0114	8.8e-03	0.008	0.009	0.008	NA	0.007	8.3e-03	0.00440	8.3e-03	NA	1.2e-02
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0878	0.0419	1.4e-05	0.039	0.025	0.027	NA	-0.002	3.4e-05	0.00072	4.4e-04	NA	5.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.6	1.8	-0.7	-0.4	-0.6	-0.6	-0.9	0.6	-1.4	-0.7	-1.0	-1.0	0.0
Bipolar Disorder or Schizophrenia	0.8	2.0	4.0	-1.4	-1.4	-1.2	-1.3	-1.5	1.2	-2.0	-1.8	-1.5	-1.4	0.0
Depressed Affect (Nagel 2018)	0.7	1.4	2.3	1.4	1.4	0.9	1.2	1.4	-1.5	1.3	0.6	1.1	1.1	0.7
Depression (Nagel 2018)	0.0	0.0	0.1	-0.0	-0.2	-0.4	-0.2	-0.1	0.2	-0.2	0.2	-0.2	-0.1	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	3.6	0.7	0.6	0.9	0.8	0.6	-0.3	0.4	1.9	0.4	0.3	0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.2	-0.6	-0.5	-0.3	-0.5	0.2	-0.7	-0.8	-0.6	-0.7	-0.6
Schizophrenia (2018)	0.7	1.5	2.9	-1.2	-1.4	-1.2	-1.2	-1.2	1.1	-1.5	-1.7	-1.1	-1.1	0.0
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	0.7	0.6	0.7	0.7	0.9	-1.1	0.9	-0.3	1.2	1.3	0.0
Worry (Nagel 2018)	3.3	7.0	11.1	-2.4	-2.9	-2.5	-2.4	-2.8	2.6	-3.3	-1.2	-3.2	-2.9	-2.2
Alzheimer’s Disease (in mother)	1.3	1.5	3.1	-1.4	-1.0	-1.4	-1.4	-1.4	0.9	-1.4	0.2	-1.2	-0.6	-1.8
Alzheimer’s Disease (in father)	0.6	0.6	1.9	-0.2	-1.2	-0.6	-0.3	-0.4	0.8	-0.7	0.7	-0.9	-1.4	0.7
Alzheimer’s Disease (including proxy)	1.1	1.7	2.3	-1.2	-1.5	-1.5	-1.4	-1.3	1.2	-1.5	0.3	-1.4	-1.3	-1.1
Crohns Disease (2017)	0.2	0.4	2.4	0.2	0.2	-0.0	0.1	0.5	-0.1	0.7	1.6	0.6	0.7	0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	-0.4	-0.3	-0.4	-0.4	-0.1	0.5	0.1	0.9	-0.0	0.0	0.1
Ulcerative Colitis (UC)	0.8	1.4	1.8	-1.4	-1.3	-1.2	-1.3	-1.3	1.4	-1.2	-0.2	-1.2	-1.2	-1.1
Major Depression (MDD)	2.1	2.5	5.4	-1.8	-1.5	-1.8	-1.8	-1.6	1.2	-1.2	2.3	-1.3	-1.2	-1.3
Reaction Time	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.2	0.1	0.3	0.4	0.1	0.3	0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.0	-0.6	-0.5	-0.3	-0.4	-0.8	0.7	-0.8	1.4	-1.2	-1.2	0.1
Breast Cancer	0.1	0.1	0.5	-0.4	0.0	-0.4	-0.3	-0.4	0.2	-0.2	-0.7	-0.5	-0.5	-0.0
Ovarian Cancer	1.9	2.5	4.8	-1.3	-2.2	-1.4	-1.4	-1.6	1.8	-1.8	-0.9	-1.7	-1.9	-0.9
Prostate Cancer	0.9	1.2	2.4	1.2	-0.1	0.8	1.0	1.3	-1.2	1.6	0.9	1.2	0.8	1.4
Age at First Birth	5.4	7.9	16.5	3.4	3.1	4.1	3.8	3.4	-3.0	3.3	1.6	0.0	0.0	0.0
Bipolar Disorder (2011)	1.0	1.0	1.8	-1.1	-0.9	-1.4	-1.3	-1.2	1.3	-1.3	0.4	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.0	1.4	0.6	1.1	1.3	1.1	-1.0	0.8	-1.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	2.1	2.6	5.2	-1.9	-2.3	-2.1	-2.0	-1.9	2.1	-1.8	0.2	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.8	0.9	0.3	0.5	0.8	0.7	-0.2	0.3	0.4	0.0	-0.2	0.0
Mean Putamen Volume	0.1	0.1	0.3	0.5	-0.2	0.6	0.6	0.3	0.2	-0.2	-0.2	-0.1	-0.3	0.0
Fasting Glucose	1.0	1.2	2.5	-0.6	-1.1	-1.6	-1.3	-1.3	1.1	-1.5	1.3	0.0	0.0	0.0
HbA1C	0.8	0.8	2.2	-0.9	-0.3	-1.2	-1.3	-1.1	1.2	-0.7	1.5	0.0	0.0	0.0
HDL Cholesterol	3.5	5.8	10.0	2.9	3.0	3.0	3.0	3.0	-3.0	3.2	-0.7	0.0	0.0	0.0
LDL Cholesterol	2.8	4.4	7.8	-2.8	-2.3	-2.6	-2.8	-2.7	2.5	-2.6	-1.1	0.0	0.0	0.0
Lupus	0.1	0.1	0.4	0.2	-0.3	0.4	0.4	0.3	-0.2	-0.0	-0.6	0.2	0.2	0.5
Neuroticism (2016)	1.2	1.7	2.2	1.3	1.3	1.5	1.4	1.5	-1.4	1.4	-0.2	1.5	1.2	1.3
Primary Biliary Cirrhosis	0.3	0.5	0.8	-0.8	-0.5	-0.7	-0.7	-0.8	0.6	-0.9	0.6	-0.8	-0.9	0.0
Rheumatoid Arthritis	1.2	1.6	4.4	0.9	2.1	1.3	1.1	1.1	-1.2	1.2	0.1	1.3	2.0	0.0
Schizophrenia (2014)	0.2	0.5	2.7	-0.4	-0.8	-0.5	-0.4	-0.5	0.4	-0.9	-1.6	-0.6	-0.7	0.0
Triglycerides	1.7	2.7	5.8	-2.4	-1.6	-2.2	-2.3	-2.1	1.8	-1.9	0.3	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	5.3	6.1	12.3	-2.9	-2.8	-3.2	-3.0	-3.0	3.5	-3.2	0.7	0.0	0.0	0.0
Ulcerative Colitis	0.4	0.6	1.1	-0.9	-0.6	-1.1	-1.0	-0.9	0.5	-0.9	0.3	-0.8	-0.7	0.0
Blood Eosinophil Count	0.1	0.8	2.9	0.0	-0.6	-0.8	-0.4	-0.5	0.3	-1.1	0.9	-1.2	-1.7	0.7
Blood Platelet Count	3.5	40.5	54.8	-6.6	-7.0	-6.9	-6.8	-6.9	6.5	-7.4	0.0	-6.9	-6.9	-4.4
Blood Red Count	0.0	0.4	1.0	0.3	0.4	-0.2	-0.0	0.7	0.2	1.0	0.5	1.0	0.8	0.7
Blood White Count	0.7	5.4	10.4	-2.0	-2.2	-2.0	-1.9	-2.5	2.3	-3.0	-0.3	-3.2	-3.1	-1.3
Heel T-Score	0.2	1.8	4.9	-0.9	-2.2	-1.3	-1.1	-1.1	0.9	-1.1	1.8	-1.2	-1.2	-1.3
BMI	0.1	0.5	4.9	0.4	0.3	0.3	0.2	0.4	-0.2	0.2	2.2	0.5	0.4	-0.2
Height	1.0	19.5	27.4	-4.5	-4.4	-4.0	-4.2	-4.8	4.8	-5.1	-2.8	-5.2	-5.1	-2.9
Waist Hip Ratio (WHR)	0.9	4.1	5.1	2.2	2.3	1.9	2.1	2.2	-1.9	2.2	1.7	2.0	1.6	2.2
Systolic Blood Pressure	0.1	0.7	2.0	-0.3	-1.1	-0.7	-0.5	-0.4	0.4	-0.5	-1.3	-0.7	-1.1	1.4
Smoking Status	0.2	0.4	1.0	0.4	1.0	0.6	0.5	0.5	-0.7	0.7	0.9	0.5	0.4	0.5
Allergy or Eczema	2.6	6.9	9.7	-2.5	-2.7	-2.6	-2.6	-2.9	2.6	-3.1	-2.1	-2.6	-2.5	-2.4
Cardiovascular Disease	0.3	0.9	6.8	-0.5	-0.7	-0.5	-0.5	-0.5	0.7	-0.8	2.6	-0.6	-0.8	-0.2
Hypothyroidism (self reported)	0.2	0.4	1.3	0.7	-0.2	0.5	0.6	0.6	-0.2	0.3	0.9	0.2	-0.3	1.1
Respiratory disease	1.2	2.7	4.3	-1.7	-1.4	-2.1	-1.9	-1.7	1.8	-2.0	-1.5	-1.5	-1.3	-1.1
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.7	1.6	1.3	1.5	1.6	1.4	-1.4	1.0	1.9	1.0	1.4	0.5
Lung FEV1/FVC ratio	0.0	0.2	0.6	0.4	-0.8	0.2	0.4	0.1	-0.4	0.3	0.2	-0.3	-0.6	-0.1
Lung FVC	2.1	10.6	15.6	-3.7	-3.1	-3.2	-3.5	-3.5	4.0	-3.1	-2.5	-3.1	-2.5	-3.2
Neuroticism	0.1	0.3	0.5	-0.5	-0.6	-0.5	-0.5	-0.5	0.6	-0.7	-0.4	-0.5	-0.4	-0.7
Chronotype (morning person)	0.0	0.1	0.3	0.2	-0.4	-0.0	0.1	0.1	-0.4	-0.0	0.5	0.1	-0.0	-0.5
Hair Pigment	0.2	5.5	47.2	-1.6	-1.1	-1.5	-1.5	-1.0	1.5	-0.4	6.9	-0.4	0.0	-1.1
Tanning	0.0	0.5	1.3	-0.3	-0.6	-0.3	-0.2	-0.7	0.4	-1.0	1.1	-1.1	-0.8	-0.2
Hand grip strength (left)	0.1	0.3	1.3	-0.0	-0.3	-0.1	-0.1	0.2	0.3	0.3	-1.1	0.3	0.1	1.1
Number of treatments/medications taken	1.8	3.2	6.5	-1.6	-2.5	-1.6	-1.6	-1.8	2.0	-2.2	0.2	-1.8	-1.9	-1.5
Average weekly spirits intake	0.2	0.2	1.5	0.3	0.3	0.0	0.2	0.1	-0.1	-0.1	-1.2	-0.2	-0.2	0.6
Sensitivity / hurt feelings	0.8	1.3	2.4	1.1	1.0	1.6	1.3	1.1	-1.3	1.1	-1.0	1.2	1.2	-0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	1.1	-0.3	-0.3	-0.5	-0.5	0.0	0.2	0.3	-1.1	0.4	0.2	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.7	-0.6	-0.5	-0.6	-0.6	0.5	-0.4	-0.1	-0.4	-0.6	-0.8
Relative age of first facial hair	0.2	0.4	1.1	-0.5	-0.8	-0.7	-0.6	-0.5	0.6	-0.3	-0.3	-0.3	-0.4	-1.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.1	-0.7	-0.7	-0.8	-0.6	-0.9	0.8	-1.4	-1.2	-1.3	-1.0	-1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.0	0.6	-0.2	0.5	0.6	0.3	-0.2	0.0	-1.0	-0.0	-0.2	0.2
Ever had hysterectomy (womb removed)	2.8	3.2	4.6	1.7	1.9	1.6	1.7	1.9	-1.9	2.1	1.4	2.0	2.0	1.1
Systolic blood pressure, automated reading	0.1	0.3	1.8	0.2	-0.1	-0.3	-0.1	0.2	-0.3	-0.1	-1.3	-0.1	-0.4	0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	-0.5	-0.6	-0.5	-0.5	-0.5	0.4	-0.8	0.6	-0.6	-0.1	-1.0
Angina	0.1	0.1	0.4	0.5	0.3	0.6	0.7	0.4	-0.2	0.1	0.2	-0.1	0.2	-0.0
Medication for hormone replacement therapy	0.9	1.0	2.1	-0.8	-0.9	-0.9	-0.8	-0.9	1.1	-1.2	-1.4	-0.9	-0.8	-0.8
Vitamin and mineral supplements	0.3	0.4	0.9	-0.9	-0.4	-0.6	-0.6	-0.7	0.7	-0.4	0.6	-0.6	-0.3	-0.9
Supplements: Zinc	0.6	0.7	5.4	-0.4	-0.5	-0.3	-0.4	-0.5	0.4	-0.6	-2.3	-0.3	-0.5	-0.5
Medication: Co-codamol	3.0	3.5	6.2	-1.9	-2.2	-1.6	-1.7	-2.0	1.7	-2.1	0.4	-1.8	-1.7	-2.5
Medication: Metformin	0.9	1.2	2.5	1.5	0.5	1.3	1.6	1.3	-0.9	0.8	0.8	0.8	1.1	0.9
Diabetes (father)	1.2	1.4	2.8	-1.2	-0.2	-1.0	-1.1	-1.4	1.1	-1.7	1.2	-1.5	-1.3	-0.8
Diabetes (mother)	0.5	0.6	1.8	-0.3	-1.1	-0.1	-0.2	-0.7	1.0	-1.0	0.8	-0.9	-1.3	-0.4
Severe depression (siblings)	0.1	0.1	0.5	-0.1	-0.4	-0.0	-0.1	0.0	0.1	-0.1	0.7	0.3	0.4	-0.7
Pack years adult smoking proportion	2.7	4.0	8.3	1.7	2.0	1.7	1.7	2.2	-1.9	2.5	-0.6	2.8	2.9	0.5
Impedance of leg (right)	1.1	5.4	7.0	-2.3	-2.5	-2.4	-2.3	-2.5	2.3	-2.3	-2.4	-2.6	-2.6	-1.4
Leg fat-free mass (left)	0.1	0.6	6.4	0.1	0.3	0.5	0.3	0.1	-0.1	-0.1	2.5	0.2	0.1	-0.1
Trunk fat percentage	0.4	1.5	2.6	-1.0	-1.0	-0.9	-0.9	-1.3	1.1	-1.6	1.3	-1.5	-1.4	-1.1
Hand grip strength (right)	0.1	0.2	1.3	-0.3	-0.4	-0.1	-0.3	0.0	0.3	0.5	-1.1	0.3	0.2	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.7	0.3	0.3	0.2	0.3	0.2	-0.1	0.1	0.8	0.0	-0.1	0.7
Current tobacco smoking	1.0	1.6	2.8	1.2	1.7	1.6	1.4	1.3	-1.5	1.2	0.1	1.1	1.2	1.1
Average weekly fortified wine intake	0.2	0.2	1.3	-0.2	-0.2	-0.3	-0.2	-0.4	-0.0	-0.5	-1.1	-0.4	-0.3	-0.4
Maternal smoking around birth	4.2	6.1	8.6	-2.6	-2.0	-2.8	-2.7	-2.8	2.4	-2.6	1.1	-2.9	-2.9	-1.7
Fed-up feelings	1.0	1.9	3.2	1.3	1.3	1.3	1.2	1.5	-1.4	1.7	1.0	1.7	1.8	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.7	0.2	-0.1	0.3	0.7	-0.2	0.8	-0.1	0.6	0.6	0.3
Relative age voice broke	2.0	3.0	5.9	-2.3	-1.5	-1.8	-2.1	-1.9	1.6	-1.3	-1.4	-1.2	-0.9	-2.4
Taking other prescription medications	1.4	2.1	3.6	-1.2	-1.9	-1.1	-1.1	-1.3	1.5	-1.7	-1.7	-1.4	-1.3	-1.7
Age when periods started (menarche)	1.5	3.7	6.2	-1.8	-2.1	-2.0	-1.8	-2.0	2.5	-2.1	0.5	-2.3	-2.0	-1.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.2	-0.1	-0.6	-0.4	-0.3	0.4	-0.5	-0.2	-0.4	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	3.8	-1.6	-2.0	-1.5	-1.6	-1.7	1.6	-1.7	1.1	-1.5	-1.5	-1.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.4	-0.7	0.1	-0.1	-0.3	0.3	-0.2	0.0	-0.2	-0.2	-0.6
Qualifications: CSEs or equivalent	1.9	2.6	3.7	-1.7	-1.9	-1.9	-1.8	-1.7	1.6	-1.4	1.4	-1.5	-1.7	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.7	0.2	0.4	0.7	0.4	-0.8	0.2	-0.7	-0.1	-0.1	0.7
High blood pressure	0.1	0.4	2.4	-0.4	-0.2	-0.4	-0.4	-0.3	0.3	-0.3	1.6	-0.1	-0.2	-0.8
Hayfever, allergic rhinitis or eczema	2.3	5.1	7.4	-2.2	-2.3	-2.3	-2.3	-2.5	2.6	-2.7	-0.9	-2.2	-2.0	-2.3
Multivitamins +/- minerals	0.4	0.5	1.0	-0.5	-0.9	-0.5	-0.6	-0.6	0.7	-0.6	-1.0	-0.5	-0.9	0.3
Stomach or abdominal pain in last month	5.8	7.2	10.3	-2.9	-3.2	-2.8	-2.8	-2.8	3.0	-2.8	-1.6	-2.5	-2.0	-2.9
Supplements: Glucosamine	0.2	0.3	2.3	-0.2	0.6	-0.1	-0.2	-0.2	-0.1	-0.1	-1.5	-0.1	-0.3	-0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.7	0.2	0.6	0.3	0.2	0.4	-0.8	0.6	-1.6	0.5	0.9	-0.3
Medication: Atenolol	0.2	0.2	0.7	-0.2	-0.8	-0.3	-0.2	-0.4	-0.0	-0.5	-0.3	-0.7	-0.7	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.5	0.3	-0.1	0.2	0.3	0.3	-0.0	0.3	0.7	0.3	-0.1	0.6
Sitting height	0.2	1.4	2.5	-1.2	-0.9	-1.0	-1.1	-1.2	1.5	-1.4	-0.6	-1.4	-1.6	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.3	-0.4	-0.5	-0.4	-0.4	0.1	-0.1	0.7	-0.6	-0.5	-0.1
High blood pressure (mother)	2.2	3.0	6.6	-1.4	-2.3	-1.6	-1.5	-1.8	1.7	-2.0	-0.7	-2.0	-2.6	-0.8
Body mass index (BMI)	0.4	1.6	6.5	1.1	1.1	1.2	1.2	1.1	-1.1	0.9	2.5	1.1	1.0	0.3
Impedance of leg (left)	1.7	8.3	11.4	-2.9	-3.1	-3.0	-2.9	-3.1	3.0	-3.0	-2.1	-3.4	-3.2	-1.7
Leg predicted mass (left)	0.1	0.6	6.1	0.1	0.2	0.4	0.2	0.1	-0.0	-0.1	2.5	0.2	0.1	-0.2
Trunk fat mass	0.2	1.0	3.5	-0.7	-0.6	-0.5	-0.6	-1.0	0.8	-1.2	1.9	-1.1	-1.0	-0.9
Waist circumference	0.5	1.9	9.9	1.1	1.4	1.1	1.1	1.1	-1.2	0.9	3.1	1.1	0.9	0.5
Number of incorrect matches in round	1.0	1.7	2.8	1.1	1.2	1.3	1.2	1.3	-1.2	1.3	-1.0	1.3	1.7	1.4
Past tobacco smoking	0.7	1.4	2.1	-1.2	-1.4	-1.2	-1.2	-1.1	0.9	-1.2	-1.2	-1.1	-1.1	-1.1
Alcohol usually taken with meals	1.6	2.6	3.5	1.6	1.5	1.6	1.6	1.6	-1.7	1.4	-1.9	1.6	1.3	1.7
Nervous feelings	1.7	3.2	4.1	-1.7	-1.5	-1.9	-1.7	-1.8	1.5	-2.0	-1.7	-2.0	-1.8	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.7	-0.9	-1.1	-0.8	-0.9	-1.0	0.9	-0.9	0.8	-0.9	-1.3	-0.5
Hearing difficulty/problems with background noise	0.3	0.5	1.4	-0.8	-1.2	-0.5	-0.7	-0.8	0.7	-0.4	0.1	-0.6	-1.1	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.3	0.3	0.3	0.4	0.1	-0.1	-0.3	-0.4	-0.0	0.2	0.2
Had menopause	1.5	1.8	4.0	1.5	1.8	1.4	1.6	1.1	-2.0	0.8	-1.0	0.5	0.2	1.8
Had other major operations	0.3	0.3	1.7	-0.5	0.7	-0.6	-0.5	-0.6	0.3	-0.4	0.1	-0.4	-0.3	-1.3
Forced vital capacity (FVC)	1.3	5.2	7.6	-2.6	-2.7	-2.2	-2.5	-2.5	2.8	-2.2	-1.0	-2.2	-1.9	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	4.7	-1.8	-2.2	-1.7	-1.8	-2.0	1.8	-2.1	1.9	-2.1	-1.9	-1.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.9	0.9	0.9	0.9	0.5	-0.9	0.4	-0.2	-0.1	-0.4	0.9
Qualifications: None of the above	0.1	0.2	0.8	-0.1	0.4	0.0	-0.1	0.2	-0.6	0.4	0.3	0.6	0.7	-0.9
Financial difficulties in last 2 years	0.5	0.7	1.1	0.9	0.6	1.1	1.0	0.8	-0.8	0.8	1.1	0.8	0.8	0.4
Mouth/teeth dental problems	0.4	0.6	1.8	0.8	0.9	0.7	0.8	0.7	-1.1	0.5	-1.3	0.5	0.6	0.4
Heart attack	0.4	0.6	1.5	0.9	0.3	0.9	1.0	0.7	-0.6	0.5	-1.0	0.2	0.1	1.2
Allergy	2.4	5.5	8.4	2.4	2.3	2.6	2.5	2.6	-2.6	2.9	1.3	2.4	2.2	1.7
Pain all over the body in last month	5.1	5.4	7.8	-2.8	-1.9	-2.7	-2.8	-2.6	2.5	-2.4	-0.9	-2.2	-2.0	-2.3
Diabetes (self-reported)	1.6	2.5	4.9	1.8	1.2	1.8	1.9	1.6	-1.4	1.1	2.2	1.2	1.4	0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.3	-0.5	-0.8	-0.7	-0.5	-0.7	0.6	-0.9	1.5	-0.8	-0.4	-1.3
Medication: Ramipril	0.3	0.4	1.1	-0.0	-0.8	-0.1	0.0	-0.3	0.8	-0.4	-1.1	-0.9	-0.9	-0.0
Medication: Simvastatin	0.1	0.1	1.1	0.3	-0.3	0.2	0.3	0.2	-0.0	-0.1	1.0	0.1	0.1	0.3
Fluid intelligence score	1.0	2.0	3.4	-1.3	-1.7	-1.2	-1.3	-1.6	1.5	-1.6	-0.5	-1.8	-1.8	-0.5
Illnesses of siblings	0.5	0.7	1.8	0.8	0.6	0.8	0.8	1.0	-0.9	0.9	0.3	1.1	1.4	0.1
Neuroticism score	0.0	0.1	0.8	-0.0	0.1	0.0	0.0	0.0	-0.2	0.1	-0.1	0.2	0.4	-0.9
Weight	0.1	0.6	5.7	0.2	0.4	0.4	0.3	0.1	-0.2	-0.2	2.4	0.0	-0.1	-0.1
Impedance of arm (right)	0.9	4.4	6.3	-2.0	-2.4	-1.9	-1.9	-2.2	2.0	-2.3	-2.5	-2.2	-2.2	-1.3
Arm fat percentage (right)	0.1	0.4	3.5	0.3	0.2	0.5	0.4	0.1	-0.2	-0.1	1.9	0.1	0.0	-0.2
Trunk fat-free mass	0.2	1.0	5.9	0.7	0.8	1.1	1.0	0.7	-0.7	0.6	2.4	0.7	0.5	0.5
Hip circumference	0.3	1.1	7.2	-0.8	-0.1	-0.5	-0.7	-0.8	0.5	-0.9	2.7	-0.6	-0.5	-1.4
Time employed in main current job	2.9	3.3	5.0	-2.0	-1.0	-1.9	-1.9	-2.1	1.6	-2.1	-0.6	-2.1	-1.7	-2.2
Alcohol intake versus 10 years previously	0.3	0.5	1.5	-0.5	-0.6	-0.2	-0.3	-0.7	0.6	-0.8	-0.3	-1.0	-1.2	-0.2
Father’s age at death	0.3	0.5	1.6	0.6	0.4	0.6	0.6	0.7	-0.5	0.7	-1.2	0.7	0.6	0.5
Worrier / anxious feelings	0.5	0.9	2.2	1.1	0.4	1.5	1.4	0.9	-0.8	0.6	-1.2	0.7	0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.2	-0.8	-0.4	-0.4	-0.1	0.7	-0.1	0.1	0.0	-0.1	-0.3
Falls in the last year	1.9	2.6	3.7	1.6	1.9	1.6	1.6	1.7	-1.7	1.7	0.0	1.8	1.6	1.4
Hair/balding pattern: Pattern 3	2.1	3.2	5.2	1.7	1.6	1.7	1.6	1.9	-2.0	2.3	0.7	2.2	1.5	1.8
Number of live births	0.7	1.1	1.8	-1.3	-1.2	-1.3	-1.3	-1.0	1.1	-0.8	0.6	-0.9	-0.9	-0.4
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	6.5	-2.3	-2.6	-2.0	-2.2	-2.2	2.4	-2.0	-0.3	-2.0	-1.9	-1.7
Pulse rate	0.1	0.2	0.9	-0.2	-0.9	-0.5	-0.4	-0.1	0.6	-0.4	-0.5	-0.3	-0.5	0.5
Happiness	0.3	0.4	1.3	0.8	0.0	0.7	0.8	0.3	-0.2	0.2	0.2	-0.3	-0.6	1.1
Noisy workplace	1.7	2.1	3.4	-1.6	-1.8	-1.7	-1.6	-1.4	1.3	-1.5	0.6	-1.4	-1.2	-1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.2	3.0	0.9	1.7	1.3	1.1	1.1	-0.8	1.1	-0.2	1.1	1.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	-0.4	-1.0	-0.3	-0.3	-0.4	0.5	-0.1	0.3	-0.3	-0.4	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	-1.0	-0.7	-0.5	-0.8	-0.8	1.0	-0.5	0.4	-0.4	-0.6	-0.5
Asthma	0.4	0.9	1.5	-0.5	-0.8	-1.2	-0.9	-0.7	1.0	-1.2	-1.1	-1.0	-1.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.2	0.4	0.1	0.4	0.4	0.2	-0.6	0.3	-1.1	0.2	-0.1	0.6
Medication: Cholesterol lowering	0.2	0.4	0.8	-0.4	-0.7	-0.5	-0.3	-0.6	0.9	-0.8	0.4	-0.9	-0.7	-0.1
Depression (self-reported)	0.3	0.4	1.0	0.7	0.6	0.8	0.7	0.6	-0.4	0.4	-1.0	0.5	0.2	0.6
Medication: Lansoprazole	0.6	0.6	1.2	-0.6	-0.9	-0.7	-0.7	-0.8	0.7	-0.9	-1.1	-0.8	-0.7	-0.9
Prospective memory result	0.2	0.2	0.5	-0.3	-0.7	-0.7	-0.5	-0.2	0.1	-0.1	-0.7	-0.3	-0.5	-0.7
Lung cancer (father)	3.4	4.0	5.1	-2.1	-2.2	-2.2	-2.1	-2.2	2.0	-2.2	1.0	-2.3	-2.0	-1.1
Illnesses of mother	1.9	2.4	5.5	1.0	2.2	1.1	1.1	1.6	-1.5	2.0	0.4	1.8	2.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	8.3	-2.7	-2.4	-2.6	-2.7	-2.8	2.9	-2.7	0.2	-2.7	-2.6	-1.8
Pulse wave Arterial Stiffness index	1.1	1.3	2.8	-1.0	-1.6	-1.0	-1.0	-1.1	0.9	-1.0	-0.4	-1.3	-1.7	-1.0
Impedance of arm (left)	1.0	4.8	7.0	-2.2	-2.4	-2.2	-2.2	-2.3	2.0	-2.3	-2.6	-2.2	-2.0	-1.5
Arm fat mass (right)	0.1	0.6	6.0	0.1	0.1	0.3	0.2	-0.1	-0.1	-0.3	2.5	-0.1	-0.2	-0.4
Trunk predicted mass	0.2	1.2	6.1	0.8	0.9	1.2	1.1	0.8	-0.8	0.7	2.5	0.7	0.6	0.6
Standing height	0.4	4.1	6.0	-2.2	-1.9	-1.9	-2.0	-2.3	2.1	-2.5	-0.2	-2.3	-2.4	-1.1
Length of working week for main job	1.1	1.2	7.6	0.9	0.4	0.8	0.9	0.9	-0.6	0.9	2.8	0.7	0.6	0.6
Exposure to tobacco smoke at home	2.7	3.1	4.1	-1.8	-1.6	-1.7	-1.8	-1.9	1.6	-2.0	1.8	-1.8	-1.8	-1.2
Breastfed as a baby	1.5	1.8	2.9	1.5	1.7	1.7	1.6	1.3	-1.4	0.9	1.1	1.2	1.0	1.1
Tense / ‘highly strung’	2.1	3.5	5.3	-1.9	-2.1	-2.0	-1.9	-2.0	1.7	-2.3	0.1	-2.0	-1.8	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.8	0.2	-0.5	0.3	0.2	0.2	0.1	0.2	-0.9	0.5	0.1	0.0
Hair/balding pattern: Pattern 4	4.6	11.1	36.8	-2.8	-2.6	-2.8	-2.7	-3.1	3.4	-3.1	6.1	-3.5	-2.8	-2.3
Birth weight of first child	1.5	2.7	4.8	1.6	2.2	1.5	1.6	1.8	-1.8	1.8	0.7	1.8	1.8	0.9
Peak expiratory flow (PEF)	1.8	4.2	5.8	-2.3	-2.4	-2.1	-2.2	-2.3	2.3	-2.1	0.2	-2.0	-1.9	-1.7
Pulse wave reflection index	0.1	0.1	0.4	0.2	0.1	0.5	0.4	-0.0	-0.4	0.2	-0.3	-0.2	-0.3	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.5	-0.9	-0.2	-0.4	-0.4	0.6	-0.4	0.3	-0.3	-0.5	-0.2
Loud music exposure frequency	4.5	4.9	8.9	-2.0	-2.5	-2.2	-2.1	-2.3	2.5	-2.5	1.1	-2.5	-3.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.7	1.2	1.9	1.5	1.4	1.1	-1.0	1.1	-0.7	0.9	0.9	1.0
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	2.2	1.3	1.5	1.3	1.3	1.3	-1.3	1.5	0.8	1.4	1.4	0.9
Blood clot in the leg (DVT)	0.1	0.2	1.2	0.1	0.5	-0.0	0.1	0.2	-0.3	0.1	-1.1	0.2	0.5	-0.2
Medication: Paracetamol	4.9	8.2	14.7	-3.0	-3.8	-2.9	-3.0	-2.9	3.1	-3.0	-0.4	-2.5	-2.6	-3.0
Headache pain in last month	2.7	4.7	7.1	-2.2	-2.7	-2.5	-2.3	-2.2	2.5	-2.1	0.7	-2.2	-2.2	-1.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	1.0	-0.0	-0.2	-0.1	-0.2	-0.1	-0.1	0.1	-1.0	0.1	-0.2	-0.0
Glaucoma (self-reported)	0.1	0.2	0.8	-0.2	0.5	-0.3	-0.3	-0.2	0.1	-0.1	0.9	-0.0	0.2	-0.7
Gout (self-reported)	1.0	1.4	2.7	1.2	1.1	0.9	1.0	1.4	-1.1	1.6	0.2	1.4	1.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.0	1.3	0.5	1.1	1.3	1.2	-1.0	1.0	0.8	0.8	0.5	1.4
Medication: Amlodipine	0.3	0.5	2.2	0.9	0.6	0.5	0.7	0.6	-0.7	0.1	0.3	0.2	-0.3	1.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	0.9	-0.9	-0.9	-1.0	-0.9	-0.8	0.8	-0.8	0.9	-0.6	-0.5	-0.6
Birth weight	3.8	8.2	12.2	2.6	3.5	2.8	2.7	3.0	-3.0	3.2	1.1	3.2	3.2	2.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.6	-0.3	-0.2	-0.3	-0.7	0.2	-0.7	-0.4	-0.9	-0.7	-0.3
High blood pressure (siblings)	0.1	0.2	0.9	0.2	0.4	-0.1	0.1	0.0	-0.2	0.1	1.0	-0.2	-0.3	0.7
Forced vital capacity (FVC), Best measure	2.2	8.2	11.8	-3.3	-2.8	-3.0	-3.1	-3.3	3.4	-3.1	-0.1	-3.0	-2.8	-2.1
Body fat percentage	0.3	1.1	2.2	-0.8	-0.8	-0.7	-0.7	-1.1	0.9	-1.3	1.5	-1.3	-1.2	-1.0
Leg fat percentage (right)	0.1	0.4	1.8	-0.4	-0.4	-0.2	-0.3	-0.6	0.4	-0.7	1.3	-0.7	-0.7	-0.8
Arm fat-free mass (right)	0.2	0.9	9.1	0.2	0.6	0.5	0.3	0.2	-0.2	0.1	3.0	0.1	0.1	0.1
Exposure to tobacco smoke outside home	0.3	0.4	1.4	0.8	-0.5	0.6	0.7	0.7	-0.4	0.4	0.7	0.5	0.0	1.2
Comparative body size at age 10	5.6	15.4	20.2	4.1	3.8	4.1	4.1	4.3	-4.3	4.5	0.0	4.4	4.3	3.0
Number of full brothers	0.2	0.2	1.4	0.1	0.1	0.3	0.2	0.2	-0.3	0.2	1.2	0.4	0.5	-0.7
Worry too long after embarrassment	0.2	0.3	2.1	-0.5	-0.1	-0.0	-0.3	-0.4	0.3	-0.1	-1.4	0.0	-0.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.7	-0.7	-1.3	-0.6	-0.6	-0.8	0.8	-1.0	-0.5	-0.8	-1.2	-0.7
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	-0.4	-0.6	-0.8	-0.6	-0.3	0.5	-0.4	-0.2	-0.3	-0.4	0.1
Number of children fathered	0.6	0.6	1.1	-0.7	-0.9	-0.6	-0.6	-0.7	1.0	-0.7	-0.8	-0.7	-0.7	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	0.5	0.0	0.2	0.3	0.6	-0.6	0.9	-1.2	0.8	0.4	1.2
Age at first live birth	0.3	0.5	1.2	0.2	0.8	0.5	0.3	0.5	-0.4	0.9	-0.9	1.1	1.1	0.4
Pulse wave peak to peak time	0.7	0.8	2.0	0.7	1.4	0.8	0.7	0.9	-0.7	0.8	0.2	1.0	1.4	0.9
Health satisfaction	0.1	0.2	0.4	0.5	-0.1	0.5	0.5	0.5	0.1	0.3	0.4	0.3	0.1	0.6
Shortness of breath walking on level ground	1.0	1.2	2.4	0.9	1.0	0.8	0.8	1.2	-1.2	1.4	0.9	1.5	1.5	0.3
Qualifications: College or University degree	0.6	1.9	3.4	1.5	1.0	1.2	1.3	1.6	-1.1	1.8	-0.6	1.7	1.3	1.6
Eye problems/disorders: None of the above	0.5	0.6	3.6	0.8	0.1	0.3	0.5	0.6	-0.3	0.5	1.0	0.3	-0.6	1.9
Mouth/teeth dental problems: Loose teeth	2.2	2.6	3.7	-1.8	-1.8	-1.9	-1.9	-1.7	1.6	-1.6	1.0	-1.6	-1.5	-1.0
Emphysema/chronic bronchitis	1.6	1.8	4.0	0.8	0.8	1.0	0.8	1.4	-1.4	1.7	1.4	2.0	1.8	1.0
Medication for pain relief, constipation, heartburn	4.3	7.3	12.0	2.8	3.5	2.4	2.6	2.9	-2.9	3.0	1.1	2.8	2.6	2.6
Neck or shoulder pain in last month	2.8	3.9	6.3	-2.1	-2.0	-2.1	-2.1	-2.1	2.1	-2.2	-0.1	-1.9	-1.6	-2.5
Medication: Blood pressure	0.1	0.1	0.5	0.0	0.5	0.3	0.2	0.1	0.1	0.1	0.7	0.1	0.3	0.2
Angina (self-reported)	0.1	0.1	0.4	0.5	0.4	0.6	0.7	0.4	-0.2	0.1	0.2	-0.1	0.3	-0.1
Migraine (self-reported)	2.0	2.4	3.0	-1.5	-1.7	-1.7	-1.7	-1.6	1.5	-1.7	0.7	-1.6	-1.7	-1.4
Medication: Ibuprofen	0.4	0.5	1.2	0.9	0.7	0.8	0.8	0.7	-1.1	0.5	-0.1	0.7	0.3	0.8
Medication: Allopurinol	0.4	0.6	1.1	0.9	0.6	0.5	0.7	1.0	-0.8	1.1	-0.2	0.9	0.8	0.7
Medication: Omeprazole	1.6	2.0	2.6	-1.5	-1.5	-1.2	-1.3	-1.5	1.3	-1.5	0.9	-1.6	-1.3	-1.6
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	0.2	0.4	0.4	0.2	-0.4	-0.2	-0.2	-0.0	0.1	0.2
Mean time to correctly identify matches	0.1	0.1	0.6	0.2	0.8	0.1	0.2	0.1	-0.3	0.3	-0.6	0.2	0.3	-0.3
Heart disease (mother)	3.2	3.9	8.2	-1.4	-2.9	-1.8	-1.6	-1.9	2.1	-2.3	-0.4	-2.4	-2.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.9	1.4	1.2	1.2	1.3	1.2	-1.3	1.0	0.0	1.1	1.1	0.9
Whole body fat mass	0.2	1.0	5.3	-0.6	-0.4	-0.4	-0.5	-0.8	0.6	-1.1	2.3	-1.0	-0.9	-0.9
Leg fat mass (right)	0.2	0.7	4.8	-0.4	-0.2	-0.2	-0.3	-0.5	0.4	-0.7	2.2	-0.6	-0.6	-0.7
Arm predicted mass (right)	0.2	0.8	6.7	0.3	0.7	0.6	0.5	0.3	-0.4	0.3	2.6	0.3	0.3	0.3
Pulse rate, automated reading	0.9	3.0	4.3	-1.7	-1.5	-1.9	-1.8	-1.6	1.9	-2.1	-2.0	-1.5	-1.0	-1.8
Alcohol intake frequency.	0.4	1.0	2.2	-0.9	-1.5	-1.1	-1.1	-0.8	1.2	-0.8	-1.2	-0.6	-1.1	-0.2
Comparative height size at age 10	0.3	1.5	3.8	1.3	1.6	1.5	1.4	1.1	-1.3	0.7	-0.3	0.7	0.3	1.9
Number of full sisters	3.8	4.7	10.6	-2.5	-1.7	-2.5	-2.5	-2.3	2.0	-2.2	0.6	-1.9	-1.0	-3.3
Suffer from ‘nerves’	3.4	5.3	6.6	-2.2	-2.4	-2.6	-2.4	-2.3	2.3	-2.5	-2.1	-2.4	-2.5	-1.5
Overall health rating	3.2	6.8	10.5	-2.9	-3.0	-2.7	-2.9	-2.7	3.2	-2.4	-0.4	-2.3	-2.4	-2.7
Chest pain or discomfort	1.0	1.5	2.0	1.2	0.9	1.2	1.2	1.4	-1.1	1.4	-1.4	1.4	1.1	1.0
Had major operations	1.5	1.8	4.2	0.8	1.4	1.1	0.9	1.2	-1.2	1.3	2.0	1.8	1.7	-0.1
Age at last live birth	0.4	0.6	1.1	-1.0	-0.6	-1.0	-1.1	-0.8	1.0	-0.7	0.1	-0.4	-0.3	-0.6
Family relationship satisfaction	1.7	2.1	3.1	1.5	1.6	1.6	1.5	1.5	-1.5	1.7	-0.2	1.5	1.8	0.7
Leg pain on walking	0.5	0.6	1.5	-0.8	-0.4	-0.7	-0.8	-0.8	0.9	-0.8	-0.1	-0.8	-0.6	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.5	-1.3	-1.9	-1.5	-1.5	-1.3	1.4	-1.4	1.4	-1.2	-1.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.5	-0.3	-0.8	-0.1	-0.1	-0.5	0.5	-0.8	-0.3	-0.9	-1.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.2	0.4	0.2	0.2	0.2	-0.1	0.0	0.2	0.1	0.1	0.2
Medication: Aspirin	1.7	2.3	4.7	-1.5	-2.2	-1.2	-1.3	-1.6	1.5	-1.7	0.3	-1.8	-1.7	-1.3
Supplements: Vitamin C	1.3	1.5	2.7	1.1	1.2	1.0	1.0	1.3	-1.0	1.0	-1.7	1.6	1.6	0.3
Knee pain experienced in last month	0.1	0.2	0.4	0.6	0.5	0.6	0.7	0.4	-0.6	0.2	-0.6	0.2	0.1	0.3
Hypertension (Self-reported)	0.3	0.7	1.8	-0.8	-0.6	-0.8	-0.9	-0.8	0.7	-0.7	1.3	-0.5	-0.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	2.9	-1.7	-1.0	-1.3	-1.6	-1.4	1.4	-1.4	1.2	-0.6	-0.7	-1.7
Illnesses of father: Heart disease	1.1	1.6	3.4	-1.0	-1.8	-1.1	-1.1	-1.2	1.3	-1.3	-0.6	-1.5	-1.8	0.3
Illnesses of siblings: Diabetes	0.8	0.9	1.9	-0.9	-0.9	-0.6	-0.8	-1.1	1.3	-1.3	0.2	-1.1	-1.4	-0.3
Smoking status: Previous	0.3	0.4	2.0	0.6	0.7	0.5	0.6	0.5	-0.1	0.4	1.4	0.4	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	8.5	-2.8	-2.3	-2.3	-2.6	-2.4	2.9	-2.3	-0.2	-2.1	-2.2	-1.1
Whole body fat-free mass	0.1	0.8	7.3	0.4	0.4	0.7	0.6	0.3	-0.3	0.2	2.7	0.3	0.2	0.2
Leg fat-free mass (right)	0.1	0.6	6.1	-0.2	-0.1	0.1	-0.1	-0.2	0.3	-0.4	2.5	-0.1	-0.2	-0.3
Arm fat percentage (left)	0.1	0.3	3.4	0.1	0.1	0.2	0.1	-0.0	-0.1	-0.2	1.8	0.0	0.1	-0.5
Average weekly red wine intake	2.0	3.0	5.1	1.6	1.6	1.6	1.5	1.9	-1.9	2.2	-0.0	2.3	2.3	0.9
Handedness (chirality/laterality): Left-handed	2.4	2.9	4.8	2.0	1.4	1.5	1.8	1.9	-1.8	1.8	0.2	1.8	1.6	2.2
Mood swings	0.2	0.3	2.7	0.5	0.2	0.1	0.3	0.3	-0.5	0.3	1.7	0.1	-0.1	0.5
Loneliness, isolation	0.4	0.6	2.0	0.5	0.6	0.2	0.3	0.8	-0.8	1.1	-0.2	1.3	1.4	-0.0
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.3	-0.8	-0.3	-0.3	-0.3	0.3	-0.6	-0.3	-0.4	-0.4	-0.4
Ever had bowel cancer screening	0.1	0.1	0.5	0.1	0.2	0.2	0.1	0.1	-0.1	0.1	-0.4	0.3	0.1	-0.7
Diabetes diagnosed by doctor	0.6	1.1	3.0	1.2	0.8	1.1	1.2	1.0	-1.0	0.6	1.7	0.8	1.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.7	0.4	0.7	0.4	0.3	0.9	-0.1	1.1	0.7	1.4	1.6	-0.2
Friendships satisfaction	1.9	2.3	4.4	1.5	1.3	1.8	1.7	1.5	-1.7	2.1	0.4	1.5	1.5	1.1
Qualifications: nursing, teaching	1.6	2.4	4.7	-1.6	-2.2	-1.5	-1.4	-1.6	1.9	-1.3	-1.4	-1.8	-1.2	-1.2
Commuting to job workplace: Walk	3.6	3.9	5.1	2.1	2.2	2.1	2.1	2.1	-2.1	2.0	-1.0	2.3	1.9	1.7
Eye problems/disorders: Cataract	1.7	2.0	4.5	-1.6	-1.1	-1.5	-1.6	-1.5	1.4	-1.4	0.1	-1.3	-1.0	-2.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.3	-0.3	-1.1	-0.6	-0.4	-0.4	0.8	-0.5	-0.1	-0.7	-0.9	0.0
Medication for cholesterol	0.1	0.1	0.4	-0.2	0.6	0.3	0.0	-0.1	-0.3	0.3	-0.5	-0.0	0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.0	-1.4	-1.1	-1.3	-1.3	-1.3	1.4	-1.2	-1.0	-1.1	-1.0	-1.2
Back pain experienced in last month	1.0	1.4	2.9	-0.9	-1.2	-1.5	-1.1	-1.1	1.2	-1.3	0.3	-1.5	-1.7	0.2
Mineral and other dietary supplements	0.4	0.5	3.7	-0.4	-0.5	-0.5	-0.4	-0.4	0.5	-0.4	1.9	-0.6	-0.2	-0.2
Breast cancer (self-reported)	0.9	1.0	2.7	1.2	1.6	0.8	1.0	1.0	-1.3	0.9	-0.5	0.8	1.0	0.3
Asthma (self-reported)	0.8	1.6	2.7	-1.0	-1.2	-1.6	-1.3	-1.2	1.5	-1.6	-0.9	-1.4	-1.4	-0.0
Osteoporosis (self-reported)	7.3	9.0	13.3	3.0	3.6	3.5	3.4	3.1	-3.3	3.3	0.0	3.0	3.4	1.3
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.5	1.0	0.6	0.5	0.3	-0.8	0.1	1.0	0.1	-0.1	0.5
Medication: Aspirin	1.2	1.6	3.1	-1.2	-1.8	-0.9	-1.1	-1.3	1.2	-1.4	0.7	-1.4	-1.2	-1.2
Medication: Gliclazide	0.2	0.2	1.3	0.2	-0.3	0.2	0.4	0.0	0.4	-0.5	1.2	-0.4	-0.2	-0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.7	0.5	1.6	1.1	0.7	0.8	-0.9	1.0	-0.7	1.3	1.7	-0.6
Smoking status: Current	0.7	1.2	2.1	0.9	1.5	1.4	1.2	1.0	-1.3	1.0	0.5	0.9	0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.9	-1.4	-1.0	-1.7	-1.6	-1.4	1.4	-1.0	-0.6	-1.1	-0.9	-1.1
Whole body water mass	0.2	0.9	7.3	0.5	0.6	0.9	0.7	0.5	-0.4	0.3	2.7	0.5	0.4	0.2
Leg predicted mass (right)	0.1	0.7	6.5	-0.3	-0.2	0.0	-0.1	-0.3	0.3	-0.5	2.5	-0.2	-0.3	-0.3
Arm fat mass (left)	0.2	0.6	6.4	0.2	0.2	0.4	0.3	0.0	-0.2	-0.2	2.5	0.0	-0.0	-0.4
Number of self-reported non-cancer illnesses	1.6	2.9	4.9	-1.5	-1.4	-1.8	-1.7	-1.8	1.8	-2.2	0.0	-1.8	-1.4	-2.2
Average weekly champagne plus white wine intake	0.9	1.3	4.1	1.2	2.0	1.0	1.2	0.9	-1.7	0.8	0.7	0.8	0.9	0.2
Miserableness	1.3	2.3	3.0	1.6	1.5	1.6	1.6	1.7	-1.5	1.7	-1.1	1.7	1.6	0.9
Guilty feelings	0.6	0.9	2.0	-1.0	-0.6	-1.2	-1.2	-0.9	1.0	-0.9	-0.7	-0.5	-0.3	-1.4
Wears glasses or contact lenses	0.5	0.5	1.1	0.8	1.0	0.8	0.7	0.7	-1.1	0.8	-0.4	0.8	0.3	0.2
Ever taken oral contraceptive pill	0.7	0.8	1.9	-0.9	-1.0	-0.9	-1.0	-0.8	0.9	-0.7	-1.4	-0.6	-0.8	-0.3
Hearing aid user	0.2	0.3	2.3	-0.3	0.2	-0.0	-0.2	-0.3	0.1	-0.3	-0.5	-0.0	0.4	-1.5
Mother’s age at death	0.3	0.3	0.9	-0.0	1.0	0.2	0.1	0.1	-0.6	0.4	0.8	0.4	0.9	-0.8
Financial situation satisfaction	0.9	1.1	2.1	1.3	1.1	1.4	1.4	0.9	-1.0	0.8	1.2	0.5	0.3	1.2
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.8	-0.5	-0.9	-0.6	-0.6	-0.4	0.6	-0.5	-1.4	-0.5	-0.4	-0.4
Commuting to job workplace: Public transport	4.3	5.2	8.1	2.4	2.0	1.7	2.1	2.5	-2.5	2.9	-1.8	2.4	2.1	2.5
Eye problems/disorders: Glaucoma	0.4	0.4	1.0	-0.5	0.1	-0.4	-0.4	-0.7	0.4	-0.9	0.9	-0.8	-0.4	-1.0
Medication: Blood pressure	0.5	0.9	1.8	-0.6	-1.2	-1.0	-0.8	-0.7	0.9	-0.9	1.4	-0.8	-0.9	-0.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.9	-1.5	-0.8	-1.1	-1.3	-1.4	1.2	-1.3	-0.2	-1.0	-1.0	-1.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.7	-1.2	-1.1	-1.1	-1.3	-1.2	1.1	-1.1	-1.1	-0.8	-1.1	-0.9
High cholesterol (Self-reported)	0.5	0.9	1.7	-0.6	-1.2	-1.3	-1.0	-0.7	1.1	-0.9	1.0	-0.8	-0.7	-0.7
Medication: Bendroflumethiazide	0.9	1.3	2.4	-1.1	-1.3	-0.7	-0.9	-1.2	1.5	-1.4	1.2	-1.1	-1.3	-0.4
Medication: Paracetamol	6.0	9.3	14.4	-3.3	-3.8	-3.2	-3.3	-3.1	3.3	-3.2	-0.3	-2.6	-2.6	-3.4
Medication: Lisinopril	0.2	0.3	1.5	-0.2	-0.4	-0.6	-0.4	0.1	0.4	0.1	1.2	0.4	0.5	-0.4
Medication: Atorvastatin	0.1	0.1	0.5	-0.0	0.3	0.0	0.1	-0.2	0.1	-0.4	0.3	-0.7	-0.2	-0.7
Illnesses of father: High blood pressure	0.3	0.4	1.7	0.6	-0.2	0.1	0.3	0.6	-0.3	0.4	1.3	0.2	0.0	1.0
Alcohol drinker status: Never	0.1	0.2	0.4	-0.2	-0.2	-0.2	-0.2	-0.5	-0.0	-0.6	-0.7	-0.5	-0.6	-0.2
Ever smoked	3.0	5.3	7.2	2.4	2.7	2.3	2.3	2.5	-2.2	2.6	0.4	2.5	2.2	2.3
Basal metabolic rate	0.1	0.7	7.6	0.1	0.2	0.4	0.3	0.0	-0.0	-0.1	2.8	0.0	-0.0	-0.1
Leg fat percentage (left)	0.2	0.7	2.8	-0.5	-0.6	-0.4	-0.4	-0.7	0.6	-0.9	1.7	-1.0	-0.9	-0.9
Arm fat-free mass (left)	0.2	0.9	8.4	0.3	0.6	0.7	0.5	0.1	-0.2	-0.1	2.9	-0.1	-0.3	0.4
Number of operations (self-reported)	0.4	0.5	1.5	0.1	1.0	0.1	0.0	0.3	-0.3	0.5	1.2	0.8	1.0	-1.1
Average weekly beer plus cider intake	2.8	4.0	5.6	-2.4	-2.2	-1.9	-2.2	-2.2	2.2	-2.3	1.2	-1.7	-1.9	-1.6
Irritability	0.1	0.1	1.3	-0.0	-0.3	0.2	0.1	-0.0	-0.2	-0.0	-1.1	-0.1	-0.3	-0.0
Risk taking	0.9	1.4	2.5	-1.1	-1.2	-1.1	-1.0	-1.2	1.4	-1.6	-0.2	-1.4	-1.1	-0.9
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.5	-1.2	-1.0	-1.5	-1.4	-1.0	1.0	-0.6	-1.6	-0.6	-0.4	-1.5
Fractured/broken bones in last 5 years	1.9	2.5	3.9	1.7	1.2	2.0	1.9	1.7	-1.8	1.6	0.6	1.7	1.6	1.1
Age started oral contraceptive pill	4.7	5.9	8.9	2.7	2.4	3.0	2.9	2.6	-2.8	2.5	0.4	2.4	2.2	1.9
Diastolic blood pressure, automated reading	0.3	1.0	1.9	-1.2	-1.0	-1.4	-1.4	-1.0	1.2	-0.9	-0.7	-0.6	-0.8	-0.5
Ever depressed for a whole week	0.2	0.3	1.8	0.5	0.0	0.0	0.3	0.3	-0.1	0.5	0.0	-0.2	-0.9	1.4
Unable to work because of sickness or disability	0.4	0.5	2.0	-0.7	-0.8	-0.5	-0.7	-0.5	0.6	-0.6	-0.3	-0.2	0.1	-1.4
Commuting to job workplace: Cycle	3.1	3.8	5.7	1.9	2.3	2.1	2.0	1.9	-2.4	2.0	0.9	2.1	2.3	0.7
Myopia	0.1	0.1	0.4	-0.2	0.0	-0.2	-0.2	-0.2	0.6	-0.1	0.3	-0.0	0.3	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	2.8	0.4	0.3	0.4	0.4	0.4	-0.4	0.4	-1.7	0.3	0.4	0.5
Cholesterol lowering medication	0.4	0.6	2.2	0.7	0.0	0.2	0.4	0.8	-0.7	0.9	1.5	1.0	0.7	0.3
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	5.1	-2.0	-1.9	-1.7	-1.7	-2.1	1.9	-2.2	1.0	-2.2	-1.7	-2.1
Pain experienced in last month	3.2	5.3	8.0	2.6	2.0	2.6	2.6	2.6	-2.3	2.6	0.2	2.3	1.8	2.8
Supplements: Calcium	1.1	1.2	2.4	1.1	1.4	1.2	1.2	0.9	-1.2	0.7	-1.5	0.7	0.7	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	-0.8	-0.7	-1.1	-1.0	-0.6	0.6	-0.3	1.4	-0.3	-0.1	-1.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	1.0	0.4	0.9	1.0	0.7	-0.7	0.6	-1.0	0.2	0.1	1.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	1.1	0.2	0.4	0.0	0.2	0.3	-0.2	0.2	-1.1	0.3	0.4	0.1
Heart disease (siblings)	0.3	0.3	1.4	-0.1	-0.5	-0.0	-0.0	-0.4	0.0	-0.4	-0.5	-0.8	-1.2	0.7
Alcohol drinker status: Previous	3.1	3.5	5.7	-1.9	-2.4	-2.1	-2.0	-1.9	2.1	-1.9	-1.1	-1.8	-2.2	-0.9
Pack years of smoking	4.3	6.4	10.6	2.4	2.6	2.3	2.3	2.9	-2.6	3.1	-0.5	3.3	3.2	1.1
Impedance of whole body	1.7	8.7	10.2	-3.0	-3.1	-3.1	-3.0	-3.1	2.9	-3.1	-2.6	-3.2	-3.1	-1.8
Leg fat mass (left)	0.2	0.8	5.9	-0.4	-0.3	-0.3	-0.3	-0.6	0.5	-0.8	2.4	-0.7	-0.8	-0.8
Arm predicted mass (left)	0.2	0.8	8.2	0.3	0.5	0.5	0.5	0.1	-0.2	-0.0	2.9	-0.1	-0.2	0.1