Hub : Traits :

Exposure to tobacco smoke outside home

7 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	242723236	244345666	2	1	2.2e-09	1.9e-08	0.029	85	SDCCAG8
2	7	116660803	118207833	1	1	1.7e-07	1.7e-07	0.075	88	CTTNBP2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Medication: Paracetamol	12.58	1	1	2.2	1	SDCCAG8
Miserableness	11.44	2	0	0.0	1	CTTNBP2 SDCCAG8
Medication: Paracetamol	10.86	1	1	2.2	1	SDCCAG8
Ever smoked	10.77	1	1	2.2	1	CTTNBP2
Smoking Status	10.70	1	1	2.2	1	CTTNBP2
Overall health rating	10.66	1	1	2.2	1	SDCCAG8
Fed-up feelings	10.38	2	1	2.2	1	CTTNBP2 SDCCAG8
Alcohol usually taken with meals	9.40	1	1	2.2	1	CTTNBP2
Average weekly beer plus cider intake	9.22	2	0	0.0	1	CTTNBP2 SDCCAG8
Qualifications: College or University degree	8.38	2	1	2.2	1	CTTNBP2 SDCCAG8
Financial difficulties in last 2 years	8.22	2	0	0.0	1	CTTNBP2 SDCCAG8
Medication for pain relief, constipation, heartburn	8.20	1	0	0.0	1	SDCCAG8
Qualifications: nursing, teaching	8.17	2	0	0.0	1	CTTNBP2 SDCCAG8
Illness, injury, bereavement, stress in last 2 years	8.10	1	0	0.0	1	CTTNBP2
Current tobacco smoking	7.76	1	0	0.0	1	CTTNBP2
Mouth/teeth dental problems	7.62	1	0	0.0	1	SDCCAG8
Townsend deprivation index at recruitment	7.60	1	0	0.0	1	CTTNBP2
Wears glasses or contact lenses	7.58	1	0	0.0	1	SDCCAG8
Diastolic blood pressure, automated reading	7.47	1	1	2.2	1	SDCCAG8
Qualifications: A levels/AS levels or equivalent	7.30	2	0	0.0	1	CTTNBP2 SDCCAG8
Qualifications: NVQ or HND or HNC or equivalent	7.24	1	0	0.0	1	SDCCAG8
Seen doctor (GP) for nerves, anxiety, tension or depression	7.15	1	0	0.0	1	CTTNBP2
Mother's age at death	7.15	1	0	0.0	1	SDCCAG8
Frequency of unenthusiasm / disinterest in last 2 weeks	6.91	1	0	0.0	1	CTTNBP2
Depressed Affect (Nagel 2018)	6.79	2	0	0.0	1	CTTNBP2 SDCCAG8
Qualifications: None of the above	6.35	1	0	0.0	1	SDCCAG8
Fractured/broken bones in last 5 years	6.32	1	0	0.0	1	CTTNBP2
Number of treatments/medications taken	6.23	1	0	0.0	1	SDCCAG8
Mood swings	6.21	1	0	0.0	1	CTTNBP2
Neuroticism score	6.20	1	0	0.0	1	CTTNBP2
Reaction Time	6.12	1	0	0.0	1	SDCCAG8
Type 2 Diabetes (T2D) (2012)	6.01	1	0	0.0	1	CTTNBP2
Rheumatoid Arthritis	5.96	1	0	0.0	1	SDCCAG8
Smoking status: Current	5.90	1	0	0.0	1	CTTNBP2
Bipolar Disorder (2011)	5.74	1	0	0.0	1	CTTNBP2
Major Depression (MDD)	5.56	1	0	0.0	1	CTTNBP2
Seen a psychiatrist for nerves, anxiety, tension or depression	5.38	1	0	0.0	1	CTTNBP2
Knee pain experienced in last month	5.34	1	0	0.0	1	SDCCAG8
Neuroticism (Nagel 2018)	5.32	1	0	0.0	1	CTTNBP2
Medication: Metformin	5.30	1	0	0.0	1	CTTNBP2
Qualifications: O levels/GCSEs or equivalent	5.16	1	0	0.0	1	SDCCAG8
Frequency of tiredness / lethargy in last 2 weeks	5.09	2	0	0.0	1	CTTNBP2 SDCCAG8
Average weekly red wine intake	4.97	1	0	0.0	1	CTTNBP2
Neuroticism	4.96	1	0	0.0	1	CTTNBP2
Alcohol drinker status: Previous	4.95	1	0	0.0	1	CTTNBP2
Alcohol intake versus 10 years previously	4.94	1	0	0.0	1	CTTNBP2
Leg fat percentage (left)	4.84	1	1	2.2	1	SDCCAG8
Past tobacco smoking	4.83	1	0	0.0	1	CTTNBP2
Guilty feelings	4.76	1	0	0.0	1	CTTNBP2
Neck or shoulder pain in last month	4.70	1	0	0.0	1	SDCCAG8
Leg fat percentage (right)	4.45	1	1	2.2	1	SDCCAG8
Medication: Seretide 50 evohaler	4.44	1	0	0.0	1	SDCCAG8
Age at first live birth	4.41	1	0	0.0	1	CTTNBP2
Age at last live birth	4.31	1	0	0.0	1	SDCCAG8
Leg fat mass (left)	4.30	1	1	2.2	1	SDCCAG8
Glaucoma (self-reported)	4.28	1	0	0.0	1	CTTNBP2
Length of working week for main job	4.27	1	0	0.0	1	CTTNBP2
Mouth/teeth dental problems: Mouth ulcers	4.25	1	0	0.0	1	SDCCAG8
Qualifications: CSEs or equivalent	4.23	1	0	0.0	1	SDCCAG8
Diabetes (self-reported)	4.23	1	0	0.0	1	CTTNBP2
Chronotype (morning person)	4.17	1	0	0.0	1	SDCCAG8
Chronic bronchitis/emphysema (mother)	4.13	1	0	0.0	1	SDCCAG8
Leg fat mass (right)	4.13	1	1	2.2	1	SDCCAG8
Worry too long after embarrassment	4.09	1	0	0.0	1	CTTNBP2
Ever had bowel cancer screening	4.06	1	0	0.0	1	CTTNBP2
Average weekly champagne plus white wine intake	4.05	1	0	0.0	1	SDCCAG8
Father's age at death	4.03	1	0	0.0	1	CTTNBP2
Body fat percentage	3.98	1	1	2.2	1	SDCCAG8
Frequency of depressed mood in last 2 weeks	3.97	1	0	0.0	1	CTTNBP2
Waist circumference	3.96	1	1	2.2	1	SDCCAG8
Neuroticism (2016)	3.94	1	0	0.0	1	CTTNBP2
Pain experienced in last month	3.92	1	0	0.0	1	SDCCAG8
Sensitivity / hurt feelings	3.91	1	0	0.0	1	CTTNBP2
Headache pain in last month	3.88	1	0	0.0	1	SDCCAG8
Type 2 Diabetes (T2D) (2018)	3.81	1	0	0.0	1	CTTNBP2
Number of incorrect matches in round	3.81	1	0	0.0	1	CTTNBP2
Arm fat percentage (right)	3.78	1	0	0.0	1	SDCCAG8
Illnesses of siblings	3.76	1	0	0.0	1	SDCCAG8
Financial situation satisfaction	3.71	1	0	0.0	1	SDCCAG8
Medication: Ibuprofen (e.g. Nurofen)	3.55	1	0	0.0	1	SDCCAG8
Maternal smoking around birth	3.51	1	0	0.0	1	CTTNBP2
Body mass index (BMI)	3.46	1	1	2.2	1	SDCCAG8
Serious illness, injury or assault to yourself	3.42	1	0	0.0	1	CTTNBP2
Arm fat mass (right)	3.35	1	0	0.0	1	SDCCAG8
Arm fat percentage (left)	3.33	1	0	0.0	1	SDCCAG8
Trunk fat percentage	3.31	1	1	2.2	1	SDCCAG8
Number of self-reported non-cancer illnesses	3.25	1	0	0.0	1	SDCCAG8
Mean time to correctly identify matches	3.24	1	0	0.0	1	SDCCAG8
Whole body fat mass	3.23	1	1	2.2	1	SDCCAG8
Number of operations (self-reported)	3.20	1	0	0.0	1	SDCCAG8
Arm fat mass (left)	3.13	1	0	0.0	1	SDCCAG8
Trunk fat mass	2.97	1	0	0.0	1	SDCCAG8
Mouth/teeth dental problems: Dentures	2.96	1	0	0.0	1	SDCCAG8
Health satisfaction	2.94	1	0	0.0	1	SDCCAG8
High blood pressure (siblings)	2.72	1	0	0.0	1	SDCCAG8
Alcohol intake frequency.	2.69	1	0	0.0	1	SDCCAG8
Peak expiratory flow (PEF)	2.59	1	0	0.0	1	CTTNBP2
High blood pressure	2.27	1	0	0.0	1	SDCCAG8
BMI	2.12	1	0	0.0	1	SDCCAG8
Weight	2.07	1	0	0.0	1	SDCCAG8
Waist Hip Ratio (WHR)	2.02	1	0	0.0	1	CTTNBP2
Forced expiratory volume in 1-second (FEV1)	2.01	1	0	0.0	1	CTTNBP2
Worrier / anxious feelings	2.00	1	0	0.0	1	CTTNBP2
Lung FEV1/FVC ratio	1.97	1	0	0.0	1	CTTNBP2
Hypertension (Self-reported)	1.97	1	0	0.0	1	SDCCAG8
Blood White Count	1.92	2	0	0.0	1	CTTNBP2 SDCCAG8
Cardiovascular Disease	1.86	1	0	0.0	1	SDCCAG8
Hip circumference	1.80	1	0	0.0	1	SDCCAG8
Vascular/heart problems diagnosed by doctor	1.75	1	0	0.0	1	SDCCAG8
Sitting height	1.39	2	0	0.0	1	CTTNBP2 SDCCAG8
Lung FVC	1.31	1	0	0.0	1	CTTNBP2
Systolic Blood Pressure	1.21	1	0	0.0	1	SDCCAG8
Arm predicted mass (left)	1.06	1	0	0.0	1	SDCCAG8
Arm fat-free mass (left)	1.03	1	0	0.0	1	SDCCAG8
Comparative height size at age 10	0.93	1	0	0.0	1	CTTNBP2
Basal metabolic rate	0.83	1	0	0.0	1	SDCCAG8
Tanning	0.79	1	0	0.0	1	SDCCAG8
Leg predicted mass (left)	0.78	1	0	0.0	1	SDCCAG8
Blood Red Count	0.73	1	0	0.0	1	SDCCAG8
Leg fat-free mass (left)	0.73	1	0	0.0	1	SDCCAG8
Leg fat-free mass (right)	0.71	1	0	0.0	1	SDCCAG8
Blood Platelet Count	0.62	1	0	0.0	1	CTTNBP2
Heel T-Score	0.55	1	0	0.0	1	CTTNBP2
Height	0.50	1	0	0.0	1	CTTNBP2
Standing height	0.45	1	0	0.0	1	CTTNBP2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Adipose Visceral Omentum	1	0.049	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	1	0.024	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Muscle Skeletal	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
NTR	Blood	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
YFS	Blood	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2