TWAS hub - CRHBP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Prostate Adenocarcinoma	0.195	0.0599	1.7e-08	0.075	0.097	0.115	NA	0.107	2.9e-08	2.5e-10	5.1e-12	NA	2.8e-11
2	TCGA	Thyroid Carcinoma	0.218	0.0470	0.0e+00	0.255	0.255	0.264	NA	0.270	9.4e-25	1.1e-24	1.2e-25	NA	2.4e-26

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illnesses of siblings: Diabetes	4.6	5.7	10.3	3.2	-1.0
Blood Platelet Count	4.2	48.5	96.0	-9.8	-1.0
Number of full brothers	3.9	4.9	6.4	1.9	-2.5
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.3	8.2	-0.5	-2.9
Medication: Ibuprofen	3.0	3.5	7.0	-0.2	-2.7
Depression (Nagel 2018)	2.9	4.4	8.8	-3.0	0.1
Prospective memory result	2.7	3.3	5.9	-0.9	-2.4
Number of full sisters	2.7	3.2	6.4	-0.2	-2.5
Risk taking	2.6	3.8	6.2	-1.2	-2.5
Noisy workplace	2.5	3.1	5.6	0.7	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	7.8	14.3	3.8	-1.2
Number of incorrect matches in round	2.4	3.9	6.9	-2.6	1.0
Hayfever/allergic rhinitis (self-reported)	2.4	3.1	4.1	1.5	2.0
Fluid intelligence score	2.4	5.0	7.6	2.8	1.6
Medication: Seretide 50 evohaler	2.4	2.7	4.0	2.0	1.2
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	5.6	-0.5	2.4
Wears glasses or contact lenses	2.4	2.8	3.4	-1.8	1.5
HDL Cholesterol	2.3	3.8	5.7	1.4	2.4
Crohns Disease (2017)	2.2	4.9	7.8	-2.8	1.4
Irritable Bowel Disease (IBD)	2.2	5.2	8.5	-2.9	1.4
Type 2 Diabetes (T2D) (2012)	2.2	2.5	4.2	-0.9	2.1
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.1	-2.0	1.0
Medication: Lansoprazole	2.2	2.6	4.0	-1.0	2.0
Age started oral contraceptive pill	2.2	2.8	4.8	-0.9	2.2
Relative age voice broke	2.1	3.2	6.5	-2.5	0.2
Commuting to job workplace: Car/motor vehicle	2.1	2.4	4.5	0.6	-2.1
Intelligence (Savage-Jansen 2018)	2.0	6.3	11.4	3.4	1.1
Stomach or abdominal pain in last month	2.0	2.4	3.3	-1.8	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	7.5	1.0	-2.7
Supplements: Fish oil (including cod liver oil)	2.0	2.6	2.9	1.7	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.3	7.4	1.1	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.7	-1.9	0.8
Medication for cholesterol	1.9	2.9	5.7	-2.4	-0.3
Medication: Aspirin	1.9	2.5	3.7	-1.1	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	7.0	1.0	-2.6
Gout (self-reported)	1.8	2.5	4.7	2.2	-0.5
Medication: Aspirin	1.8	2.4	3.8	-1.0	1.9
Number of live births	1.7	2.4	3.1	-1.3	-1.8
Headache pain in last month	1.7	2.9	4.1	1.3	-2.0
Smoking status: Previous	1.7	2.5	4.7	-2.2	-0.6
Long-standing illness, disability or infirmity	1.7	2.6	3.1	-1.4	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.6	1.9	0.0
Mineral and other dietary supplements	1.7	2.3	3.4	-1.8	1.1
Commuting to job workplace: Public transport	1.7	2.0	3.2	-1.0	1.8
Time employed in main current job	1.6	1.9	3.1	-0.8	1.8
Breastfed as a baby	1.6	2.0	3.5	-1.9	0.6
Pain experienced in last month	1.6	2.6	4.0	1.1	2.0
Multivitamins +/- minerals	1.5	1.9	3.7	1.9	-0.3
Medication: Paracetamol	1.5	2.4	4.7	0.4	-2.2
Medication: Ramipril	1.4	1.8	3.5	0.2	-1.9
Birth weight of first child	1.4	2.6	5.2	2.3	-0.1
Glaucoma (self-reported)	1.4	1.7	3.3	-1.8	0.3
Age at first live birth	1.4	2.6	4.6	0.7	2.2
Alcohol drinker status: Never	1.4	1.7	2.3	1.1	1.5
Ever depressed for a whole week	1.4	1.8	2.0	1.4	1.2
Commuting to job workplace: Cycle	1.4	1.7	3.1	1.8	0.6
Fasting Glucose	1.3	1.5	2.7	-0.6	-1.6
Chronotype (morning person)	1.3	3.1	4.7	1.2	-2.2
Peak expiratory flow (PEF)	1.3	3.1	5.9	2.4	-0.6
Forced vital capacity (FVC), Best measure	1.3	4.7	7.7	2.8	-1.3
Emphysema/chronic bronchitis	1.3	1.5	2.7	-0.5	-1.7
Medication: Gliclazide	1.3	1.5	2.3	-0.8	1.5
Medication: Paracetamol	1.3	2.0	4.1	-0.2	-2.0
Bipolar Disorder or Schizophrenia	1.2	2.9	3.9	1.4	2.0
Coronary Artery Disease (CAD)	1.2	1.4	2.7	-1.6	-0.2
Frequency of depressed mood in last 2 weeks	1.2	1.6	3.3	-1.8	0.0
Illnesses of siblings	1.2	1.7	2.5	-0.9	1.6
Mouth/teeth dental problems: Dentures	1.2	2.1	3.9	-2.0	-0.5
Suffer from ‘nerves’	1.2	1.9	3.7	1.9	-0.3
Knee pain experienced in last month	1.2	1.9	3.7	0.4	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.6	0.5	-1.6
Unable to work because of sickness or disability	1.2	1.5	1.9	1.0	-1.4
Supplements: Zinc	1.1	1.2	2.3	1.5	0.4
Chronic bronchitis/emphysema (father)	1.1	1.3	2.3	1.5	0.5
Migraine (self-reported)	1.1	1.4	2.6	-0.4	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.5	-1.1	1.2
Average weekly champagne plus white wine intake	1.1	1.5	1.9	1.4	-1.0
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.4	1.6	0.2
Medication: Bendroflumethiazide	1.1	1.7	3.1	0.6	-1.8
Medication: Lisinopril	1.1	1.4	2.8	0.1	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.6	1.6	-0.4
Heart disease (siblings)	1.1	1.3	2.0	-1.4	-0.8
Blood Red Count	1.0	9.3	18.7	4.3	-0.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	5.1	2.3	-1.2
Medication: Cholesterol lowering	1.0	1.6	3.0	-1.7	0.3
Lung cancer (father)	1.0	1.2	2.1	1.5	-0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.2	1.1	1.1
Shortness of breath walking on level ground	1.0	1.2	1.9	-1.4	-0.7
Age at last live birth	1.0	1.4	2.8	0.1	1.7
Leg pain on walking	1.0	1.3	1.5	-1.2	-1.1
Leg fat-free mass (right)	1.0	5.2	5.3	2.3	-2.3
Leg predicted mass (right)	1.0	5.5	5.7	2.4	-2.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-1.5	-0.0
Medication: Blood pressure	1.0	1.9	2.9	1.7	-1.0
Pack years of smoking	1.0	1.5	2.8	-1.7	-0.5
Bipolar Disorder (2018)	0.9	1.4	1.6	1.3	1.1
Schizophrenia (2018)	0.9	1.9	2.6	1.1	1.6
Verbal and Numeric Reasoning (VNR)	0.9	2.1	2.4	1.3	1.6
Lupus	0.9	1.3	2.2	1.5	-0.6
Rheumatoid Arthritis	0.9	1.2	1.3	1.0	1.1
Vitamin and mineral supplements	0.9	1.2	1.7	-1.3	0.8
Diabetes (father)	0.9	1.1	1.3	1.1	-0.9
Severe depression (siblings)	0.9	1.0	1.6	-1.3	-0.6
Leg fat-free mass (left)	0.9	4.5	4.8	2.2	-2.1
Average weekly fortified wine intake	0.9	1.1	1.9	1.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	-0.1	1.4
Hayfever, allergic rhinitis or eczema	0.9	1.9	2.1	1.4	1.3
Leg predicted mass (left)	0.9	4.8	5.2	2.3	-2.1
Blood clot in the leg (DVT)	0.9	1.2	2.4	1.6	-0.2
Medication: Amlodipine	0.9	1.3	2.3	-1.5	-0.4
Arm fat-free mass (right)	0.9	4.5	4.8	2.0	-2.2
Exposure to tobacco smoke outside home	0.9	1.2	2.4	-1.5	-0.0
Medication: Allopurinol	0.9	1.2	2.2	1.5	-0.4
Qualifications: nursing, teaching	0.9	1.3	2.5	1.6	-0.4
Basal metabolic rate	0.9	4.9	5.2	2.2	-2.3
Irritability	0.9	1.5	1.6	1.2	-1.3
Alzheimer’s Disease (in mother)	0.8	0.9	1.7	1.3	-0.4
Crohns Disease (2012)	0.8	1.3	2.7	-1.6	0.2
Smoking Status	0.8	2.0	2.8	-1.1	-1.7
Current tobacco smoking	0.8	1.3	2.3	-0.6	-1.5
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.5	1.2	0.8
Mouth/teeth dental problems	0.8	1.2	1.9	1.4	0.7
Arm fat mass (right)	0.8	3.2	3.5	1.7	-1.9
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.5	0.8	-1.2
Health satisfaction	0.8	1.0	1.4	-1.2	-0.8
Arm predicted mass (right)	0.8	4.3	4.8	2.0	-2.2
Loneliness, isolation	0.8	1.2	1.4	1.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.4	0.1	-1.5
Smoking status: Current	0.8	1.2	2.4	-0.3	-1.5
Arm fat mass (left)	0.8	3.2	3.8	1.6	-1.9
Ever smoked	0.8	1.4	2.7	0.2	-1.6
Fractured/broken bones in last 5 years	0.8	1.0	1.5	0.8	-1.2
Alcohol drinker status: Previous	0.8	0.9	1.4	0.7	-1.2
Arm predicted mass (left)	0.8	4.1	4.8	1.8	-2.2
Ulcerative Colitis (UC)	0.7	1.4	2.3	-1.5	0.7
Prostate Cancer	0.7	1.0	1.4	1.2	0.7
Body Mass Index (BMI) (2010)	0.7	0.9	1.1	1.1	-0.8
Diabetes (mother)	0.7	0.8	1.4	-0.5	-1.2
Taking other prescription medications	0.7	1.2	2.3	-1.5	-0.1
Weight	0.7	3.6	3.6	1.9	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	1.3	1.1	-0.5
Pulse wave reflection index	0.7	0.8	1.5	1.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	1.6	1.2	0.6
Alcohol intake frequency.	0.7	1.5	3.1	1.8	0.0
Whole body fat-free mass	0.7	4.0	4.1	2.0	-2.0
Whole body water mass	0.7	4.1	4.3	2.0	-2.1
Hearing aid user	0.7	0.8	1.5	1.2	-0.4
Mother’s age at death	0.7	0.8	1.6	0.2	1.3
Arm fat-free mass (left)	0.7	3.7	4.2	1.8	-2.0
Myopia	0.7	1.1	1.7	-0.6	1.3
Basal cell carcinoma (self-reported)	0.7	0.8	1.5	1.2	0.3
HbA1C	0.6	0.7	1.0	-1.0	0.6
BMI	0.6	3.7	5.9	2.4	-1.2
Allergy or Eczema	0.6	1.5	2.9	1.7	0.2
Hypothyroidism (self reported)	0.6	1.3	2.3	-1.5	0.6
Hearing difficulty/problems: Yes	0.6	0.9	1.6	-0.4	-1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	-1.3	0.0
Pack years adult smoking proportion	0.6	1.0	1.6	-1.3	-0.5
Age when periods started (menarche)	0.6	1.4	2.4	-0.6	1.6
Medication: Atenolol	0.6	0.7	1.2	-1.1	0.5
Medication: Levothyroxine sodium	0.6	1.0	1.2	-1.1	0.8
Body mass index (BMI)	0.6	2.7	3.7	1.3	-1.9
Past tobacco smoking	0.6	1.1	1.4	1.2	0.9
Hearing difficulty/problems with background noise	0.6	1.0	1.8	1.3	-0.5
Arm fat percentage (right)	0.6	2.2	2.6	1.3	-1.6
Trunk fat-free mass	0.6	3.3	3.8	1.7	-1.9
Falls in the last year	0.6	0.7	1.5	1.2	0.1
Pulse rate	0.6	1.0	1.9	-1.4	0.3
Trunk predicted mass	0.6	3.3	4.0	1.6	-2.0
Length of working week for main job	0.6	0.6	0.7	-0.7	0.9
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.6	0.5	1.2
Worry too long after embarrassment	0.6	1.0	1.5	-1.2	0.7
Leg fat mass (right)	0.6	2.3	2.7	1.4	-1.6
Arm fat percentage (left)	0.6	2.6	3.3	1.3	-1.8
Handedness (chirality/laterality): Left-handed	0.6	0.8	0.9	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.4	1.2	1.0
Cholesterol lowering medication	0.6	0.9	1.5	1.2	-0.6
Leg fat mass (left)	0.6	2.5	2.8	1.5	-1.7
Major Depression (MDD)	0.5	0.6	0.7	0.7	0.8
LDL Cholesterol	0.5	0.8	0.9	0.9	-1.0
Schizophrenia (2014)	0.5	1.0	1.7	0.6	1.3
Cardiovascular Disease	0.5	1.6	1.9	1.1	-1.4
Sensitivity / hurt feelings	0.5	0.8	1.0	-1.0	0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.2	-1.1	-0.3
High blood pressure (mother)	0.5	0.7	0.8	-0.9	-0.7
Hair/balding pattern: Pattern 2	0.5	0.7	1.2	1.1	0.4
Forced vital capacity (FVC)	0.5	2.0	2.7	1.6	-1.1
Allergy	0.5	1.2	1.4	-1.2	-1.0
Hip circumference	0.5	2.3	2.3	1.5	-1.5
Worrier / anxious feelings	0.5	0.9	1.6	1.3	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.2	0.8	1.1
Whole body fat mass	0.5	2.0	2.1	1.4	-1.4
Chest pain or discomfort	0.5	0.7	1.0	-0.6	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	-1.1	0.1
Ever had bowel cancer screening	0.5	0.6	1.0	-0.4	1.0
Guilty feelings	0.5	0.7	1.4	-1.2	0.2
Medication: Atorvastatin	0.5	0.6	0.8	-0.9	0.6
Number of operations (self-reported)	0.5	0.8	0.9	0.8	0.9
Diastolic blood pressure, automated reading	0.5	1.6	2.8	0.7	-1.7
Vascular/heart problems diagnosed by doctor	0.5	1.2	2.1	-0.6	1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	0.8	-0.9	0.7
Neuroticism (Nagel 2018)	0.4	1.0	1.6	-0.7	1.3
Alzheimer’s Disease (in father)	0.4	0.5	0.8	-0.9	-0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	0.9	0.9	-0.6
Ovarian Cancer	0.4	0.5	0.7	-0.5	-0.9
Average weekly spirits intake	0.4	0.5	1.0	-0.0	-1.0
Trunk fat mass	0.4	1.7	1.8	1.3	-1.3
Alcohol usually taken with meals	0.4	0.7	1.3	1.2	0.0
Hair/balding pattern: Pattern 3	0.4	0.5	0.7	0.8	-0.6
Exposure to tobacco smoke at home	0.4	0.4	0.7	-0.4	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.8	-0.6	0.9
Loud music exposure frequency	0.4	0.5	0.9	-0.1	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	-0.4	0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	1.1	0.4
Neck or shoulder pain in last month	0.4	0.6	0.8	-0.7	-0.9
Medication: Blood pressure	0.4	0.8	1.4	-0.4	-1.2
Family relationship satisfaction	0.4	0.5	0.9	-0.2	0.9
Breast cancer (self-reported)	0.4	0.5	1.0	-1.0	0.1
Asthma (self-reported)	0.4	0.8	1.2	0.7	1.1
Number of self-reported non-cancer illnesses	0.4	0.6	0.9	-0.6	1.0
Financial situation satisfaction	0.4	0.4	0.6	-0.8	-0.5
Breast Cancer	0.3	0.7	1.2	1.1	-0.5
Neuroticism (2016)	0.3	0.5	0.8	-0.4	-0.9
Ulcerative Colitis	0.3	0.4	0.8	-0.9	-0.1
Blood Eosinophil Count	0.3	1.9	3.7	1.9	-0.5
Waist Hip Ratio (WHR)	0.3	1.5	2.3	0.8	1.5
Tanning	0.3	3.7	7.0	-2.6	0.6
Systolic blood pressure, automated reading	0.3	0.9	0.9	-0.9	-0.9
Medication: Co-codamol	0.3	0.4	0.7	0.8	-0.3
Trunk fat percentage	0.3	1.2	1.3	1.0	-1.1
Fed-up feelings	0.3	0.6	0.6	0.8	-0.8
High blood pressure	0.3	0.9	0.9	1.0	-0.9
Waist circumference	0.3	1.1	1.4	1.2	-0.8
Asthma	0.3	0.5	0.6	0.7	0.8
Depression (self-reported)	0.3	0.3	0.4	-0.7	-0.4
Tense / ‘highly strung’	0.3	0.6	1.0	1.0	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.8	0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	-1.0	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	0.8	0.2
High blood pressure (siblings)	0.3	0.4	0.9	0.9	-0.1
Number of children fathered	0.3	0.4	0.6	-0.4	-0.7
Medication: Omeprazole	0.3	0.4	0.4	-0.7	0.6
Mean time to correctly identify matches	0.3	0.5	0.5	-0.7	0.7
Had major operations	0.3	0.3	0.5	0.7	0.2
Supplements: Vitamin C	0.3	0.3	0.4	0.6	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.3	0.4	-0.7	0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.9	-0.2
Supplements: Calcium	0.3	0.4	0.6	0.4	0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	-0.7	-0.1
Worry (Nagel 2018)	0.2	0.4	0.6	0.5	0.8
Reaction Time	0.2	0.5	0.5	0.6	-0.7
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.6	-0.3
Blood White Count	0.2	1.5	2.8	-1.7	-0.3
Lung FEV1/FVC ratio	0.2	0.8	1.2	1.1	-0.6
Number of treatments/medications taken	0.2	0.4	0.8	-0.2	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.5	0.0	0.7
Medication: Metformin	0.2	0.3	0.6	-0.3	0.7
Impedance of leg (right)	0.2	1.1	1.7	-0.7	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.6	0.0
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.3	-0.7
Impedance of leg (left)	0.2	0.8	1.0	-0.8	1.0
Had other major operations	0.2	0.2	0.3	-0.6	0.3
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.4	-0.6
Medication: Simvastatin	0.2	0.2	0.4	-0.7	0.1
Father’s age at death	0.2	0.2	0.4	-0.1	0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.2	0.5	0.4
Body fat percentage	0.2	0.9	1.2	0.8	-1.1
Leg fat percentage (right)	0.2	0.6	1.2	0.3	-1.1
Pulse wave peak to peak time	0.2	0.2	0.2	-0.4	-0.4
Pulse rate, automated reading	0.2	0.7	1.4	-1.2	0.2
Comparative height size at age 10	0.2	1.2	2.4	1.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.3	-0.5	-0.5
Average weekly red wine intake	0.2	0.3	0.5	-0.4	-0.7
Mood swings	0.2	0.4	0.8	0.9	0.3
Commuting to job workplace: Walk	0.2	0.2	0.2	-0.4	0.5
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.6	0.3
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.1	0.8
Leg fat percentage (left)	0.2	0.8	1.5	0.4	-1.2
Average weekly beer plus cider intake	0.2	0.3	0.4	-0.5	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.1	0.7
Mean Putamen Volume	0.1	0.1	0.1	0.4	0.3
Triglycerides	0.1	0.2	0.2	0.4	-0.5
Heel T-Score	0.1	0.8	1.0	1.0	0.7
Height	0.1	2.7	3.9	1.3	2.0
Systolic Blood Pressure	0.1	0.5	0.7	-0.8	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.6	-0.1
Lung FVC	0.1	0.6	1.1	-1.1	0.1
Neuroticism	0.1	0.3	0.5	0.2	0.7
Relative age of first facial hair	0.1	0.2	0.4	-0.6	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.1	0.4
Hand grip strength (right)	0.1	0.1	0.3	-0.5	0.1
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.5	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.0	-0.5
Serious illness, injury or assault to yourself	0.1	0.2	0.2	-0.4	-0.4
Sitting height	0.1	0.7	1.3	1.1	-0.4
Nervous feelings	0.1	0.2	0.4	-0.6	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	-0.3	-0.3
Had menopause	0.1	0.1	0.2	-0.5	0.1
Qualifications: None of the above	0.1	0.2	0.3	-0.4	0.5
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.3
Diabetes (self-reported)	0.1	0.1	0.1	-0.2	0.3
Impedance of arm (right)	0.1	0.5	0.7	-0.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.5	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.3	0.5
Illnesses of mother	0.1	0.1	0.2	0.4	0.4
Impedance of arm (left)	0.1	0.2	0.3	-0.4	0.5
Standing height	0.1	0.8	1.7	1.3	-0.0
Birth weight	0.1	0.2	0.4	-0.6	0.2
Wheeze or whistling in the chest in last year	0.1	0.3	0.5	0.1	-0.7
Heart disease (mother)	0.1	0.2	0.3	-0.6	0.0
Hypertension (Self-reported)	0.1	0.4	0.5	0.4	-0.7
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.0	-0.4
Friendships satisfaction	0.1	0.2	0.2	0.4	-0.4
Back pain experienced in last month	0.1	0.1	0.2	-0.2	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	-0.2
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.1	0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.1	-0.4
Impedance of whole body	0.1	0.8	1.1	-0.6	1.1
Age at First Birth	0.0	0.0	0.0	-0.1	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Respiratory disease	0.0	0.1	0.1	0.0	0.3
Hair Pigment	0.0	0.5	1.0	-1.0	-0.1
Hand grip strength (left)	0.0	0.0	0.1	0.1	0.3
Angina	0.0	0.0	0.0	0.1	0.1
Maternal smoking around birth	0.0	0.0	0.0	-0.2	0.1
Supplements: Glucosamine	0.0	0.1	0.1	0.1	0.3
Heart attack	0.0	0.0	0.1	-0.2	-0.3
Neuroticism score	0.0	0.1	0.2	0.4	0.0
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.0	0.1
Happiness	0.0	0.0	0.1	-0.2	-0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.3	0.4
Comparative body size at age 10	0.0	0.1	0.1	-0.3	0.3
Qualifications: College or University degree	0.0	0.1	0.2	0.1	-0.5
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.2	0.2
Angina (self-reported)	0.0	0.0	0.0	0.0	-0.1
Overall health rating	0.0	0.0	0.0	0.0	-0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.3	0.0
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.1	-0.0
Miserableness	0.0	0.0	0.0	-0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.3	-0.2

Hub : Genes

CRHBP

Models

Trait associations