TWAS hub - MEF2D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1683	0.0413	8.0e-06	0.102	NA	0.087	NA	0.086	2.3e-08	NA	2.6e-07	NA	3.1e-07
2	TCGA	Brain Lower Grade Glioma	0.0373	0.0211	9.4e-04	0.034	0.019	0.010	NA	0.020	8.7e-05	0.0026	2.5e-02	NA	2.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Headache pain in last month	12.9	22.1	39.8	6.3	2.1
Medication for pain relief, constipation, heartburn	12.1	20.7	39.3	-6.3	1.4
Medication: Aspirin	11.5	15.0	21.7	4.7	-2.9
Medication: Aspirin	11.1	14.6	22.7	4.8	-2.5
Migraine (self-reported)	10.9	13.6	25.8	5.1	-1.1
Medication: Ibuprofen	7.5	8.9	16.9	4.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	6.5	8.2	16.2	4.0	-0.5
Medication: Paracetamol	6.3	10.5	20.9	4.6	-0.4
Number of treatments/medications taken	6.1	10.9	17.6	4.2	-2.1
Angina	5.3	6.9	13.6	3.7	-0.4
Waist Hip Ratio (WHR)	5.2	23.5	45.0	6.7	-1.4
Lung cancer (father)	5.2	6.1	11.0	-1.1	3.3
Pulse rate, automated reading	5.2	16.9	33.3	-5.8	-0.6
Blood Platelet Count	5.0	57.6	112.4	10.6	1.7
Medication: Cholesterol lowering	4.7	7.3	14.1	3.8	-0.7
Body Mass Index (BMI) (2010)	4.5	6.1	8.7	-3.0	1.9
Reason for reducing amount of alcohol drunk: Health precaution	4.5	5.2	7.5	1.7	-2.7
Pulse wave reflection index	4.4	5.4	6.5	-2.1	2.5
Angina (self-reported)	4.4	5.7	11.5	3.4	-0.1
Vascular/heart problems diagnosed by doctor	4.3	11.7	15.4	-3.9	2.8
High blood pressure (mother)	4.2	5.8	6.9	2.2	-2.6
Pulse wave Arterial Stiffness index	4.2	4.9	5.1	-2.3	2.2
Exposure to tobacco smoke at home	4.2	4.7	7.3	-1.4	2.7
Pulse wave peak to peak time	4.2	5.0	5.2	2.3	-2.2
High cholesterol (Self-reported)	4.1	7.2	11.3	3.4	-1.8
Number of self-reported non-cancer illnesses	3.9	6.8	11.6	3.4	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	5.0	7.7	2.8	-1.5
Medication: Simvastatin	3.6	5.4	8.9	3.0	-1.3
Illnesses of siblings	3.6	5.0	6.6	-2.6	1.8
Medication: Paracetamol	3.5	5.4	10.5	3.2	-0.6
Wears glasses or contact lenses	3.4	3.9	3.9	2.0	-2.0
Illnesses of mother	3.2	4.0	4.3	-1.9	2.1
Medication for cholesterol, blood pressure or diabetes	3.2	5.4	8.2	-2.9	1.6
Hypertension (Self-reported)	3.2	9.0	9.2	3.0	-3.0
Alcohol drinker status: Previous	3.2	3.6	7.1	2.7	-0.3
High blood pressure	3.1	8.7	10.2	3.2	-2.7
Ever depressed for a whole week	3.0	3.8	5.8	2.4	-1.3
Diabetes diagnosed by doctor	2.9	4.8	7.7	2.8	-1.4
High blood pressure (siblings)	2.8	4.0	6.2	2.5	-1.3
Depression (Nagel 2018)	2.7	4.1	6.7	2.6	-1.3
Eye problems/disorders: None of the above	2.7	3.1	6.1	-0.1	-2.5
Average weekly fortified wine intake	2.6	3.0	5.7	-2.4	0.6
Mean time to correctly identify matches	2.6	4.9	9.1	0.9	-3.0
Tinnitus: Yes, now most or all of the time	2.6	3.0	3.1	-1.8	1.7
Medication: Blood pressure	2.6	4.9	7.6	2.8	-1.5
Lung FEV1/FVC ratio	2.5	12.7	25.4	5.0	0.1
Medication: Blood pressure	2.5	4.4	5.0	2.2	-2.0
Lung FVC	2.4	12.1	21.8	-4.7	-1.6
Average weekly spirits intake	2.4	3.0	5.2	-2.3	0.9
Hand grip strength (right)	2.4	6.4	9.1	-3.0	1.9
Medication: Bendroflumethiazide	2.4	3.7	4.4	1.7	-2.1
Systolic Blood Pressure	2.3	11.7	18.9	4.3	-2.1
Townsend deprivation index at recruitment	2.1	3.0	5.2	-0.9	2.3
Commuting to job workplace: Walk	2.1	2.3	4.5	-2.1	-0.1
HbA1C	2.0	2.3	4.1	2.0	-0.7
Pain all over the body in last month	2.0	2.1	3.3	1.8	-0.9
Illnesses of siblings: Diabetes	2.0	2.4	4.0	0.9	-2.0
Eye problems/disorders: Cataract	2.0	2.3	3.5	1.1	1.9
Medication: Atorvastatin	2.0	2.5	5.0	2.2	-0.1
Pulse rate	1.9	3.3	6.5	-2.5	0.1
Alcohol intake frequency.	1.9	4.5	8.1	2.8	0.9
Smoking status: Current	1.9	3.0	5.4	-0.8	2.3
Pain experienced in last month	1.9	3.2	4.9	-2.2	-1.2
BMI	1.8	10.5	20.4	-4.5	0.8
Cardiovascular Disease	1.8	6.0	8.2	2.9	-1.9
Current tobacco smoking	1.8	3.0	5.6	-0.6	2.4
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	3.5	1.9	0.6
Diabetes (self-reported)	1.8	2.8	3.8	1.9	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	7.4	2.7	-0.4
Risk taking	1.7	2.5	3.4	-1.3	1.8
Age when periods started (menarche)	1.6	3.9	5.1	1.6	2.3
Medication: Atenolol	1.6	2.0	3.1	1.8	-1.0
Tense / ‘highly strung’	1.6	2.7	4.8	2.2	0.8
Health satisfaction	1.6	2.1	3.0	-1.7	1.0
Irritability	1.6	2.6	4.2	-1.0	2.1
Heel T-Score	1.5	12.2	17.4	4.2	-2.6
Chronic bronchitis/emphysema (father)	1.5	1.7	3.4	-1.8	0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	6.1	2.5	-1.0
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	4.0	2.0	0.1
Fluid intelligence score	1.5	3.2	4.4	-2.1	-1.4
Number of live births	1.5	2.2	3.3	1.8	-1.0
Comparative body size at age 10	1.5	4.2	8.2	-2.9	0.4
Commuting to job workplace: Public transport	1.5	1.8	2.8	-1.7	0.9
Age started oral contraceptive pill	1.5	1.8	2.5	1.6	-1.1
Reaction Time	1.4	2.7	4.5	1.0	-2.1
Hearing difficulty/problems with background noise	1.4	2.2	2.8	-1.7	1.3
Chronotype (morning person)	1.3	3.0	5.8	-2.4	0.5
Taking other prescription medications	1.3	2.0	3.3	1.8	-0.8
Medication for cholesterol	1.3	2.0	2.2	-1.5	1.3
Illnesses of father: None of the above (group 1)	1.3	1.7	3.3	-0.0	1.8
Miserableness	1.3	2.2	2.6	1.6	1.4
Hearing difficulty/problems: Yes	1.2	1.8	3.4	-1.8	0.6
Prospective memory result	1.2	1.5	3.0	0.2	1.7
Impedance of arm (left)	1.2	5.6	11.3	3.4	0.0
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.5	-1.6	-0.6
Depressed Affect (Nagel 2018)	1.1	2.3	3.7	1.9	1.0
Major Depression (MDD)	1.1	1.4	2.7	0.0	1.6
Neuroticism (2016)	1.1	1.7	1.8	-1.2	1.4
Triglycerides	1.1	1.9	3.5	-0.5	1.9
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.1	1.8	0.0
Supplements: Zinc	1.1	1.2	1.6	-1.3	0.9
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.3	1.5	-0.4
Medication: Ramipril	1.1	1.4	2.3	1.5	-0.7
Impedance of arm (right)	1.1	5.1	10.2	3.2	-0.1
Comparative height size at age 10	1.1	6.3	12.2	3.5	0.7
Overall health rating	1.1	2.4	3.8	2.0	0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.6	1.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	1.5	1.0	1.2
Back pain experienced in last month	1.1	1.5	2.0	-1.4	1.1
Financial situation satisfaction	1.1	1.4	2.4	-0.7	1.5
Blood White Count	1.0	7.5	14.3	3.8	-0.8
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	-0.0	1.6
Father’s age at death	1.0	1.3	1.6	-1.3	-1.0
Length of working week for main job	1.0	1.1	1.7	-0.6	1.3
Birth weight of first child	1.0	1.8	3.5	1.9	-0.4
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.1	-1.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.6	-0.9	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.4	1.4	1.5
Ever taken oral contraceptive pill	1.0	1.1	2.1	-1.5	0.1
Mother’s age at death	1.0	1.3	2.5	0.2	-1.6
Impedance of whole body	1.0	5.0	9.9	3.1	0.2
Height	0.9	18.3	36.5	6.0	-0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.8	1.7	-0.8
Medication: Metformin	0.9	1.3	1.6	1.0	-1.2
Pack years adult smoking proportion	0.9	1.4	2.7	0.4	1.6
Maternal smoking around birth	0.9	1.3	1.6	1.3	1.0
Body mass index (BMI)	0.9	3.7	7.5	-2.7	0.1
Supplements: Vitamin C	0.9	1.1	1.8	1.3	-0.7
Alcohol drinker status: Never	0.9	1.0	1.1	1.0	1.1
Number of operations (self-reported)	0.9	1.3	1.4	1.2	1.1
Cholesterol lowering medication	0.9	1.3	2.3	1.5	-0.4
Alzheimer’s Disease (in mother)	0.8	0.9	1.8	1.4	-0.2
Ulcerative Colitis	0.8	1.1	1.8	0.6	-1.3
Hand grip strength (left)	0.8	2.0	4.0	-2.0	0.3
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	1.3	-0.3
Time employed in main current job	0.8	0.9	1.6	0.3	-1.3
Alcohol intake versus 10 years previously	0.8	1.2	2.1	0.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.5	1.6	0.1
Glaucoma (self-reported)	0.8	1.0	1.9	1.4	-0.3
Leg pain on walking	0.8	1.0	1.0	1.0	1.0
Loneliness, isolation	0.8	1.1	1.9	1.4	0.6
Ever had bowel cancer screening	0.8	0.9	1.1	-0.8	-1.1
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.8	-1.9	-0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.7	-1.6	-0.7
Age at First Birth	0.7	1.0	2.0	-0.4	-1.4
Fasting Glucose	0.7	0.9	1.6	0.3	1.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.7	0.1	-1.3
Impedance of leg (left)	0.7	3.6	7.2	2.7	-0.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.6	-1.3	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-1.3	0.1
Number of full sisters	0.7	0.8	1.5	1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.0	-1.0	0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	-0.2	1.3
Mood swings	0.7	1.2	2.1	0.6	1.4
Osteoporosis (self-reported)	0.7	0.8	1.7	-0.0	1.3
Arm fat-free mass (left)	0.7	3.4	4.0	-1.7	2.0
Heart disease (siblings)	0.7	0.9	1.0	0.9	-1.0
Pack years of smoking	0.7	1.1	1.9	0.5	1.4
Arm predicted mass (left)	0.7	3.4	4.0	-1.7	2.0
Bipolar Disorder or Schizophrenia	0.6	1.4	2.1	1.5	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.9	0.9	0.9	-0.9
Prostate Cancer	0.6	0.9	1.7	1.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	0.5	1.0
Blood Red Count	0.6	5.6	8.8	-3.0	1.5
Impedance of leg (right)	0.6	3.1	6.2	2.5	-0.1
Leg fat-free mass (left)	0.6	3.1	3.8	-1.6	1.9
Leg predicted mass (left)	0.6	3.3	4.0	-1.6	2.0
Number of incorrect matches in round	0.6	1.0	1.5	-1.2	-0.8
Hair/balding pattern: Pattern 3	0.6	0.9	1.4	0.7	-1.2
Medication: Lansoprazole	0.6	0.7	1.3	0.3	1.1
Neck or shoulder pain in last month	0.6	0.9	1.8	0.3	1.3
Leg fat-free mass (right)	0.6	3.0	3.9	-1.4	2.0
Leg predicted mass (right)	0.6	3.3	4.3	-1.5	2.1
Guilty feelings	0.6	1.0	1.1	1.0	-0.9
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	0.5	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.4	1.2	-0.2
Neuroticism (Nagel 2018)	0.5	1.1	2.1	1.4	0.3
HDL Cholesterol	0.5	0.9	1.2	-0.7	-1.1
Rheumatoid Arthritis	0.5	0.7	1.1	-0.5	1.1
Allergy or Eczema	0.5	1.3	2.2	0.7	-1.5
Systolic blood pressure, automated reading	0.5	1.4	2.0	0.9	-1.4
Multivitamins +/- minerals	0.5	0.7	1.4	-1.2	-0.0
Sitting height	0.5	3.8	7.5	2.7	-0.0
Heart attack	0.5	0.7	1.0	1.0	-0.6
Hip circumference	0.5	2.2	3.0	-1.7	1.2
Standing height	0.5	4.6	7.0	2.6	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.1	0.7	1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.0	1.0	0.7
Leg fat percentage (right)	0.5	1.7	3.3	-1.8	-0.2
Exposure to tobacco smoke outside home	0.5	0.7	1.0	0.7	1.0
Number of full brothers	0.5	0.6	1.1	-1.1	0.3
Arm predicted mass (right)	0.5	2.7	3.3	-1.5	1.8
Suffer from ‘nerves’	0.5	0.8	1.4	0.4	1.2
Age at last live birth	0.5	0.8	1.4	1.2	-0.4
Illnesses of father: Heart disease	0.5	0.6	1.3	0.0	-1.1
Whole body fat-free mass	0.5	2.6	2.9	-1.5	1.7
Qualifications: nursing, teaching	0.5	0.8	1.5	-0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.0	-0.2	-1.4
Basal metabolic rate	0.5	2.8	3.2	-1.6	1.8
Bipolar Disorder (2018)	0.4	0.7	0.8	0.9	-0.7
Schizophrenia (2018)	0.4	0.8	1.4	1.2	-0.5
Ulcerative Colitis (UC)	0.4	0.7	1.3	0.1	-1.2
Breast Cancer	0.4	1.1	2.0	-1.4	0.3
Primary Biliary Cirrhosis	0.4	0.6	1.0	0.5	1.0
Medication for hormone replacement therapy	0.4	0.5	0.6	0.8	0.6
Medication: Co-codamol	0.4	0.5	0.8	0.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	0.8	0.8	-0.9
Financial difficulties in last 2 years	0.4	0.5	0.9	0.9	0.4
Mouth/teeth dental problems	0.4	0.6	1.0	-0.5	-1.0
Worrier / anxious feelings	0.4	0.7	1.5	1.2	-0.1
Arm fat mass (right)	0.4	1.8	3.5	-1.9	0.4
Blood clot in the leg (DVT)	0.4	0.5	0.9	1.0	-0.4
Arm fat-free mass (right)	0.4	2.0	2.4	-1.3	1.6
Emphysema/chronic bronchitis	0.4	0.5	0.5	-0.6	-0.7
Medication: Allopurinol	0.4	0.5	0.5	-0.7	0.7
Leg fat mass (right)	0.4	1.5	3.0	-1.7	0.3
Knee pain experienced in last month	0.4	0.6	1.0	-1.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	-0.1	0.9
Asthma (self-reported)	0.4	0.7	1.4	-0.1	-1.2
Whole body water mass	0.4	2.5	2.6	-1.5	1.6
Arm fat mass (left)	0.4	1.5	2.8	-1.7	0.5
Hearing aid user	0.4	0.4	0.6	-0.8	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-1.0	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.7	0.7	-0.8
Illnesses of father: High blood pressure	0.4	0.5	1.0	1.0	0.2
Commuting to job workplace: Cycle	0.4	0.4	0.5	0.7	-0.6
Worry (Nagel 2018)	0.3	0.7	1.2	1.1	0.4
LDL Cholesterol	0.3	0.4	0.5	0.5	0.7
Schizophrenia (2014)	0.3	0.6	1.3	1.1	-0.0
Smoking Status	0.3	0.8	1.5	-0.5	1.2
Respiratory disease	0.3	0.7	0.7	-0.9	-0.8
Neuroticism	0.3	0.6	1.3	1.1	0.1
Sensitivity / hurt feelings	0.3	0.6	0.8	0.6	-0.9
Relative age of first facial hair	0.3	0.5	1.0	0.2	-1.0
Diabetes (father)	0.3	0.4	0.6	0.8	-0.4
Fed-up feelings	0.3	0.5	0.8	0.9	0.5
Relative age voice broke	0.3	0.4	0.7	-0.2	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.5	0.9	0.4	-1.0
Stomach or abdominal pain in last month	0.3	0.4	0.4	-0.6	0.7
Nervous feelings	0.3	0.5	0.6	0.8	-0.7
Had menopause	0.3	0.4	0.7	0.4	-0.8
Had other major operations	0.3	0.3	0.4	-0.4	0.7
Qualifications: None of the above	0.3	0.6	1.2	0.2	1.1
Allergy	0.3	0.7	1.4	-0.2	1.2
Neuroticism score	0.3	0.5	0.6	0.8	0.7
Weight	0.3	1.3	2.0	-1.4	0.8
Arm fat percentage (right)	0.3	1.1	2.1	-1.5	0.1
Trunk fat-free mass	0.3	1.6	1.6	-1.3	1.2
Noisy workplace	0.3	0.3	0.6	0.8	0.1
Asthma	0.3	0.6	0.9	-0.5	-1.0
Depression (self-reported)	0.3	0.3	0.6	0.8	-0.1
Trunk predicted mass	0.3	1.8	1.8	-1.3	1.3
Breastfed as a baby	0.3	0.4	0.6	0.3	-0.8
Peak expiratory flow (PEF)	0.3	0.8	1.2	-0.6	1.1
Number of children fathered	0.3	0.3	0.6	-0.8	-0.0
Chest pain or discomfort	0.3	0.5	1.0	1.0	0.1
Had major operations	0.3	0.4	0.5	0.7	0.5
Smoking status: Previous	0.3	0.4	0.6	0.3	-0.8
Friendships satisfaction	0.3	0.4	0.8	0.9	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	1.0	-0.1
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.9	0.3
Medication: Lisinopril	0.3	0.4	0.8	0.1	-0.9
Leg fat percentage (left)	0.3	1.2	2.5	-1.6	-0.1
Unable to work because of sickness or disability	0.3	0.4	0.5	0.6	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.9	-0.3
Leg fat mass (left)	0.3	1.2	2.3	-1.5	0.4
Ovarian Cancer	0.2	0.3	0.4	0.4	-0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.6	0.1
Crohns Disease (2012)	0.2	0.3	0.4	0.3	0.7
Lupus	0.2	0.4	0.7	0.8	-0.1
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.8	-0.5
Hair Pigment	0.2	5.0	9.7	-3.1	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	-0.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.6	-0.0
Vitamin and mineral supplements	0.2	0.3	0.3	0.5	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.2	-0.7
Alcohol usually taken with meals	0.2	0.3	0.4	0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.5	-0.4	-0.7
Loud music exposure frequency	0.2	0.3	0.5	-0.7	0.2
Birth weight	0.2	0.4	0.6	0.5	0.8
Forced vital capacity (FVC), Best measure	0.2	0.6	1.0	-1.0	-0.4
Worry too long after embarrassment	0.2	0.4	0.6	0.8	-0.4
Qualifications: College or University degree	0.2	0.6	0.6	-0.8	0.7
Medication: Omeprazole	0.2	0.3	0.5	0.3	0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	-0.4
Whole body fat mass	0.2	0.8	1.4	-1.2	0.4
Arm fat percentage (left)	0.2	0.8	1.5	-1.2	0.0
Long-standing illness, disability or infirmity	0.2	0.2	0.5	0.7	0.1
Breast cancer (self-reported)	0.2	0.2	0.3	-0.4	-0.5
Medication: Gliclazide	0.2	0.3	0.4	0.6	-0.4
Average weekly beer plus cider intake	0.2	0.3	0.4	-0.4	-0.6
Myopia	0.2	0.4	0.7	-0.1	-0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.3	-0.5	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	-0.2	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.1	-0.3	-0.3
Crohns Disease (2017)	0.1	0.2	0.3	-0.3	0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.2	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	-0.5
Blood Eosinophil Count	0.1	1.1	1.3	1.2	-0.9
Tanning	0.1	1.7	2.9	1.7	0.7
Severe depression (siblings)	0.1	0.1	0.3	-0.5	0.2
Trunk fat percentage	0.1	0.2	0.3	-0.4	0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.0	0.4
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.4	0.0
Trunk fat mass	0.1	0.5	0.6	-0.7	0.6
Waist circumference	0.1	0.2	0.4	0.6	0.1
Forced vital capacity (FVC)	0.1	0.5	0.9	-0.9	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.3	-0.3
Happiness	0.1	0.2	0.3	0.6	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.3	0.1
Gout (self-reported)	0.1	0.1	0.1	-0.2	-0.3
Medication: Amlodipine	0.1	0.1	0.2	-0.5	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.1	-0.3
Body fat percentage	0.1	0.4	0.7	-0.9	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.2	0.3
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.2	0.5
Age at first live birth	0.1	0.2	0.3	-0.5	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	0.2	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.3	0.2
Heart disease (mother)	0.1	0.1	0.2	0.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.3	0.3
Mineral and other dietary supplements	0.1	0.1	0.3	-0.0	0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.2	0.3	-0.5
Ever smoked	0.1	0.1	0.2	-0.4	0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.2	0.3	0.5
Supplements: Calcium	0.1	0.1	0.2	0.1	0.4
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.0
Diabetes (mother)	0.0	0.1	0.1	-0.3	0.2
Supplements: Glucosamine	0.0	0.0	0.1	-0.3	-0.1
Past tobacco smoking	0.0	0.1	0.1	-0.1	0.3
Falls in the last year	0.0	0.1	0.1	0.2	0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.2	0.4
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.2	0.0
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.2	-0.2
Family relationship satisfaction	0.0	0.0	0.1	0.0	-0.2
Average weekly red wine intake	0.0	0.0	0.0	-0.2	-0.0
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.3	0.0
Fractured/broken bones in last 5 years	0.0	0.0	0.0	0.2	-0.1

Hub : Genes

MEF2D

Models

Trait associations