TWAS hub - AGGF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2620	0.0920	0.00950	-0.005	NA	0.025	NA	0.002	0.50000	NA	0.0530	NA	0.28000
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0525	0.0268	0.00650	0.003	0.012	0.012	NA	0.010	0.13000	0.0140	0.0150	NA	0.02500
3	TCGA	Brain Lower Grade Glioma	0.0667	0.0269	0.00011	0.040	0.021	0.014	NA	0.028	0.00002	0.0017	0.0078	NA	0.00035

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3
Lung cancer (father)	3.1	3.7	7.5	2.7	1.9
HbA1C	2.7	3.0	6.0	-2.5	-1.7
Ever had hysterectomy (womb removed)	2.2	2.5	7.2	0.4	2.7
Back pain experienced in last month	2.1	3.1	8.3	-0.9	-2.9
Smoking status: Current	2.0	3.1	7.1	1.5	2.7
Blood Platelet Count	1.8	21.4	42.6	-4.7	-6.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	10.9	0.7	-3.3
Hearing difficulty/problems: Yes	1.7	2.5	6.0	1.3	2.5
Current tobacco smoking	1.7	2.9	7.2	1.2	2.7
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	4.5	1.5	-2.1
Pulse wave reflection index	1.6	1.9	3.2	1.6	-1.8
Worry too long after embarrassment	1.6	2.7	4.3	-2.1	-1.9
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.0	1.7	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.2	-1.8	-1.4
Osteoporosis (self-reported)	1.4	1.8	2.9	1.7	1.5
Myopia	1.4	2.1	6.0	-2.4	-0.5
Medication: Lansoprazole	1.3	1.5	2.9	-1.2	-1.7
Illnesses of mother	1.3	1.6	3.7	-1.0	-1.9
Medication: Ibuprofen	1.3	1.5	3.1	1.3	1.7
Medication: Seretide 50 evohaler	1.3	1.5	4.1	2.0	-0.6
Alcohol intake frequency.	1.3	3.1	5.2	2.0	2.3
Medication: Allopurinol	1.2	1.6	4.6	2.1	-0.3
Ovarian Cancer	1.1	1.4	3.9	0.7	2.0
Prostate Cancer	1.1	1.5	2.6	1.6	1.4
Impedance of leg (left)	1.1	5.3	12.2	-3.5	-1.9
Hearing difficulty/problems with background noise	1.1	1.8	2.7	1.6	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.4	-0.6	-1.8
Commuting to job workplace: Cycle	1.1	1.3	2.2	1.5	1.3
BMI	1.0	5.9	12.6	3.5	2.3
Supplements: Glucosamine	1.0	1.3	3.8	0.3	2.0
Weight	1.0	5.0	9.6	3.1	2.3
Hip circumference	1.0	4.3	7.2	2.7	2.4
Prospective memory result	1.0	1.2	2.8	0.9	1.7
Arm fat mass (right)	1.0	4.1	8.2	2.9	2.0
Number of children fathered	1.0	1.1	2.7	1.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.5	-1.9	0.3
Heart disease (mother)	1.0	1.2	3.3	0.5	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.0	-1.7	-0.8
Arm fat mass (left)	1.0	4.3	8.5	2.9	2.1
Ever taken oral contraceptive pill	1.0	1.1	3.2	-1.8	-0.4
Commuting to job workplace: Public transport	1.0	1.2	3.3	0.4	1.8
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.8	-1.7	-0.4
Hand grip strength (left)	0.9	2.4	4.0	-1.8	-2.0
Medication: Metformin	0.9	1.3	3.5	0.6	1.9
Impedance of leg (right)	0.9	4.4	9.7	-3.1	-1.9
Leg fat-free mass (left)	0.9	4.5	9.8	3.1	1.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.9	1.4	1.1
Body mass index (BMI)	0.9	3.7	8.1	2.9	1.7
Number of incorrect matches in round	0.9	1.4	3.8	-1.9	-0.7
Arm fat percentage (right)	0.9	3.7	6.6	2.6	2.1
Breastfed as a baby	0.9	1.1	2.7	-1.6	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.9	-1.7	-0.5
Number of full sisters	0.9	1.1	2.9	0.5	1.7
Reaction Time	0.8	1.4	4.1	2.0	-0.4
Sensitivity / hurt feelings	0.8	1.5	2.3	-1.4	-1.5
Diabetes (mother)	0.8	1.1	3.2	-0.1	1.8
Severe depression (siblings)	0.8	0.9	1.5	-1.1	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	1.3	1.0
Leg predicted mass (left)	0.8	4.5	9.7	3.1	1.9
Financial difficulties in last 2 years	0.8	1.1	1.8	1.2	1.4
Number of live births	0.8	1.2	2.2	-1.2	-1.5
Medication: Amlodipine	0.8	1.1	2.9	1.7	-0.5
Leg fat-free mass (right)	0.8	4.5	9.6	3.1	2.0
Arm fat percentage (left)	0.8	3.3	6.1	2.5	1.9
Leg predicted mass (right)	0.8	4.4	9.4	3.1	1.9
Major Depression (MDD)	0.7	0.8	1.9	-0.7	1.4
Respiratory disease	0.7	1.6	4.7	0.2	-2.2
Number of treatments/medications taken	0.7	1.3	3.2	1.8	0.9
Diabetes (father)	0.7	0.9	2.7	-1.7	-0.0
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.5	2.1	-0.3
Trunk fat mass	0.7	3.2	5.0	2.2	2.2
Waist circumference	0.7	2.6	4.5	1.8	2.1
Medication: Ramipril	0.7	1.0	2.7	1.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.2	0.7	1.5
Medication: Cholesterol lowering	0.7	1.1	3.1	-1.8	-0.5
Blood clot in the leg (DVT)	0.7	0.9	2.4	1.6	0.6
Gout (self-reported)	0.7	0.9	2.7	1.6	-0.1
Shortness of breath walking on level ground	0.7	0.9	1.8	-1.3	0.9
Whole body fat mass	0.7	3.0	5.2	2.3	1.9
Age at last live birth	0.7	1.0	2.5	-0.7	-1.6
Diabetes diagnosed by doctor	0.7	1.2	3.5	0.3	1.9
Osteoarthritis (self-reported)	0.7	0.9	2.5	0.5	1.6
Mother’s age at death	0.7	0.9	2.5	1.6	0.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	-1.6	0.1
Medication: Blood pressure	0.7	1.4	4.1	2.0	0.1
Basal metabolic rate	0.7	3.6	7.7	2.8	1.8
Lupus	0.6	0.8	1.4	1.1	1.2
Medication for hormone replacement therapy	0.6	0.6	1.3	-1.2	-0.7
Trunk fat percentage	0.6	2.6	4.6	1.8	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.2	0.3	-2.1
Alcohol intake versus 10 years previously	0.6	0.9	1.3	1.2	1.2
Mouth/teeth dental problems: Dentures	0.6	1.1	3.2	-1.8	-0.3
Exposure to tobacco smoke at home	0.6	0.7	1.9	-0.6	-1.4
Birth weight of first child	0.6	1.0	2.9	1.7	-0.4
Glaucoma (self-reported)	0.6	0.7	1.9	-1.4	-0.4
Pulse wave peak to peak time	0.6	0.7	2.2	-0.1	1.5
Comparative height size at age 10	0.6	3.2	7.2	1.6	2.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	0.7	-1.3
Smoking status: Previous	0.6	0.8	2.5	-1.6	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.3	-1.1	-0.9
Eye problems/disorders: Cataract	0.6	0.7	1.9	-0.4	-1.4
Medication for cholesterol	0.6	0.8	2.4	-1.6	0.3
Illnesses of father: None of the above (group 1)	0.6	0.8	1.8	0.7	-1.3
Whole body water mass	0.6	3.3	7.2	2.7	1.6
Arm fat-free mass (left)	0.6	2.9	6.2	2.5	1.6
Number of operations (self-reported)	0.6	0.8	2.3	1.5	-0.5
Cholesterol lowering medication	0.6	0.9	2.8	1.7	-0.1
Supplements: Calcium	0.6	0.6	1.2	0.8	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.7	1.3	0.7
Arm predicted mass (left)	0.6	2.8	6.0	2.5	1.6
Blood Red Count	0.5	5.2	11.7	2.0	3.4
Allergy or Eczema	0.5	1.4	3.6	1.9	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.4	0.4	1.2
Taking other prescription medications	0.5	0.7	1.1	-1.1	-1.0
Age when periods started (menarche)	0.5	1.3	3.4	-0.7	-1.8
Falls in the last year	0.5	0.7	1.7	1.3	-0.7
Asthma	0.5	1.0	2.8	0.4	-1.7
Pulse wave Arterial Stiffness index	0.5	0.5	1.6	0.3	-1.2
Peak expiratory flow (PEF)	0.5	1.1	3.2	1.8	-0.4
Body fat percentage	0.5	2.2	3.7	1.7	1.9
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-1.2	0.8
Age at first live birth	0.5	0.9	2.6	0.1	-1.6
Leg fat mass (right)	0.5	1.9	3.9	2.0	1.4
Arm predicted mass (right)	0.5	2.6	5.8	2.4	1.4
Leg pain on walking	0.5	0.6	1.2	-1.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	-0.6	-1.2
Whole body fat-free mass	0.5	2.8	6.4	2.5	1.5
Friendships satisfaction	0.5	0.6	1.3	-1.1	-0.8
Qualifications: nursing, teaching	0.5	0.8	1.8	-0.8	-1.3
Mineral and other dietary supplements	0.5	0.6	1.6	-0.5	-1.3
Asthma (self-reported)	0.5	0.9	2.4	0.6	-1.6
Leg fat mass (left)	0.5	2.0	3.8	1.9	1.5
Bipolar Disorder (2018)	0.4	0.6	1.6	1.3	0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	1.1	-0.6
Irritable Bowel Disease (IBD)	0.4	0.9	1.6	-1.1	-1.2
Ulcerative Colitis (UC)	0.4	0.7	1.1	-1.0	-1.0
Mean Putamen Volume	0.4	0.5	1.4	1.2	-0.2
Lung FEV1/FVC ratio	0.4	1.9	3.9	2.0	-1.3
Supplements: Zinc	0.4	0.5	1.3	1.1	-0.4
Hand grip strength (right)	0.4	1.2	3.3	-1.8	-0.5
Qualifications: CSEs or equivalent	0.4	0.5	1.4	0.4	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	1.0	0.8
High blood pressure (mother)	0.4	0.6	1.7	-0.4	1.3
Allergy	0.4	0.8	1.8	-1.3	0.8
Pain all over the body in last month	0.4	0.4	1.1	1.1	0.2
Time employed in main current job	0.4	0.5	1.4	-0.2	-1.2
Arm fat-free mass (right)	0.4	2.1	4.9	2.2	1.2
Migraine (self-reported)	0.4	0.5	1.4	1.2	-0.2
Medication: Omeprazole	0.4	0.5	1.1	-1.1	0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.2	0.6	1.1
Long-standing illness, disability or infirmity	0.4	0.7	1.9	-0.2	1.4
Age started oral contraceptive pill	0.4	0.5	1.1	-1.1	0.5
Impedance of whole body	0.4	2.2	6.0	-2.5	-0.7
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	0.7	-0.7
Breast Cancer	0.3	0.6	1.4	1.2	-0.7
Age at First Birth	0.3	0.4	1.3	-0.1	-1.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	1.1	0.3
Fasting Glucose	0.3	0.4	1.0	0.4	1.0
Triglycerides	0.3	0.5	1.4	0.5	1.2
Blood Eosinophil Count	0.3	2.5	6.0	2.4	1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	0.5	1.3
Average weekly spirits intake	0.3	0.4	1.1	0.2	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	-0.3	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	0.8	0.8
Serious illness, injury or assault to yourself	0.3	0.4	1.2	1.1	-0.1
Past tobacco smoking	0.3	0.5	0.9	1.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.8	-0.9	-0.9
Trunk fat-free mass	0.3	1.9	4.2	2.0	1.2
Happiness	0.3	0.3	0.5	0.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.7	1.6	-0.5
Trunk predicted mass	0.3	1.7	4.1	2.0	1.1
Length of working week for main job	0.3	0.4	1.1	0.1	1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.4	-1.1
Medication: Paracetamol	0.3	0.6	1.7	1.3	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	1.1	-0.0
Health satisfaction	0.3	0.3	0.9	-1.0	-0.3
Had major operations	0.3	0.4	0.8	-0.9	-0.5
Knee pain experienced in last month	0.3	0.4	0.7	0.7	0.8
Commuting to job workplace: Walk	0.3	0.4	0.7	-0.8	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	-0.9	-0.7
Miserableness	0.3	0.5	1.5	-0.2	-1.2
Wears glasses or contact lenses	0.3	0.3	0.6	-0.6	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-1.0	-0.6
High cholesterol (Self-reported)	0.3	0.6	1.8	-1.3	0.0
Medication: Lisinopril	0.3	0.3	0.8	0.9	0.4
Risk taking	0.3	0.4	0.9	-1.0	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	1.1	1.0	0.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.8	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.9	0.3	-1.4
Alzheimer’s Disease (including proxy)	0.2	0.2	0.7	-0.0	-0.8
Crohns Disease (2012)	0.2	0.3	0.6	0.6	-0.8
LDL Cholesterol	0.2	0.3	0.5	0.7	-0.7
Neuroticism (2016)	0.2	0.3	0.8	0.9	-0.1
Primary Biliary Cirrhosis	0.2	0.2	0.6	-0.3	0.8
Rheumatoid Arthritis	0.2	0.2	0.5	-0.4	-0.7
Ulcerative Colitis	0.2	0.3	0.6	-0.8	-0.5
Smoking Status	0.2	0.4	1.2	-0.1	1.1
Medication: Co-codamol	0.2	0.3	0.7	-0.4	-0.8
Townsend deprivation index at recruitment	0.2	0.3	0.8	-0.9	0.2
Maternal smoking around birth	0.2	0.4	0.8	0.9	0.5
Relative age voice broke	0.2	0.2	0.7	-0.8	-0.1
High blood pressure	0.2	0.7	1.8	1.3	0.5
Medication: Levothyroxine sodium	0.2	0.3	0.4	0.7	0.6
Alcohol usually taken with meals	0.2	0.4	0.7	-0.8	0.7
Had menopause	0.2	0.2	0.6	0.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	0.6	-1.1
Heart attack	0.2	0.2	0.6	-0.8	-0.2
Medication: Simvastatin	0.2	0.3	0.8	-0.9	0.2
Illnesses of siblings	0.2	0.2	0.6	-0.3	-0.8
Father’s age at death	0.2	0.3	0.8	0.3	0.9
Worrier / anxious feelings	0.2	0.4	1.0	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	1.1	-0.6
Pulse rate	0.2	0.4	0.8	-0.6	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	-0.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-1.0	-0.3
Leg fat percentage (right)	0.2	0.9	1.5	1.2	1.0
Medication: Blood pressure	0.2	0.4	0.8	0.9	0.5
Mean time to correctly identify matches	0.2	0.5	1.2	1.1	-0.4
Family relationship satisfaction	0.2	0.2	0.4	0.7	0.4
Supplements: Vitamin C	0.2	0.2	0.6	-0.8	-0.1
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.2	0.9
Ever had bowel cancer screening	0.2	0.3	0.5	-0.7	-0.6
Medication: Aspirin	0.2	0.2	0.5	-0.4	0.7
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	0.7	0.6
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.0	-0.9
Medication: Bendroflumethiazide	0.2	0.2	0.7	0.8	-0.1
Medication: Paracetamol	0.2	0.3	0.7	0.8	0.2
Leg fat percentage (left)	0.2	0.7	1.2	1.1	1.0
Average weekly beer plus cider intake	0.2	0.3	0.5	0.7	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.6	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	-0.9	-0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.6
Depression (Nagel 2018)	0.1	0.1	0.2	-0.5	-0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-1.0	-0.1
Schizophrenia (2018)	0.1	0.3	0.9	-0.9	-0.3
Alzheimer’s Disease (in father)	0.1	0.2	0.3	-0.5	-0.4
Crohns Disease (2017)	0.1	0.3	0.8	-0.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	-0.8	-0.2
Blood White Count	0.1	0.7	1.7	0.7	1.3
Height	0.1	1.0	2.6	1.6	0.7
Systolic Blood Pressure	0.1	0.7	2.0	-0.5	1.4
Cardiovascular Disease	0.1	0.3	0.6	0.6	0.8
Neuroticism	0.1	0.1	0.2	-0.5	-0.4
Chronotype (morning person)	0.1	0.2	0.6	0.1	-0.8
Tanning	0.1	1.7	2.7	-1.5	-1.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.4	-0.7
Systolic blood pressure, automated reading	0.1	0.4	1.1	-1.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.5	0.5
Medication: Atenolol	0.1	0.2	0.5	0.1	0.7
Sitting height	0.1	0.5	1.4	1.2	-0.2
Had other major operations	0.1	0.2	0.4	0.7	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.0	-0.7
Qualifications: None of the above	0.1	0.3	0.6	0.5	0.8
Mouth/teeth dental problems	0.1	0.1	0.3	0.6	-0.2
Diabetes (self-reported)	0.1	0.2	0.4	-0.3	0.7
Impedance of arm (right)	0.1	0.5	1.3	-1.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.6	0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.6	-0.5
Noisy workplace	0.1	0.2	0.5	-0.0	0.7
Depression (self-reported)	0.1	0.2	0.4	-0.6	-0.3
Impedance of arm (left)	0.1	0.6	1.7	-1.3	0.3
Standing height	0.1	0.8	1.8	0.8	1.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	-0.8	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.3	0.8
Headache pain in last month	0.1	0.2	0.5	0.7	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.7	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.5	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	1.1	0.1
Comparative body size at age 10	0.1	0.2	0.4	0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.7	0.1
Wheeze or whistling in the chest in last year	0.1	0.3	0.8	0.2	-0.9
Qualifications: College or University degree	0.1	0.2	0.3	-0.6	-0.4
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.2	0.7
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.4	-0.4
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.7	0.2
Pulse rate, automated reading	0.1	0.2	0.7	-0.9	-0.0
Suffer from ‘nerves’	0.1	0.2	0.5	0.2	-0.7
Overall health rating	0.1	0.2	0.5	-0.7	-0.4
Chest pain or discomfort	0.1	0.1	0.4	0.2	-0.6
Medication: Aspirin	0.1	0.2	0.5	-0.7	0.1
Hypertension (Self-reported)	0.1	0.4	1.0	1.0	0.5
Average weekly red wine intake	0.1	0.1	0.2	-0.3	0.4
Loneliness, isolation	0.1	0.2	0.6	0.8	0.2
Breast cancer (self-reported)	0.1	0.1	0.3	-0.6	-0.0
Medication: Gliclazide	0.1	0.1	0.2	-0.4	0.5
Guilty feelings	0.1	0.2	0.5	-0.7	0.4
Hearing aid user	0.1	0.1	0.2	-0.5	0.0
Financial situation satisfaction	0.1	0.1	0.3	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.4	0.2
Medication: Atorvastatin	0.1	0.1	0.2	-0.5	0.4
Alcohol drinker status: Never	0.1	0.1	0.4	-0.1	0.6
Ever depressed for a whole week	0.1	0.2	0.4	-0.4	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.5	0.7	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.9	-0.5
Heart disease (siblings)	0.1	0.2	0.3	-0.6	0.5
Alcohol drinker status: Previous	0.1	0.2	0.3	0.4	0.6
Pack years of smoking	0.1	0.1	0.3	-0.2	0.5
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.1	0.0
Worry (Nagel 2018)	0.0	0.0	0.1	0.2	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.1	0.2	0.1
Schizophrenia (2014)	0.0	0.1	0.2	0.4	0.2
Heel T-Score	0.0	0.3	0.7	0.8	-0.5
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.5	-0.1
Hypothyroidism (self reported)	0.0	0.0	0.0	0.2	-0.1
Lung FVC	0.0	0.1	0.3	-0.2	-0.5
Hair Pigment	0.0	0.3	0.8	0.9	-0.2
Relative age of first facial hair	0.0	0.1	0.2	-0.3	0.4
Angina	0.0	0.1	0.1	-0.4	-0.2
Vitamin and mineral supplements	0.0	0.0	0.1	-0.4	0.1
Pack years adult smoking proportion	0.0	0.0	0.1	0.1	0.3
Average weekly fortified wine intake	0.0	0.0	0.1	0.2	0.3
Fed-up feelings	0.0	0.0	0.0	-0.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.1	0.2
Multivitamins +/- minerals	0.0	0.0	0.0	0.2	0.2
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.4	-0.1
Nervous feelings	0.0	0.0	0.1	0.0	-0.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.0	-0.0
Forced vital capacity (FVC)	0.0	0.0	0.1	0.2	-0.2
Fluid intelligence score	0.0	0.0	0.1	-0.3	0.0
Neuroticism score	0.0	0.1	0.2	-0.5	-0.3
Tense / ‘highly strung’	0.0	0.1	0.1	-0.3	0.4
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.3	-0.0
Loud music exposure frequency	0.0	0.0	0.1	-0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.2	-0.2
Birth weight	0.0	0.1	0.2	-0.1	-0.5
High blood pressure (siblings)	0.0	0.1	0.2	-0.0	0.4
Number of full brothers	0.0	0.0	0.1	-0.2	-0.3
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.0	0.2
Angina (self-reported)	0.0	0.0	0.0	-0.2	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.1	0.3
Mood swings	0.0	0.0	0.0	0.2	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.1	-0.2	0.2
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.3	0.0
Ever smoked	0.0	0.1	0.1	-0.4	0.1
Irritability	0.0	0.0	0.1	0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.1	-0.3	-0.2
Diastolic blood pressure, automated reading	0.0	0.0	0.0	0.1	-0.1
Pain experienced in last month	0.0	0.0	0.1	0.3	0.2

Hub : Genes

AGGF1

Models

Trait associations