Hub : Traits :

Major Depression (MDD)

6 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	71163715	73435171	1	1	6.4e-08	2.2e-08	0.045	87	NEGR1
2	14	41845956	42611960	1	1	4.6e-08	8.2e-09	1.000	100	LRFN5

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Comparative body size at age 10	20.75	1	1	2.2	1	NEGR1
Seen doctor (GP) for nerves, anxiety, tension or depression	20.29	2	1	2.2	1	LRFN5 NEGR1
Body Mass Index (BMI) (2010)	20.25	1	1	2.2	1	NEGR1
Intelligence (Savage-Jansen 2018)	17.02	1	1	2.2	1	NEGR1
Qualifications: College or University degree	16.39	1	1	2.2	1	NEGR1
Verbal and Numeric Reasoning (VNR)	15.64	1	1	2.2	1	NEGR1
Qualifications: nursing, teaching	12.58	1	1	2.2	1	NEGR1
Age when periods started (menarche)	12.11	1	1	2.2	1	NEGR1
BMI	11.23	1	1	2.2	1	NEGR1
Number of self-reported non-cancer illnesses	10.97	2	1	2.2	1	LRFN5 NEGR1
Commuting to job workplace: Cycle	10.66	2	0	0.0	1	LRFN5 NEGR1
Fluid intelligence score	10.49	1	1	2.2	1	NEGR1
Qualifications: None of the above	10.43	1	1	2.2	1	NEGR1
Alcohol usually taken with meals	10.19	2	0	0.0	1	LRFN5 NEGR1
Leg fat mass (left)	9.33	1	1	2.2	1	NEGR1
Number of treatments/medications taken	9.19	2	0	0.0	1	LRFN5 NEGR1
Leg fat mass (right)	9.15	1	1	2.2	1	NEGR1
Long-standing illness, disability or infirmity	8.57	1	0	0.0	1	NEGR1
Average weekly red wine intake	8.49	2	0	0.0	1	LRFN5 NEGR1
Body mass index (BMI)	8.43	1	1	2.2	1	NEGR1
Leg fat percentage (left)	8.39	1	1	2.2	1	NEGR1
Leg fat percentage (right)	8.25	1	1	2.2	1	NEGR1
Arm fat mass (left)	8.19	1	1	2.2	1	NEGR1
Number of operations (self-reported)	8.17	2	0	0.0	1	LRFN5 NEGR1
Arm fat mass (right)	8.01	1	1	2.2	1	NEGR1
Commuting to job workplace: Car/motor vehicle	8.01	1	0	0.0	1	NEGR1
Severe depression (siblings)	7.98	2	0	0.0	1	LRFN5 NEGR1
Seen a psychiatrist for nerves, anxiety, tension or depression	7.89	2	0	0.0	1	LRFN5 NEGR1
Whole body fat mass	7.65	1	1	2.2	1	NEGR1
Arm fat percentage (left)	7.62	1	1	2.2	1	NEGR1
Commuting to job workplace: Public transport	7.43	1	0	0.0	1	NEGR1
Qualifications: A levels/AS levels or equivalent	7.30	1	1	2.2	1	NEGR1
Stomach or abdominal pain in last month	7.24	1	0	0.0	1	NEGR1
Hip circumference	7.20	1	1	2.2	1	NEGR1
Alcohol intake versus 10 years previously	7.12	1	0	0.0	1	NEGR1
Waist circumference	7.08	1	1	2.2	1	NEGR1
Arm fat percentage (right)	7.04	1	1	2.2	1	NEGR1
Body fat percentage	6.96	1	1	2.2	1	NEGR1
Guilty feelings	6.65	1	0	0.0	1	LRFN5
Frequency of tenseness / restlessness in last 2 weeks	6.14	1	0	0.0	1	LRFN5
Other serious medical condition/disability diagnosed by doctor	6.09	1	0	0.0	1	NEGR1
Pain experienced in last month	6.07	1	0	0.0	1	LRFN5
Depression (self-reported)	6.03	1	0	0.0	1	LRFN5
Weight	5.94	1	1	2.2	1	NEGR1
Trunk fat mass	5.92	1	1	2.2	1	NEGR1
Mouth/teeth dental problems: Dentures	5.88	1	0	0.0	1	NEGR1
Multivitamins +/- minerals	5.71	1	0	0.0	1	NEGR1
Taking other prescription medications	5.57	1	0	0.0	1	NEGR1
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.49	1	0	0.0	1	LRFN5
Neck or shoulder pain in last month	5.45	1	0	0.0	1	LRFN5
Average weekly beer plus cider intake	5.42	1	0	0.0	1	NEGR1
Current tobacco smoking	5.21	1	0	0.0	1	NEGR1
Mouth/teeth dental problems	5.16	1	0	0.0	1	NEGR1
Vitamin and mineral supplements	5.13	1	0	0.0	1	NEGR1
Back pain experienced in last month	5.07	1	0	0.0	1	LRFN5
Medication: Paracetamol	5.01	1	0	0.0	1	LRFN5
Trunk fat percentage	4.92	1	1	2.2	1	NEGR1
Pulse rate, automated reading	4.88	1	1	2.2	1	NEGR1
Worrier / anxious feelings	4.87	1	0	0.0	1	LRFN5
High blood pressure	4.68	1	0	0.0	1	NEGR1
Allergy or Eczema	4.60	1	0	0.0	1	NEGR1
Frequency of tiredness / lethargy in last 2 weeks	4.54	1	0	0.0	1	LRFN5
Smoking status: Current	4.51	1	0	0.0	1	NEGR1
Chronic bronchitis/emphysema (father)	4.47	1	0	0.0	1	LRFN5
Medication for pain relief, constipation, heartburn	4.44	1	0	0.0	1	LRFN5
Ever used hormone-replacement therapy (HRT)	4.39	1	0	0.0	1	LRFN5
Osteoarthritis (self-reported)	4.39	1	0	0.0	1	NEGR1
Cardiovascular Disease	4.36	1	1	2.2	1	NEGR1
Ever had bowel cancer screening	4.31	1	0	0.0	1	LRFN5
Frequency of depressed mood in last 2 weeks	4.25	1	0	0.0	1	LRFN5
Smoking status: Previous	4.14	1	0	0.0	1	NEGR1
Hayfever, allergic rhinitis or eczema	3.98	1	0	0.0	1	NEGR1
Medication for cholesterol, blood pressure or diabetes	3.98	1	0	0.0	1	NEGR1
Alcohol intake frequency.	3.97	1	0	0.0	1	NEGR1
Commuting to job workplace: Walk	3.97	1	0	0.0	1	NEGR1
Cholesterol lowering medication	3.91	1	0	0.0	1	LRFN5
Neuroticism score	3.80	1	0	0.0	1	LRFN5
Medication: Paracetamol	3.80	1	0	0.0	1	LRFN5
Falls in the last year	3.71	1	0	0.0	1	NEGR1
Vascular/heart problems diagnosed by doctor	3.66	1	0	0.0	1	NEGR1
Chronotype (morning person)	3.65	1	0	0.0	1	LRFN5
Impedance of arm (right)	3.56	1	1	2.2	1	NEGR1
Lung FEV1/FVC ratio	3.53	1	1	2.2	1	NEGR1
Allergy	3.53	1	0	0.0	1	NEGR1
Hypertension (Self-reported)	3.52	1	0	0.0	1	NEGR1
Ever had prostate specific antigen (PSA) test	3.52	1	0	0.0	1	NEGR1
Arm fat-free mass (right)	3.51	1	1	2.2	1	NEGR1
Arm predicted mass (right)	3.51	1	1	2.2	1	NEGR1
Arm fat-free mass (left)	3.45	1	1	2.2	1	NEGR1
Arm predicted mass (left)	3.45	1	1	2.2	1	NEGR1
Relative age of first facial hair	3.42	1	0	0.0	1	NEGR1
Leg fat-free mass (left)	3.42	1	1	2.2	1	NEGR1
Leg predicted mass (left)	3.37	1	1	2.2	1	NEGR1
Friendships satisfaction	3.35	1	0	0.0	1	NEGR1
Fed-up feelings	3.32	1	0	0.0	1	LRFN5
Medication: Blood pressure	3.22	1	0	0.0	1	NEGR1
Illnesses of father: Heart disease	3.20	1	0	0.0	1	NEGR1
Basal metabolic rate	3.20	1	1	2.2	1	NEGR1
Medication for cholesterol	3.19	1	0	0.0	1	LRFN5
Suffer from 'nerves'	3.11	1	0	0.0	1	LRFN5
Respiratory disease	3.03	1	0	0.0	1	NEGR1
Tense / 'highly strung'	2.97	1	0	0.0	1	LRFN5
Leg predicted mass (right)	2.97	1	1	2.2	1	NEGR1
Impedance of whole body	2.96	1	1	2.2	1	NEGR1
Neuroticism (Nagel 2018)	2.91	1	0	0.0	1	LRFN5
Leg fat-free mass (right)	2.91	1	1	2.2	1	NEGR1
Impedance of arm (left)	2.87	1	0	0.0	1	NEGR1
Depression (Nagel 2018)	2.78	1	0	0.0	1	LRFN5
Whole body water mass	2.53	1	1	2.2	1	NEGR1
Smoking Status	2.51	1	0	0.0	1	LRFN5
Impedance of leg (right)	2.51	1	0	0.0	1	NEGR1
Worry (Nagel 2018)	2.49	1	0	0.0	1	LRFN5
Neuroticism	2.48	1	0	0.0	1	LRFN5
Hearing difficulty/problems: Yes	2.46	1	0	0.0	1	LRFN5
Whole body fat-free mass	2.43	1	1	2.2	1	NEGR1
Relative age voice broke	2.40	1	0	0.0	1	NEGR1
Overall health rating	2.38	1	0	0.0	1	LRFN5
Impedance of leg (left)	2.37	1	0	0.0	1	NEGR1
Mean time to correctly identify matches	2.35	1	0	0.0	1	LRFN5
Breast Cancer	2.26	1	0	0.0	1	NEGR1
Asthma (self-reported)	2.17	1	0	0.0	1	NEGR1
Asthma	2.14	1	0	0.0	1	NEGR1
Heel T-Score	2.05	1	1	2.2	1	NEGR1
Waist Hip Ratio (WHR)	1.78	1	0	0.0	1	LRFN5
Trunk predicted mass	1.63	1	0	0.0	1	NEGR1
Trunk fat-free mass	1.53	1	0	0.0	1	NEGR1
Systolic Blood Pressure	0.92	1	0	0.0	1	NEGR1
Tanning	0.68	1	0	0.0	1	NEGR1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	0	0.000	1.6
GTEx	Artery Coronary	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Thyroid	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.056	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Lung	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
METSIM	Adipose	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	1	0.025	1.4
YFS	Blood	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.026	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.067	1.4
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
NTR	Blood	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.028	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.022	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2