TWAS hub - IQGAP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.2700	0.0590	3.6e-05	0.036	NA	0.081	NA	0.064	9.3e-04	NA	8.8e-07	NA	1.2e-05
2	GTEx	Whole Blood	0.2150	0.0550	2.2e-04	0.072	NA	0.069	NA	0.071	3.4e-07	NA	5.6e-07	NA	4.3e-07
3	NTR	Blood	0.0726	0.0155	8.3e-09	0.060	0.026	0.050	0.054	0.057	1.5e-18	8.3e-09	1.0e-15	8.2e-17	1.1e-17
4	YFS	Blood	0.2881	0.0260	0.0e+00	0.286	0.250	0.287	0.285	0.286	1.4e-94	4.5e-81	7.1e-95	5.0e-94	1.0e-94
5	TCGA	Colon Adenocarcinoma	0.2760	0.0940	5.4e-03	0.029	0.029	0.009	NA	0.022	7.9e-03	8.5e-03	8.8e-02	NA	1.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Qualifications: NVQ or HND or HNC or equivalent	7.8	9.4	14.7	-2.8	-3.3	-3.6	-3.8	0.9
Blood Platelet Count	7.0	80.9	193.2	-13.9	-5.0	-8.8	-9.3	4.7
Eye problems/disorders: Diabetes related eye disease	4.8	5.2	8.5	-2.9	-2.6	-2.3	-2.4	-0.3
Relative age voice broke	3.7	5.7	8.5	-2.3	-2.5	-2.9	-2.9	0.9
Medication: Omeprazole	3.5	4.1	7.2	-2.7	-2.1	-2.2	-2.1	0.3
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	5.4	2.3	1.4	2.1	2.2	1.3
Heart disease (mother)	3.1	3.7	6.5	-1.6	-2.5	-2.0	-2.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	3.1	3.8	8.6	-2.9	-1.6	-2.0	-1.9	0.3
Breastfed as a baby	2.8	3.5	5.3	1.4	2.3	2.3	2.2	0.0
Eye problems/disorders: None of the above	2.8	3.2	5.9	1.0	1.9	2.4	2.3	-0.5
Chronic bronchitis/emphysema (mother)	2.7	3.1	4.5	0.5	1.7	2.1	1.9	-2.1
Prospective memory result	2.6	3.2	5.7	1.9	1.5	2.4	2.1	-0.1
Ever had prostate specific antigen (PSA) test	2.6	3.0	4.0	1.9	1.8	2.0	1.9	-0.9
Blood White Count	2.5	18.2	26.0	-4.2	-4.8	-4.9	-5.1	-0.4
Myopia	2.5	3.6	6.2	0.1	2.3	2.5	2.5	0.4
Body Mass Index (BMI) (2010)	2.4	3.3	4.7	2.0	1.8	2.2	2.1	0.3
Coronary Artery Disease (CAD)	2.4	2.8	4.5	1.6	2.1	1.9	1.9	0.0
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	4.8	-1.9	-2.2	-1.9	-1.6	0.8
Commuting to job workplace: Walk	2.4	2.6	3.5	-1.3	-1.8	-1.7	-1.9	-1.3
Exposure to tobacco smoke at home	2.3	2.5	4.2	0.7	2.0	1.6	1.9	1.3
Medication: Atorvastatin	2.3	2.8	6.3	-2.5	-1.6	-1.7	-1.5	0.1
Cholesterol lowering medication	2.2	3.2	4.5	-2.1	-1.7	-2.0	-2.1	0.7
Birth weight	2.1	4.5	6.3	1.7	2.3	2.5	2.4	-1.5
Medication: Ibuprofen	2.1	2.5	4.9	-1.4	-2.2	-1.7	-1.6	0.3
Irritability	2.1	3.6	8.8	3.0	1.5	1.6	1.9	0.9
Stomach or abdominal pain in last month	2.0	2.5	4.0	-1.4	-1.6	-1.9	-2.0	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	2.9	-1.5	-1.2	-1.7	-1.7	1.4
Age started oral contraceptive pill	2.0	2.5	3.7	0.7	1.4	1.9	1.7	-1.9
Glaucoma (self-reported)	1.9	2.3	4.1	-1.1	-1.6	-2.0	-1.7	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	3.5	-0.7	-1.3	-1.6	-1.7	1.9
Medication: Metformin	1.8	2.6	9.9	-1.7	-0.5	0.2	0.1	3.1
Tense / ‘highly strung’	1.8	3.0	4.5	2.1	1.0	1.4	1.8	2.1
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.2	-0.7	-1.1	-1.7	-1.7	2.0
Headache pain in last month	1.8	3.1	4.0	-1.8	-1.9	-2.0	-2.0	0.6
Friendships satisfaction	1.8	2.3	3.9	-2.0	-1.0	-1.6	-1.6	-1.2
Qualifications: CSEs or equivalent	1.6	2.1	3.5	-1.5	-1.1	-1.9	-1.8	-0.2
Medication: Blood pressure	1.6	2.9	6.8	2.6	1.4	1.7	1.6	-0.6
Hearing aid user	1.6	1.8	2.7	-1.4	-1.2	-1.4	-1.6	-0.9
Primary Biliary Cirrhosis	1.5	2.1	4.5	2.1	0.9	1.4	1.8	0.4
Townsend deprivation index at recruitment	1.5	2.0	3.4	1.1	1.5	1.8	1.9	-0.3
Number of incorrect matches in round	1.5	2.5	3.4	1.1	1.7	1.6	1.6	-1.8
Pulse wave reflection index	1.5	1.9	4.2	0.9	2.1	1.5	1.4	0.3
Medication for pain relief, constipation, heartburn	1.5	2.5	3.5	1.9	1.4	1.5	1.2	-1.9
Average weekly champagne plus white wine intake	1.5	2.0	3.3	-1.3	-1.2	-1.4	-1.3	1.8
Average weekly beer plus cider intake	1.5	2.2	4.9	0.9	1.0	1.4	1.4	-2.2
HDL Cholesterol	1.4	2.4	4.2	0.6	1.6	2.0	2.0	-0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.9	-2.2	-1.3	-1.5	-1.5	0.5
Medication: Seretide 50 evohaler	1.4	1.6	5.0	-2.2	-0.6	-0.9	-0.8	0.9
Current tobacco smoking	1.3	2.1	4.9	-1.3	-2.2	-1.3	-1.4	0.6
Qualifications: None of the above	1.3	2.8	4.8	2.2	1.2	1.7	1.9	-1.1
Medication: Gliclazide	1.3	1.4	5.4	-2.3	0.4	0.6	0.4	1.1
Smoking status: Current	1.3	2.1	4.9	-1.2	-2.2	-1.3	-1.4	0.6
Mother’s age at death	1.3	1.6	4.2	2.1	0.7	1.0	1.2	0.9
Pain type(s) experienced in last month: Hip pain	1.3	1.6	5.7	-0.4	-0.6	-1.0	-0.9	2.4
Risk taking	1.3	1.9	2.7	1.2	1.6	1.6	1.6	0.8
Fasting Glucose	1.2	1.5	4.4	-0.4	-1.0	-0.7	-1.1	-2.1
Type 2 Diabetes (T2D) (2018)	1.2	2.2	10.9	-0.3	-0.3	0.3	0.1	3.3
Systolic blood pressure, automated reading	1.2	3.3	5.8	2.4	1.6	2.0	2.0	0.8
Medication: Amlodipine	1.2	1.7	2.1	0.9	1.4	1.3	1.4	-1.3
Loneliness, isolation	1.2	1.7	2.6	-0.1	-1.4	-1.6	-1.4	1.3
Guilty feelings	1.2	1.8	2.6	-1.1	-1.5	-1.6	-1.5	1.0
HbA1C	1.1	1.2	3.4	0.6	1.8	1.2	0.8	-0.2
LDL Cholesterol	1.1	1.8	3.1	0.7	-1.1	-1.6	-1.8	-1.2
Taking other prescription medications	1.1	1.7	3.0	0.9	1.7	1.5	1.5	0.3
Medication: Atenolol	1.1	1.4	2.1	-0.7	-1.5	-1.4	-1.4	-0.9
Medication: Ramipril	1.1	1.4	1.6	1.3	0.9	1.2	1.1	1.2
Illnesses of siblings	1.1	1.6	3.7	-1.9	-0.9	-1.3	-1.1	0.5
Depression (self-reported)	1.1	1.3	1.6	0.7	1.3	1.2	1.3	1.2
Medication: Paracetamol	1.1	1.8	2.5	-0.9	-1.3	-1.4	-1.5	1.6
Gout (self-reported)	1.1	1.6	2.2	1.3	1.4	1.5	1.4	0.4
Exposure to tobacco smoke outside home	1.1	1.5	2.4	-0.5	-1.6	-1.4	-1.5	0.7
Medication: Aspirin	1.1	1.4	5.8	-1.1	-0.0	0.1	0.1	2.4
Osteoarthritis (self-reported)	1.1	1.4	2.9	0.8	0.8	1.6	1.7	-0.4
Commuting to job workplace: Public transport	1.1	1.3	4.3	0.1	-1.2	-0.6	-0.6	2.1
High cholesterol (Self-reported)	1.1	2.0	4.7	-2.2	-1.2	-1.4	-1.4	0.1
Pack years of smoking	1.1	1.7	3.1	-0.3	1.4	1.8	1.8	0.2
Depression (Nagel 2018)	1.0	1.5	5.3	-0.1	-0.8	-1.0	-0.6	2.3
Triglycerides	1.0	1.6	2.8	0.7	-1.7	-1.4	-1.2	-0.9
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.8	0.5	0.5	0.9	1.0	1.9
Medication for hormone replacement therapy	1.0	1.1	1.4	1.2	1.2	1.1	1.1	0.8
Maternal smoking around birth	1.0	1.5	3.0	1.1	0.9	1.3	1.0	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	6.2	0.6	-0.4	-0.5	0.1	2.5
Birth weight of first child	1.0	1.9	7.5	-0.3	0.8	0.8	0.7	-2.7
Loud music exposure frequency	1.0	1.1	3.1	-1.8	-0.7	-0.9	-1.0	-0.2
Breast cancer (self-reported)	1.0	1.2	5.1	0.5	0.2	0.3	0.5	2.3
Depressed Affect (Nagel 2018)	0.9	1.8	4.4	-0.7	-1.1	-1.4	-1.1	2.1
Neuroticism (Nagel 2018)	0.9	2.0	3.1	-0.4	-1.6	-1.8	-1.5	1.5
Alcohol usually taken with meals	0.9	1.5	6.8	-0.1	0.1	0.4	0.6	2.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.9	-2.0	0.0	-0.9	-0.9	-0.4
Happiness	0.9	1.0	2.0	-0.5	-1.4	-1.3	-1.0	0.3
Pulse wave Arterial Stiffness index	0.9	1.0	2.9	-0.4	1.0	0.6	0.7	1.7
Medication: Allopurinol	0.9	1.2	1.8	1.0	1.3	1.3	1.2	0.4
Medication for cholesterol	0.9	1.3	1.7	0.8	1.1	1.3	1.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.4	-1.1	-0.4	-1.9	-2.1	-0.1
Medication: Bendroflumethiazide	0.9	1.4	1.8	1.3	1.3	1.3	1.3	-0.0
Medication: Paracetamol	0.9	1.4	3.6	-0.3	-1.0	-1.1	-1.1	1.9
Alzheimer’s Disease (including proxy)	0.8	1.2	3.8	0.2	1.1	0.8	0.8	-2.0
Blood Eosinophil Count	0.8	6.1	8.5	-2.4	-2.9	-2.7	-2.9	-0.8
Sensitivity / hurt feelings	0.8	1.3	2.1	-1.4	-0.7	-1.4	-1.3	0.6
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.9	-0.6	-0.8	-1.2	-0.7	1.7
Pack years adult smoking proportion	0.8	1.2	2.3	-0.5	1.3	1.5	1.4	0.1
Hand grip strength (right)	0.8	2.2	4.5	-2.1	-1.2	-1.5	-1.6	-0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.7	-0.2	1.2	1.0	1.3	-1.1
Neck or shoulder pain in last month	0.8	1.1	2.2	0.2	1.2	1.4	1.5	0.4
Arm predicted mass (right)	0.8	3.9	7.1	1.6	1.7	2.6	2.7	0.0
Leg pain on walking	0.8	1.0	1.8	-0.8	-1.1	-0.8	-0.7	1.4
Smoking status: Previous	0.8	1.2	3.3	1.8	0.7	0.8	0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.8	1.9	0.9	1.2	1.3	-0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.2	-0.8	-0.2	-0.6	-0.5	1.8
Medication: Aspirin	0.8	1.0	4.0	-0.9	-0.4	-0.1	-0.1	2.0
Miserableness	0.8	1.4	3.5	-0.4	-0.6	-1.3	-1.1	1.9
Ever taken oral contraceptive pill	0.8	0.9	1.5	-0.5	1.2	1.2	1.1	-0.3
Pain experienced in last month	0.8	1.3	2.6	1.6	0.9	1.2	0.7	-1.1
Alzheimer’s Disease (in mother)	0.7	0.8	3.2	-0.1	0.7	0.5	0.5	-1.8
Crohns Disease (2017)	0.7	1.6	2.9	-1.0	-0.7	-1.3	-1.5	-1.7
Supplements: Zinc	0.7	0.8	1.1	-1.0	-0.8	-1.0	-1.0	0.4
Medication: Co-codamol	0.7	0.8	1.3	-0.3	1.2	0.9	0.9	0.9
Diabetes (father)	0.7	0.8	2.6	-0.9	0.4	0.5	0.5	1.6
Average weekly fortified wine intake	0.7	0.9	4.0	-2.0	-0.4	-0.2	-0.4	0.2
Age when periods started (menarche)	0.7	1.6	6.7	-2.6	0.1	-0.7	-0.7	-0.3
Impedance of arm (right)	0.7	3.4	5.7	-0.9	-2.2	-2.3	-2.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.3	0.7	0.2	0.3	0.7	2.1
Pulse rate	0.7	1.2	5.0	-2.2	-0.8	-0.5	-0.2	0.1
Noisy workplace	0.7	0.8	1.5	-0.9	-0.8	-0.7	-0.8	-1.2
Arm fat-free mass (right)	0.7	3.7	6.9	1.5	1.8	2.5	2.6	0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	1.4	0.9	0.4	0.4	-0.8
Illnesses of siblings: Diabetes	0.7	0.9	2.9	0.9	-0.6	-0.2	-0.5	1.7
Whole body fat-free mass	0.7	4.3	7.3	1.9	1.8	2.7	2.7	0.0
Leg fat-free mass (right)	0.7	3.9	7.0	1.7	1.6	2.6	2.6	0.2
Mood swings	0.7	1.3	3.1	0.0	0.9	1.0	1.3	1.8
Long-standing illness, disability or infirmity	0.7	1.1	2.2	1.0	0.7	1.5	1.4	0.2
Diabetes diagnosed by doctor	0.7	1.1	4.9	-0.7	-0.4	0.3	0.0	2.2
Illnesses of father: None of the above (group 1)	0.7	0.9	3.5	-1.9	0.3	-0.2	-0.2	-1.0
Whole body water mass	0.7	3.9	6.8	1.8	1.7	2.6	2.6	-0.1
Leg predicted mass (right)	0.7	3.7	6.8	1.7	1.6	2.6	2.6	0.2
Basal metabolic rate	0.7	3.7	6.6	1.8	1.5	2.5	2.6	0.2
Alcohol drinker status: Previous	0.7	0.8	1.6	1.3	-1.1	-0.9	-0.5	-0.3
Arm predicted mass (left)	0.7	3.6	6.1	1.9	1.5	2.4	2.5	0.1
Ulcerative Colitis (UC)	0.6	1.0	1.8	0.7	1.3	1.1	1.1	-0.6
Major Depression (MDD)	0.6	0.8	1.5	-1.2	-1.1	-0.6	-0.3	0.9
Age at First Birth	0.6	0.9	1.6	-0.7	-0.5	-1.1	-1.3	1.0
Bipolar Disorder (2011)	0.6	0.6	1.4	1.2	0.6	0.6	0.6	-0.7
Ulcerative Colitis	0.6	0.9	1.8	1.4	0.9	0.7	0.9	-0.8
Ever had hysterectomy (womb removed)	0.6	0.7	2.4	-0.2	-1.6	-0.6	-0.6	-0.7
Angina	0.6	0.8	1.4	-0.3	-0.8	-1.1	-1.2	0.7
Severe depression (siblings)	0.6	0.7	1.7	0.4	0.6	1.3	1.2	-0.0
Leg fat-free mass (left)	0.6	3.3	6.0	1.6	1.4	2.4	2.5	0.0
Leg predicted mass (left)	0.6	3.1	5.9	1.5	1.4	2.4	2.4	0.0
Trunk fat-free mass	0.6	3.5	5.7	1.9	1.6	2.3	2.4	-0.1
Trunk predicted mass	0.6	3.7	5.9	1.9	1.7	2.4	2.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.0	-1.4	-0.7	-1.0	-0.7	0.5
High blood pressure (siblings)	0.6	0.8	2.7	1.7	0.6	0.8	0.7	-0.1
Number of children fathered	0.6	0.7	1.3	-0.3	-0.9	-0.8	-0.7	-1.1
Pulse wave peak to peak time	0.6	0.7	2.4	0.8	-0.7	-0.1	-0.3	-1.5
Emphysema/chronic bronchitis	0.6	0.6	1.0	-0.3	-1.0	-1.0	-0.9	-0.4
Angina (self-reported)	0.6	0.8	1.3	-0.1	-0.9	-1.1	-1.1	0.9
Age at last live birth	0.6	0.9	1.2	-1.0	-0.4	-1.1	-1.1	1.0
Back pain experienced in last month	0.6	0.9	2.9	-1.7	0.1	-1.1	-0.6	0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-1.1	-0.5	-0.9	-1.0	-0.4
Commuting to job workplace: Cycle	0.6	0.7	2.2	1.5	0.1	0.7	0.8	-0.1
Impedance of whole body	0.6	3.3	5.8	-0.9	-1.9	-2.4	-2.4	0.8
Schizophrenia vs Biploar Disorder	0.5	0.6	1.6	-1.3	0.2	-0.2	-0.1	-1.2
Mean Putamen Volume	0.5	0.5	2.0	-0.2	-0.4	-0.5	-0.4	-1.4
Systolic Blood Pressure	0.5	2.3	3.0	1.7	0.9	1.7	1.5	1.5
Diabetes (mother)	0.5	0.6	1.4	0.4	-1.2	-0.5	-0.4	1.1
Impedance of leg (right)	0.5	2.4	4.6	-0.9	-1.3	-2.1	-2.1	0.6
Had other major operations	0.5	0.6	2.0	-1.4	-0.6	-0.7	-0.5	-0.3
Mouth/teeth dental problems	0.5	0.8	2.4	0.6	0.7	0.7	0.7	-1.6
Diabetes (self-reported)	0.5	0.7	1.9	-1.2	-0.3	-0.1	-0.3	1.4
Weight	0.5	2.4	4.7	1.5	0.8	2.0	2.2	0.5
Asthma	0.5	1.0	3.9	-2.0	0.0	-0.6	-0.5	0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	0.5	0.7	0.8	1.3	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	0.2	-1.2	-0.6	-0.5	1.1
Comparative height size at age 10	0.5	2.5	4.2	1.8	0.6	2.0	2.0	-0.9
Chest pain or discomfort	0.5	0.7	1.1	0.9	1.0	0.9	0.9	-0.4
Asthma (self-reported)	0.5	0.9	3.7	-1.9	0.0	-0.6	-0.5	0.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.1	-1.0	-1.1	-0.8	0.3
Arm fat-free mass (left)	0.5	2.7	5.1	1.4	1.3	2.2	2.2	0.3
Diastolic blood pressure, automated reading	0.5	1.6	4.7	2.2	1.0	1.1	1.2	-0.2
Leg fat mass (left)	0.5	2.1	3.9	1.4	0.9	1.8	2.0	0.9
Schizophrenia (2018)	0.4	0.8	2.1	1.5	0.2	0.0	0.2	-1.4
Alzheimer’s Disease (in father)	0.4	0.4	0.6	-0.5	-0.4	-0.7	-0.8	-0.8
Crohns Disease (2012)	0.4	0.6	2.3	-0.2	-0.1	-0.4	-0.5	-1.5
Rheumatoid Arthritis	0.4	0.5	1.4	1.2	0.7	0.6	0.3	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	0.5	0.9	0.8	0.5	-0.4
Smoking Status	0.4	1.0	2.1	-0.0	-1.2	-0.8	-0.9	1.5
Neuroticism	0.4	1.0	2.3	-0.2	-1.1	-1.5	-1.2	-0.1
Hearing difficulty/problems: Yes	0.4	0.6	1.9	-0.3	-0.9	0.1	0.3	1.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	0.8	0.3	0.7	0.8	0.3
Sitting height	0.4	2.8	4.7	0.3	1.9	2.2	2.1	1.0
Impedance of leg (left)	0.4	1.8	3.1	-0.6	-1.0	-1.8	-1.8	1.1
Heart attack	0.4	0.5	1.0	0.4	0.8	0.8	1.0	0.1
Alcohol intake versus 10 years previously	0.4	0.5	0.9	0.8	0.5	1.0	0.8	-0.4
Impedance of arm (left)	0.4	2.0	3.4	-0.7	-1.7	-1.8	-1.9	0.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	-1.4	-0.5	-0.9	-0.7	-0.2
Leg fat mass (right)	0.4	1.7	3.2	1.3	0.8	1.6	1.8	0.8
Number of full sisters	0.4	0.5	2.3	1.5	-0.5	0.1	0.3	0.1
Knee pain experienced in last month	0.4	0.6	1.8	-1.3	-0.7	-0.4	-0.2	0.6
Qualifications: nursing, teaching	0.4	0.6	2.3	-0.5	0.7	0.3	0.3	1.5
Wears glasses or contact lenses	0.4	0.5	2.0	-1.4	-0.2	0.2	0.2	0.4
Medication: Blood pressure	0.4	0.9	1.1	-0.5	-0.9	-1.0	-1.1	1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.3	0.7	0.8	0.8	0.7
Illnesses of father: High blood pressure	0.4	0.4	1.5	1.2	0.4	0.3	0.3	0.6
Ever depressed for a whole week	0.4	0.6	1.8	-1.3	0.5	0.2	0.6	-0.6
Unable to work because of sickness or disability	0.4	0.6	0.9	-0.9	-0.6	-0.7	-0.6	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.3	0.4	0.8	0.8	1.1	0.3
Bipolar Disorder (2018)	0.3	0.5	2.2	0.5	0.2	0.4	0.3	1.5
Ovarian Cancer	0.3	0.4	1.0	0.5	-0.7	0.1	0.3	-1.0
Prostate Cancer	0.3	0.5	1.3	1.2	-0.7	-0.3	-0.6	0.0
Schizophrenia (2014)	0.3	0.6	2.1	1.4	-0.5	-0.6	-0.4	-0.3
BMI	0.3	1.8	3.5	1.5	0.5	1.6	1.9	0.9
Allergy or Eczema	0.3	0.8	2.4	-0.2	-0.4	-0.7	-0.8	-1.6
Cardiovascular Disease	0.3	1.1	4.1	0.7	-0.7	-0.6	-0.4	2.0
Lung FEV1/FVC ratio	0.3	1.6	2.4	-0.5	-0.8	-1.6	-1.5	1.5
Chronotype (morning person)	0.3	0.7	1.4	1.0	0.7	0.4	0.5	-1.2
Hand grip strength (left)	0.3	0.9	1.4	-1.2	-0.2	-1.0	-1.1	-0.8
Average weekly spirits intake	0.3	0.3	1.0	-1.0	-0.7	-0.3	-0.2	0.3
Fed-up feelings	0.3	0.6	2.1	-0.8	-0.2	-0.2	0.2	1.5
Serious illness, injury or assault to yourself	0.3	0.4	1.3	0.5	0.4	0.4	0.3	-1.1
Multivitamins +/- minerals	0.3	0.4	1.7	-0.3	0.1	0.1	0.0	1.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.7	0.4	0.7	0.6	0.8
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.2	0.4	0.7	0.8	0.2
High blood pressure (mother)	0.3	0.4	1.4	0.5	-0.4	0.2	0.3	1.2
Waist circumference	0.3	1.2	2.1	1.4	0.2	1.3	1.5	0.7
Past tobacco smoking	0.3	0.5	1.4	-1.2	0.3	-0.1	-0.1	-0.9
Pain all over the body in last month	0.3	0.3	0.9	0.6	-0.3	-0.3	0.0	-0.9
Fluid intelligence score	0.3	0.6	2.0	0.4	-0.6	-0.6	-0.6	1.4
Falls in the last year	0.3	0.5	1.9	0.6	0.2	-0.0	0.1	1.4
Number of live births	0.3	0.4	0.8	0.7	0.9	0.4	0.4	-0.8
Medication: Cholesterol lowering	0.3	0.5	0.8	0.8	0.9	0.7	0.7	-0.3
Standing height	0.3	2.6	4.3	1.7	1.3	2.1	2.0	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	-0.8	-0.5	-0.3	-0.5	1.1
Blood clot in the leg (DVT)	0.3	0.3	0.6	0.1	-0.8	-0.7	-0.7	0.4
Forced vital capacity (FVC), Best measure	0.3	0.9	2.5	1.6	0.8	1.0	0.7	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	-1.0	-0.4	-0.2	-0.3	0.7
Overall health rating	0.3	0.6	1.1	0.8	0.7	0.6	0.6	1.1
Had major operations	0.3	0.3	1.3	0.3	-0.2	-0.5	-0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	-1.0	0.5	-0.0	-0.4	0.4
Hypertension (Self-reported)	0.3	0.8	2.5	1.6	0.2	0.4	0.5	1.0
Illnesses of father: Heart disease	0.3	0.4	1.1	0.8	0.0	0.5	0.5	1.0
Ever had bowel cancer screening	0.3	0.4	0.9	-0.6	-0.1	-0.4	-0.6	-1.0
Alcohol drinker status: Never	0.3	0.4	1.7	0.5	-0.1	0.2	0.1	1.3
Ever smoked	0.3	0.6	2.1	0.9	-0.3	-0.2	-0.2	1.4
Leg fat percentage (left)	0.3	1.1	1.6	1.2	0.4	1.0	1.3	1.1
Fractured/broken bones in last 5 years	0.3	0.4	1.2	-0.4	-0.5	-0.5	-0.3	1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	0.4	-0.7	-0.7	-0.6	0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	2.2	1.5	0.2	0.2	0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.5	-0.3	-0.1	-0.6	-0.7	1.6
Worry (Nagel 2018)	0.2	0.4	0.7	0.4	-0.8	-0.8	-0.6	0.4
Reaction Time	0.2	0.4	1.7	1.3	0.1	-0.2	-0.5	-0.1
Breast Cancer	0.2	0.6	1.5	-0.1	-0.7	-1.2	-0.9	-0.1
Height	0.2	3.8	7.7	0.3	2.2	2.8	2.5	0.3
Lung FVC	0.2	0.9	3.8	-0.4	-0.0	-0.3	-0.7	-1.9
Number of treatments/medications taken	0.2	0.4	1.4	-1.2	-0.5	-0.2	-0.2	0.4
Relative age of first facial hair	0.2	0.3	1.1	-0.6	0.0	0.2	0.4	1.1
High blood pressure	0.2	0.6	1.5	1.2	-0.1	0.1	0.1	1.1
Body mass index (BMI)	0.2	0.9	2.0	1.0	0.4	1.2	1.4	0.4
Trunk fat mass	0.2	1.1	1.9	1.1	0.1	1.2	1.4	0.8
Nervous feelings	0.2	0.3	1.3	1.1	-0.3	-0.4	-0.2	0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.7	-0.7	-0.1	-0.1	0.9
Allergy	0.2	0.4	0.7	0.6	0.4	0.8	0.7	0.3
Medication: Simvastatin	0.2	0.2	0.4	0.4	0.3	0.5	0.4	0.6
Hip circumference	0.2	0.7	1.2	0.8	-0.2	0.9	1.1	0.8
Hair/balding pattern: Pattern 3	0.2	0.4	1.0	0.8	0.1	-0.1	-0.4	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.6	-0.8	0.1	-0.4	-0.7	0.7
Medication: Lansoprazole	0.2	0.2	0.5	-0.6	0.1	-0.7	-0.5	0.0
Illnesses of mother	0.2	0.3	0.7	0.9	0.3	-0.5	-0.4	0.5
Length of working week for main job	0.2	0.3	0.5	-0.6	-0.7	-0.5	-0.5	0.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.4	1.2	0.4	0.5	0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	0.2	-0.3	-0.5	-0.7	-0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.8	0.1	0.2	0.5	0.7
Leg fat percentage (right)	0.2	0.7	1.2	1.1	0.2	0.8	1.1	0.8
Comparative body size at age 10	0.2	0.6	1.1	-0.1	1.1	1.0	0.9	-0.3
Number of full brothers	0.2	0.3	1.4	-0.2	-0.1	-0.2	-0.2	-1.2
Age at first live birth	0.2	0.4	1.0	-0.7	0.5	-0.1	-0.3	1.0
Health satisfaction	0.2	0.3	0.6	0.4	-0.4	-0.5	-0.3	0.8
Mean time to correctly identify matches	0.2	0.4	1.4	1.2	0.5	0.4	0.2	0.1
Whole body fat mass	0.2	0.9	1.6	1.1	0.1	1.1	1.3	0.8
Pulse rate, automated reading	0.2	0.8	2.3	-1.5	-0.2	-0.2	-0.0	1.2
Alcohol intake frequency.	0.2	0.4	1.4	1.2	-0.6	0.4	0.5	-0.1
Suffer from ‘nerves’	0.2	0.3	0.6	-0.3	-0.4	-0.8	-0.7	-0.4
Family relationship satisfaction	0.2	0.2	0.5	-0.3	-0.5	-0.5	-0.7	-0.2
Average weekly red wine intake	0.2	0.3	0.4	-0.5	-0.6	-0.6	-0.7	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.2	-0.4	0.1	-0.5	-0.5	0.5
Arm fat mass (left)	0.2	0.8	1.3	1.2	-0.0	0.9	1.1	0.8
Medication: Lisinopril	0.2	0.2	1.1	-0.1	-0.2	-0.1	-0.1	-1.1
Number of operations (self-reported)	0.2	0.4	0.6	-0.8	-0.3	-0.7	-0.6	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.7	-0.9	0.1	-0.0	-0.1	-1.3
Supplements: Calcium	0.2	0.2	0.7	-0.5	-0.2	0.2	0.3	0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.0	-0.3	-0.7	-0.7	0.6
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	-0.2	0.5	0.0	0.0	-1.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.3	-0.6	-0.7	-0.6	0.6
Lupus	0.1	0.2	0.6	0.8	-0.5	-0.1	0.0	0.1
Blood Red Count	0.1	1.3	4.7	-0.5	-2.2	-0.9	-0.5	-0.5
Heel T-Score	0.1	0.8	2.7	-0.0	-0.7	-0.9	-0.6	1.6
Waist Hip Ratio (WHR)	0.1	0.3	1.6	1.3	-0.1	-0.0	-0.1	-0.2
Hypothyroidism (self reported)	0.1	0.2	0.3	0.6	-0.3	-0.4	-0.6	0.2
Respiratory disease	0.1	0.3	1.1	-1.0	0.5	-0.3	-0.4	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.4	-0.4	-0.0	0.1	-0.5
Vitamin and mineral supplements	0.1	0.2	0.3	0.4	-0.6	-0.6	-0.4	-0.2
Trunk fat percentage	0.1	0.4	0.9	0.5	-0.8	0.2	0.4	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	-0.1	0.3	-0.5	-0.4	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.3	-0.3	-0.0	-0.1	-0.1	-1.1
Supplements: Glucosamine	0.1	0.1	0.2	0.0	-0.4	0.4	0.4	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.7	0.1	-0.3	-0.0	-0.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.2	0.4	-0.1	0.4	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.5	-0.2	-0.3	0.0	-0.4
Had menopause	0.1	0.1	0.3	0.1	-0.1	0.3	0.3	0.5
Forced vital capacity (FVC)	0.1	0.3	0.7	0.6	0.5	0.4	0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.3	0.3	-0.0	-0.0	0.8
Financial difficulties in last 2 years	0.1	0.2	0.4	0.3	-0.2	0.4	0.6	0.4
Arm fat percentage (right)	0.1	0.3	0.9	0.4	-0.9	-0.1	0.1	0.4
Time employed in main current job	0.1	0.1	0.3	-0.2	0.5	-0.1	-0.4	-0.5
Worrier / anxious feelings	0.1	0.3	0.6	0.0	0.8	0.5	0.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.1	-0.3	-0.4	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	1.1	-1.0	0.0	-0.0	0.1	0.3
Lung cancer (father)	0.1	0.2	0.3	-0.3	-0.5	0.3	0.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	0.8	0.3	0.1	-0.1	0.3
Arm fat mass (right)	0.1	0.4	0.7	0.8	-0.3	0.7	0.8	0.4
Peak expiratory flow (PEF)	0.1	0.2	0.6	0.6	0.0	-0.2	-0.3	0.8
Body fat percentage	0.1	0.4	0.9	0.5	-0.7	0.2	0.4	1.0
Worry too long after embarrassment	0.1	0.1	0.2	-0.2	0.3	-0.4	-0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.0	0.5	0.5	0.4	0.5
Shortness of breath walking on level ground	0.1	0.1	0.2	0.3	-0.4	-0.2	0.1	-0.0
Supplements: Vitamin C	0.1	0.1	0.2	-0.3	-0.0	-0.1	-0.2	-0.4
Arm fat percentage (left)	0.1	0.3	0.4	0.6	-0.7	0.1	0.4	0.6
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.5	0.0	-0.6	-0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	0.2	0.4	-0.4	-0.6	-0.3
Mineral and other dietary supplements	0.1	0.2	0.5	0.4	0.3	-0.2	-0.2	-0.7
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.5	-0.1	0.4	0.5	0.0
Number of self-reported non-cancer illnesses	0.1	0.3	0.4	-0.6	0.3	0.6	0.6	0.2
Financial situation satisfaction	0.1	0.2	0.6	-0.0	-0.5	-0.2	-0.1	-0.8
Heart disease (siblings)	0.1	0.1	0.2	-0.1	0.2	0.5	0.3	0.0
Neuroticism (2016)	0.0	0.0	0.2	0.5	0.1	0.0	-0.0	-0.2
Hair Pigment	0.0	1.2	2.0	0.8	1.2	1.3	1.4	0.7
Tanning	0.0	0.2	0.7	-0.2	0.9	0.2	-0.1	0.1
Neuroticism score	0.0	0.1	0.2	0.0	-0.2	-0.4	-0.1	0.2
Father’s age at death	0.0	0.1	0.3	0.1	-0.5	-0.1	0.0	-0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	0.3	0.1	-0.1	-0.4	0.1
Qualifications: College or University degree	0.0	0.1	0.4	0.2	0.2	0.1	-0.2	0.6
Migraine (self-reported)	0.0	0.1	0.3	-0.2	0.1	-0.0	-0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.2	0.0	0.4	0.2	0.0	0.2

Hub : Genes

IQGAP2

Models

Trait associations