Hub : Traits :

Major Depression (MDD)

6 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 71163715 73435171 1 1 6.4e-08 2.2e-08 0.045 87 NEGR1
2 14 41845956 42611960 1 1 4.6e-08 8.2e-09 1.000 100 LRFN5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depression (Nagel 2018) 2.78 1 0 0.0 0 1 LRFN5
Intelligence (Savage-Jansen 2018) 17.02 1 1 2.2 0 1 NEGR1
Neuroticism (Nagel 2018) 2.91 1 0 0.0 0 1 LRFN5
Worry (Nagel 2018) 2.49 1 0 0.0 0 1 LRFN5
Verbal and Numeric Reasoning (VNR) 15.64 1 1 2.2 0 1 NEGR1
Breast Cancer 2.26 1 0 0.0 0 1 NEGR1
Body Mass Index (BMI) (2010) 20.25 1 1 2.2 0 1 NEGR1
Heel T-Score 2.05 1 1 2.2 0 1 NEGR1
BMI 11.23 1 1 2.2 0 1 NEGR1
Waist Hip Ratio (WHR) 1.78 1 0 0.0 0 1 LRFN5
Systolic Blood Pressure 0.92 1 0 0.0 0 1 NEGR1
Smoking Status 2.51 1 0 0.0 0 1 LRFN5
Allergy or Eczema 4.60 1 0 0.0 0 1 NEGR1
Cardiovascular Disease 4.36 1 1 2.2 0 1 NEGR1
Respiratory disease 3.03 1 0 0.0 0 1 NEGR1
Lung FEV1/FVC ratio 3.53 1 1 2.2 0 1 NEGR1
Neuroticism 2.48 1 0 0.0 0 1 LRFN5
Chronotype (morning person) 3.65 1 0 0.0 0 1 LRFN5
Tanning 0.68 1 0 0.0 0 1 NEGR1
Number of treatments/medications taken 9.19 2 0 0.0 0 1 LRFN5 NEGR1
Frequency of depressed mood in last 2 weeks 4.25 1 0 0.0 0 1 LRFN5
Hearing difficulty/problems: Yes 2.46 1 0 0.0 0 1 LRFN5
Relative age of first facial hair 3.42 1 0 0.0 0 1 NEGR1
Other serious medical condition/disability diagnosed by doctor 6.09 1 0 0.0 0 1 NEGR1
Ever used hormone-replacement therapy (HRT) 4.39 1 0 0.0 0 1 LRFN5
Vitamin and mineral supplements 5.13 1 0 0.0 0 1 NEGR1
Severe depression (siblings) 7.98 2 0 0.0 0 1 LRFN5 NEGR1
Impedance of leg (right) 2.51 1 0 0.0 0 1 NEGR1
Leg fat-free mass (left) 3.42 1 1 2.2 0 1 NEGR1
Trunk fat percentage 4.92 1 1 2.2 0 1 NEGR1
Current tobacco smoking 5.21 1 0 0.0 0 1 NEGR1
Fed-up feelings 3.32 1 0 0.0 0 1 LRFN5
Relative age voice broke 2.40 1 0 0.0 0 1 NEGR1
Taking other prescription medications 5.57 1 0 0.0 0 1 NEGR1
Age when periods started (menarche) 12.11 1 1 2.2 0 1 NEGR1
High blood pressure 4.68 1 0 0.0 0 1 NEGR1
Hayfever, allergic rhinitis or eczema 3.98 1 0 0.0 0 1 NEGR1
Multivitamins +/- minerals 5.71 1 0 0.0 0 1 NEGR1
Stomach or abdominal pain in last month 7.24 1 0 0.0 0 1 NEGR1
Chronic bronchitis/emphysema (father) 4.47 1 0 0.0 0 1 LRFN5
Body mass index (BMI) 8.43 1 1 2.2 0 1 NEGR1
Impedance of leg (left) 2.37 1 0 0.0 0 1 NEGR1
Leg predicted mass (left) 3.37 1 1 2.2 0 1 NEGR1
Trunk fat mass 5.92 1 1 2.2 0 1 NEGR1
Waist circumference 7.08 1 1 2.2 0 1 NEGR1
Alcohol usually taken with meals 10.19 2 0 0.0 0 1 LRFN5 NEGR1
Frequency of tenseness / restlessness in last 2 weeks 6.14 1 0 0.0 0 1 LRFN5
Qualifications: None of the above 10.43 1 1 2.2 0 1 NEGR1
Mouth/teeth dental problems 5.16 1 0 0.0 0 1 NEGR1
Allergy 3.53 1 0 0.0 0 1 NEGR1
Fluid intelligence score 10.49 1 1 2.2 0 1 NEGR1
Neuroticism score 3.80 1 0 0.0 0 1 LRFN5
Weight 5.94 1 1 2.2 0 1 NEGR1
Impedance of arm (right) 3.56 1 1 2.2 0 1 NEGR1
Arm fat percentage (right) 7.04 1 1 2.2 0 1 NEGR1
Trunk fat-free mass 1.53 1 0 0.0 0 1 NEGR1
Hip circumference 7.20 1 1 2.2 0 1 NEGR1
Alcohol intake versus 10 years previously 7.12 1 0 0.0 0 1 NEGR1
Worrier / anxious feelings 4.87 1 0 0.0 0 1 LRFN5
Frequency of tiredness / lethargy in last 2 weeks 4.54 1 0 0.0 0 1 LRFN5
Falls in the last year 3.71 1 0 0.0 0 1 NEGR1
Qualifications: A levels/AS levels or equivalent 7.30 1 1 2.2 0 1 NEGR1
Mouth/teeth dental problems: Dentures 5.88 1 0 0.0 0 1 NEGR1
Asthma 2.14 1 0 0.0 0 1 NEGR1
Depression (self-reported) 6.03 1 0 0.0 0 1 LRFN5
Impedance of arm (left) 2.87 1 0 0.0 0 1 NEGR1
Arm fat mass (right) 8.01 1 1 2.2 0 1 NEGR1
Trunk predicted mass 1.63 1 0 0.0 0 1 NEGR1
Tense / 'highly strung' 2.97 1 0 0.0 0 1 LRFN5
Seen doctor (GP) for nerves, anxiety, tension or depression 20.29 2 1 2.2 0 1 LRFN5 NEGR1
Medication: Paracetamol 3.80 1 0 0.0 0 1 LRFN5
Medication for cholesterol, blood pressure or diabetes 3.98 1 0 0.0 0 1 NEGR1
Body fat percentage 6.96 1 1 2.2 0 1 NEGR1
Leg fat percentage (right) 8.25 1 1 2.2 0 1 NEGR1
Arm fat-free mass (right) 3.51 1 1 2.2 0 1 NEGR1
Comparative body size at age 10 20.75 1 1 2.2 0 1 NEGR1
Seen a psychiatrist for nerves, anxiety, tension or depression 7.89 2 0 0.0 0 1 LRFN5 NEGR1
Qualifications: College or University degree 16.39 1 1 2.2 0 1 NEGR1
Medication for pain relief, constipation, heartburn 4.44 1 0 0.0 0 1 LRFN5
Neck or shoulder pain in last month 5.45 1 0 0.0 0 1 LRFN5
Medication: Blood pressure 3.22 1 0 0.0 0 1 NEGR1
Mean time to correctly identify matches 2.35 1 0 0.0 0 1 LRFN5
Whole body fat mass 7.65 1 1 2.2 0 1 NEGR1
Leg fat mass (right) 9.15 1 1 2.2 0 1 NEGR1
Arm predicted mass (right) 3.51 1 1 2.2 0 1 NEGR1
Pulse rate, automated reading 4.88 1 1 2.2 0 1 NEGR1
Alcohol intake frequency. 3.97 1 0 0.0 0 1 NEGR1
Suffer from 'nerves' 3.11 1 0 0.0 0 1 LRFN5
Overall health rating 2.38 1 0 0.0 0 1 LRFN5
Commuting to job workplace: Car/motor vehicle 8.01 1 0 0.0 0 1 NEGR1
Hypertension (Self-reported) 3.52 1 0 0.0 0 1 NEGR1
Illnesses of father: Heart disease 3.20 1 0 0.0 0 1 NEGR1
Smoking status: Previous 4.14 1 0 0.0 0 1 NEGR1
Whole body fat-free mass 2.43 1 1 2.2 0 1 NEGR1
Leg fat-free mass (right) 2.91 1 1 2.2 0 1 NEGR1
Arm fat percentage (left) 7.62 1 1 2.2 0 1 NEGR1
Average weekly red wine intake 8.49 2 0 0.0 0 1 LRFN5 NEGR1
Long-standing illness, disability or infirmity 8.57 1 0 0.0 0 1 NEGR1
Ever had bowel cancer screening 4.31 1 0 0.0 0 1 LRFN5
Friendships satisfaction 3.35 1 0 0.0 0 1 NEGR1
Qualifications: nursing, teaching 12.58 1 1 2.2 0 1 NEGR1
Commuting to job workplace: Walk 3.97 1 0 0.0 0 1 NEGR1
Medication for cholesterol 3.19 1 0 0.0 0 1 LRFN5
Medication: Laxatives (e.g. Dulcolax, Senokot) 5.49 1 0 0.0 0 1 LRFN5
Back pain experienced in last month 5.07 1 0 0.0 0 1 LRFN5
Asthma (self-reported) 2.17 1 0 0.0 0 1 NEGR1
Osteoarthritis (self-reported) 4.39 1 0 0.0 0 1 NEGR1
Smoking status: Current 4.51 1 0 0.0 0 1 NEGR1
Whole body water mass 2.53 1 1 2.2 0 1 NEGR1
Leg predicted mass (right) 2.97 1 1 2.2 0 1 NEGR1
Arm fat mass (left) 8.19 1 1 2.2 0 1 NEGR1
Number of self-reported non-cancer illnesses 10.97 2 1 2.2 0 1 LRFN5 NEGR1
Guilty feelings 6.65 1 0 0.0 0 1 LRFN5
Commuting to job workplace: Public transport 7.43 1 0 0.0 0 1 NEGR1
Medication: Paracetamol 5.01 1 0 0.0 0 1 LRFN5
Basal metabolic rate 3.20 1 1 2.2 0 1 NEGR1
Leg fat percentage (left) 8.39 1 1 2.2 0 1 NEGR1
Arm fat-free mass (left) 3.45 1 1 2.2 0 1 NEGR1
Number of operations (self-reported) 8.17 2 0 0.0 0 1 LRFN5 NEGR1
Average weekly beer plus cider intake 5.42 1 0 0.0 0 1 NEGR1
Ever had prostate specific antigen (PSA) test 3.52 1 0 0.0 0 1 NEGR1
Commuting to job workplace: Cycle 10.66 2 0 0.0 0 1 LRFN5 NEGR1
Vascular/heart problems diagnosed by doctor 3.66 1 0 0.0 0 1 NEGR1
Cholesterol lowering medication 3.91 1 0 0.0 0 1 LRFN5
Pain experienced in last month 6.07 1 0 0.0 0 1 LRFN5
Impedance of whole body 2.96 1 1 2.2 0 1 NEGR1
Leg fat mass (left) 9.33 1 1 2.2 0 1 NEGR1
Arm predicted mass (left) 3.45 1 1 2.2 0 1 NEGR1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.5
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.4
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.6
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.4
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.5
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.4
METSIM Adipose 0 0.000 1.4
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 1 0.025 1.4
YFS Blood 0 0.000 1.4
CommonMind Brain Pre-frontal Cortex 0 0.000 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.026 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.056 1.5
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.028 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.067 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 1 0.022 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2