TWAS hub - F2RL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0374	0.0118	4.5e-04	0.023	0.013	0.020	0.022	0.021	5.0e-08	2.4e-05	2.4e-07	7.7e-08	1.4e-07
2	TCGA	Breast Invasive Carcinoma	0.0173	0.0102	9.2e-03	0.000	0.001	0.003	NA	-0.001	2.4e-01	1.4e-01	7.0e-02	NA	4.6e-01
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0946	0.0326	5.4e-09	0.081	0.084	0.093	NA	0.088	2.3e-09	1.1e-09	1.2e-10	NA	4.2e-10
4	TCGA	Brain Lower Grade Glioma	0.0302	0.0146	8.2e-04	0.017	0.020	0.021	NA	0.017	4.0e-03	2.3e-03	1.7e-03	NA	3.9e-03
5	TCGA	Pheochromocytoma and Paraganglioma	0.1090	0.0610	7.4e-03	0.021	0.029	-0.001	NA	0.004	5.0e-02	2.6e-02	3.6e-01	NA	2.1e-01
6	TCGA	Prostate Adenocarcinoma	0.0831	0.0313	6.8e-06	0.016	0.035	0.026	NA	0.030	7.2e-03	1.2e-04	9.3e-04	NA	4.1e-04
7	TCGA	Thyroid Carcinoma	0.1070	0.0370	6.2e-09	0.129	0.076	0.129	NA	0.103	1.7e-12	7.4e-08	1.5e-12	NA	3.5e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Shortness of breath walking on level ground	5.2	6.2	9.8	0.4	2.4	2.3	3.1	2.9	2.6	2.5
Ever taken oral contraceptive pill	4.5	5.0	7.6	2.3	2.4	2.0	2.7	2.8	2.1	0.7
Medication: Gliclazide	3.6	4.1	6.3	0.3	2.1	2.5	2.3	2.5	1.9	1.7
Prostate Cancer	3.5	4.9	9.0	-1.0	-2.6	-1.7	-2.5	-2.8	-0.1	-3.0
Alcohol drinker status: Previous	3.3	3.7	8.0	-1.1	-1.8	-2.1	-2.8	-2.3	-1.3	-1.5
Hayfever/allergic rhinitis (self-reported)	3.1	4.2	9.2	-0.7	-1.4	-3.0	-2.2	-1.8	-2.2	-2.1
Supplements: Vitamin C	3.1	3.7	5.7	-1.1	-1.3	-1.6	-2.1	-2.4	-2.2	-2.3
Chronic bronchitis/emphysema (father)	3.0	3.5	5.6	0.9	1.7	2.3	1.6	2.4	2.0	1.6
Commuting to job workplace: Car/motor vehicle	3.0	3.5	7.5	1.1	2.0	2.7	1.8	1.9	1.9	1.0
Medication for hormone replacement therapy	2.9	3.3	6.8	0.4	-0.7	-2.3	-2.6	-2.5	-2.0	-0.1
Health satisfaction	2.9	3.7	5.5	-0.6	1.9	2.2	2.3	2.3	2.0	1.5
Medication: Ramipril	2.7	3.4	5.7	1.7	1.1	2.0	2.4	2.3	2.1	0.7
Blood Platelet Count	2.4	27.5	83.9	-9.2	0.6	3.0	5.0	5.6	0.5	6.5
Number of live births	2.4	3.5	6.2	0.9	2.2	2.5	1.8	2.2	1.9	1.1
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	4.8	-1.7	1.6	1.9	2.2	1.8	1.6	0.7
Reaction Time	2.2	4.1	13.6	-0.4	-1.6	-1.7	-0.9	-2.1	-3.7	-2.1
Stomach or abdominal pain in last month	2.2	2.7	3.9	-2.0	1.7	2.0	1.4	1.6	1.1	1.6
Emphysema/chronic bronchitis	2.2	2.5	5.4	-0.7	1.3	1.3	2.3	2.1	1.0	1.7
Asthma	2.1	4.2	8.2	-0.4	-2.5	-2.9	-1.7	-1.8	-1.1	-2.7
Hypothyroidism/myxoedema (self-reported)	2.1	4.0	6.9	0.1	2.4	2.4	2.6	2.3	1.9	0.9
Ulcerative Colitis (UC)	1.9	3.5	8.5	0.8	-1.7	-2.9	-1.8	-1.9	-1.3	-1.9
Allergy or Eczema	1.9	4.9	9.2	-0.6	-1.7	-2.2	-3.0	-2.4	-1.9	-2.8
Supplements: Zinc	1.9	2.0	4.3	-1.6	-0.6	-1.3	-2.1	-2.0	-0.4	-1.1
Gout (self-reported)	1.9	2.6	6.4	2.0	-1.9	-0.7	-1.1	-1.5	-0.6	-2.5
Mean time to correctly identify matches	1.9	3.6	7.9	0.0	-1.9	-1.6	-0.6	-2.0	-2.6	-2.8
Verbal and Numeric Reasoning (VNR)	1.8	4.3	13.3	-1.2	-3.6	-2.0	-1.2	-1.7	-2.4	-1.1
Mouth/teeth dental problems: Dentures	1.8	3.1	6.2	-0.0	2.1	2.5	1.6	1.3	1.9	1.6
Medication: Ventolin 100micrograms inhaler	1.8	2.3	5.6	0.7	-2.2	-1.7	-1.0	-1.0	-0.8	-2.4
Birth weight	1.8	3.9	11.2	3.4	-1.6	-1.3	-1.5	-1.4	-2.4	-1.2
Medication: Omeprazole	1.8	2.1	4.1	-2.0	1.5	1.6	1.4	1.3	1.1	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.4	-0.2	1.4	1.7	1.8	1.5	1.5	0.4
Commuting to job workplace: Walk	1.8	1.9	4.6	-2.1	-0.5	-1.9	-1.3	-1.3	-1.1	-0.3
Asthma (self-reported)	1.8	3.5	7.3	-0.2	-2.4	-2.7	-1.6	-1.5	-0.8	-2.5
Medication for pain relief, constipation, heartburn	1.7	3.0	6.3	1.1	-1.4	-1.8	-2.5	-2.1	-1.3	-1.3
Unable to work because of sickness or disability	1.7	2.2	3.9	-0.4	2.0	1.6	1.9	1.7	1.5	0.7
Coronary Artery Disease (CAD)	1.6	2.0	5.4	1.8	2.3	1.4	0.9	0.6	0.7	1.1
Ever had hysterectomy (womb removed)	1.6	1.8	3.2	-1.8	-1.3	-0.5	-1.8	-1.5	-0.8	-1.1
High blood pressure (mother)	1.6	2.3	3.7	0.0	1.7	1.9	1.8	1.4	1.9	1.0
Noisy workplace	1.6	1.9	4.0	-0.3	2.0	1.4	0.6	1.4	1.6	1.6
Lung cancer (father)	1.6	1.8	6.4	0.3	0.5	0.9	1.4	1.7	0.7	2.5
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.3	-1.6	-1.3	-1.6	-1.1	-1.8	0.9	-0.9
Hearing aid user	1.6	1.8	3.4	-1.9	-0.7	-1.4	-0.7	-1.7	-0.2	-1.8
Medication: Metformin	1.5	2.1	4.8	-0.5	1.3	1.6	1.3	1.5	2.2	1.2
Relative age voice broke	1.5	2.4	9.9	-3.1	-0.8	-0.8	-1.6	-1.3	-1.1	0.1
Prospective memory result	1.5	1.8	4.0	1.9	1.3	1.3	0.5	0.8	2.0	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	10.5	-3.2	-0.5	-0.3	-0.6	-0.6	-1.0	0.0
Alzheimer’s Disease (including proxy)	1.4	2.0	4.1	0.5	-0.5	-1.1	-1.7	-1.8	-1.5	-2.0
Fasting Glucose	1.4	1.7	3.5	-0.2	1.6	1.0	1.4	1.6	0.4	1.9
Ulcerative Colitis	1.4	2.1	5.4	1.0	-1.2	-2.3	-1.6	-1.6	-0.5	-1.1
Past tobacco smoking	1.4	2.6	6.1	-0.6	-2.5	-0.8	-1.6	-1.4	-2.1	-1.5
Fluid intelligence score	1.4	2.9	7.5	-1.0	-2.7	-2.0	-1.0	-1.4	-2.1	-1.0
Leg pain on walking	1.4	1.7	6.2	-1.0	0.5	0.9	1.3	0.7	2.5	1.4
Intelligence (Savage-Jansen 2018)	1.3	3.9	13.4	-1.5	-3.7	-1.8	-1.3	-1.6	-1.5	-1.3
Respiratory disease	1.3	2.9	7.6	0.1	-1.5	-2.8	-1.2	-1.5	-0.8	-2.4
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.7	2.4	1.2	1.2	-0.1	0.6	1.3	0.3
Average weekly champagne plus white wine intake	1.3	1.7	3.7	-1.9	0.0	-0.7	-1.1	-1.8	-1.8	-0.8
Ovarian Cancer	1.2	1.6	2.9	0.4	-0.2	-1.6	-1.3	-1.7	-1.1	-1.6
Severe depression (siblings)	1.2	1.3	2.7	0.8	-1.0	-1.2	-1.6	-1.4	-0.9	-1.1
Had menopause	1.2	1.5	3.1	0.4	-1.7	-1.8	-1.2	-1.5	-0.8	-0.5
Medication: Lansoprazole	1.2	1.4	4.0	-0.7	-1.0	-1.0	-0.7	-0.9	-1.4	-2.0
Number of children fathered	1.2	1.3	6.2	-1.2	2.5	0.4	-0.1	-0.3	0.7	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	5.8	-2.4	-0.9	-0.7	-0.9	-1.3	-0.7	0.4
Alcohol intake frequency.	1.2	2.8	5.3	-0.4	-1.8	-1.4	-2.1	-2.3	-1.6	-1.3
Smoking status: Previous	1.2	1.8	4.2	0.8	2.1	0.6	1.5	0.9	1.7	1.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.7	-0.1	-1.3	-1.7	-1.4	-1.9	-1.3	-1.1
Hayfever, allergic rhinitis or eczema	1.1	2.4	4.8	0.1	-1.4	-2.2	-2.1	-1.2	-0.7	-1.9
Number of incorrect matches in round	1.1	1.8	3.5	1.7	0.3	-1.4	-0.6	-0.9	-1.9	-1.6
Falls in the last year	1.1	1.5	3.2	0.5	-0.0	1.7	1.2	1.5	0.8	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.6	-0.7	-1.5	-1.5	-1.6	-0.9	-0.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	4.2	-0.3	2.0	1.2	1.1	1.3	0.6	1.5
Mood swings	1.1	2.0	3.5	1.9	1.4	1.5	1.7	1.6	0.2	0.8
Depression (Nagel 2018)	1.0	1.4	3.7	-1.6	-1.3	-1.2	-0.7	-0.3	-1.9	-0.1
LDL Cholesterol	1.0	1.7	3.2	-1.3	0.9	1.4	0.9	1.4	1.1	1.8
Hypothyroidism (self reported)	1.0	2.4	5.8	-0.0	1.3	1.9	2.4	1.9	1.1	0.5
Impedance of leg (right)	1.0	4.9	6.2	-2.2	2.2	2.5	2.3	2.4	1.4	2.4
Average weekly fortified wine intake	1.0	1.2	2.4	-1.1	-1.6	-1.5	-0.6	-0.7	-1.2	-0.7
Fed-up feelings	1.0	1.8	3.9	0.1	1.0	1.5	1.4	2.0	1.0	1.6
Qualifications: None of the above	1.0	2.1	5.0	2.2	2.0	1.5	0.7	0.6	1.3	0.8
Illnesses of siblings	1.0	1.4	3.4	-1.6	-1.4	-1.8	0.1	0.1	-0.9	-1.0
Illnesses of mother	1.0	1.2	2.4	-0.5	-1.6	-1.1	-1.1	-1.0	-1.4	-0.4
High blood pressure (siblings)	1.0	1.4	4.1	1.1	1.5	2.0	0.9	0.7	-0.0	1.1
Handedness (chirality/laterality): Left-handed	1.0	1.3	4.0	-0.6	0.3	0.6	1.1	1.0	2.0	1.3
Medication: Aspirin	1.0	1.4	3.1	-0.1	1.2	1.4	1.8	1.1	1.0	0.8
Fractured/broken bones in last 5 years	1.0	1.3	2.6	-0.7	0.6	1.2	1.4	1.2	0.9	1.6
Age started oral contraceptive pill	1.0	1.2	3.1	1.7	-0.5	-0.3	-0.9	-1.1	-0.2	-1.8
Commuting to job workplace: Cycle	1.0	1.2	3.3	0.3	-1.2	-1.1	-1.1	-1.0	-1.8	-0.7
Irritable Bowel Disease (IBD)	0.9	2.2	6.2	0.1	-0.8	-2.5	-1.7	-1.5	-0.4	-1.8
Frequency of depressed mood in last 2 weeks	0.9	1.2	4.4	-1.4	-0.8	-0.7	-0.8	-0.7	-2.1	-0.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	4.3	-2.1	0.6	0.8	-0.0	0.2	1.0	-0.8
Medication: Co-codamol	0.9	1.0	2.9	0.5	-1.7	-0.7	-0.7	-0.9	-0.5	-1.3
Diabetes (mother)	0.9	1.1	3.2	-0.3	1.0	0.9	0.7	1.2	0.8	1.8
Alcohol usually taken with meals	0.9	1.5	3.7	-0.6	-1.8	-0.8	-1.3	-1.9	-0.8	-0.4
Number of full brothers	0.9	1.1	3.3	0.2	-0.5	-1.1	-0.5	-0.9	-1.8	-1.3
Eye problems/disorders: None of the above	0.9	1.1	3.8	1.9	0.3	0.9	1.0	1.0	0.6	-0.5
Neck or shoulder pain in last month	0.9	1.3	4.0	2.0	0.3	0.3	0.9	1.2	1.0	1.2
Medication: Seretide 50 evohaler	0.9	1.0	3.2	-0.7	-1.6	-0.7	0.3	-0.0	-0.6	-1.8
Friendships satisfaction	0.9	1.2	2.7	-1.5	0.3	-0.3	-1.6	-1.6	-0.2	-0.7
Eye problems/disorders: Glaucoma	0.9	1.1	2.8	-0.9	-1.0	-0.5	-0.5	-1.2	-1.7	-0.9
Medication: Blood pressure	0.9	1.7	4.4	-0.5	1.2	1.3	2.1	1.2	1.7	-0.4
Alzheimer’s Disease (in father)	0.8	0.9	1.9	-0.3	-1.1	-0.7	-1.1	-1.1	-0.4	-1.4
HDL Cholesterol	0.8	1.4	2.9	1.7	-0.6	-1.0	-1.2	-1.2	-1.3	-0.6
Triglycerides	0.8	1.3	2.1	-1.4	-1.3	-0.5	-1.0	-1.0	-1.3	-1.0
Waist Hip Ratio (WHR)	0.8	3.4	6.7	-0.8	-1.5	-1.9	-2.6	-2.5	-1.5	-1.5
Lung FVC	0.8	4.0	6.6	-0.2	-1.7	-2.3	-2.6	-2.5	-2.3	-1.1
Neuroticism	0.8	1.9	5.6	-0.8	-0.8	-1.2	-1.4	-1.4	-2.4	-1.2
Age when periods started (menarche)	0.8	1.9	3.8	-0.3	1.4	1.0	1.9	1.9	1.5	0.6
Medication: Levothyroxine sodium	0.8	1.4	2.2	0.3	1.0	1.4	1.4	1.5	1.4	0.6
Impedance of leg (left)	0.8	4.1	6.8	-1.7	1.9	2.2	2.6	2.4	1.2	1.9
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.3	1.5	1.1	0.6	0.3	0.5	1.1	1.0
Diabetes (self-reported)	0.8	1.2	3.1	-0.6	0.6	1.4	1.0	1.3	1.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.7	-1.9	0.9	0.8	0.7	0.9	0.0	0.6
Depression (self-reported)	0.8	1.0	2.1	1.4	0.2	1.1	1.3	0.9	1.0	0.6
Exposure to tobacco smoke at home	0.8	0.8	2.4	1.5	1.0	0.5	0.8	0.6	0.5	1.0
Pulse wave reflection index	0.8	1.0	2.1	1.5	-1.4	-0.7	-0.3	-0.7	-1.2	0.8
Qualifications: College or University degree	0.8	2.4	3.7	-1.0	-1.5	-1.4	-1.8	-1.9	-1.6	-1.5
Mother’s age at death	0.8	1.1	2.3	1.2	1.5	0.6	0.6	0.5	1.4	0.8
Average weekly beer plus cider intake	0.8	1.1	3.9	2.0	1.3	1.2	0.3	0.8	0.3	0.1
Irritability	0.8	1.3	3.2	1.8	-0.2	-1.5	-1.0	-0.9	-1.1	-0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.3	1.8	0.5	0.3	-0.4	-1.2	-1.0	-0.7
Schizophrenia vs Biploar Disorder	0.7	0.9	1.3	-0.8	1.1	1.0	0.7	1.1	0.9	0.9
Crohns Disease (2017)	0.7	1.4	2.6	-1.2	-0.0	-1.5	-1.6	-1.2	0.0	-1.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.3	0.9	-0.6	-1.5	-0.5	-1.4	-0.3	-1.0
Vitamin and mineral supplements	0.7	0.9	1.8	0.3	0.4	0.9	1.2	1.3	1.1	0.8
Taking other prescription medications	0.7	1.1	2.5	1.6	1.0	1.1	1.1	0.6	1.1	-0.4
Sitting height	0.7	4.9	11.7	2.4	1.4	1.7	2.2	2.2	1.4	3.4
Financial difficulties in last 2 years	0.7	1.0	2.3	1.2	1.2	1.5	0.8	0.5	0.7	0.6
Allergy	0.7	1.7	3.4	0.4	1.4	1.8	1.6	1.2	0.4	1.5
Alcohol intake versus 10 years previously	0.7	1.1	3.5	0.2	-1.3	-0.4	-0.8	-1.1	-1.9	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.5	0.8	0.9	1.6	0.8	1.1	-0.2	1.5
Pulse rate	0.7	1.2	2.5	-0.0	1.3	0.7	0.7	1.6	1.0	1.4
Breastfed as a baby	0.7	0.8	4.4	2.1	1.0	0.1	-0.0	0.5	0.4	0.2
Glaucoma (self-reported)	0.7	0.8	2.5	-1.6	-0.5	-0.2	-0.6	-0.9	-1.2	-0.8
Age at first live birth	0.7	1.2	2.7	-0.9	-1.6	-0.2	-0.4	-1.0	-1.1	-1.6
Chest pain or discomfort	0.7	1.0	2.6	1.6	1.2	-0.2	0.2	0.8	-0.2	1.4
Eye problems/disorders: Cataract	0.7	0.9	2.3	0.0	-0.3	-1.4	-0.7	-1.0	-1.5	0.2
Guilty feelings	0.7	1.0	2.6	-1.0	1.0	1.6	1.1	1.1	0.2	0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.3	-1.3	-1.5	-0.7	-0.1	-0.7	-0.9	-0.3
Ever smoked	0.7	1.2	2.5	0.6	1.6	0.4	1.1	1.1	1.4	1.0
Myopia	0.7	1.0	5.8	2.4	0.3	-0.2	0.1	0.2	0.8	0.3
Pack years of smoking	0.7	1.0	2.8	1.7	0.4	0.8	0.2	1.3	1.1	0.8
Worry (Nagel 2018)	0.6	1.3	2.9	-0.3	-0.5	-1.1	-1.7	-1.4	-1.4	-0.8
Age at First Birth	0.6	0.9	3.1	-1.8	0.2	0.9	0.9	0.6	-1.0	0.6
Crohns Disease (2012)	0.6	1.0	2.9	-0.3	0.4	-1.5	-1.7	-1.2	-0.5	-0.3
Blood White Count	0.6	4.4	25.6	-5.1	1.1	0.7	-0.6	-1.0	-0.8	-1.4
Pack years adult smoking proportion	0.6	0.9	1.8	1.3	0.4	0.8	0.3	1.3	0.9	0.8
Hand grip strength (right)	0.6	1.5	3.1	-1.8	-0.5	-1.1	-1.7	-1.4	-0.8	-0.6
Townsend deprivation index at recruitment	0.6	0.9	5.3	2.3	-0.5	-0.2	0.2	-0.1	-0.7	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.1	1.8	-0.3	-0.6	-0.9	-0.5	-0.0	0.1
Serious illness, injury or assault to yourself	0.6	0.7	1.6	0.3	1.1	-0.5	-0.8	-0.5	-1.0	1.2
Medication: Atenolol	0.6	0.8	2.4	-1.6	0.4	1.2	1.0	-0.2	0.3	-0.4
Tense / ‘highly strung’	0.6	0.9	3.5	1.9	-0.1	-0.8	-0.7	-0.6	-1.2	-0.0
Birth weight of first child	0.6	1.0	3.3	1.8	1.5	0.1	0.7	1.0	-0.4	0.2
Peak expiratory flow (PEF)	0.6	1.5	5.3	0.4	-0.8	-2.3	-1.5	-1.2	-0.5	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.1	5.0	1.3	-0.7	-1.7	-1.7	-1.4	-2.2	0.2
Medication: Ibuprofen	0.6	0.7	3.4	-1.8	0.6	0.5	0.3	0.5	-0.3	0.7
Medication: Aspirin	0.6	0.8	2.3	-0.0	0.7	0.9	1.5	0.9	0.8	0.6
Diabetes diagnosed by doctor	0.6	1.0	3.0	-0.4	0.9	1.1	1.0	0.8	1.7	0.4
Osteoporosis (self-reported)	0.6	0.7	1.7	0.8	-1.3	-1.0	0.6	0.3	0.0	-1.0
Wears glasses or contact lenses	0.6	0.7	1.7	0.4	0.7	-0.1	-0.7	-0.6	-1.0	-1.3
Commuting to job workplace: Public transport	0.6	0.8	2.3	-0.6	-0.9	-1.5	-0.7	-1.1	-0.4	0.1
Illnesses of father: High blood pressure	0.6	0.8	4.1	0.5	-0.2	0.1	-0.6	-0.8	-2.0	0.1
Impedance of whole body	0.6	2.8	5.1	-2.3	1.8	1.2	2.0	1.7	0.3	1.6
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	0.2	0.5	-0.2	-0.9	-1.1	-1.2	-0.8
Number of treatments/medications taken	0.5	0.9	1.7	0.4	1.3	1.1	1.0	1.0	0.9	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.2	-0.0	1.5	0.8	0.9	0.2	-0.6	-0.8
High blood pressure	0.5	1.3	3.5	0.0	1.1	1.3	1.4	0.9	1.9	0.1
Supplements: Glucosamine	0.5	0.6	1.7	0.1	-1.3	-0.1	-1.3	-0.8	0.1	-0.3
Heart attack	0.5	0.7	1.4	1.0	0.6	1.0	0.6	0.6	0.6	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.3	0.2	-1.0	-1.8	-1.2	-1.0	-2.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.5	0.7	-0.7	-1.7	-1.4	-1.2	-1.9	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.0	-0.2	-1.4	-0.1	0.2	0.0	-1.4	-1.0
Headache pain in last month	0.5	0.8	3.7	-1.3	-0.5	-0.3	-0.3	-0.3	-1.9	-0.3
Medication: Allopurinol	0.5	0.7	1.8	1.3	-0.1	0.4	-0.5	-1.1	-0.7	-0.8
Heart disease (mother)	0.5	0.6	3.1	-1.8	0.3	0.4	0.6	0.7	0.1	0.1
Suffer from ‘nerves’	0.5	0.8	2.6	-0.6	-0.1	-0.1	-1.0	-1.1	-1.6	-0.1
Had major operations	0.5	0.5	0.9	-0.9	-0.7	-1.0	-0.8	-0.6	-0.5	0.6
Age at last live birth	0.5	0.7	1.9	-1.4	-0.2	1.1	0.8	0.2	-0.1	-1.0
Family relationship satisfaction	0.5	0.6	1.4	-1.0	0.1	0.1	-1.2	-1.2	-0.2	0.4
Hypertension (Self-reported)	0.5	1.4	3.2	0.5	1.3	1.3	1.4	1.0	1.8	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.2	-1.8	0.4	0.4	0.4	0.1	0.2	-0.5
Breast cancer (self-reported)	0.5	0.6	1.3	0.0	-1.1	-1.1	-0.6	-0.4	-1.0	0.7
Osteoarthritis (self-reported)	0.5	0.7	4.2	2.0	-0.2	0.1	0.5	0.5	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.5	-1.9	0.3	-0.5	-1.4	-1.1	0.0	0.4
Medication: Atorvastatin	0.5	0.6	1.6	-1.1	-0.5	0.6	0.8	0.3	-1.3	-0.6
Cholesterol lowering medication	0.5	0.7	3.8	-1.9	-0.9	-0.1	-0.2	0.1	0.2	-0.2
Neuroticism (Nagel 2018)	0.4	0.9	1.6	-1.0	-0.7	-1.3	-0.3	-0.5	-1.2	-1.1
Schizophrenia (2018)	0.4	0.8	3.7	-0.1	1.9	0.2	-0.3	-0.0	-0.1	1.3
Primary Biliary Cirrhosis	0.4	0.6	2.4	1.5	-0.1	-1.0	0.0	-0.0	-0.3	0.8
Cardiovascular Disease	0.4	1.4	2.7	-0.8	1.6	1.6	1.0	0.6	1.6	0.5
Chronotype (morning person)	0.4	0.9	1.8	0.7	-1.3	-1.2	-0.2	-0.8	-0.8	-1.3
Sensitivity / hurt feelings	0.4	0.7	1.5	-1.2	0.0	1.0	1.1	0.9	0.1	0.6
Current tobacco smoking	0.4	0.7	1.5	-0.7	1.0	0.8	0.7	1.2	0.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	-0.8	-0.7	0.5	0.7	1.0	-0.5	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.6	-0.2	1.3	1.2	0.8	0.6	1.6	-0.5
Nervous feelings	0.4	0.8	2.9	0.1	1.7	1.1	0.5	0.5	0.1	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.4	0.1	-0.9	-0.7	-0.7	-0.4	-1.5	-0.6
Had other major operations	0.4	0.5	1.3	-0.4	1.1	-0.4	-0.7	-0.2	-0.7	0.9
Time employed in main current job	0.4	0.5	2.7	0.2	0.7	0.2	-0.2	0.1	1.6	0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.0	-1.2	-0.1	0.5	1.1	1.4	0.2	0.3
Leg fat percentage (right)	0.4	1.3	3.5	1.2	0.4	1.1	1.4	0.7	1.9	-0.2
Overall health rating	0.4	0.9	1.9	0.6	0.7	1.4	1.3	1.2	-0.3	-0.2
Back pain experienced in last month	0.4	0.5	1.4	-0.8	0.5	0.7	0.4	0.6	0.7	1.2
Mineral and other dietary supplements	0.4	0.5	1.1	-0.2	1.0	0.4	1.0	0.9	0.5	0.1
High cholesterol (Self-reported)	0.4	0.7	3.0	-1.7	-0.2	0.1	-1.1	-0.6	-0.4	-0.1
Medication: Lisinopril	0.4	0.6	1.1	-0.6	0.9	0.8	0.5	0.9	1.1	0.3
Risk taking	0.4	0.6	1.6	1.1	0.9	1.2	0.4	0.1	0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.4	0.9	0.4	1.0	0.5	0.5	0.4	1.2
Leg fat mass (left)	0.4	1.4	6.2	2.5	-0.0	0.5	1.1	0.3	1.4	-0.5
Body Mass Index (BMI) (2010)	0.3	0.4	2.4	1.6	0.1	-0.2	-0.7	-0.3	0.2	-0.2
Rheumatoid Arthritis	0.3	0.5	2.0	0.2	-0.1	-0.3	-0.0	0.2	-1.4	1.0
Schizophrenia (2014)	0.3	0.8	2.4	-0.8	1.5	0.2	0.5	0.4	0.3	1.3
Blood Red Count	0.3	3.1	6.4	-2.0	-1.3	-1.5	-2.3	-2.5	-0.6	-1.3
Smoking Status	0.3	0.8	2.0	-0.5	1.4	0.1	0.9	1.2	0.5	1.1
Lung FEV1/FVC ratio	0.3	1.5	3.3	-0.7	-0.8	-1.8	-1.4	-1.1	-1.7	-0.6
Tanning	0.3	3.1	5.5	0.2	1.5	2.4	2.1	2.0	1.7	1.5
Average weekly spirits intake	0.3	0.4	1.9	-0.2	-0.1	-1.4	-0.2	-0.1	-0.5	-0.7
Hearing difficulty/problems: Yes	0.3	0.5	1.2	-0.3	-0.9	-0.5	-0.0	-0.6	-1.1	-0.7
Angina	0.3	0.4	1.0	-0.5	1.0	1.0	0.6	0.2	-0.5	0.1
Leg fat-free mass (left)	0.3	1.4	7.3	2.7	-0.7	-1.0	-0.6	-0.8	-0.4	-0.3
Trunk fat percentage	0.3	1.3	3.8	0.8	1.0	0.8	1.5	0.9	1.9	0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.4	1.2	-0.3	1.0	-0.1	-0.2	0.1	0.1
Qualifications: CSEs or equivalent	0.3	0.4	1.3	-1.1	0.0	-0.1	0.9	0.7	-0.6	-0.1
Leg predicted mass (left)	0.3	1.4	7.2	2.7	-0.7	-1.0	-0.5	-0.7	-0.4	-0.2
Trunk fat mass	0.3	1.2	3.3	1.8	0.7	0.6	1.2	0.5	1.6	0.1
Forced vital capacity (FVC)	0.3	1.2	3.8	0.7	-0.4	-1.3	-1.1	-0.7	-2.0	0.7
Medication: Simvastatin	0.3	0.5	1.7	-0.3	0.2	0.3	-0.4	0.6	1.0	1.3
Impedance of arm (right)	0.3	1.2	5.2	-2.3	1.6	-0.2	0.4	0.3	-0.2	0.7
Father’s age at death	0.3	0.4	1.1	0.2	-0.4	-1.0	-0.5	-0.6	-1.0	-0.2
Happiness	0.3	0.4	1.6	-1.3	-0.3	0.1	-0.5	-0.7	-0.4	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.2	0.0	-1.1	-0.2	0.8	0.4	0.7	0.3
Length of working week for main job	0.3	0.4	0.7	-0.3	-0.8	-0.5	-0.6	-0.4	-0.6	-0.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	1.0	-0.9	-0.5	-0.7	0.0	0.1	-0.3
Loud music exposure frequency	0.3	0.3	1.0	-0.7	-0.1	-0.1	0.2	0.3	1.0	-0.6
Body fat percentage	0.3	1.1	3.7	0.8	0.6	0.7	1.4	0.8	1.9	-0.0
Exposure to tobacco smoke outside home	0.3	0.4	1.4	-1.2	1.0	-0.4	-0.1	-0.1	0.6	0.1
Comparative body size at age 10	0.3	0.7	1.6	1.3	-0.3	0.7	0.8	1.0	0.9	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.9	0.0	-0.2	-0.6	-0.8	-0.7	-0.6
Pulse wave peak to peak time	0.3	0.4	1.1	0.3	1.0	0.2	-0.8	-0.4	-0.7	-0.3
Medication: Blood pressure	0.3	0.5	2.5	1.6	0.2	-0.1	-0.7	-0.8	-0.3	-0.3
Angina (self-reported)	0.3	0.3	0.8	-0.5	0.8	0.8	0.4	-0.2	-0.9	-0.0
Migraine (self-reported)	0.3	0.4	0.8	0.0	-0.7	-0.7	-0.1	-0.6	-0.8	-0.9
Leg fat mass (right)	0.3	1.3	5.1	2.2	-0.0	0.6	1.1	0.4	1.4	-0.6
Number of full sisters	0.3	0.3	0.9	0.1	-0.6	-0.1	-0.8	-0.5	-0.9	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.3	-0.5	-0.4	-0.6	0.1	-0.4	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.2	1.5	0.9	0.5	0.6	0.6	-0.1	0.9
Whole body fat-free mass	0.3	1.4	7.7	2.8	-0.7	-0.7	-0.6	-0.8	-0.3	-0.2
Leg fat-free mass (right)	0.3	1.8	8.6	2.9	-0.8	-1.2	-0.7	-0.9	-0.8	-0.4
Ever had bowel cancer screening	0.3	0.3	1.0	-0.6	-0.1	0.8	1.0	0.1	-0.5	-0.4
Smoking status: Current	0.3	0.5	1.4	-0.7	0.9	0.5	0.6	1.2	0.2	0.7
Leg predicted mass (right)	0.3	1.9	8.3	2.9	-0.9	-1.3	-0.7	-1.0	-0.8	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	2.1	-1.5	0.3	0.0	0.1	0.3	0.3	0.0
Alcohol drinker status: Never	0.3	0.3	0.8	0.9	0.6	0.2	0.7	0.2	0.6	-0.1
Leg fat percentage (left)	0.3	1.2	2.8	1.5	0.1	0.9	1.4	0.6	1.7	-0.4
Number of operations (self-reported)	0.3	0.5	1.0	-0.9	0.8	-0.2	-0.8	-0.2	-0.3	1.0
Ever depressed for a whole week	0.3	0.3	0.8	0.8	-0.1	0.3	0.7	0.9	-0.5	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.8	0.1	-1.2	-1.3	-1.1	-0.3	-1.3	-0.1
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	-0.2	-0.1	0.9	0.9	0.7	0.2	-0.1
Heart disease (siblings)	0.3	0.4	1.8	0.3	0.4	1.3	0.6	0.4	0.5	-0.2
Major Depression (MDD)	0.2	0.3	0.9	-0.3	-0.3	-0.6	-0.1	0.3	0.9	-0.7
Neuroticism (2016)	0.2	0.3	0.7	0.5	0.8	-0.5	0.4	-0.3	-0.6	-0.3
Blood Eosinophil Count	0.2	1.3	7.1	-2.7	0.2	0.2	-0.1	-0.5	-1.1	-0.4
Heel T-Score	0.2	1.6	5.3	-0.8	1.1	0.7	1.5	0.9	2.3	0.4
BMI	0.2	1.0	4.7	2.2	-0.2	0.4	0.8	-0.2	1.0	-0.7
Height	0.2	4.8	9.4	3.1	1.2	1.8	2.3	2.5	0.8	2.7
Systolic Blood Pressure	0.2	1.1	1.9	1.2	1.4	1.3	1.2	0.7	0.5	0.7
Hand grip strength (left)	0.2	0.5	1.6	-1.2	-0.8	-0.4	-1.0	-0.5	0.0	-0.2
Diabetes (father)	0.2	0.2	0.9	-0.1	-1.0	-0.9	0.1	-0.1	-0.1	-0.1
Maternal smoking around birth	0.2	0.3	2.0	1.4	0.3	-0.1	-0.0	0.1	0.4	0.2
Body mass index (BMI)	0.2	0.8	2.9	1.7	-0.3	0.2	0.5	-0.1	1.4	-0.8
Waist circumference	0.2	0.6	2.3	1.5	-0.6	-0.1	0.1	-0.4	0.8	-1.0
Mouth/teeth dental problems	0.2	0.3	0.5	0.7	-0.6	-0.6	0.1	0.4	-0.5	-0.5
Weight	0.2	1.1	6.5	2.5	0.0	0.3	0.6	0.1	1.0	-0.1
Trunk fat-free mass	0.2	1.1	5.4	2.3	-0.7	-0.5	-0.8	-0.9	-0.3	-0.2
Worrier / anxious feelings	0.2	0.4	1.0	0.6	-1.0	-0.7	-0.8	-0.2	-0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	-0.6	-0.7	-0.5	-0.9	-0.9	0.0	-0.6
Medication: Cholesterol lowering	0.2	0.4	1.4	0.4	0.1	-0.3	-1.2	-0.9	-0.2	0.0
Impedance of arm (left)	0.2	1.0	3.3	-1.8	1.3	-0.1	0.9	0.5	-0.8	0.7
Arm fat mass (right)	0.2	0.7	2.1	1.4	-0.1	-0.2	0.4	-0.1	1.4	-0.4
Trunk predicted mass	0.2	1.2	5.7	2.4	-0.7	-0.6	-0.8	-1.0	-0.4	-0.3
Hair/balding pattern: Pattern 4	0.2	0.5	2.2	-0.6	-0.1	-0.4	-0.9	-1.5	0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	-0.9	-0.5	-0.8	0.2	0.1	0.0	-0.6
Blood clot in the leg (DVT)	0.2	0.3	1.1	-1.0	-0.3	0.3	0.1	-0.1	0.2	0.8
Medication: Paracetamol	0.2	0.4	1.3	-1.1	0.0	-0.0	0.9	0.6	-0.1	0.6
Medication: Amlodipine	0.2	0.3	1.6	1.3	0.4	-0.5	-0.3	0.0	0.0	-0.3
Arm fat-free mass (right)	0.2	1.2	7.9	2.8	-0.7	-0.0	0.1	-0.0	0.3	0.3
Worry too long after embarrassment	0.2	0.4	1.0	0.5	-0.5	-0.2	1.0	0.8	-0.4	-0.5
Whole body fat mass	0.2	1.0	3.1	1.8	0.5	0.3	1.0	0.4	1.6	-0.0
Arm predicted mass (right)	0.2	1.3	8.3	2.9	-0.6	-0.0	-0.0	-0.1	0.3	0.3
Comparative height size at age 10	0.2	0.9	3.3	1.8	0.1	0.5	0.3	0.6	0.4	1.4
Knee pain experienced in last month	0.2	0.4	0.9	-0.8	-0.4	-0.4	-0.9	-0.7	-0.1	-0.6
Loneliness, isolation	0.2	0.3	0.9	-1.0	0.2	0.8	-0.4	-0.3	0.3	0.0
Long-standing illness, disability or infirmity	0.2	0.3	2.0	1.4	0.2	-0.1	0.3	-0.0	-0.2	-0.5
Qualifications: nursing, teaching	0.2	0.3	0.7	0.0	-0.8	0.3	0.6	0.6	-0.5	0.3
Medication for cholesterol	0.2	0.3	1.1	1.1	0.3	0.3	0.5	0.6	-0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.2	-0.2	0.8	0.6	0.6	0.7	-0.0
Whole body water mass	0.2	1.4	7.7	2.8	-0.7	-0.7	-0.7	-0.8	-0.3	-0.2
Arm fat mass (left)	0.2	0.7	2.7	1.6	-0.2	-0.0	0.7	0.1	1.4	-0.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.8	0.8	0.6	0.9	0.3	-0.0	-0.0	0.3
Miserableness	0.2	0.4	1.4	-0.4	-0.0	0.1	1.2	0.8	-0.6	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	0.8	-0.2	-0.1	-0.6	-0.9	-0.5	0.4
Medication: Bendroflumethiazide	0.2	0.3	1.2	1.1	0.4	0.5	0.5	-0.2	0.1	-0.7
Medication: Paracetamol	0.2	0.3	0.8	-0.9	-0.3	-0.5	0.7	0.2	-0.6	0.3
Basal metabolic rate	0.2	1.3	7.8	2.8	-0.6	-0.5	-0.3	-0.6	-0.0	-0.1
Arm fat-free mass (left)	0.2	1.0	6.4	2.5	-0.5	-0.1	-0.3	-0.4	0.4	0.1
Diastolic blood pressure, automated reading	0.2	0.6	2.2	1.5	1.1	0.6	0.0	0.1	0.6	0.3
Pain experienced in last month	0.2	0.3	0.6	0.8	0.3	-0.2	-0.6	-0.7	0.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.8	-0.3	0.4	0.3	-0.0	-0.1	0.7
Arm predicted mass (left)	0.2	1.2	7.9	2.8	-0.5	-0.1	-0.1	-0.3	0.4	0.0
Bipolar Disorder (2018)	0.1	0.2	0.7	0.3	-0.8	-0.8	0.4	-0.1	-0.2	0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	1.2	0.2	1.0	-0.4	0.0	-0.1	-0.2	1.1
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.5	0.1	-0.2	0.5	0.4	-0.4	-0.3
Breast Cancer	0.1	0.3	0.8	-0.9	-0.7	0.5	0.1	-0.1	0.5	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.6	0.4	-0.1	0.0	-0.8	-0.1	0.4	0.2
Mean Putamen Volume	0.1	0.1	0.3	-0.2	-0.0	0.4	0.2	-0.2	0.4	-0.5
HbA1C	0.1	0.1	0.3	0.1	0.4	-0.1	0.1	0.5	0.6	0.4
Lupus	0.1	0.1	0.5	0.1	-0.4	0.6	-0.0	0.1	0.7	-0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.2	-0.2	-0.6	0.3	0.5	0.3	-0.2
Relative age of first facial hair	0.1	0.1	0.3	0.3	-0.4	0.0	-0.3	0.4	0.1	-0.5
Systolic blood pressure, automated reading	0.1	0.3	1.3	1.2	0.1	0.3	-0.5	-0.8	0.3	-0.1
Multivitamins +/- minerals	0.1	0.1	0.3	-0.5	-0.1	-0.1	-0.6	-0.6	-0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.2	-0.2	0.7	-0.1	-0.1	0.2	-0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.1	0.4	0.6	-0.4	-0.4	0.5	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.4	0.2	-0.1	0.5	0.3	0.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	1.0	0.3	0.0	-0.2	-0.4	-0.6	0.2	-1.0
Pain all over the body in last month	0.1	0.1	0.4	0.3	-0.6	-0.2	0.2	0.4	-0.4	-0.4
Neuroticism score	0.1	0.2	0.7	0.4	-0.2	-0.3	-0.3	-0.1	-0.8	-0.1
Arm fat percentage (right)	0.1	0.5	2.8	0.6	0.3	-0.1	0.4	-0.2	1.7	-0.6
Hip circumference	0.1	0.5	1.9	1.4	0.3	0.4	0.6	0.1	0.9	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.4	0.6	-0.6	-0.3	-0.6	-0.1	-0.4
Standing height	0.1	1.2	4.9	2.2	0.7	0.2	0.6	0.5	-0.3	1.5
Wheeze or whistling in the chest in last year	0.1	0.3	1.0	-0.4	-0.6	-0.3	0.2	0.5	0.2	-1.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.0	-0.1	0.5	0.5
Illnesses of father: Heart disease	0.1	0.2	1.0	0.1	0.1	0.5	-0.0	0.1	-1.0	0.4
Illnesses of siblings: Diabetes	0.1	0.2	0.9	-0.2	0.2	0.0	-0.3	0.1	0.4	0.9
Arm fat percentage (left)	0.1	0.6	2.2	0.8	0.3	0.1	0.9	0.2	1.5	-0.4
Average weekly red wine intake	0.1	0.2	0.4	-0.7	0.5	-0.1	0.0	-0.1	0.0	-0.6
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	0.1	0.1	-0.5	-0.3	-0.2	0.7	-0.7
Financial situation satisfaction	0.1	0.1	0.2	-0.4	0.3	0.1	0.1	0.3	0.2	0.2
Supplements: Calcium	0.1	0.2	0.6	-0.1	0.0	-0.1	0.8	0.4	0.1	0.6
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.2	0.3	0.3	0.4	-0.0	0.3	-0.3
Hair Pigment	0.0	1.1	2.2	1.3	1.1	-0.1	-1.3	-1.5	-0.5	-0.5
Pulse rate, automated reading	0.0	0.1	0.7	0.2	-0.1	-0.2	-0.1	0.3	0.3	-0.8

Hub : Genes

F2RL2

Models

Trait associations