Hub : Traits :

Medication: Omeprazole (e.g. Zanprol)

3 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 6013529 6513376 1 2 3.4e-08 4.2e-09 0.33 97 CNGA4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Intelligence (Savage-Jansen 2018) 1.39 1 0 0 0 1 CNGA4
Ulcerative Colitis (UC) 3.97 1 0 0 0 1 CNGA4
Major Depression (MDD) 5.11 1 0 0 0 1 CNGA4
Blood Red Count 1.00 1 0 0 0 1 CNGA4
BMI 2.31 1 0 0 0 1 CNGA4
Systolic Blood Pressure 2.38 1 0 0 0 1 CNGA4
Cardiovascular Disease 1.67 1 0 0 0 1 CNGA4
Average weekly spirits intake 2.37 1 0 0 0 1 CNGA4
Pack years adult smoking proportion 2.40 1 0 0 0 1 CNGA4
Impedance of leg (right) 1.48 1 0 0 0 1 CNGA4
Leg fat-free mass (left) 1.64 1 0 0 0 1 CNGA4
Trunk fat percentage 1.11 1 0 0 0 1 CNGA4
High blood pressure (mother) 2.31 1 0 0 0 1 CNGA4
Body mass index (BMI) 2.69 1 0 0 0 1 CNGA4
Impedance of leg (left) 1.55 1 0 0 0 1 CNGA4
Leg predicted mass (left) 1.64 1 0 0 0 1 CNGA4
Trunk fat mass 1.77 1 0 0 0 1 CNGA4
Waist circumference 2.96 1 0 0 0 1 CNGA4
Heel bone mineral density (BMD) T-score, automated (right) 2.23 1 0 0 0 1 CNGA4
Weight 2.20 1 0 0 0 1 CNGA4
Impedance of arm (right) 1.15 1 0 0 0 1 CNGA4
Arm fat percentage (right) 2.25 1 0 0 0 1 CNGA4
Trunk fat-free mass 0.99 1 0 0 0 1 CNGA4
Hip circumference 2.04 1 0 0 0 1 CNGA4
Impedance of arm (left) 1.24 1 0 0 0 1 CNGA4
Arm fat mass (right) 2.66 1 0 0 0 1 CNGA4
Trunk predicted mass 0.98 1 0 0 0 1 CNGA4
Body fat percentage 1.31 1 0 0 0 1 CNGA4
Leg fat percentage (right) 1.09 1 0 0 0 1 CNGA4
Arm fat-free mass (right) 1.10 1 0 0 0 1 CNGA4
Exposure to tobacco smoke outside home 3.22 1 0 0 0 1 CNGA4
Migraine (self-reported) 4.42 1 0 0 0 1 CNGA4
Medication: Omeprazole 16.63 1 0 0 0 1 CNGA4
Whole body fat mass 1.91 1 0 0 0 1 CNGA4
Leg fat mass (right) 1.93 1 0 0 0 1 CNGA4
Arm predicted mass (right) 1.00 1 0 0 0 1 CNGA4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.10 1 0 0 0 1 CNGA4
Whole body fat-free mass 1.23 1 0 0 0 1 CNGA4
Leg fat-free mass (right) 1.46 1 0 0 0 1 CNGA4
Arm fat percentage (left) 2.12 1 0 0 0 1 CNGA4
Whole body water mass 1.30 1 0 0 0 1 CNGA4
Leg predicted mass (right) 1.51 1 0 0 0 1 CNGA4
Arm fat mass (left) 2.55 1 0 0 0 1 CNGA4
Hearing aid user 5.72 1 0 0 0 1 CNGA4
Commuting to job workplace: Public transport 3.18 1 0 0 0 1 CNGA4
Medication: Bendroflumethiazide 3.24 1 0 0 0 1 CNGA4
Basal metabolic rate 1.49 1 0 0 0 1 CNGA4
Leg fat percentage (left) 1.12 1 0 0 0 1 CNGA4
Arm fat-free mass (left) 0.99 1 0 0 0 1 CNGA4
Impedance of whole body 1.96 1 0 0 0 1 CNGA4
Leg fat mass (left) 2.05 1 0 0 0 1 CNGA4
Arm predicted mass (left) 1.25 1 0 0 0 1 CNGA4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3