Hub : Genes

CRHBP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Prostate Adenocarcinoma 0.195 0.0599 1.7e-08 0.075 0.097 0.115 NA 0.107 2.9e-08 2.5e-10 5.1e-12 NA 2.8e-11
2 TCGA Thyroid Carcinoma 0.218 0.0470 0.0e+00 0.255 0.255 0.264 NA 0.270 9.4e-25 1.1e-24 1.2e-25 NA 2.4e-26

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 1.6 1.3 1.1
Bipolar Disorder or Schizophrenia 1.2 2.9 3.9 1.4 2.0
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 -0.1 0.7
Depression (Nagel 2018) 2.9 4.4 8.8 -3.0 0.1
Intelligence (Savage-Jansen 2018) 2.0 6.3 11.4 3.4 1.1
Neuroticism (Nagel 2018) 0.4 1.0 1.6 -0.7 1.3
Schizophrenia (2018) 0.9 1.9 2.6 1.1 1.6
Schizophrenia vs Biploar Disorder 0.2 0.3 0.5 -0.7 -0.1
Worry (Nagel 2018) 0.2 0.4 0.6 0.5 0.8
Alzheimer’s Disease (in mother) 0.8 0.9 1.7 1.3 -0.4
Alzheimer’s Disease (in father) 0.4 0.5 0.8 -0.9 -0.3
Alzheimer’s Disease (including proxy) 0.4 0.6 0.9 0.9 -0.6
Crohns Disease (2017) 2.2 4.9 7.8 -2.8 1.4
Irritable Bowel Disease (IBD) 2.2 5.2 8.5 -2.9 1.4
Ulcerative Colitis (UC) 0.7 1.4 2.3 -1.5 0.7
Major Depression (MDD) 0.5 0.6 0.7 0.7 0.8
Reaction Time 0.2 0.5 0.5 0.6 -0.7
Verbal and Numeric Reasoning (VNR) 0.9 2.1 2.4 1.3 1.6
Breast Cancer 0.3 0.7 1.2 1.1 -0.5
Ovarian Cancer 0.4 0.5 0.7 -0.5 -0.9
Prostate Cancer 0.7 1.0 1.4 1.2 0.7
Age at First Birth 0.0 0.0 0.0 -0.1 0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 0.9 1.1 1.1 -0.8
Coronary Artery Disease (CAD) 1.2 1.4 2.7 -1.6 -0.2
Crohns Disease (2012) 0.8 1.3 2.7 -1.6 0.2
Mean Putamen Volume 0.1 0.1 0.1 0.4 0.3
Fasting Glucose 1.3 1.5 2.7 -0.6 -1.6
HbA1C 0.6 0.7 1.0 -1.0 0.6
HDL Cholesterol 2.3 3.8 5.7 1.4 2.4
LDL Cholesterol 0.5 0.8 0.9 0.9 -1.0
Lupus 0.9 1.3 2.2 1.5 -0.6
Neuroticism (2016) 0.3 0.5 0.8 -0.4 -0.9
Primary Biliary Cirrhosis 0.2 0.3 0.4 -0.6 -0.3
Rheumatoid Arthritis 0.9 1.2 1.3 1.0 1.1
Schizophrenia (2014) 0.5 1.0 1.7 0.6 1.3
Triglycerides 0.1 0.2 0.2 0.4 -0.5
Type 2 Diabetes (T2D) (2012) 2.2 2.5 4.2 -0.9 2.1
Ulcerative Colitis 0.3 0.4 0.8 -0.9 -0.1
Blood Eosinophil Count 0.3 1.9 3.7 1.9 -0.5
Blood Platelet Count 4.2 48.5 96.0 -9.8 -1.0
Blood Red Count 1.0 9.3 18.7 4.3 -0.0
Blood White Count 0.2 1.5 2.8 -1.7 -0.3
Heel T-Score 0.1 0.8 1.0 1.0 0.7
BMI 0.6 3.7 5.9 2.4 -1.2
Height 0.1 2.7 3.9 1.3 2.0
Waist Hip Ratio (WHR) 0.3 1.5 2.3 0.8 1.5
Systolic Blood Pressure 0.1 0.5 0.7 -0.8 -0.6
Smoking Status 0.8 2.0 2.8 -1.1 -1.7
Allergy or Eczema 0.6 1.5 2.9 1.7 0.2
Cardiovascular Disease 0.5 1.6 1.9 1.1 -1.4
Hypothyroidism (self reported) 0.6 1.3 2.3 -1.5 0.6
Respiratory disease 0.0 0.1 0.1 0.0 0.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 0.6 -0.1
Lung FEV1/FVC ratio 0.2 0.8 1.2 1.1 -0.6
Lung FVC 0.1 0.6 1.1 -1.1 0.1
Neuroticism 0.1 0.3 0.5 0.2 0.7
Chronotype (morning person) 1.3 3.1 4.7 1.2 -2.2
Hair Pigment 0.0 0.5 1.0 -1.0 -0.1
Tanning 0.3 3.7 7.0 -2.6 0.6
Hand grip strength (left) 0.0 0.0 0.1 0.1 0.3
Number of treatments/medications taken 0.2 0.4 0.8 -0.2 -0.9
Average weekly spirits intake 0.4 0.5 1.0 -0.0 -1.0
Sensitivity / hurt feelings 0.5 0.8 1.0 -1.0 0.8
Frequency of depressed mood in last 2 weeks 1.2 1.6 3.3 -1.8 0.0
Hearing difficulty/problems: Yes 0.6 0.9 1.6 -0.4 -1.3
Relative age of first facial hair 0.1 0.2 0.4 -0.6 0.3
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.6 -1.3 0.0
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.2 -1.1 -0.3
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.1 0.5
Systolic blood pressure, automated reading 0.3 0.9 0.9 -0.9 -0.9
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.1 0.4
Angina 0.0 0.0 0.0 0.1 0.1
Medication for hormone replacement therapy 0.2 0.2 0.5 0.0 0.7
Vitamin and mineral supplements 0.9 1.2 1.7 -1.3 0.8
Supplements: Zinc 1.1 1.2 2.3 1.5 0.4
Medication: Co-codamol 0.3 0.4 0.7 0.8 -0.3
Medication: Metformin 0.2 0.3 0.6 -0.3 0.7
Diabetes (father) 0.9 1.1 1.3 1.1 -0.9
Diabetes (mother) 0.7 0.8 1.4 -0.5 -1.2
Severe depression (siblings) 0.9 1.0 1.6 -1.3 -0.6
Pack years adult smoking proportion 0.6 1.0 1.6 -1.3 -0.5
Impedance of leg (right) 0.2 1.1 1.7 -0.7 1.3
Leg fat-free mass (left) 0.9 4.5 4.8 2.2 -2.1
Trunk fat percentage 0.3 1.2 1.3 1.0 -1.1
Hand grip strength (right) 0.1 0.1 0.3 -0.5 0.1
Townsend deprivation index at recruitment 0.1 0.1 0.3 0.5 0.2
Current tobacco smoking 0.8 1.3 2.3 -0.6 -1.5
Average weekly fortified wine intake 0.9 1.1 1.9 1.4 0.5
Maternal smoking around birth 0.0 0.0 0.0 -0.2 0.1
Fed-up feelings 0.3 0.6 0.6 0.8 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.4 -0.6 0.0
Relative age voice broke 2.1 3.2 6.5 -2.5 0.2
Taking other prescription medications 0.7 1.2 2.3 -1.5 -0.1
Age when periods started (menarche) 0.6 1.4 2.4 -0.6 1.6
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.0 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.3 7.4 1.1 -2.7
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.0 -0.1 1.4
Qualifications: CSEs or equivalent 0.2 0.3 0.5 0.3 -0.7
Serious illness, injury or assault to yourself 0.1 0.2 0.2 -0.4 -0.4
High blood pressure 0.3 0.9 0.9 1.0 -0.9
Hayfever, allergic rhinitis or eczema 0.9 1.9 2.1 1.4 1.3
Multivitamins +/- minerals 1.5 1.9 3.7 1.9 -0.3
Stomach or abdominal pain in last month 2.0 2.4 3.3 -1.8 -1.2
Supplements: Glucosamine 0.0 0.1 0.1 0.1 0.3
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 4.1 -2.0 1.0
Medication: Atenolol 0.6 0.7 1.2 -1.1 0.5
Medication: Levothyroxine sodium 0.6 1.0 1.2 -1.1 0.8
Sitting height 0.1 0.7 1.3 1.1 -0.4
Chronic bronchitis/emphysema (father) 1.1 1.3 2.3 1.5 0.5
High blood pressure (mother) 0.5 0.7 0.8 -0.9 -0.7
Body mass index (BMI) 0.6 2.7 3.7 1.3 -1.9
Impedance of leg (left) 0.2 0.8 1.0 -0.8 1.0
Leg predicted mass (left) 0.9 4.8 5.2 2.3 -2.1
Trunk fat mass 0.4 1.7 1.8 1.3 -1.3
Waist circumference 0.3 1.1 1.4 1.2 -0.8
Number of incorrect matches in round 2.4 3.9 6.9 -2.6 1.0
Past tobacco smoking 0.6 1.1 1.4 1.2 0.9
Alcohol usually taken with meals 0.4 0.7 1.3 1.2 0.0
Nervous feelings 0.1 0.2 0.4 -0.6 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.1 -0.3 -0.3
Hearing difficulty/problems with background noise 0.6 1.0 1.8 1.3 -0.5
Hair/balding pattern: Pattern 2 0.5 0.7 1.2 1.1 0.4
Had menopause 0.1 0.1 0.2 -0.5 0.1
Had other major operations 0.2 0.2 0.3 -0.6 0.3
Forced vital capacity (FVC) 0.5 2.0 2.7 1.6 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.0 7.0 1.0 -2.6
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.5 1.2 0.8
Qualifications: None of the above 0.1 0.2 0.3 -0.4 0.5
Financial difficulties in last 2 years 0.2 0.2 0.4 -0.4 -0.6
Mouth/teeth dental problems 0.8 1.2 1.9 1.4 0.7
Heart attack 0.0 0.0 0.1 -0.2 -0.3
Allergy 0.5 1.2 1.4 -1.2 -1.0
Pain all over the body in last month 0.1 0.1 0.2 -0.4 0.3
Diabetes (self-reported) 0.1 0.1 0.1 -0.2 0.3
Hayfever/allergic rhinitis (self-reported) 2.4 3.1 4.1 1.5 2.0
Medication: Ramipril 1.4 1.8 3.5 0.2 -1.9
Medication: Simvastatin 0.2 0.2 0.4 -0.7 0.1
Fluid intelligence score 2.4 5.0 7.6 2.8 1.6
Illnesses of siblings 1.2 1.7 2.5 -0.9 1.6
Neuroticism score 0.0 0.1 0.2 0.4 0.0
Weight 0.7 3.6 3.6 1.9 -1.9
Impedance of arm (right) 0.1 0.5 0.7 -0.5 0.9
Arm fat percentage (right) 0.6 2.2 2.6 1.3 -1.6
Trunk fat-free mass 0.6 3.3 3.8 1.7 -1.9
Hip circumference 0.5 2.3 2.3 1.5 -1.5
Time employed in main current job 1.6 1.9 3.1 -0.8 1.8
Alcohol intake versus 10 years previously 0.0 0.0 0.0 -0.0 0.1
Father’s age at death 0.2 0.2 0.4 -0.1 0.7
Worrier / anxious feelings 0.5 0.9 1.6 1.3 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.3 -0.5 0.1
Falls in the last year 0.6 0.7 1.5 1.2 0.1
Hair/balding pattern: Pattern 3 0.4 0.5 0.7 0.8 -0.6
Number of live births 1.7 2.4 3.1 -1.3 -1.8
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 5.1 2.3 -1.2
Pulse rate 0.6 1.0 1.9 -1.4 0.3
Happiness 0.0 0.0 0.1 -0.2 -0.1
Noisy workplace 2.5 3.1 5.6 0.7 -2.4
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 0.3 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.7 1.3 1.1 -0.5
Mouth/teeth dental problems: Dentures 1.2 2.1 3.9 -2.0 -0.5
Asthma 0.3 0.5 0.6 0.7 0.8
Medication: Ibuprofen (e.g. Nurofen) 3.4 4.3 8.2 -0.5 -2.9
Medication: Cholesterol lowering 1.0 1.6 3.0 -1.7 0.3
Depression (self-reported) 0.3 0.3 0.4 -0.7 -0.4
Medication: Lansoprazole 2.2 2.6 4.0 -1.0 2.0
Prospective memory result 2.7 3.3 5.9 -0.9 -2.4
Lung cancer (father) 1.0 1.2 2.1 1.5 -0.6
Illnesses of mother 0.1 0.1 0.2 0.4 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 7.8 14.3 3.8 -1.2
Pulse wave Arterial Stiffness index 0.2 0.2 0.2 0.5 0.4
Impedance of arm (left) 0.1 0.2 0.3 -0.4 0.5
Arm fat mass (right) 0.8 3.2 3.5 1.7 -1.9
Trunk predicted mass 0.6 3.3 4.0 1.6 -2.0
Standing height 0.1 0.8 1.7 1.3 -0.0
Length of working week for main job 0.6 0.6 0.7 -0.7 0.9
Exposure to tobacco smoke at home 0.4 0.4 0.7 -0.4 -0.8
Breastfed as a baby 1.6 2.0 3.5 -1.9 0.6
Tense / ‘highly strung’ 0.3 0.6 1.0 1.0 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.8 -0.6 0.9
Hair/balding pattern: Pattern 4 0.0 0.1 0.1 -0.3 0.4
Birth weight of first child 1.4 2.6 5.2 2.3 -0.1
Peak expiratory flow (PEF) 1.3 3.1 5.9 2.4 -0.6
Pulse wave reflection index 0.7 0.8 1.5 1.2 0.3
Ever highly irritable/argumentative for 2 days 1.0 1.2 1.2 1.1 1.1
Loud music exposure frequency 0.4 0.5 0.9 -0.1 -1.0
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.6 0.5 1.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.7 0.8 0.4
Blood clot in the leg (DVT) 0.9 1.2 2.4 1.6 -0.2
Medication: Paracetamol 1.5 2.4 4.7 0.4 -2.2
Headache pain in last month 1.7 2.9 4.1 1.3 -2.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.2 0.8 1.1
Glaucoma (self-reported) 1.4 1.7 3.3 -1.8 0.3
Gout (self-reported) 1.8 2.5 4.7 2.2 -0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.0 -1.0 0.5
Medication: Amlodipine 0.9 1.3 2.3 -1.5 -0.4
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.5 0.8 -1.2
Birth weight 0.1 0.2 0.4 -0.6 0.2
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 0.8 0.2
High blood pressure (siblings) 0.3 0.4 0.9 0.9 -0.1
Forced vital capacity (FVC), Best measure 1.3 4.7 7.7 2.8 -1.3
Body fat percentage 0.2 0.9 1.2 0.8 -1.1
Leg fat percentage (right) 0.2 0.6 1.2 0.3 -1.1
Arm fat-free mass (right) 0.9 4.5 4.8 2.0 -2.2
Exposure to tobacco smoke outside home 0.9 1.2 2.4 -1.5 -0.0
Comparative body size at age 10 0.0 0.1 0.1 -0.3 0.3
Number of full brothers 3.9 4.9 6.4 1.9 -2.5
Worry too long after embarrassment 0.6 1.0 1.5 -1.2 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 1.6 1.2 0.6
Wheeze or whistling in the chest in last year 0.1 0.3 0.5 0.1 -0.7
Number of children fathered 0.3 0.4 0.6 -0.4 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 3.7 -1.9 0.8
Age at first live birth 1.4 2.6 4.6 0.7 2.2
Pulse wave peak to peak time 0.2 0.2 0.2 -0.4 -0.4
Health satisfaction 0.8 1.0 1.4 -1.2 -0.8
Shortness of breath walking on level ground 1.0 1.2 1.9 -1.4 -0.7
Qualifications: College or University degree 0.0 0.1 0.2 0.1 -0.5
Eye problems/disorders: None of the above 0.0 0.0 0.0 0.2 0.2
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 -0.4 0.9
Emphysema/chronic bronchitis 1.3 1.5 2.7 -0.5 -1.7
Medication for pain relief, constipation, heartburn 0.4 0.7 1.2 1.1 0.4
Neck or shoulder pain in last month 0.4 0.6 0.8 -0.7 -0.9
Medication: Blood pressure 0.4 0.8 1.4 -0.4 -1.2
Angina (self-reported) 0.0 0.0 0.0 0.0 -0.1
Migraine (self-reported) 1.1 1.4 2.6 -0.4 1.6
Medication: Ibuprofen 3.0 3.5 7.0 -0.2 -2.7
Medication: Allopurinol 0.9 1.2 2.2 1.5 -0.4
Medication: Omeprazole 0.3 0.4 0.4 -0.7 0.6
Medication: Seretide 50 evohaler 2.4 2.7 4.0 2.0 1.2
Mean time to correctly identify matches 0.3 0.5 0.5 -0.7 0.7
Heart disease (mother) 0.1 0.2 0.3 -0.6 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.5 -1.1 1.2
Whole body fat mass 0.5 2.0 2.1 1.4 -1.4
Leg fat mass (right) 0.6 2.3 2.7 1.4 -1.6
Arm predicted mass (right) 0.8 4.3 4.8 2.0 -2.2
Pulse rate, automated reading 0.2 0.7 1.4 -1.2 0.2
Alcohol intake frequency. 0.7 1.5 3.1 1.8 0.0
Comparative height size at age 10 0.2 1.2 2.4 1.6 -0.2
Number of full sisters 2.7 3.2 6.4 -0.2 -2.5
Suffer from ‘nerves’ 1.2 1.9 3.7 1.9 -0.3
Overall health rating 0.0 0.0 0.0 0.0 -0.1
Chest pain or discomfort 0.5 0.7 1.0 -0.6 -1.0
Had major operations 0.3 0.3 0.5 0.7 0.2
Age at last live birth 1.0 1.4 2.8 0.1 1.7
Family relationship satisfaction 0.4 0.5 0.9 -0.2 0.9
Leg pain on walking 1.0 1.3 1.5 -1.2 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.1 -1.1 0.1
Commuting to job workplace: Car/motor vehicle 2.1 2.4 4.5 0.6 -2.1
Illness, injury, bereavement, stress in last 2 years 2.4 2.9 5.6 -0.5 2.4
Medication: Aspirin 1.8 2.4 3.8 -1.0 1.9
Supplements: Vitamin C 0.3 0.3 0.4 0.6 -0.6
Knee pain experienced in last month 1.2 1.9 3.7 0.4 -1.9
Hypertension (Self-reported) 0.1 0.4 0.5 0.4 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 -0.6 -0.3
Illnesses of father: Heart disease 0.2 0.3 0.3 -0.5 -0.5
Illnesses of siblings: Diabetes 4.6 5.7 10.3 3.2 -1.0
Smoking status: Previous 1.7 2.5 4.7 -2.2 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.2 7.5 1.0 -2.7
Whole body fat-free mass 0.7 4.0 4.1 2.0 -2.0
Leg fat-free mass (right) 1.0 5.2 5.3 2.3 -2.3
Arm fat percentage (left) 0.6 2.6 3.3 1.3 -1.8
Average weekly red wine intake 0.2 0.3 0.5 -0.4 -0.7
Handedness (chirality/laterality): Left-handed 0.6 0.8 0.9 0.8 1.0
Mood swings 0.2 0.4 0.8 0.9 0.3
Loneliness, isolation 0.8 1.2 1.4 1.0 -1.2
Long-standing illness, disability or infirmity 1.7 2.6 3.1 -1.4 -1.8
Ever had bowel cancer screening 0.5 0.6 1.0 -0.4 1.0
Diabetes diagnosed by doctor 0.1 0.1 0.2 0.0 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 3.6 1.9 0.0
Friendships satisfaction 0.1 0.2 0.2 0.4 -0.4
Qualifications: nursing, teaching 0.9 1.3 2.5 1.6 -0.4
Commuting to job workplace: Walk 0.2 0.2 0.2 -0.4 0.5
Eye problems/disorders: Cataract 0.0 0.0 0.1 -0.3 0.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.4 0.1 -1.5
Medication for cholesterol 1.9 2.9 5.7 -2.4 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.6 0.5 -1.6
Back pain experienced in last month 0.1 0.1 0.2 -0.2 -0.4
Mineral and other dietary supplements 1.7 2.3 3.4 -1.8 1.1
Breast cancer (self-reported) 0.4 0.5 1.0 -1.0 0.1
Asthma (self-reported) 0.4 0.8 1.2 0.7 1.1
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.1 -0.0
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.6 0.3
Medication: Aspirin 1.9 2.5 3.7 -1.1 1.9
Medication: Gliclazide 1.3 1.5 2.3 -0.8 1.5
Illnesses of father: None of the above (group 1) 0.3 0.3 0.4 -0.7 0.5
Smoking status: Current 0.8 1.2 2.4 -0.3 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 1.4 1.2 1.0
Whole body water mass 0.7 4.1 4.3 2.0 -2.1
Leg predicted mass (right) 1.0 5.5 5.7 2.4 -2.3
Arm fat mass (left) 0.8 3.2 3.8 1.6 -1.9
Number of self-reported non-cancer illnesses 0.4 0.6 0.9 -0.6 1.0
Average weekly champagne plus white wine intake 1.1 1.5 1.9 1.4 -1.0
Miserableness 0.0 0.0 0.0 -0.2 -0.1
Guilty feelings 0.5 0.7 1.4 -1.2 0.2
Wears glasses or contact lenses 2.4 2.8 3.4 -1.8 1.5
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.4 -0.2
Hearing aid user 0.7 0.8 1.5 1.2 -0.4
Mother’s age at death 0.7 0.8 1.6 0.2 1.3
Financial situation satisfaction 0.4 0.4 0.6 -0.8 -0.5
Tinnitus: Yes, now most or all of the time 1.1 1.2 2.4 1.6 0.2
Commuting to job workplace: Public transport 1.7 2.0 3.2 -1.0 1.8
Eye problems/disorders: Glaucoma 1.0 1.2 2.3 -1.5 -0.0
Medication: Blood pressure 1.0 1.9 2.9 1.7 -1.0
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 -0.9 -0.2
Supplements: Fish oil (including cod liver oil) 2.0 2.6 2.9 1.7 -1.6
High cholesterol (Self-reported) 0.2 0.4 0.7 -0.1 0.8
Medication: Bendroflumethiazide 1.1 1.7 3.1 0.6 -1.8
Medication: Paracetamol 1.3 2.0 4.1 -0.2 -2.0
Medication: Lisinopril 1.1 1.4 2.8 0.1 -1.7
Medication: Atorvastatin 0.5 0.6 0.8 -0.9 0.6
Illnesses of father: High blood pressure 0.1 0.2 0.3 0.1 0.6
Alcohol drinker status: Never 1.4 1.7 2.3 1.1 1.5
Ever smoked 0.8 1.4 2.7 0.2 -1.6
Basal metabolic rate 0.9 4.9 5.2 2.2 -2.3
Leg fat percentage (left) 0.2 0.8 1.5 0.4 -1.2
Arm fat-free mass (left) 0.7 3.7 4.2 1.8 -2.0
Number of operations (self-reported) 0.5 0.8 0.9 0.8 0.9
Average weekly beer plus cider intake 0.2 0.3 0.4 -0.5 0.6
Irritability 0.9 1.5 1.6 1.2 -1.3
Risk taking 2.6 3.8 6.2 -1.2 -2.5
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.1 -0.4
Fractured/broken bones in last 5 years 0.8 1.0 1.5 0.8 -1.2
Age started oral contraceptive pill 2.2 2.8 4.8 -0.9 2.2
Diastolic blood pressure, automated reading 0.5 1.6 2.8 0.7 -1.7
Ever depressed for a whole week 1.4 1.8 2.0 1.4 1.2
Unable to work because of sickness or disability 1.2 1.5 1.9 1.0 -1.4
Commuting to job workplace: Cycle 1.4 1.7 3.1 1.8 0.6
Myopia 0.7 1.1 1.7 -0.6 1.3
Vascular/heart problems diagnosed by doctor 0.5 1.2 2.1 -0.6 1.5
Cholesterol lowering medication 0.6 0.9 1.5 1.2 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 0.8 -0.9 0.7
Pain experienced in last month 1.6 2.6 4.0 1.1 2.0
Supplements: Calcium 0.3 0.4 0.6 0.4 0.7
Basal cell carcinoma (self-reported) 0.7 0.8 1.5 1.2 0.3
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 0.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.6 1.6 -0.4
Heart disease (siblings) 1.1 1.3 2.0 -1.4 -0.8
Alcohol drinker status: Previous 0.8 0.9 1.4 0.7 -1.2
Pack years of smoking 1.0 1.5 2.8 -1.7 -0.5
Impedance of whole body 0.1 0.8 1.1 -0.6 1.1
Leg fat mass (left) 0.6 2.5 2.8 1.5 -1.7
Arm predicted mass (left) 0.8 4.1 4.8 1.8 -2.2