Hub : Traits :

Medication: Omeprazole (e.g. Zanprol)

3 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	6013529	6513376	1	2	3.4e-08	4.2e-09	0.33	97	CNGA4

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	corr P	genes
Medication: Omeprazole	16.63	1	1	CNGA4
Hearing aid user	5.72	1	1	CNGA4
Major Depression (MDD)	5.11	1	1	CNGA4
Migraine (self-reported)	4.42	1	1	CNGA4
Ulcerative Colitis (UC)	3.97	1	1	CNGA4
Medication: Bendroflumethiazide	3.24	1	1	CNGA4
Exposure to tobacco smoke outside home	3.22	1	1	CNGA4
Commuting to job workplace: Public transport	3.18	1	1	CNGA4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.10	1	1	CNGA4
Waist circumference	2.96	1	1	CNGA4
Body mass index (BMI)	2.69	1	1	CNGA4
Arm fat mass (right)	2.66	1	1	CNGA4
Arm fat mass (left)	2.55	1	1	CNGA4
Pack years adult smoking proportion	2.40	1	1	CNGA4
Systolic Blood Pressure	2.38	1	1	CNGA4
Average weekly spirits intake	2.37	1	1	CNGA4
BMI	2.31	1	1	CNGA4
High blood pressure (mother)	2.31	1	1	CNGA4
Arm fat percentage (right)	2.25	1	1	CNGA4
Heel bone mineral density (BMD) T-score, automated (right)	2.23	1	1	CNGA4
Weight	2.20	1	1	CNGA4
Arm fat percentage (left)	2.12	1	1	CNGA4
Leg fat mass (left)	2.05	1	1	CNGA4
Hip circumference	2.04	1	1	CNGA4
Impedance of whole body	1.96	1	1	CNGA4
Leg fat mass (right)	1.93	1	1	CNGA4
Whole body fat mass	1.91	1	1	CNGA4
Trunk fat mass	1.77	1	1	CNGA4
Cardiovascular Disease	1.67	1	1	CNGA4
Leg fat-free mass (left)	1.64	1	1	CNGA4
Leg predicted mass (left)	1.64	1	1	CNGA4
Impedance of leg (left)	1.55	1	1	CNGA4
Leg predicted mass (right)	1.51	1	1	CNGA4
Basal metabolic rate	1.49	1	1	CNGA4
Impedance of leg (right)	1.48	1	1	CNGA4
Leg fat-free mass (right)	1.46	1	1	CNGA4
Intelligence (Savage-Jansen 2018)	1.39	1	1	CNGA4
Body fat percentage	1.31	1	1	CNGA4
Whole body water mass	1.30	1	1	CNGA4
Arm predicted mass (left)	1.25	1	1	CNGA4
Impedance of arm (left)	1.24	1	1	CNGA4
Whole body fat-free mass	1.23	1	1	CNGA4
Impedance of arm (right)	1.15	1	1	CNGA4
Leg fat percentage (left)	1.12	1	1	CNGA4
Trunk fat percentage	1.11	1	1	CNGA4
Arm fat-free mass (right)	1.10	1	1	CNGA4
Leg fat percentage (right)	1.09	1	1	CNGA4
Blood Red Count	1.00	1	1	CNGA4
Arm predicted mass (right)	1.00	1	1	CNGA4
Trunk fat-free mass	0.99	1	1	CNGA4
Arm fat-free mass (left)	0.99	1	1	CNGA4
Trunk predicted mass	0.98	1	1	CNGA4

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2