Hub : Traits :

Exposure to tobacco smoke outside home

7 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 242723236 244345666 2 1 2.2e-09 1.9e-08 0.029 85 SDCCAG8
2 7 116660803 118207833 1 1 1.7e-07 1.7e-07 0.075 88 CTTNBP2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 6.79 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Neuroticism (Nagel 2018) 5.32 1 0 0.0 0 1 CTTNBP2
Major Depression (MDD) 5.56 1 0 0.0 0 1 CTTNBP2
Reaction Time 6.12 1 0 0.0 0 1 SDCCAG8
Bipolar Disorder (2011) 5.74 1 0 0.0 0 1 CTTNBP2
Neuroticism (2016) 3.94 1 0 0.0 0 1 CTTNBP2
Rheumatoid Arthritis 5.96 1 0 0.0 0 1 SDCCAG8
Type 2 Diabetes (T2D) (2012) 6.01 1 0 0.0 0 1 CTTNBP2
Blood Platelet Count 0.62 1 0 0.0 0 1 CTTNBP2
Blood Red Count 0.73 1 0 0.0 0 1 SDCCAG8
Blood White Count 1.92 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Heel T-Score 0.55 1 0 0.0 0 1 CTTNBP2
BMI 2.12 1 0 0.0 0 1 SDCCAG8
Height 0.50 1 0 0.0 0 1 CTTNBP2
Waist Hip Ratio (WHR) 2.02 1 0 0.0 0 1 CTTNBP2
Systolic Blood Pressure 1.21 1 0 0.0 0 1 SDCCAG8
Smoking Status 10.70 1 1 2.2 0 1 CTTNBP2
Cardiovascular Disease 1.86 1 0 0.0 0 1 SDCCAG8
Type 2 Diabetes (T2D) (2018) 3.81 1 0 0.0 0 1 CTTNBP2
Lung FEV1/FVC ratio 1.97 1 0 0.0 0 1 CTTNBP2
Lung FVC 1.31 1 0 0.0 0 1 CTTNBP2
Neuroticism 4.96 1 0 0.0 0 1 CTTNBP2
Chronotype (morning person) 4.17 1 0 0.0 0 1 SDCCAG8
Tanning 0.79 1 0 0.0 0 1 SDCCAG8
Number of treatments/medications taken 6.23 1 0 0.0 0 1 SDCCAG8
Sensitivity / hurt feelings 3.91 1 0 0.0 0 1 CTTNBP2
Frequency of depressed mood in last 2 weeks 3.97 1 0 0.0 0 1 CTTNBP2
Medication: Metformin 5.30 1 0 0.0 0 1 CTTNBP2
Leg fat-free mass (left) 0.73 1 0 0.0 0 1 SDCCAG8
Trunk fat percentage 3.31 1 1 2.2 0 1 SDCCAG8
Townsend deprivation index at recruitment 7.60 1 0 0.0 0 1 CTTNBP2
Current tobacco smoking 7.76 1 0 0.0 0 1 CTTNBP2
Maternal smoking around birth 3.51 1 0 0.0 0 1 CTTNBP2
Fed-up feelings 10.38 2 1 2.2 0 1 CTTNBP2 SDCCAG8
Frequency of unenthusiasm / disinterest in last 2 weeks 6.91 1 0 0.0 0 1 CTTNBP2
Qualifications: CSEs or equivalent 4.23 1 0 0.0 0 1 SDCCAG8
Serious illness, injury or assault to yourself 3.42 1 0 0.0 0 1 CTTNBP2
High blood pressure 2.27 1 0 0.0 0 1 SDCCAG8
Sitting height 1.39 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Body mass index (BMI) 3.46 1 1 2.2 0 1 SDCCAG8
Leg predicted mass (left) 0.78 1 0 0.0 0 1 SDCCAG8
Trunk fat mass 2.97 1 0 0.0 0 1 SDCCAG8
Waist circumference 3.96 1 1 2.2 0 1 SDCCAG8
Number of incorrect matches in round 3.81 1 0 0.0 0 1 CTTNBP2
Past tobacco smoking 4.83 1 0 0.0 0 1 CTTNBP2
Alcohol usually taken with meals 9.40 1 1 2.2 0 1 CTTNBP2
Qualifications: None of the above 6.35 1 0 0.0 0 1 SDCCAG8
Financial difficulties in last 2 years 8.22 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Mouth/teeth dental problems 7.62 1 0 0.0 0 1 SDCCAG8
Diabetes (self-reported) 4.23 1 0 0.0 0 1 CTTNBP2
Illnesses of siblings 3.76 1 0 0.0 0 1 SDCCAG8
Neuroticism score 6.20 1 0 0.0 0 1 CTTNBP2
Weight 2.07 1 0 0.0 0 1 SDCCAG8
Arm fat percentage (right) 3.78 1 0 0.0 0 1 SDCCAG8
Hip circumference 1.80 1 0 0.0 0 1 SDCCAG8
Alcohol intake versus 10 years previously 4.94 1 0 0.0 0 1 CTTNBP2
Father's age at death 4.03 1 0 0.0 0 1 CTTNBP2
Worrier / anxious feelings 2.00 1 0 0.0 0 1 CTTNBP2
Frequency of tiredness / lethargy in last 2 weeks 5.09 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Forced expiratory volume in 1-second (FEV1) 2.01 1 0 0.0 0 1 CTTNBP2
Qualifications: A levels/AS levels or equivalent 7.30 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Mouth/teeth dental problems: Dentures 2.96 1 0 0.0 0 1 SDCCAG8
Medication: Ibuprofen (e.g. Nurofen) 3.55 1 0 0.0 0 1 SDCCAG8
Arm fat mass (right) 3.35 1 0 0.0 0 1 SDCCAG8
Standing height 0.45 1 0 0.0 0 1 CTTNBP2
Length of working week for main job 4.27 1 0 0.0 0 1 CTTNBP2
Seen doctor (GP) for nerves, anxiety, tension or depression 7.15 1 0 0.0 0 1 CTTNBP2
Peak expiratory flow (PEF) 2.59 1 0 0.0 0 1 CTTNBP2
Qualifications: O levels/GCSEs or equivalent 5.16 1 0 0.0 0 1 SDCCAG8
Medication: Paracetamol 12.58 1 1 2.2 0 1 SDCCAG8
Headache pain in last month 3.88 1 0 0.0 0 1 SDCCAG8
Glaucoma (self-reported) 4.28 1 0 0.0 0 1 CTTNBP2
Chronic bronchitis/emphysema (mother) 4.13 1 0 0.0 0 1 SDCCAG8
High blood pressure (siblings) 2.72 1 0 0.0 0 1 SDCCAG8
Body fat percentage 3.98 1 1 2.2 0 1 SDCCAG8
Leg fat percentage (right) 4.45 1 1 2.2 0 1 SDCCAG8
Worry too long after embarrassment 4.09 1 0 0.0 0 1 CTTNBP2
Seen a psychiatrist for nerves, anxiety, tension or depression 5.38 1 0 0.0 0 1 CTTNBP2
Age at first live birth 4.41 1 0 0.0 0 1 CTTNBP2
Health satisfaction 2.94 1 0 0.0 0 1 SDCCAG8
Qualifications: College or University degree 8.38 2 1 2.2 0 1 CTTNBP2 SDCCAG8
Medication for pain relief, constipation, heartburn 8.20 1 0 0.0 0 1 SDCCAG8
Neck or shoulder pain in last month 4.70 1 0 0.0 0 1 SDCCAG8
Medication: Seretide 50 evohaler 4.44 1 0 0.0 0 1 SDCCAG8
Mean time to correctly identify matches 3.24 1 0 0.0 0 1 SDCCAG8
Whole body fat mass 3.23 1 1 2.2 0 1 SDCCAG8
Leg fat mass (right) 4.13 1 1 2.2 0 1 SDCCAG8
Alcohol intake frequency. 2.69 1 0 0.0 0 1 SDCCAG8
Comparative height size at age 10 0.93 1 0 0.0 0 1 CTTNBP2
Overall health rating 10.66 1 1 2.2 0 1 SDCCAG8
Age at last live birth 4.31 1 0 0.0 0 1 SDCCAG8
Qualifications: NVQ or HND or HNC or equivalent 7.24 1 0 0.0 0 1 SDCCAG8
Illness, injury, bereavement, stress in last 2 years 8.10 1 0 0.0 0 1 CTTNBP2
Knee pain experienced in last month 5.34 1 0 0.0 0 1 SDCCAG8
Hypertension (Self-reported) 1.97 1 0 0.0 0 1 SDCCAG8
Leg fat-free mass (right) 0.71 1 0 0.0 0 1 SDCCAG8
Arm fat percentage (left) 3.33 1 0 0.0 0 1 SDCCAG8
Average weekly red wine intake 4.97 1 0 0.0 0 1 CTTNBP2
Mood swings 6.21 1 0 0.0 0 1 CTTNBP2
Ever had bowel cancer screening 4.06 1 0 0.0 0 1 CTTNBP2
Qualifications: nursing, teaching 8.17 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Mouth/teeth dental problems: Mouth ulcers 4.25 1 0 0.0 0 1 SDCCAG8
Smoking status: Current 5.90 1 0 0.0 0 1 CTTNBP2
Arm fat mass (left) 3.13 1 0 0.0 0 1 SDCCAG8
Number of self-reported non-cancer illnesses 3.25 1 0 0.0 0 1 SDCCAG8
Average weekly champagne plus white wine intake 4.05 1 0 0.0 0 1 SDCCAG8
Miserableness 11.44 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Guilty feelings 4.76 1 0 0.0 0 1 CTTNBP2
Wears glasses or contact lenses 7.58 1 0 0.0 0 1 SDCCAG8
Mother's age at death 7.15 1 0 0.0 0 1 SDCCAG8
Financial situation satisfaction 3.71 1 0 0.0 0 1 SDCCAG8
Medication: Paracetamol 10.86 1 1 2.2 0 1 SDCCAG8
Ever smoked 10.77 1 1 2.2 0 1 CTTNBP2
Basal metabolic rate 0.83 1 0 0.0 0 1 SDCCAG8
Leg fat percentage (left) 4.84 1 1 2.2 0 1 SDCCAG8
Arm fat-free mass (left) 1.03 1 0 0.0 0 1 SDCCAG8
Number of operations (self-reported) 3.20 1 0 0.0 0 1 SDCCAG8
Average weekly beer plus cider intake 9.22 2 0 0.0 0 1 CTTNBP2 SDCCAG8
Fractured/broken bones in last 5 years 6.32 1 0 0.0 0 1 CTTNBP2
Diastolic blood pressure, automated reading 7.47 1 1 2.2 0 1 SDCCAG8
Vascular/heart problems diagnosed by doctor 1.75 1 0 0.0 0 1 SDCCAG8
Pain experienced in last month 3.92 1 0 0.0 0 1 SDCCAG8
Alcohol drinker status: Previous 4.95 1 0 0.0 0 1 CTTNBP2
Leg fat mass (left) 4.30 1 1 2.2 0 1 SDCCAG8
Arm predicted mass (left) 1.06 1 0 0.0 0 1 SDCCAG8

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 1 0.049 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.5
GTEx Brain Frontal Cortex BA9 0 0.000 1.5
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.4
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.4
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3