[Hub]/) : Traits : Whole body fat-free mass : ← →

chr2:23,453,834-29,344,127

Best TWAS P=5.01e-44 · Best GWAS P=4.37e-41 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-13.400	13.9	5.0e-44	-0.99	0.00	0.96	TRUE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	8.700	10.8	2.8e-27	-0.40	0.19	0.14	TRUE
52	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	8.610	-8.8	1.7e-18	-0.05	0.04	0.92	TRUE
15	GTEx	Breast Mammary Tissue (Female)	AC074117.10	0.06	0.01	lasso	2	0.04	2.7e-02	6.920	7.7	1.1e-14	-0.23	0.04	0.05	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	4.730	-7.1	9.7e-13	0.72	0.28	0.72	TRUE
39	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-3.810	-6.7	1.7e-11	0.01	0.52	0.02	TRUE
58	GTEx	Thyroid	RP11-373D23.3	0.16	0.07	enet	19	0.04	2.6e-04	4.350	-6.5	8.8e-11	0.15	0.52	0.12	TRUE
20	GTEx	Colon Sigmoid	DNMT3A	0.19	-0.01	lasso	8	0.00	4.5e-01	-2.190	-6.5	1.1e-10	0.06	0.07	0.19	TRUE
71	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	5.770	-6.3	3.8e-10	0.09	0.00	1.00	TRUE
27	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	-7.020	-6.2	5.0e-10	0.08	0.11	0.08	TRUE
84	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SUPT7L	0.06	0.03	blup	29	0.05	2.0e-03	8.600	6.1	1.1e-09	-0.04	0.04	0.04	TRUE
28	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	4.810	-6.1	1.3e-09	0.64	0.43	0.30	TRUE
97	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-5.000	-5.8	8.2e-09	0.01	0.00	0.77	TRUE
56	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	8.400	11.6	6.6e-31	-0.69	0.67	0.33	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	8.580	11.5	1.5e-30	-0.70	0.41	0.59	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	8.400	10.9	1.8e-27	-0.64	0.91	0.09	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	9.210	10.3	5.6e-25	-0.54	0.02	0.27	FALSE
55	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	4.820	-9.4	8.3e-21	0.85	0.05	0.94	FALSE
53	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	6.210	9.0	1.8e-19	-0.36	0.20	0.08	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	-10.500	-8.9	3.7e-19	0.54	0.00	0.99	FALSE
34	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	6.210	-8.7	3.4e-18	0.82	0.01	0.97	FALSE
54	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	6.210	-8.5	1.5e-17	0.80	0.03	0.96	FALSE
36	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	-7.330	-8.1	7.5e-16	0.02	0.23	0.28	FALSE
32	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	6.210	-8.0	1.3e-15	0.74	0.94	0.06	FALSE
47	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	4.770	-7.9	2.8e-15	0.77	0.04	0.80	FALSE
23	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-7.480	-7.9	3.5e-15	-0.06	0.07	0.70	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	5.460	7.7	1.6e-14	-0.63	0.43	0.49	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	-7.250	7.5	7.8e-14	-0.04	0.35	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	-8.280	7.4	1.7e-13	-0.03	1.00	0.00	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	-7.270	7.3	3.6e-13	-0.03	0.36	0.14	FALSE
59	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	4.130	-7.2	5.8e-13	0.72	0.08	0.57	FALSE
30	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	1.410	-7.2	7.9e-13	0.05	0.10	0.18	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	4.640	7.0	1.8e-12	-0.75	0.48	0.52	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	-5.510	-7.0	3.2e-12	0.06	0.26	0.25	FALSE
33	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-3.680	-6.8	8.2e-12	0.01	0.06	0.28	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	3.390	6.8	1.0e-11	-0.55	0.02	0.34	FALSE
38	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	-5.480	-6.8	1.3e-11	0.05	1.00	0.00	FALSE
68	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	-7.430	-6.6	3.7e-11	0.00	0.86	0.13	FALSE
64	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	6.210	-6.5	6.2e-11	0.67	1.00	0.00	FALSE
44	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	-2.130	-6.3	2.1e-10	0.43	0.29	0.07	FALSE
35	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	6.210	-6.3	2.4e-10	0.65	0.73	0.26	FALSE
51	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	-7.300	-6.3	2.4e-10	-0.08	0.03	0.88	FALSE
5	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	6.210	-6.3	3.0e-10	0.65	0.45	0.27	FALSE
85	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	6.210	-6.2	4.0e-10	0.67	0.02	0.09	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	6.210	-6.2	4.1e-10	0.65	0.04	0.70	FALSE
37	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	1.410	-6.2	5.2e-10	0.12	0.64	0.06	FALSE
12	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	4.620	-6.1	8.3e-10	0.66	0.29	0.12	FALSE
10	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-3.420	-6.1	1.4e-09	-0.01	0.07	0.04	FALSE
60	GTEx	Whole Blood	UBXN2A	0.17	0.07	lasso	8	0.09	2.1e-08	-1.140	-6.0	1.7e-09	-0.08	0.04	0.96	FALSE
7	GTEx	Adipose Visceral Omentum	UBXN2A	0.10	0.08	enet	29	0.03	9.8e-03	-7.380	-6.0	1.9e-09	-0.08	0.11	0.86	FALSE
67	METSIM	Adipose	SLC5A6	0.03	0.02	bslmm	298	0.01	3.9e-03	3.260	-6.0	2.0e-09	0.43	0.25	0.04	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	-5.510	6.0	2.0e-09	-0.08	0.43	0.06	FALSE
79	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	4.840	-5.9	2.9e-09	0.66	0.03	0.51	FALSE
31	GTEx	Esophagus Mucosa	PFN4	0.16	0.15	lasso	4	0.15	3.6e-10	-5.510	-5.9	4.0e-09	0.05	1.00	0.00	FALSE
75	YFS	Blood	EIF2B4	0.01	0.00	enet	9	0.00	8.5e-02	2.750	5.8	4.9e-09	-0.52	0.04	0.03	FALSE
50	GTEx	Skin Sun Exposed Lower leg	UBXN2A	0.08	0.04	enet	17	0.03	1.3e-03	-7.430	-5.8	5.0e-09	-0.06	0.54	0.37	FALSE
76	YFS	Blood	MRPL33	0.02	0.01	blup	385	0.01	6.4e-05	6.490	-5.8	5.1e-09	0.22	0.97	0.00	FALSE
13	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	5.460	-5.8	5.6e-09	0.62	0.99	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	6.210	-5.8	6.7e-09	0.66	0.87	0.13	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC4A1AP	0.02	0.03	lasso	2	0.03	3.7e-04	-1.630	5.8	7.4e-09	-0.47	0.01	0.83	FALSE
77	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	4.820	-5.8	8.2e-09	0.61	0.99	0.00	FALSE
4	GTEx	Adipose Subcutaneous	UBXN2A	0.06	0.04	lasso	5	0.04	5.2e-04	-7.460	-5.7	1.2e-08	-0.07	0.32	0.65	FALSE
43	GTEx	Muscle Skeletal	PFN4	0.12	0.09	lasso	4	0.09	5.6e-09	-5.510	-5.7	1.4e-08	0.07	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	6.210	-5.7	1.4e-08	0.61	0.28	0.61	FALSE
18	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	5.460	-5.7	1.5e-08	0.61	0.95	0.04	FALSE
63	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	4.650	5.6	1.9e-08	-0.52	0.96	0.03	FALSE
101	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SLC4A1AP	0.17	0.05	blup	26	0.08	4.4e-03	-10.500	5.6	2.0e-08	-0.47	0.01	0.72	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFN4	0.09	0.07	blup	43	0.08	5.3e-09	-5.510	-5.6	2.1e-08	0.09	0.00	1.00	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFN4	0.12	0.08	lasso	6	0.07	6.3e-08	-5.510	-5.6	2.2e-08	0.07	0.00	1.00	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	SF3B14	0.10	0.01	lasso	8	0.00	3.5e-01	-3.110	-5.6	2.3e-08	0.01	0.09	0.27	FALSE
69	NTR	Blood	ITSN2	0.02	0.00	bslmm	345	0.01	2.9e-03	-3.810	5.6	2.3e-08	0.07	0.05	0.02	FALSE
42	GTEx	Lung	RP11-373D23.3	0.08	0.00	enet	21	0.02	2.3e-02	3.550	-5.5	2.9e-08	0.23	0.16	0.30	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	4.130	-5.5	2.9e-08	0.64	0.67	0.08	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	PFN4	0.05	0.03	lasso	1	0.03	1.7e-04	-5.510	-5.5	3.5e-08	0.05	0.40	0.04	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	PFN4	0.15	0.09	lasso	3	0.09	7.3e-11	-5.510	-5.5	3.5e-08	0.05	0.00	1.00	FALSE
83	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PFN4	0.19	0.16	lasso	2	0.15	5.5e-08	-5.510	-5.5	3.6e-08	0.05	0.00	1.00	FALSE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PFN4	0.10	0.07	lasso	2	0.06	1.1e-07	-5.510	-5.5	3.6e-08	0.05	0.00	1.00	FALSE
24	GTEx	Colon Transverse	PFN4	0.14	0.07	lasso	2	0.04	3.3e-03	-5.480	-5.5	3.9e-08	0.05	0.07	0.43	FALSE
14	GTEx	Breast Mammary Tissue (Male)	NCOA1	0.13	-0.01	lasso	3	0.04	4.8e-02	-4.190	-5.5	4.0e-08	0.09	0.05	0.06	FALSE
100	The Cancer Genome Atlas	Rectum Adenocarcinoma	PFN4	0.38	0.11	lasso	5	0.05	2.8e-02	-5.510	-5.5	4.2e-08	0.04	0.00	0.74	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PFN4	0.13	0.07	lasso	4	0.06	4.4e-07	-5.510	-5.5	4.3e-08	0.07	0.00	1.00	FALSE
96	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PFN4	0.20	0.18	lasso	1	0.16	4.3e-07	-5.480	-5.5	4.3e-08	0.05	0.00	1.00	FALSE
62	METSIM	Adipose	BRE	0.03	0.00	blup	534	0.00	1.3e-01	0.004	-5.5	4.4e-08	0.30	0.10	0.05	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	RP11-373D23.3	0.17	0.01	enet	15	0.04	1.2e-02	4.450	-5.5	4.6e-08	0.28	0.07	0.31	FALSE
46	GTEx	Nerve Tibial	PFN4	0.25	0.16	lasso	5	0.20	3.8e-14	-5.510	-5.4	5.5e-08	0.09	1.00	0.00	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PFN4	0.10	0.07	enet	5	0.08	5.5e-09	-5.510	-5.4	5.8e-08	0.09	0.00	1.00	FALSE
11	GTEx	Artery Aorta	AC074117.10	0.06	0.04	lasso	3	0.03	6.8e-03	5.460	-5.4	5.9e-08	0.58	0.24	0.14	FALSE
22	GTEx	Colon Transverse	NRBP1	0.08	0.03	enet	14	0.00	2.0e-01	5.460	-5.4	5.9e-08	0.59	0.16	0.14	FALSE
6	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	4.770	-5.4	6.6e-08	0.64	0.11	0.28	FALSE
40	GTEx	Lung	UBXN2A	0.09	0.06	enet	7	0.07	6.1e-06	-1.090	-5.4	8.4e-08	-0.07	0.42	0.57	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	NRBP1	0.11	0.13	enet	13	0.15	1.2e-05	4.670	-5.4	8.5e-08	0.62	0.57	0.10	FALSE
21	GTEx	Colon Sigmoid	AC074117.10	0.13	0.18	lasso	3	0.14	1.1e-05	5.460	-5.3	9.6e-08	0.60	0.85	0.08	FALSE
49	GTEx	Pituitary	AC074117.10	0.23	0.23	lasso	8	0.29	5.6e-08	4.090	-5.3	1.1e-07	0.66	0.34	0.57	FALSE
61	METSIM	Adipose	ATRAID	0.11	0.09	bslmm	297	0.10	1.4e-14	2.750	5.3	1.1e-07	-0.47	1.00	0.00	FALSE
8	GTEx	Adipose Visceral Omentum	AC074117.10	0.14	0.09	lasso	3	0.08	5.0e-05	5.460	-5.3	1.2e-07	0.60	0.85	0.08	FALSE
9	GTEx	Adrenal Gland	PFN4	0.20	0.15	lasso	2	0.18	3.9e-07	-5.510	-5.2	1.5e-07	0.09	0.21	0.09	FALSE
41	GTEx	Lung	PFN4	0.14	0.12	enet	8	0.15	7.6e-12	-5.510	-5.2	1.5e-07	0.10	1.00	0.00	FALSE
65	METSIM	Adipose	PREB	0.04	0.01	bslmm	302	0.02	5.6e-04	2.570	5.2	1.9e-07	-0.36	0.07	0.30	FALSE
66	METSIM	Adipose	SLC35F6	0.04	0.01	blup	362	0.02	1.1e-03	3.940	5.2	1.9e-07	-0.03	0.17	0.09	FALSE
78	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PFN4	0.11	0.00	enet	8	0.03	9.2e-04	-5.510	-5.2	2.0e-07	0.09	0.00	0.99	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	NRBP1	0.11	0.01	enet	23	0.02	7.7e-02	2.740	-5.2	2.3e-07	0.53	0.12	0.24	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	NRBP1	0.03	0.01	blup	30	0.02	5.3e-03	6.210	-5.2	2.3e-07	0.62	0.32	0.05	FALSE
48	GTEx	Pituitary	PFN4	0.34	0.03	lasso	14	0.02	1.1e-01	-5.510	-5.2	2.5e-07	0.05	0.04	0.07	FALSE
57	GTEx	Thyroid	AC074117.10	0.17	0.14	lasso	4	0.15	2.7e-11	4.810	-5.2	2.6e-07	0.61	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PFN4	0.14	0.02	blup	43	0.03	5.4e-03	-5.510	-5.1	2.7e-07	0.12	0.00	0.93	FALSE