Hub : Genes

RP1-178F15.5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.307 0.0650 3.1e-12 0.195 NA 0.162 NA 0.188 7.9e-16 NA 3.2e-13 NA 3.0e-15
2 GTEx Artery Aorta 0.104 0.0470 4.8e-03 0.085 NA 0.060 NA 0.057 2.0e-05 NA 3.2e-04 NA 4.3e-04
3 GTEx Artery Tibial 0.141 0.0467 1.8e-05 0.038 NA 0.056 NA 0.060 5.6e-04 NA 3.3e-05 NA 1.6e-05
4 GTEx Brain Cerebellum 0.189 0.0720 8.0e-04 0.172 NA 0.181 NA 0.179 8.7e-06 NA 4.8e-06 NA 5.6e-06
5 GTEx Brain Cortex 0.409 0.0860 7.6e-08 0.283 NA 0.339 NA 0.360 1.7e-08 NA 3.6e-10 NA 7.8e-11
6 GTEx Brain Frontal Cortex BA9 0.214 0.0776 9.7e-04 0.062 NA 0.162 NA 0.129 9.7e-03 NA 4.7e-05 NA 2.8e-04
7 GTEx Brain Hippocampus 0.201 0.0876 6.0e-03 0.022 NA 0.025 NA 0.025 9.9e-02 NA 8.4e-02 NA 8.5e-02
8 GTEx Brain Putamen basal ganglia 0.334 0.1180 5.1e-04 0.169 NA 0.056 NA 0.048 8.4e-05 NA 1.9e-02 NA 2.7e-02
9 GTEx Cells EBV-transformed lymphocytes 0.208 0.0690 2.7e-04 0.209 NA 0.215 NA 0.227 2.1e-07 NA 1.4e-07 NA 5.7e-08
10 GTEx Cells Transformed fibroblasts 0.085 0.0330 7.1e-04 0.066 NA 0.063 NA 0.061 1.1e-05 NA 1.7e-05 NA 2.3e-05
11 GTEx Colon Sigmoid 0.400 0.0810 6.0e-08 0.273 NA 0.285 NA 0.235 3.4e-10 NA 1.3e-10 NA 7.9e-09
12 GTEx Liver 0.214 0.1010 6.6e-03 -0.011 NA 0.037 NA 0.005 9.2e-01 NA 3.4e-02 NA 2.3e-01
13 GTEx Nerve Tibial 0.140 0.0441 1.1e-04 0.039 NA 0.090 NA 0.059 8.8e-04 NA 6.3e-07 NA 5.1e-05
14 GTEx Skin Not Sun Exposed Suprapubic 0.210 0.0610 4.9e-05 0.140 NA 0.126 NA 0.138 4.4e-08 NA 2.2e-07 NA 5.6e-08
15 GTEx Skin Sun Exposed Lower leg 0.105 0.0410 2.2e-04 0.063 NA 0.041 NA 0.055 6.2e-06 NA 2.4e-04 NA 2.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 0.7 1.1 3.6 -1.1 0.1 -0.3 1.1 1.0 -0.6 0.9 -1.4 -0.9 0.8 -0.5 1.0 -1.9 -1.2 -1.5
Bipolar Disorder or Schizophrenia 1.3 3.2 8.9 -1.7 1.2 -1.6 1.9 1.3 -0.0 1.6 -2.2 -1.5 1.5 -0.8 3.0 -2.7 -1.6 -2.1
Depressed Affect (Nagel 2018) 0.6 1.2 5.5 1.2 -0.7 0.8 -0.5 -1.5 -1.2 -1.2 2.3 1.0 -1.2 0.4 -0.3 0.6 0.9 1.1
Depression (Nagel 2018) 0.3 0.4 2.1 -0.4 0.6 -0.7 0.6 -0.0 -0.8 -0.0 0.3 -0.7 0.4 0.7 1.5 -0.9 -0.4 -0.3
Intelligence (Savage-Jansen 2018) 0.6 1.8 7.3 0.4 -1.7 2.7 -1.7 -0.5 -1.2 -0.4 -2.4 0.6 -0.7 0.9 -1.4 1.5 0.1 0.6
Neuroticism (Nagel 2018) 0.7 1.6 5.7 -1.0 1.3 -1.5 1.3 0.4 0.2 0.4 2.4 -0.7 0.7 -1.0 2.0 -1.9 -0.8 -0.9
Schizophrenia (2018) 1.0 2.1 9.4 -1.3 0.5 -1.9 1.6 0.9 0.4 1.3 -1.4 -1.3 1.2 -0.9 3.1 -1.7 -1.1 -1.5
Schizophrenia vs Biploar Disorder 0.5 0.6 1.4 1.1 -1.0 -0.2 -0.6 -1.2 -0.6 -0.8 0.3 1.0 -1.0 0.3 0.1 0.6 1.1 1.1
Worry (Nagel 2018) 4.9 10.3 19.5 -3.5 3.1 -4.2 3.3 2.8 2.2 2.6 2.2 -2.9 2.9 -2.6 3.4 -4.4 -3.4 -3.6
Alzheimer’s Disease (in mother) 1.2 1.4 3.5 -1.0 1.1 -1.6 0.7 1.4 0.8 1.4 1.1 -0.8 1.2 -1.9 1.3 -0.9 -0.9 -0.9
Alzheimer’s Disease (in father) 0.9 1.0 3.6 -0.9 0.2 -1.8 0.6 0.8 1.9 0.3 -0.7 -1.0 0.7 0.7 0.6 -1.2 -1.0 -0.9
Alzheimer’s Disease (including proxy) 1.3 1.8 4.8 -1.1 1.1 -2.2 0.9 1.6 1.7 1.4 0.7 -1.4 1.5 -1.5 1.2 -1.3 -1.0 -1.0
Crohns Disease (2017) 0.5 1.1 5.1 1.2 -1.7 1.7 -0.3 -0.3 -0.1 -0.4 -0.5 0.4 -0.1 0.7 -2.3 0.7 1.0 1.4
Irritable Bowel Disease (IBD) 0.1 0.3 1.4 0.5 -0.6 0.7 0.2 0.3 0.4 0.1 0.7 -0.3 0.4 -0.2 -1.2 0.5 0.4 0.6
Ulcerative Colitis (UC) 0.7 1.3 2.1 -1.0 1.1 -1.3 1.4 1.3 1.1 1.1 1.4 -1.2 1.3 -1.4 0.8 -0.5 -1.0 -1.0
Major Depression (MDD) 1.6 2.0 6.4 -1.1 1.6 -2.5 1.4 1.6 0.2 1.4 0.6 -1.4 1.5 -0.7 2.5 0.3 -1.2 -0.6
Reaction Time 0.2 0.4 1.7 0.5 -0.1 0.8 -0.4 -0.0 -0.5 0.1 -0.8 -0.2 0.2 0.8 0.9 1.3 0.5 0.4
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.2 -1.2 1.3 0.7 -0.2 1.0 -0.0 0.5 -0.5 -0.9 0.5 0.2 -0.7 -0.0 -1.5 -1.0
Breast Cancer 0.1 0.2 1.3 -0.4 -0.3 -0.0 0.5 0.1 0.5 0.0 -0.6 -0.1 0.2 0.2 -1.1 -0.1 -0.5 -0.7
Ovarian Cancer 2.2 2.9 7.4 -2.0 1.7 -1.7 1.5 1.5 2.7 1.6 0.4 -1.7 1.6 -0.9 1.7 -1.5 -1.8 -2.1
Prostate Cancer 1.1 1.6 4.7 1.2 -0.2 -1.6 -0.8 -1.4 -0.2 -1.6 -1.4 1.1 -1.0 2.2 0.6 1.3 1.3 1.3
Age at First Birth 7.7 11.1 25.3 2.8 -2.7 5.0 -4.1 -3.6 -3.1 -3.4 -2.5 3.2 -3.6 3.3 -3.8 2.2 2.7 2.9
Bipolar Disorder (2011) 1.1 1.1 2.2 -1.1 0.0 -0.8 1.1 1.4 0.2 1.3 -0.2 -1.4 1.4 -1.0 0.6 -1.5 -1.0 -1.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.7 0.3 -0.3 -0.2 -1.2 -0.9 -0.3 -1.3 -0.3 0.9 -0.9 0.8 0.7 -1.3 0.5 0.2
Coronary Artery Disease (CAD) 2.2 2.6 4.5 -1.7 0.0 -1.8 2.0 1.8 2.1 1.8 1.0 -1.9 2.0 -1.0 -0.9 -1.9 -1.5 -1.6
Crohns Disease (2012) 0.3 0.5 3.5 0.1 -0.3 0.3 -0.3 -0.5 0.3 -0.7 -1.9 0.1 -0.4 1.4 -0.9 -0.7 0.0 0.0
Mean Putamen Volume 0.4 0.5 2.7 -0.3 0.2 1.3 0.2 0.1 0.5 -0.1 0.5 -0.2 0.1 0.9 -1.7 -1.1 -0.2 -0.3
Fasting Glucose 1.7 2.0 4.7 -1.5 1.5 -2.2 1.7 1.5 0.8 1.3 -1.3 -1.4 1.4 -0.4 1.5 -1.3 -1.6 -1.1
HbA1C 0.7 0.8 1.8 -0.7 0.4 -0.3 0.6 1.3 0.6 1.0 1.3 -0.8 0.9 -1.3 0.1 0.8 -1.2 -0.7
HDL Cholesterol 4.5 7.5 14.1 2.8 -3.8 3.3 -2.8 -3.2 -1.4 -3.1 0.3 3.0 -3.1 2.2 -3.3 2.0 2.5 2.3
LDL Cholesterol 2.7 4.3 8.1 -2.0 1.6 -2.5 2.8 2.8 0.8 2.8 0.3 -2.1 2.5 -1.6 1.8 -1.5 -2.1 -2.2
Lupus 0.4 0.6 5.8 0.4 0.0 0.9 -1.2 -0.3 0.2 -0.2 0.6 0.2 -0.2 -0.2 -2.4 -0.1 0.4 0.0
Neuroticism (2016) 1.1 1.6 3.3 1.4 -1.0 0.7 -0.7 -1.3 -1.8 -1.6 1.1 1.1 -1.1 0.7 1.2 1.6 1.5 1.6
Primary Biliary Cirrhosis 0.3 0.5 0.9 -0.7 0.4 -0.0 -0.3 0.8 0.3 0.9 -0.8 -0.9 0.8 -0.5 -0.7 -0.6 -0.9 -0.8
Rheumatoid Arthritis 1.3 1.8 3.1 1.5 -1.3 1.8 -1.3 -1.1 -1.6 -0.9 -0.9 1.6 -1.4 1.2 -0.8 1.3 1.4 1.7
Schizophrenia (2014) 0.7 1.5 7.1 -0.8 0.4 -1.6 0.6 0.2 -0.9 0.6 -2.0 -0.7 0.5 0.0 2.7 -1.8 -0.7 -1.2
Triglycerides 1.9 3.2 12.0 -1.3 1.8 -2.3 1.7 2.3 1.1 2.4 -0.7 -1.5 2.0 -1.3 3.5 0.4 -1.0 -0.8
Type 2 Diabetes (T2D) (2012) 6.0 6.9 11.8 -2.8 0.0 -2.0 2.9 3.4 2.1 3.3 1.5 -3.3 3.2 -3.0 -0.2 -1.8 -3.2 -3.2
Ulcerative Colitis 0.4 0.6 1.3 -0.6 1.0 -1.1 0.6 0.8 0.3 0.8 0.4 -0.7 0.7 -0.9 1.1 -0.4 -0.6 -0.7
Blood Eosinophil Count 0.2 1.7 6.6 -1.7 1.1 -1.3 1.1 0.4 1.8 0.1 0.4 -0.5 0.3 -0.7 1.9 -2.6 -1.7 -1.4
Blood Platelet Count 3.4 39.1 76.7 -6.5 5.8 -8.8 6.3 6.4 5.8 6.5 1.3 -6.5 7.0 -6.0 5.4 -6.1 -6.5 -6.3
Blood Red Count 0.1 0.9 2.6 1.2 -1.4 1.4 0.3 -0.3 1.6 -0.5 -0.3 0.5 -0.1 0.7 0.0 0.4 1.4 1.5
Blood White Count 1.0 7.2 15.5 -3.3 2.1 -3.5 2.5 2.2 2.0 2.3 1.1 -2.3 2.0 -3.1 1.2 -3.9 -3.3 -3.4
Heel T-Score 0.1 1.1 2.1 -1.4 1.1 -0.5 0.3 1.1 0.8 1.0 0.9 -1.4 1.2 -1.4 -0.4 -0.8 -1.2 -1.1
BMI 0.1 0.6 3.3 0.4 -0.5 0.9 -0.2 -0.7 -0.6 -0.2 1.4 0.2 -0.4 -0.4 -1.8 1.1 0.2 0.8
Height 1.2 22.8 31.7 -5.1 4.8 -5.5 4.5 5.1 5.2 4.6 1.9 -4.9 5.0 -4.6 4.9 -3.8 -4.9 -5.6
Waist Hip Ratio (WHR) 0.8 3.6 5.6 2.1 -1.9 2.4 -2.3 -1.9 0.1 -2.1 -1.0 1.9 -2.0 1.6 -2.0 1.9 1.9 2.1
Systolic Blood Pressure 0.2 1.0 4.5 -0.4 0.9 1.4 -0.4 0.6 1.0 0.6 0.4 -0.7 0.7 -1.5 -2.1 -1.0 -0.2 -0.9
Smoking Status 0.2 0.5 1.4 0.7 -1.2 -0.3 -0.7 -0.4 -0.7 -0.5 -0.5 0.7 -0.7 0.8 1.1 -0.1 0.6 0.8
Allergy or Eczema 2.8 7.4 16.8 -3.4 1.6 -4.1 3.5 2.0 2.9 2.2 -0.2 -2.6 2.3 -1.8 2.1 -2.6 -3.4 -3.7
Cardiovascular Disease 0.2 0.7 2.1 -0.5 0.2 1.2 -0.4 0.7 1.1 0.9 1.0 -0.6 0.8 -1.1 -1.5 0.9 -0.7 -0.3
Hypothyroidism (self reported) 0.1 0.2 0.9 0.1 0.2 0.6 -0.9 -0.2 -0.6 -0.5 0.1 -0.1 0.0 -0.1 -0.0 -0.7 -0.0 0.2
Respiratory disease 1.4 3.1 10.5 -1.6 -0.2 -2.5 2.1 1.2 0.9 1.6 2.0 -1.5 1.4 -3.2 1.3 -1.2 -1.5 -2.0
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.5 1.0 -0.9 1.1 -1.1 -1.2 -1.1 -1.3 -1.5 1.4 -1.5 1.6 -1.1 0.2 1.0 1.4
Lung FEV1/FVC ratio 0.1 0.3 2.3 -0.6 1.5 -0.3 0.7 0.1 0.4 -0.4 -0.0 -0.2 0.0 0.7 0.2 -0.3 -0.8 -0.5
Lung FVC 1.4 7.3 14.4 -2.9 3.1 -1.1 3.0 3.3 1.8 3.8 0.2 -3.2 3.5 -2.5 2.2 -1.8 -2.7 -3.0
Neuroticism 0.4 1.0 8.1 -0.4 0.4 -1.1 0.9 0.5 0.2 0.8 2.8 -0.6 0.8 -0.8 1.1 -0.9 -0.5 -0.4
Chronotype (morning person) 0.1 0.2 0.9 -0.2 -0.1 -0.9 0.8 -0.3 0.5 -0.2 -0.1 0.1 -0.1 0.6 0.7 0.4 -0.1 -0.0
Hair Pigment 0.1 1.8 7.9 0.5 0.2 -0.2 0.8 1.6 -0.6 1.5 1.6 -1.1 1.2 -1.4 -1.9 2.8 0.1 1.5
Tanning 0.1 1.1 4.1 -1.5 1.2 -2.0 0.8 0.8 0.5 0.6 -0.3 -0.9 0.5 -0.6 0.4 -1.1 -1.5 -1.0
Hand grip strength (left) 0.1 0.2 0.8 0.5 -0.4 -0.4 0.2 0.1 0.8 -0.1 -0.9 -0.0 0.3 0.9 0.5 0.3 0.6 0.4
Number of treatments/medications taken 1.7 3.1 5.8 -1.8 2.0 -1.5 1.8 1.6 2.4 1.9 0.2 -2.1 2.1 -1.5 0.6 -1.7 -1.8 -1.8
Average weekly spirits intake 0.2 0.3 1.9 -0.3 0.4 0.3 0.3 -0.6 0.4 -0.3 0.2 -0.1 -0.0 0.2 -0.8 -1.4 -0.3 -0.4
Sensitivity / hurt feelings 0.6 1.1 4.1 0.8 -1.0 0.1 -1.2 -1.5 -2.0 -1.1 0.9 1.0 -1.2 0.9 0.3 -0.1 0.8 0.8
Frequency of depressed mood in last 2 weeks 0.4 0.5 4.5 0.5 0.6 -0.6 1.0 -0.3 -0.2 -0.2 0.6 -0.2 0.2 0.0 2.1 -0.2 0.6 0.4
Hearing difficulty/problems: Yes 0.3 0.5 2.3 -0.4 1.1 -0.6 0.5 0.7 1.0 0.7 0.0 -0.6 0.7 -0.1 1.5 -0.1 -0.2 -0.2
Relative age of first facial hair 0.2 0.4 2.1 -0.3 0.4 0.9 0.5 0.7 1.4 0.4 0.1 -0.6 0.6 0.4 -0.4 -0.2 -0.5 -0.5
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 3.1 -1.4 1.4 -1.7 1.1 0.8 1.5 1.0 -0.4 -0.9 1.0 -1.1 1.8 -1.8 -1.3 -1.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.7 -0.3 0.7 0.3 -0.9 -0.3 0.3 -0.3 -0.8 -0.2 -0.0 0.7 -0.4 -1.3 -0.3 -0.7
Ever had hysterectomy (womb removed) 2.4 2.8 5.0 2.2 -1.7 1.6 -1.2 -1.9 -0.4 -1.8 0.1 2.1 -1.9 1.0 -0.5 1.9 2.1 2.2
Systolic blood pressure, automated reading 0.2 0.5 2.2 0.1 0.6 1.0 -0.0 -0.2 0.9 -0.0 0.8 0.1 -0.0 -0.8 -1.5 -1.1 0.4 -0.2
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 3.2 -0.4 1.0 -0.7 0.1 0.6 -0.1 0.6 -1.8 -0.4 0.5 -0.0 0.9 -0.9 -0.4 -0.4
Angina 0.3 0.3 3.5 0.1 -0.1 0.6 -0.6 0.1 -0.6 -0.3 0.6 0.1 -0.4 0.1 -1.9 0.0 -0.1 0.0
Medication for hormone replacement therapy 1.3 1.4 4.9 -1.2 1.3 -1.5 0.9 0.8 1.1 0.7 -0.1 -1.0 1.0 -0.7 2.2 -1.6 -1.0 -1.3
Vitamin and mineral supplements 0.2 0.3 1.2 -0.4 1.1 -0.7 -0.0 0.7 0.3 0.5 -0.6 -0.6 0.7 -0.2 0.7 0.2 -0.5 -0.2
Supplements: Zinc 1.0 1.1 4.4 -0.8 0.0 -1.1 1.6 0.2 1.0 0.2 2.1 -0.5 0.4 -1.3 1.2 -1.4 -0.7 -0.9
Medication: Co-codamol 2.7 3.2 4.9 -2.1 1.9 -1.7 2.0 1.7 1.0 1.7 0.0 -1.9 2.0 -1.6 1.8 -2.2 -2.0 -1.8
Medication: Metformin 0.6 0.8 1.6 0.8 -0.8 1.3 -1.2 -0.7 -0.7 -1.3 -0.2 0.9 -0.9 0.5 -1.3 -0.3 0.7 0.7
Diabetes (father) 0.9 1.1 3.4 -1.8 0.6 -0.9 0.7 1.2 0.8 1.0 -0.5 -1.2 1.0 -0.2 -0.0 -0.8 -1.8 -1.4
Diabetes (mother) 0.7 0.9 2.9 -1.1 0.3 -0.3 -0.3 0.6 1.7 0.6 1.6 -0.8 0.7 -1.1 0.5 -0.2 -1.4 -1.2
Severe depression (siblings) 0.2 0.2 1.4 0.2 0.3 -0.3 0.6 -0.1 0.3 0.1 -0.0 0.3 0.2 0.5 1.2 -0.1 0.4 0.6
Pack years adult smoking proportion 2.8 4.2 10.0 3.2 -2.5 2.6 -1.3 -2.3 -1.0 -1.8 -0.3 2.2 -1.8 1.3 0.1 1.1 3.1 3.0
Impedance of leg (right) 1.3 6.4 13.2 -2.5 2.2 -3.3 2.5 2.9 3.6 2.0 1.3 -2.3 2.3 -2.4 2.8 -1.6 -2.3 -2.9
Leg fat-free mass (left) 0.0 0.2 1.0 0.2 -0.5 0.3 -0.3 -0.4 -0.9 0.0 -0.5 0.1 0.0 0.1 -0.6 1.0 0.0 0.7
Trunk fat percentage 0.4 1.6 4.8 -1.8 0.7 -2.2 1.6 0.8 0.9 1.0 0.7 -1.2 0.9 -1.1 0.1 -0.8 -1.9 -1.5
Hand grip strength (right) 0.1 0.3 1.9 0.8 -0.2 0.3 0.0 0.2 1.4 0.1 0.2 0.2 0.3 0.3 0.7 0.4 1.0 0.6
Townsend deprivation index at recruitment 0.3 0.5 2.7 -0.2 -0.7 -0.5 0.2 -0.4 -0.8 -0.3 1.5 -0.3 -0.1 -0.5 -1.6 0.3 -0.3 -0.2
Current tobacco smoking 0.8 1.3 3.6 1.3 -1.9 0.9 -1.2 -1.4 -1.2 -1.1 -0.7 1.5 -1.5 0.6 -0.3 -0.0 1.2 1.1
Average weekly fortified wine intake 0.3 0.4 1.5 -0.7 1.1 -1.2 0.3 0.1 -0.1 0.0 -0.5 -0.3 0.2 -0.5 0.8 -0.9 -0.6 -0.7
Maternal smoking around birth 3.5 5.0 7.6 -2.8 2.7 -2.8 2.5 2.5 2.2 2.4 0.3 -2.6 2.3 -1.3 0.3 -1.2 -2.7 -2.5
Fed-up feelings 1.1 1.9 3.8 1.9 -0.7 1.7 -1.1 -1.3 -1.6 -1.1 0.8 1.1 -1.2 1.2 -0.2 1.7 1.9 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.3 0.7 0.5 0.4 0.0 -0.6 -0.5 -0.7 0.5 0.1 -0.2 0.5 1.2 0.1 0.6 0.6
Relative age voice broke 1.2 1.9 7.9 -0.9 1.2 0.3 1.3 1.7 2.8 1.7 -0.5 -1.2 1.7 -0.7 1.5 -0.8 -0.9 -1.2
Taking other prescription medications 1.6 2.5 4.9 -1.5 1.3 -1.6 1.9 1.1 1.7 1.3 -0.2 -1.6 1.5 -1.4 2.2 -2.1 -1.5 -1.8
Age when periods started (menarche) 1.2 2.9 5.7 -2.2 2.0 -0.3 1.6 1.9 1.1 1.6 0.1 -2.1 1.8 -1.8 -1.5 -1.0 -2.4 -2.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.3 -0.4 1.1 -0.9 0.5 0.6 0.8 0.7 -0.5 -0.3 0.6 -0.3 1.2 -0.9 -0.4 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 8.8 -1.5 1.4 -1.0 1.1 1.8 1.2 1.7 3.0 -1.7 1.6 -2.3 -0.1 -1.1 -1.6 -1.3
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 2.7 0.1 0.4 0.7 -0.6 0.4 1.6 0.2 0.3 0.1 0.3 -0.7 -0.5 -0.3 -0.0 -0.2
Qualifications: CSEs or equivalent 1.3 1.8 3.2 -1.5 1.4 -1.3 1.6 1.6 0.7 1.7 0.1 -1.6 1.8 -1.8 0.6 -0.4 -1.2 -0.9
Serious illness, injury or assault to yourself 0.2 0.3 1.3 -0.2 0.2 -0.3 0.2 -0.3 -0.3 -0.7 -1.1 0.3 -0.6 1.1 -0.0 -0.1 0.0 -0.1
High blood pressure 0.2 0.7 3.9 -0.0 -0.2 1.9 0.2 0.2 0.8 0.5 0.1 -0.4 0.4 -0.7 -2.0 0.6 -0.1 0.2
Hayfever, allergic rhinitis or eczema 2.5 5.4 13.6 -2.9 1.1 -3.7 3.0 1.9 2.2 2.1 -0.1 -2.3 2.0 -1.4 1.7 -2.1 -2.8 -2.9
Multivitamins +/- minerals 0.5 0.6 3.2 -0.6 0.3 -0.1 1.3 0.6 0.2 0.6 1.8 -0.8 0.7 -0.3 -0.5 -0.7 -0.5 -0.8
Stomach or abdominal pain in last month 6.0 7.5 14.6 -2.2 2.9 -2.9 3.8 2.9 3.3 2.8 2.1 -2.5 2.8 -3.6 2.4 -1.4 -2.1 -2.4
Supplements: Glucosamine 0.1 0.2 2.0 0.1 -0.1 0.2 0.3 -0.0 1.4 0.3 0.1 0.2 0.0 0.0 0.2 -0.2 0.3 0.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 3.8 0.8 1.1 -0.4 -0.5 -0.5 1.1 -0.4 0.1 0.8 -0.4 -0.5 1.9 0.0 0.8 0.4
Medication: Atenolol 0.7 0.8 7.8 -0.7 0.9 0.5 0.2 0.6 2.8 0.0 -0.4 -0.1 0.2 0.0 -0.4 -0.9 -0.7 -1.0
Medication: Levothyroxine sodium 0.2 0.3 1.0 0.4 -0.0 0.8 -1.0 -0.3 -0.5 -0.3 1.0 0.0 0.1 -0.3 -0.3 -0.1 0.3 0.6
Sitting height 0.2 1.7 5.2 -1.1 0.7 -0.9 1.0 1.8 1.6 1.5 0.2 -1.1 1.6 -1.6 2.3 -0.9 -1.0 -1.0
Chronic bronchitis/emphysema (father) 0.3 0.3 3.0 -0.4 0.7 -0.0 0.1 0.2 0.5 -0.0 -1.7 -0.1 0.1 0.5 0.7 0.2 -0.2 -0.3
High blood pressure (mother) 2.3 3.2 7.3 -2.7 1.4 -1.7 2.0 1.6 1.9 1.4 -0.2 -1.7 1.6 -1.0 1.4 -1.4 -2.5 -2.7
Body mass index (BMI) 0.3 1.4 3.2 0.9 -1.3 1.0 -0.5 -1.5 -1.5 -1.1 0.9 0.9 -1.2 0.5 -1.8 1.3 0.7 1.5
Impedance of leg (left) 2.0 9.7 15.8 -3.2 3.1 -4.0 3.1 3.6 4.0 2.6 1.5 -2.9 2.9 -2.6 3.4 -2.4 -3.1 -3.6
Leg predicted mass (left) 0.0 0.2 1.0 0.1 -0.5 0.3 -0.2 -0.4 -0.8 0.1 -0.4 0.0 0.1 -0.0 -0.6 1.0 0.0 0.7
Trunk fat mass 0.2 0.8 2.6 -1.4 0.4 -1.6 1.1 0.4 0.5 0.7 0.4 -0.9 0.7 -0.7 0.0 -0.3 -1.5 -0.9
Waist circumference 0.3 1.2 2.4 0.9 -1.4 0.9 -0.7 -1.5 -0.9 -1.1 0.4 1.0 -1.2 0.5 -1.4 1.4 0.8 1.6
Number of incorrect matches in round 0.9 1.5 4.0 1.7 -1.1 0.8 -1.1 -1.2 -2.0 -0.7 0.5 1.2 -1.1 0.0 -0.4 1.3 1.7 1.8
Past tobacco smoking 0.5 1.0 2.0 -0.8 1.4 -0.2 0.8 0.9 1.2 1.3 -0.6 -0.9 1.2 -1.1 0.1 -1.2 -0.8 -1.1
Alcohol usually taken with meals 1.4 2.3 4.1 1.4 -1.9 2.0 -1.7 -1.9 -1.6 -1.7 -1.9 1.5 -1.6 1.0 -0.2 -0.5 1.4 1.2
Nervous feelings 2.5 4.7 12.1 -2.2 1.7 -3.3 3.1 1.5 1.3 1.5 0.7 -1.7 1.6 -1.5 2.6 -3.5 -2.0 -2.3
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 6.8 -1.1 1.3 -1.7 1.1 0.7 -0.0 0.8 -0.9 -1.2 1.1 0.3 2.6 -1.1 -1.1 -0.9
Hearing difficulty/problems with background noise 0.5 0.8 3.0 -0.8 0.5 -1.3 1.3 0.8 1.7 0.6 0.7 -0.7 0.7 -0.7 1.2 -0.1 -0.6 -0.6
Hair/balding pattern: Pattern 2 0.1 0.1 0.4 -0.3 0.2 -0.6 0.0 -0.1 -0.2 -0.2 0.5 0.2 -0.1 -0.6 0.3 -0.6 -0.3 -0.4
Had menopause 0.9 1.1 3.5 -0.0 -0.3 0.2 -1.1 -1.9 -0.2 -1.6 -0.4 1.1 -1.5 1.0 -1.1 -1.7 -0.1 -0.2
Had other major operations 0.3 0.4 2.9 -0.7 -0.0 0.1 0.3 0.1 0.2 0.2 -1.7 -0.5 0.1 0.0 0.7 -0.7 -0.6 -0.7
Forced vital capacity (FVC) 1.2 4.8 9.5 -2.1 2.5 -2.2 2.4 2.6 1.8 2.8 -0.4 -2.2 2.9 -1.7 3.1 -0.8 -1.8 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 12.8 -2.1 1.8 -1.5 1.3 2.2 1.0 2.0 3.6 -1.9 1.8 -2.8 0.4 -1.5 -2.1 -1.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.2 -0.6 -0.5 -1.0 -0.9 -0.9 -0.9 -1.1 0.8 0.3 -1.0 1.5 0.1 -0.7 -0.6 -0.7
Qualifications: None of the above 0.2 0.3 1.0 0.8 -0.2 -0.6 0.4 -0.3 -1.0 0.0 0.6 0.4 -0.2 -0.4 0.9 0.5 0.8 0.5
Financial difficulties in last 2 years 0.5 0.6 1.3 0.6 -0.9 1.0 -0.4 -0.5 -0.6 -0.8 -0.5 0.9 -1.0 1.1 -0.9 0.7 0.7 0.8
Mouth/teeth dental problems 0.4 0.6 1.7 0.1 -0.2 -1.3 -0.5 -0.9 -0.8 -0.7 0.1 0.6 -0.8 0.9 1.3 -1.2 0.2 0.1
Heart attack 0.4 0.6 2.2 -0.1 -0.8 0.8 -0.6 -0.5 0.3 -1.1 -0.9 0.3 -0.8 1.2 -1.5 -0.3 -0.1 -0.3
Allergy 2.8 6.3 19.4 2.8 -1.5 4.4 -3.2 -1.8 -2.0 -2.2 -0.6 2.5 -2.2 2.0 -2.4 2.1 2.8 3.0
Pain all over the body in last month 3.1 3.4 7.3 -1.8 1.4 -1.6 2.1 2.3 2.2 2.7 0.1 -2.0 2.3 -1.5 1.1 -1.0 -1.7 -1.9
Diabetes (self-reported) 1.2 1.8 3.4 1.1 -1.1 1.5 -1.9 -1.5 -1.2 -1.4 -1.3 1.3 -1.4 1.8 -1.1 0.3 1.0 1.4
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.7 -1.1 0.7 -1.6 0.5 0.7 1.3 0.4 0.0 -0.5 0.4 -0.4 1.7 -0.6 -1.1 -0.8
Medication: Ramipril 0.5 0.7 1.8 -1.1 0.7 -0.5 1.1 0.6 1.4 0.1 0.3 -0.9 0.5 0.4 -0.5 -0.9 -1.1 -1.0
Medication: Simvastatin 0.1 0.1 0.5 -0.1 0.1 -0.3 0.4 0.1 0.2 -0.1 -0.1 -0.1 0.1 0.4 -0.7 -0.5 -0.2 -0.2
Fluid intelligence score 0.8 1.7 4.2 -1.9 1.4 0.2 0.2 1.4 0.7 1.4 -1.0 -1.5 1.3 -0.8 -0.4 -1.4 -2.0 -2.0
Illnesses of siblings 0.5 0.7 2.0 1.1 -0.7 0.0 -0.4 -0.7 -1.4 -0.7 -0.5 0.9 -0.9 0.8 0.7 0.2 1.1 1.4
Neuroticism score 0.2 0.4 3.9 0.2 0.2 -0.7 0.6 -0.1 -0.7 0.1 2.0 0.1 -0.1 -0.1 1.0 -0.2 0.2 0.3
Weight 0.0 0.1 0.4 -0.2 -0.4 -0.4 0.1 -0.4 -0.4 -0.1 0.6 0.0 -0.1 -0.3 -0.2 0.5 -0.3 0.4
Impedance of arm (right) 1.0 4.7 12.7 -2.4 1.6 -3.6 2.2 2.0 2.1 2.0 -0.8 -1.7 1.8 -1.3 2.1 -2.1 -2.4 -3.0
Arm fat percentage (right) 0.1 0.3 2.1 -0.3 -0.9 -0.4 0.3 -0.7 -0.7 -0.3 0.4 0.2 -0.5 0.0 -1.4 0.5 -0.4 0.1
Trunk fat-free mass 0.1 0.6 1.6 0.6 -0.6 0.9 -1.1 -0.8 -1.0 -0.6 -0.3 0.5 -0.5 0.3 -0.3 1.2 0.5 1.1
Hip circumference 0.2 0.7 3.1 -0.8 -0.1 -1.6 1.0 0.3 -0.5 0.7 1.8 -0.5 0.5 -1.2 0.3 0.6 -0.9 -0.0
Time employed in main current job 2.7 3.1 6.0 -2.0 1.4 -1.8 2.1 1.9 0.9 2.0 0.2 -1.5 1.5 -2.0 2.4 -1.5 -2.0 -2.0
Alcohol intake versus 10 years previously 0.7 1.0 3.6 -1.0 1.2 -1.9 0.2 0.9 -0.0 0.6 0.5 -1.3 0.9 -0.6 0.8 -0.5 -1.3 -1.2
Father’s age at death 0.2 0.3 0.8 0.5 -0.6 -0.4 -0.1 -0.8 -0.5 -0.7 -0.8 0.3 -0.6 0.9 0.7 -0.5 0.3 0.3
Worrier / anxious feelings 0.3 0.5 1.4 0.2 0.1 -0.3 -0.9 -1.0 -1.2 -0.8 0.4 0.4 -0.7 0.9 1.0 -1.0 0.2 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 12.3 0.1 0.3 -0.4 0.5 0.8 -0.3 0.4 -0.1 -0.6 0.8 0.2 3.5 0.0 0.2 0.2
Falls in the last year 1.9 2.6 6.0 1.8 -1.7 2.5 -1.2 -1.9 -1.0 -1.7 0.2 1.8 -1.8 1.1 -1.8 1.2 1.8 1.8
Hair/balding pattern: Pattern 3 2.8 4.2 8.6 2.3 -2.1 2.8 -1.6 -2.1 -1.4 -1.9 -0.3 1.9 -1.9 1.8 -2.9 1.5 2.3 2.4
Number of live births 0.7 1.0 3.3 -0.5 0.4 -1.8 1.8 1.3 -0.1 0.9 0.9 -1.2 1.2 -1.3 0.6 0.1 -0.4 -0.4
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 6.4 -2.0 2.5 -2.0 2.3 2.4 1.3 2.4 -0.4 -2.0 2.5 -1.2 2.5 -0.2 -1.8 -1.7
Pulse rate 0.2 0.3 0.7 0.0 0.6 -0.8 0.3 0.2 0.8 0.6 0.1 -0.5 0.8 0.2 0.6 -0.5 0.1 0.1
Happiness 0.6 0.7 2.6 -0.7 0.7 -0.2 -0.4 -0.4 1.0 -0.8 1.4 -0.2 -0.3 0.7 -1.6 -0.9 -0.9 -0.9
Noisy workplace 1.8 2.2 6.5 -1.0 1.5 -2.6 2.3 1.5 1.7 1.5 1.4 -1.4 1.7 -1.0 0.6 -1.0 -0.8 -0.7
Qualifications: A levels/AS levels or equivalent 0.9 1.9 3.7 1.1 -0.8 1.8 -1.9 -0.9 -1.9 -0.9 -1.8 1.3 -1.5 1.3 -0.5 1.6 1.2 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.2 0.2 0.5 -0.1 0.6 0.7 0.2 -0.5 -0.3 0.6 0.5 -0.8 0.1 -0.2 -0.2
Mouth/teeth dental problems: Dentures 0.3 0.4 1.3 -0.1 -0.1 1.0 0.3 0.7 0.5 0.7 -0.1 -0.8 0.9 -1.1 -1.2 0.4 -0.2 -0.2
Asthma 0.8 1.6 6.2 -1.1 -0.3 -2.5 1.3 0.4 1.0 0.6 1.2 -0.9 0.7 -1.9 1.1 -1.4 -1.2 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.8 -0.2 0.5 -0.4 0.4 -0.5 -0.1 -0.7 -0.7 0.2 -0.5 0.7 1.3 -0.1 0.0 -0.1
Medication: Cholesterol lowering 0.4 0.6 1.2 -0.7 0.3 -0.2 1.1 0.9 0.6 0.8 0.6 -0.9 0.9 -0.6 -0.8 -0.9 -0.8 -0.9
Depression (self-reported) 0.2 0.3 1.2 0.3 -0.2 0.7 -0.4 -0.8 -0.5 -0.4 -0.5 0.3 -0.3 1.1 0.5 -0.6 0.3 0.1
Medication: Lansoprazole 0.6 0.7 1.9 -0.9 0.6 -0.4 1.0 0.6 0.7 0.7 0.3 -0.8 0.9 -0.5 -0.4 -1.4 -1.1 -1.1
Prospective memory result 0.6 0.8 3.3 -0.1 0.7 -1.6 1.8 0.5 0.4 0.2 0.9 -0.3 0.4 -0.5 1.8 0.2 -0.1 -0.3
Lung cancer (father) 3.8 4.4 9.7 -2.0 1.3 -1.9 2.2 1.7 2.4 2.0 2.8 -1.8 2.0 -3.1 -0.8 -2.5 -2.0 -1.9
Illnesses of mother 2.3 2.9 7.7 2.4 -1.4 1.4 -1.0 -1.4 -1.9 -1.3 -0.3 1.6 -1.5 1.2 -1.0 1.9 2.6 2.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.6 8.1 -2.8 2.6 -2.6 2.7 2.7 1.4 2.7 -0.3 -2.5 2.8 -1.7 2.7 -1.1 -2.6 -2.4
Pulse wave Arterial Stiffness index 1.1 1.3 3.0 -1.2 0.7 -0.5 1.1 1.4 0.7 1.2 -0.6 -1.7 1.6 -0.5 0.2 -1.4 -1.5 -1.5
Impedance of arm (left) 1.0 4.7 12.5 -2.3 1.8 -3.5 2.1 2.2 2.2 2.0 -0.8 -1.8 1.9 -1.4 2.4 -2.1 -2.1 -2.8
Arm fat mass (right) 0.1 0.3 1.4 -0.4 -0.6 -0.5 0.4 -0.5 -0.6 -0.1 0.9 -0.0 -0.2 -0.3 -1.2 0.5 -0.5 0.1
Trunk predicted mass 0.1 0.6 1.5 0.6 -0.7 0.9 -1.1 -0.8 -1.1 -0.7 -0.3 0.6 -0.5 0.3 -0.4 1.2 0.5 1.1
Standing height 0.5 5.2 11.6 -2.4 2.0 -3.1 1.7 2.4 2.5 2.3 -0.3 -2.0 2.5 -2.0 3.4 -1.4 -2.2 -2.3
Length of working week for main job 0.7 0.8 4.3 0.7 -0.8 0.2 -0.9 -0.4 0.1 -0.9 1.3 0.7 -0.7 0.4 -0.5 2.1 0.5 1.1
Exposure to tobacco smoke at home 2.3 2.6 4.8 -2.1 1.7 -2.2 1.4 1.7 0.4 1.8 1.0 -1.7 1.7 -1.6 0.3 -1.2 -2.1 -1.9
Breastfed as a baby 1.2 1.5 4.5 0.8 -1.5 1.7 -2.1 -1.4 -1.5 -1.3 0.3 1.3 -1.4 0.6 -0.5 0.5 0.9 1.2
Tense / ‘highly strung’ 2.7 4.5 7.5 -2.1 2.6 -2.7 2.5 2.1 2.3 1.9 1.2 -1.6 1.9 -2.1 2.0 -2.6 -1.9 -1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.4 0.3 -0.7 0.4 -0.0 -0.2 -1.0 0.1 1.2 -0.2 0.1 -0.1 -1.1 0.5 0.1 0.1
Hair/balding pattern: Pattern 4 2.3 5.6 11.7 -3.1 2.4 -0.5 0.9 3.4 1.1 3.2 -0.1 -3.1 2.8 -2.8 -1.8 -0.2 -3.3 -2.2
Birth weight of first child 1.5 2.7 4.0 1.8 -2.0 1.3 -1.3 -2.0 -1.5 -1.6 0.1 1.8 -1.8 1.7 0.6 1.9 1.9 2.0
Peak expiratory flow (PEF) 1.5 3.4 5.6 -2.1 2.4 -2.2 2.1 2.2 1.1 2.1 -1.1 -2.0 2.3 -0.3 1.4 -0.7 -2.0 -1.9
Pulse wave reflection index 0.2 0.2 0.8 -0.5 -0.4 0.9 -0.5 0.2 -0.3 -0.3 -0.4 -0.1 -0.2 0.4 -0.6 -0.5 -0.6 -0.8
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.9 -0.4 0.3 -0.3 1.0 0.6 0.6 0.4 0.8 -0.4 0.7 -0.1 0.0 0.3 -0.4 -0.2
Loud music exposure frequency 5.1 5.6 8.2 -2.5 1.5 -2.9 2.6 2.5 2.4 2.2 1.6 -2.6 2.6 -2.5 2.0 -2.5 -2.5 -2.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.2 0.6 -1.0 0.7 -1.2 -1.1 -1.0 -1.3 -1.5 1.3 -1.4 1.5 0.5 0.3 0.8 0.7
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 3.6 1.4 -1.9 1.8 -1.2 -1.3 -1.1 -1.6 -0.3 1.5 -1.6 1.0 -1.8 1.9 1.2 1.5
Blood clot in the leg (DVT) 0.1 0.1 0.7 0.1 0.3 0.1 0.8 -0.4 -0.6 -0.2 -0.3 0.1 -0.2 0.8 -0.0 0.1 0.1 0.0
Medication: Paracetamol 4.6 7.6 16.7 -2.4 2.7 -2.9 3.5 2.6 4.1 2.9 1.4 -2.5 3.0 -2.6 3.4 -1.6 -2.2 -2.3
Headache pain in last month 2.7 4.7 9.9 -2.0 2.2 -2.6 2.5 2.4 2.1 2.1 1.4 -2.5 2.4 -1.5 3.1 -1.0 -1.9 -1.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 3.3 -0.4 0.4 -1.3 -0.1 0.1 0.5 -0.3 0.6 -0.0 -0.1 -0.2 1.8 -0.5 -0.2 -0.3
Glaucoma (self-reported) 0.5 0.5 4.0 -0.0 -0.1 0.4 -0.5 -0.0 -1.4 0.0 -2.0 0.0 -0.0 1.2 -0.3 0.7 -0.1 0.0
Gout (self-reported) 1.2 1.7 4.9 1.9 -1.2 1.3 -0.5 -1.1 0.1 -1.0 1.7 1.4 -1.0 0.2 -0.0 2.2 1.6 1.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.1 0.7 -1.0 1.2 -1.5 -1.0 -1.3 -1.2 0.7 0.7 -0.8 0.3 -0.4 -0.3 0.6 0.8
Medication: Amlodipine 0.4 0.6 2.0 -0.3 -0.3 0.7 -0.8 -0.7 -0.8 -0.4 -1.0 0.2 -0.4 1.4 -1.0 -1.4 -0.1 -0.2
Medication: Ventolin 100micrograms inhaler 0.8 1.1 5.1 -0.6 0.3 -2.3 0.9 0.6 0.7 0.7 1.2 -0.5 0.6 -1.6 1.9 0.0 -0.5 -0.4
Birth weight 4.2 9.2 17.8 3.6 -3.8 3.5 -3.1 -2.9 -3.0 -2.5 -0.7 3.1 -2.8 1.6 -0.7 4.2 3.6 3.8
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.2 -1.0 1.4 -1.5 0.2 0.3 -0.4 0.4 -0.8 -0.5 0.1 0.2 0.2 -0.4 -1.0 -1.1
High blood pressure (siblings) 0.2 0.2 1.9 -0.3 -0.2 0.8 -0.4 -0.1 0.3 -0.3 -0.3 0.2 -0.3 0.2 -1.4 0.5 -0.4 -0.2
Forced vital capacity (FVC), Best measure 2.0 7.2 10.6 -3.0 2.6 -2.8 3.0 3.1 2.1 3.2 -0.2 -2.8 3.3 -2.3 3.1 -1.5 -2.7 -2.7
Body fat percentage 0.3 1.1 3.1 -1.5 0.5 -1.8 1.4 0.6 0.8 0.7 0.9 -1.0 0.8 -0.9 -0.1 -0.5 -1.6 -1.1
Leg fat percentage (right) 0.1 0.5 1.6 -0.8 0.1 -1.0 1.1 0.2 0.5 0.2 1.3 -0.7 0.4 -0.8 -0.5 0.1 -1.0 -0.4
Arm fat-free mass (right) 0.0 0.2 1.1 0.1 -0.3 0.5 -0.5 -0.3 -0.6 -0.2 0.4 0.0 -0.0 -0.2 -0.6 1.1 0.1 0.8
Exposure to tobacco smoke outside home 0.5 0.6 5.4 0.5 0.3 -0.9 -0.2 -0.4 -0.0 -0.5 2.3 0.3 -0.1 0.8 -0.4 0.8 0.5 0.6
Comparative body size at age 10 5.9 16.3 23.6 4.3 -4.7 4.9 -3.6 -4.5 -4.1 -4.1 -1.3 4.2 -4.4 3.8 -4.7 2.1 4.2 4.1
Number of full brothers 0.3 0.4 2.2 0.3 0.3 -0.3 -0.3 -0.1 -0.9 -0.1 0.7 0.4 -0.2 -0.4 1.5 1.4 0.4 0.5
Worry too long after embarrassment 0.1 0.2 1.5 -0.0 -0.4 -0.3 0.1 0.4 0.2 0.3 -0.3 -0.1 0.3 -0.3 1.2 0.2 0.0 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.9 -0.8 0.6 -0.9 0.9 0.8 0.4 0.9 1.7 -1.2 1.0 -0.8 0.4 -1.5 -0.8 -1.0
Wheeze or whistling in the chest in last year 0.5 0.9 4.6 0.0 -0.4 -1.5 1.0 0.3 0.8 0.3 1.7 -0.4 0.4 -1.4 2.1 0.3 -0.0 -0.2
Number of children fathered 0.6 0.7 2.1 -0.9 0.5 -0.3 0.9 0.8 0.0 0.8 0.6 -1.1 1.0 -0.7 1.4 -0.8 -0.6 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.8 1.1 -0.7 0.4 -0.1 -0.8 0.4 -0.6 0.6 0.5 -0.3 -0.2 -1.4 0.2 1.1 0.8
Age at first live birth 1.2 2.1 7.8 1.3 -0.3 2.8 -0.5 -0.8 -0.7 -0.4 -2.5 0.8 -0.7 1.4 -2.6 1.3 1.3 1.1
Pulse wave peak to peak time 0.7 0.9 2.4 1.0 -0.4 0.1 -0.8 -1.1 -0.3 -0.9 0.5 1.6 -1.3 0.3 0.2 1.2 1.3 1.2
Health satisfaction 0.4 0.5 2.1 0.4 0.5 0.2 -0.4 -0.2 1.2 -0.1 -1.4 0.2 -0.1 0.8 1.4 0.5 0.4 0.5
Shortness of breath walking on level ground 1.5 1.7 3.7 1.8 -0.7 1.5 -1.4 -1.3 -1.4 -1.2 -0.5 1.3 -1.1 1.1 0.1 1.5 1.6 1.9
Qualifications: College or University degree 1.0 3.1 8.9 1.9 -1.4 3.0 -1.9 -1.4 0.1 -1.4 -1.5 1.4 -1.3 1.9 -1.6 2.4 1.8 1.9
Eye problems/disorders: None of the above 0.1 0.1 0.5 0.0 0.0 0.6 -0.1 -0.3 0.0 -0.5 0.1 0.1 -0.4 0.4 -0.3 0.7 -0.0 0.2
Mouth/teeth dental problems: Loose teeth 1.5 1.8 5.0 -1.2 2.2 -1.2 0.9 1.5 1.5 1.9 0.7 -1.3 1.7 -1.3 0.8 -0.4 -1.2 -0.9
Emphysema/chronic bronchitis 2.8 3.2 7.0 2.4 -1.0 1.7 -2.2 -1.5 -2.2 -0.8 -1.6 1.5 -1.0 1.1 1.1 2.1 2.4 2.6
Medication for pain relief, constipation, heartburn 4.2 7.2 10.7 2.9 -2.9 2.5 -3.3 -2.8 -2.9 -2.6 -0.6 2.9 -3.0 2.3 -2.1 2.9 2.6 2.9
Neck or shoulder pain in last month 2.7 3.9 9.3 -1.9 2.4 -2.3 2.7 2.0 1.0 1.9 0.2 -1.9 2.0 -1.4 3.1 -1.1 -1.8 -1.8
Medication: Blood pressure 0.4 0.8 5.8 0.5 -0.8 1.8 -0.0 -0.2 -0.7 0.2 -0.7 0.1 -0.1 0.5 -2.4 0.4 0.4 0.4
Angina (self-reported) 0.2 0.3 2.6 0.1 -0.1 0.5 -0.5 0.1 -0.4 -0.3 0.7 0.2 -0.5 0.0 -1.6 0.0 -0.1 -0.0
Migraine (self-reported) 2.7 3.3 11.9 -1.7 1.7 -2.1 2.0 1.3 2.0 1.5 0.3 -1.6 1.7 -1.9 3.5 -1.4 -1.7 -1.5
Medication: Ibuprofen 0.5 0.7 2.0 0.1 -0.3 -0.3 -0.2 -1.1 -0.7 -1.1 -1.1 0.7 -1.0 1.4 1.3 0.3 0.3 0.4
Medication: Allopurinol 0.6 0.8 2.9 1.3 -0.4 0.8 -0.2 -0.7 0.5 -0.6 1.3 0.9 -0.5 0.1 0.2 1.7 1.3 1.2
Medication: Omeprazole 1.4 1.7 4.9 -1.3 1.2 -2.2 1.6 1.4 1.2 1.3 0.6 -1.4 1.2 -1.3 0.5 -0.0 -1.4 -1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.8 -0.2 -0.0 -0.7 -0.6 -0.5 -0.7 -0.3 0.3 0.2 -0.5 -0.0 -0.9 -0.1 -0.0 -0.2
Mean time to correctly identify matches 0.1 0.2 0.7 0.0 0.0 0.8 -0.8 -0.6 -0.7 -0.3 -0.8 0.1 -0.4 0.4 0.4 -0.2 -0.1 -0.2
Heart disease (mother) 3.8 4.7 8.6 -2.6 2.2 -1.9 1.6 2.1 2.4 1.4 1.6 -2.3 2.0 -1.6 0.7 -2.9 -2.8 -2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.2 0.3 -1.8 -0.5 -0.4 -1.5 -1.4 -1.4 -1.1 1.1 -1.4 1.6 0.9 -0.3 0.6 0.4
Whole body fat mass 0.1 0.6 1.7 -1.2 0.2 -1.3 1.0 0.3 0.3 0.6 0.8 -0.8 0.6 -0.8 -0.4 0.0 -1.3 -0.7
Leg fat mass (right) 0.1 0.3 1.1 -0.7 -0.0 -0.7 0.9 0.1 0.3 0.3 1.1 -0.6 0.4 -0.7 -0.6 0.4 -0.8 -0.2
Arm predicted mass (right) 0.1 0.3 1.2 0.4 -0.2 0.6 -0.7 -0.4 -0.6 -0.3 0.6 0.2 -0.2 -0.3 -0.3 1.1 0.4 1.0
Pulse rate, automated reading 1.0 3.1 7.7 -1.3 1.2 -2.3 2.8 1.3 0.8 2.2 1.1 -1.5 1.9 -2.6 1.8 -1.6 -1.2 -1.5
Alcohol intake frequency. 0.3 0.8 1.9 -0.7 0.9 -0.9 1.4 0.6 0.7 1.0 -0.1 -1.1 1.2 -0.5 0.9 -0.4 -0.7 -1.0
Comparative height size at age 10 0.1 0.5 1.2 0.3 -0.4 -1.1 -0.1 -1.0 -0.4 -1.1 -0.2 0.8 -0.9 1.1 0.8 -0.6 0.4 0.3
Number of full sisters 2.4 2.9 5.8 -1.3 1.1 -2.1 2.3 2.4 1.2 2.1 0.5 -1.7 2.0 -2.4 1.6 -0.1 -1.3 -1.3
Suffer from ‘nerves’ 4.2 6.6 12.3 -2.4 2.1 -3.5 3.4 2.4 2.5 2.0 1.5 -2.5 2.5 -1.9 3.1 -3.2 -2.3 -2.6
Overall health rating 3.0 6.4 14.7 -1.7 3.1 -2.2 2.9 3.1 3.8 2.9 0.9 -2.8 3.1 -2.2 2.8 -1.1 -1.5 -1.8
Chest pain or discomfort 0.9 1.2 2.4 1.6 -0.9 0.4 -0.5 -1.3 -0.9 -1.4 0.6 1.0 -1.1 1.1 0.8 1.3 1.5 1.4
Had major operations 2.2 2.5 10.5 2.0 -1.2 1.8 -1.8 -1.3 -0.8 -0.8 1.1 1.3 -1.0 0.2 0.1 3.2 1.8 2.3
Age at last live birth 0.7 1.0 6.9 -0.3 0.8 1.1 0.6 1.0 -0.2 0.9 -1.8 -0.7 0.8 0.2 -2.6 0.5 -0.2 -0.2
Family relationship satisfaction 1.8 2.2 4.2 1.5 -1.5 1.5 -1.5 -1.8 -1.3 -1.6 -0.4 1.4 -1.6 1.8 -2.1 0.9 1.1 1.3
Leg pain on walking 0.6 0.7 2.8 -0.9 1.1 -1.0 0.8 0.8 1.7 0.9 0.5 -0.4 0.7 -0.9 0.7 -0.3 -0.8 -0.6
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.6 -1.1 1.0 -1.3 1.3 1.6 0.6 1.5 0.2 -1.4 1.6 -1.4 -0.0 -0.6 -1.1 -0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.2 -1.1 0.8 -0.5 0.1 0.2 1.0 0.4 0.3 -0.8 0.6 -0.5 0.5 -0.4 -1.0 -0.9
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 1.1 0.0 0.1 0.5 -0.5 -0.4 -0.1 -0.0 0.5 0.1 -0.2 -0.4 -1.0 -0.3 -0.1 0.2
Medication: Aspirin 1.8 2.4 3.9 -1.7 1.5 -0.5 1.1 1.7 1.9 1.4 1.4 -1.8 1.8 -1.8 -0.2 -2.0 -1.6 -1.7
Supplements: Vitamin C 0.9 1.0 2.4 1.4 -1.2 1.4 -0.2 -1.2 -0.3 -0.7 -0.4 1.5 -1.3 0.3 -0.1 0.5 1.5 1.1
Knee pain experienced in last month 0.1 0.2 0.6 -0.0 -0.1 -0.2 -0.7 -0.6 -0.3 -0.7 0.4 0.6 -0.6 -0.1 0.1 -0.1 -0.0 -0.0
Hypertension (Self-reported) 0.3 0.8 3.6 -0.4 0.1 1.5 0.5 0.6 1.1 1.0 0.6 -0.8 0.8 -1.2 -1.9 0.4 -0.4 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.5 -0.7 0.9 -1.3 1.3 0.7 0.7 1.5 0.6 -0.9 1.2 -2.1 2.1 1.0 -0.7 -0.4
Illnesses of father: Heart disease 1.2 1.7 4.7 -1.2 2.2 -0.2 0.2 1.3 1.4 1.1 -1.7 -1.5 1.6 0.0 -0.5 -1.4 -1.5 -1.5
Illnesses of siblings: Diabetes 0.9 1.2 2.3 -1.2 1.2 -0.5 1.1 1.4 1.5 1.0 0.5 -1.1 1.2 -1.1 0.1 -0.5 -1.2 -1.4
Smoking status: Previous 0.2 0.3 1.2 -0.0 -0.3 -0.5 -0.3 -0.2 -0.9 -0.6 1.1 0.1 -0.5 0.7 0.1 0.6 0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 9.5 -1.3 1.4 -2.0 2.1 2.6 2.2 3.1 -1.2 -1.9 2.9 -1.4 2.3 -0.0 -1.1 -1.3
Whole body fat-free mass 0.0 0.3 1.1 0.3 -0.4 0.6 -0.6 -0.5 -0.9 -0.2 -0.3 0.2 -0.1 0.0 -0.4 1.1 0.1 0.8
Leg fat-free mass (right) 0.0 0.1 0.6 -0.2 -0.1 -0.0 -0.0 -0.1 -0.8 0.4 -0.3 -0.2 0.3 -0.2 -0.1 0.6 -0.2 0.4
Arm fat percentage (left) 0.1 0.2 1.3 -0.2 -0.7 -0.5 0.4 -0.5 -0.7 -0.1 0.3 0.1 -0.3 -0.1 -1.1 0.6 -0.3 0.2
Average weekly red wine intake 2.8 4.1 8.1 2.5 -2.3 2.9 -1.5 -2.0 -1.7 -1.5 -0.3 1.9 -1.7 1.6 -2.2 2.3 2.3 2.4
Handedness (chirality/laterality): Left-handed 1.7 2.1 4.1 1.5 -0.9 0.6 -1.5 -2.0 -1.1 -2.0 -0.9 1.7 -1.7 1.8 0.8 1.1 1.5 1.5
Mood swings 0.2 0.3 3.1 0.1 0.3 -0.3 0.1 -0.4 -0.4 -0.5 1.8 -0.0 -0.2 0.3 -0.6 0.8 -0.0 0.3
Loneliness, isolation 0.8 1.1 2.9 1.5 -0.4 0.5 -0.7 -0.7 -1.7 -0.5 0.2 0.9 -0.7 0.4 1.6 1.2 1.6 1.5
Long-standing illness, disability or infirmity 0.3 0.5 2.2 -0.3 0.9 -0.8 1.0 0.3 1.5 0.5 0.1 -0.5 0.5 -0.3 -0.5 -1.1 -0.3 -0.3
Ever had bowel cancer screening 0.2 0.3 2.1 0.2 -0.3 0.4 -0.5 -0.5 -0.5 0.1 -0.8 0.2 -0.1 0.0 1.4 0.1 0.2 -0.0
Diabetes diagnosed by doctor 0.4 0.6 1.5 0.6 -0.3 0.6 -1.1 -1.0 -0.7 -1.0 -0.9 0.9 -0.9 1.2 -0.2 -0.3 0.6 0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.9 1.8 -1.6 1.1 -0.1 -0.4 -1.3 -0.4 0.2 0.8 -0.7 -0.1 -0.5 2.0 1.8 1.9
Friendships satisfaction 1.5 1.8 3.8 1.5 -1.0 0.8 -1.7 -1.9 -1.0 -1.9 1.1 1.2 -1.5 1.5 0.2 1.1 1.3 1.4
Qualifications: nursing, teaching 1.1 1.7 3.2 -1.5 1.3 -0.7 1.3 1.8 1.7 1.5 -0.6 -1.5 1.6 -0.7 0.3 -1.3 -1.3 -1.5
Commuting to job workplace: Walk 3.3 3.5 9.2 1.8 -3.0 1.7 -0.5 -2.3 -1.2 -2.0 -0.2 2.4 -2.3 1.9 -2.3 1.0 1.9 1.6
Eye problems/disorders: Cataract 1.2 1.4 2.6 -1.1 1.2 -0.8 1.2 1.3 1.4 1.4 0.7 -1.4 1.6 -1.2 0.3 -1.6 -1.1 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.3 -0.5 1.1 0.2 0.8 0.7 0.7 0.6 -1.0 -0.8 0.7 -0.7 0.3 -0.1 -0.5 -0.7
Medication for cholesterol 0.2 0.3 1.8 0.3 -1.3 0.2 0.3 -0.2 -0.6 0.1 1.1 0.3 -0.2 -0.4 -0.1 0.5 0.3 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 6.0 -1.1 1.5 -0.5 1.2 1.6 1.7 1.4 -2.0 -1.1 1.6 0.5 2.5 -1.2 -1.0 -1.3
Back pain experienced in last month 1.6 2.4 5.3 -1.3 1.6 -2.3 1.7 1.2 0.7 1.2 1.7 -1.2 1.4 -2.1 2.3 -1.2 -1.2 -1.1
Mineral and other dietary supplements 0.3 0.4 2.2 -0.5 1.5 -0.9 -0.2 0.7 -1.0 0.5 -0.4 -0.7 0.5 -0.1 0.3 0.5 -0.6 -0.1
Breast cancer (self-reported) 0.8 0.9 2.7 0.4 -1.6 0.0 -0.1 -1.2 -0.7 -1.3 0.7 1.5 -1.6 0.9 -0.9 0.0 0.4 0.4
Asthma (self-reported) 1.3 2.6 9.1 -1.5 -0.1 -3.0 1.8 0.8 1.3 1.0 1.6 -1.3 1.1 -2.4 1.2 -1.4 -1.5 -1.8
Osteoporosis (self-reported) 6.1 7.6 12.0 3.1 -3.0 3.0 -2.9 -3.0 -2.8 -2.9 -0.3 3.4 -3.5 1.6 -0.5 2.3 3.3 3.2
Osteoarthritis (self-reported) 0.2 0.2 0.7 -0.3 0.2 -0.3 -0.6 -0.8 -0.5 -0.6 -0.3 0.6 -0.7 -0.2 0.8 -0.2 -0.2 -0.1
Medication: Aspirin 1.2 1.5 2.7 -1.3 1.1 0.0 0.6 1.5 1.7 1.2 1.0 -1.4 1.5 -1.5 -0.8 -1.5 -1.2 -1.3
Medication: Gliclazide 0.1 0.2 0.9 -0.5 0.0 -0.2 -0.4 0.4 0.4 -0.1 -0.4 -0.2 0.1 0.4 -0.2 -0.9 -0.4 -0.4
Illnesses of father: None of the above (group 1) 1.1 1.4 6.2 1.1 -1.7 0.5 0.1 -1.1 -0.5 -0.7 2.5 1.4 -1.2 -0.6 0.4 0.7 1.3 1.2
Smoking status: Current 0.6 0.9 3.7 1.0 -1.9 0.7 -1.1 -1.0 -0.9 -0.9 -0.7 1.1 -1.2 0.4 -0.4 0.1 0.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.0 -1.2 1.3 -0.6 1.3 1.0 0.0 1.4 -1.2 -1.3 1.3 -0.4 0.7 -0.7 -1.1 -1.2
Whole body water mass 0.1 0.4 1.3 0.4 -0.7 0.7 -0.8 -0.6 -1.0 -0.3 -0.3 0.3 -0.3 0.1 -0.5 1.1 0.3 1.0
Leg predicted mass (right) 0.0 0.1 0.6 -0.2 -0.0 -0.1 0.0 0.0 -0.8 0.4 -0.3 -0.3 0.4 -0.3 -0.2 0.6 -0.3 0.3
Arm fat mass (left) 0.1 0.2 1.0 -0.2 -0.7 -0.4 0.2 -0.6 -0.6 -0.2 0.7 0.1 -0.3 -0.2 -1.0 0.7 -0.3 0.3
Number of self-reported non-cancer illnesses 1.5 2.7 4.1 -2.0 1.2 -1.5 1.7 1.2 1.8 1.8 0.3 -1.7 1.6 -1.9 1.1 -1.7 -2.0 -2.0
Average weekly champagne plus white wine intake 0.8 1.2 5.0 0.2 -0.8 -0.1 -1.7 -1.3 -2.2 -1.5 -0.9 0.9 -1.6 0.3 -0.4 -0.6 0.1 0.3
Miserableness 1.1 2.0 2.9 1.7 -1.5 1.0 -0.4 -1.6 -1.4 -1.5 1.3 1.4 -1.6 1.5 -1.1 1.4 1.6 1.4
Guilty feelings 0.8 1.3 8.1 -0.7 0.8 -1.4 1.6 0.8 0.6 1.0 0.7 -0.5 0.9 -0.8 2.8 -0.5 -0.5 -0.6
Wears glasses or contact lenses 0.5 0.6 2.5 0.5 -1.6 1.3 -1.2 -1.2 -0.3 -0.7 -0.3 0.6 -0.8 -0.0 -0.6 -0.3 0.3 0.3
Ever taken oral contraceptive pill 0.7 0.8 2.4 -0.5 0.4 -1.4 1.6 0.8 0.8 0.6 -0.7 -1.0 0.9 -0.5 1.4 -0.2 -0.5 -0.8
Hearing aid user 0.1 0.2 0.6 -0.4 -0.1 0.1 0.6 -0.1 -0.3 0.4 0.6 0.1 -0.1 -0.8 -0.2 -0.5 -0.3 -0.3
Mother’s age at death 0.2 0.3 0.6 0.3 -0.3 0.8 -0.1 -0.5 -0.8 -0.1 -0.4 0.6 -0.5 0.7 0.7 0.5 0.4 0.5
Financial situation satisfaction 0.4 0.5 2.1 0.0 -0.3 0.1 -1.0 -1.2 -0.4 -1.4 0.2 0.5 -1.0 1.4 -0.4 0.2 -0.1 0.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.4 -0.3 0.3 -0.7 1.4 0.3 1.3 0.6 1.6 -0.4 0.7 -1.1 1.2 -1.4 -0.1 -0.2
Commuting to job workplace: Public transport 3.3 3.9 7.1 2.3 -2.0 1.4 -1.8 -2.5 -1.7 -2.7 -1.1 2.2 -2.5 2.6 -0.7 -0.0 2.2 1.8
Eye problems/disorders: Glaucoma 0.4 0.4 1.3 -1.0 0.5 -0.6 -0.0 0.4 -0.7 0.4 -1.1 -0.6 0.3 0.4 0.7 -0.2 -1.1 -0.8
Medication: Blood pressure 0.4 0.8 1.7 -0.9 1.3 -0.1 0.2 0.9 1.1 0.7 0.6 -0.9 0.8 -1.0 -1.3 -0.5 -1.0 -0.7
Pain type(s) experienced in last month: Hip pain 1.6 2.0 6.3 -1.3 1.1 -2.1 2.5 1.3 1.3 1.3 1.3 -1.1 1.2 -1.2 1.7 -0.2 -1.1 -1.0
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.7 -0.8 -0.2 -0.6 1.2 0.9 1.6 1.2 1.0 -0.9 1.1 -1.2 0.6 -0.8 -0.8 -1.2
High cholesterol (Self-reported) 0.4 0.6 1.1 -0.9 0.6 -0.8 1.1 0.9 0.9 0.8 0.3 -0.8 0.9 -0.7 0.5 -0.5 -0.8 -0.9
Medication: Bendroflumethiazide 0.9 1.3 4.7 -1.2 0.3 0.2 0.2 1.0 0.8 1.3 0.1 -1.4 1.3 -1.8 -2.2 -0.8 -1.3 -1.1
Medication: Paracetamol 5.4 8.4 17.0 -2.4 2.5 -3.1 3.7 2.8 4.1 3.3 1.9 -2.6 3.2 -3.0 3.7 -1.2 -2.3 -2.3
Medication: Lisinopril 0.4 0.5 1.3 0.8 -1.0 0.9 0.8 0.3 -0.2 0.5 0.1 0.0 0.4 -0.4 -0.2 1.1 0.9 1.1
Medication: Atorvastatin 0.3 0.4 2.3 -0.7 0.2 0.1 0.4 0.8 0.3 -0.1 0.9 -0.3 -0.1 -0.2 -1.5 -0.4 -0.7 -0.7
Illnesses of father: High blood pressure 0.5 0.6 4.7 0.4 0.1 0.8 0.1 0.1 -1.3 -0.3 -0.1 0.0 -0.1 0.5 -2.2 0.8 0.4 0.7
Alcohol drinker status: Never 0.4 0.5 2.8 -0.9 -0.1 -0.6 0.8 0.3 -0.1 0.2 0.7 -0.3 0.2 -0.1 0.4 -1.7 -1.0 -1.1
Ever smoked 2.3 4.0 8.0 2.2 -2.8 1.5 -1.3 -2.3 -1.6 -2.6 0.4 2.3 -2.5 1.8 -0.1 1.7 2.2 2.4
Basal metabolic rate 0.0 0.1 0.7 -0.0 -0.3 0.1 -0.2 -0.2 -0.6 0.0 0.1 -0.1 0.1 -0.3 -0.2 0.9 -0.1 0.6
Leg fat percentage (left) 0.2 0.6 1.5 -1.1 0.5 -1.2 1.2 0.5 0.7 0.4 1.1 -0.8 0.6 -0.6 0.0 -0.2 -1.2 -0.6
Arm fat-free mass (left) 0.0 0.2 0.9 -0.2 -0.2 0.2 -0.3 -0.3 -0.3 -0.2 1.0 0.0 -0.1 -0.3 -0.5 0.6 -0.3 0.4
Number of operations (self-reported) 0.5 0.7 2.8 0.8 -1.1 1.7 -1.5 -0.6 -0.5 -0.1 -0.8 0.4 -0.4 0.4 0.1 1.0 0.8 0.8
Average weekly beer plus cider intake 2.3 3.3 6.7 -1.4 2.2 -1.9 1.8 2.0 1.3 2.3 1.1 -2.0 2.2 -2.6 1.8 -0.8 -1.5 -1.2
Irritability 0.1 0.2 0.8 -0.0 0.8 0.8 -0.3 0.2 -0.6 -0.2 0.9 -0.2 0.1 0.3 -0.6 -0.7 -0.2 -0.3
Risk taking 1.0 1.5 3.9 -1.4 0.7 -1.6 1.3 1.5 0.3 1.3 2.0 -1.4 1.4 -1.1 0.8 -0.7 -1.2 -1.0
Ever had prostate specific antigen (PSA) test 0.9 1.0 7.8 -0.2 0.2 -1.2 0.7 0.5 0.6 1.2 -0.8 -0.7 1.0 -0.6 2.8 -0.3 -0.1 -0.6
Fractured/broken bones in last 5 years 1.8 2.4 4.4 1.6 -1.1 1.9 -2.1 -1.8 -0.5 -1.6 0.6 1.7 -1.6 1.5 -1.9 1.1 1.5 1.6
Age started oral contraceptive pill 4.1 5.2 11.0 2.0 -1.6 2.7 -3.1 -2.8 -1.2 -2.8 -0.8 2.3 -2.8 2.3 -3.3 -0.3 1.9 1.8
Diastolic blood pressure, automated reading 0.3 1.0 3.5 -0.2 1.0 1.1 0.9 1.1 1.3 1.3 1.0 -0.9 1.4 -1.9 -0.2 0.1 -0.0 -0.2
Ever depressed for a whole week 0.4 0.6 2.5 -0.5 0.1 -0.5 -0.1 -0.7 0.4 -0.8 0.9 -0.2 -0.3 1.6 -1.5 -0.7 -0.4 -0.5
Unable to work because of sickness or disability 0.3 0.4 1.6 -0.0 0.6 -0.4 1.0 0.3 1.0 0.8 1.3 -0.2 0.5 -0.8 0.3 -0.8 -0.0 0.0
Commuting to job workplace: Cycle 3.4 4.1 7.8 1.6 -2.8 1.6 -1.9 -1.9 -2.8 -2.2 1.8 2.2 -2.5 1.3 -1.9 1.5 1.6 2.0
Myopia 0.3 0.4 3.0 -0.1 -0.2 0.4 0.2 0.3 0.9 0.5 -1.7 0.3 0.1 0.2 -0.7 0.9 -0.0 0.1
Vascular/heart problems diagnosed by doctor 0.3 0.9 6.9 0.3 0.1 -1.8 -0.1 -0.4 -0.9 -0.5 -0.4 0.7 -0.5 0.9 2.6 -0.4 0.3 0.1
Cholesterol lowering medication 0.3 0.5 1.4 0.9 0.2 0.8 -0.3 -0.2 0.3 -0.7 -0.8 0.7 -0.5 1.2 -0.5 0.5 0.8 1.1
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 6.6 -2.1 1.9 -2.6 1.9 2.0 1.4 1.8 0.9 -2.0 1.8 -1.9 -0.4 -1.2 -2.2 -2.1
Pain experienced in last month 3.7 6.2 19.7 2.4 -2.8 3.6 -2.6 -2.3 -1.4 -2.3 -1.3 2.1 -2.4 2.2 -4.4 1.1 2.1 2.2
Supplements: Calcium 0.7 0.8 1.5 0.2 -1.0 0.9 -0.7 -1.2 -1.2 -1.1 -0.1 1.0 -1.2 0.8 -0.9 -0.8 0.6 0.1
Basal cell carcinoma (self-reported) 0.3 0.4 1.4 -0.4 0.9 -0.5 1.1 0.4 0.4 0.4 0.2 -0.5 0.7 0.8 1.2 -0.1 -0.3 0.1
Heart attack/myocardial infarction (self-reported) 0.6 0.7 2.2 -0.1 -0.9 1.0 -0.7 -0.6 0.2 -1.1 -1.5 0.3 -0.9 1.4 -1.4 -0.3 -0.1 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 1.1 0.3 0.4 0.3 0.7 -0.4 -0.4 -0.2 -0.2 0.2 -0.2 1.1 -0.2 0.3 0.2 0.2
Heart disease (siblings) 0.2 0.3 1.2 -0.8 0.8 -0.5 -0.0 0.2 -0.0 0.0 0.1 -0.4 0.3 -0.2 -0.0 -0.5 -0.9 -1.1
Alcohol drinker status: Previous 2.6 2.9 5.8 -1.5 1.9 -1.7 1.6 1.8 2.2 1.8 -0.7 -2.4 2.4 -1.0 0.4 -1.4 -1.6 -1.9
Pack years of smoking 4.2 6.1 11.9 3.4 -3.0 3.2 -1.9 -2.9 -1.5 -2.6 -0.5 2.6 -2.4 1.9 -0.3 1.0 3.4 3.3
Impedance of whole body 1.8 9.3 19.4 -3.2 2.8 -4.4 3.1 3.4 3.5 2.7 0.7 -2.7 2.9 -2.4 3.4 -2.6 -3.0 -3.6
Leg fat mass (left) 0.1 0.4 1.2 -0.9 0.2 -0.9 1.0 0.3 0.4 0.4 1.1 -0.7 0.5 -0.6 -0.3 0.2 -1.0 -0.3
Arm predicted mass (left) 0.0 0.2 0.8 -0.2 -0.1 0.1 -0.2 -0.2 -0.4 -0.2 0.9 0.0 -0.0 -0.4 -0.5 0.7 -0.3 0.4