Hub : Traits :

Commuting to job workplace: Public transport

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 231030554 232441175 1 1 3.9e-08 1.2e-03 0.0059 28 ITM2C
2 20 29833609 30854378 1 1 1.6e-07 1.3e-07 0.0968 90 HM13-AS1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Mean Putamen Volume 4.88 1 0 0.0 0 1 HM13-AS1
Type 2 Diabetes (T2D) (2012) 3.83 1 0 0.0 0 1 ITM2C
Blood Eosinophil Count 1.18 1 0 0.0 0 1 HM13-AS1
Blood Platelet Count 4.21 1 1 2.2 0 1 HM13-AS1
Blood Red Count 5.66 2 1 2.2 0 1 HM13-AS1 ITM2C
Heel T-Score 2.99 1 1 2.2 0 1 HM13-AS1
BMI 1.78 1 0 0.0 0 1 HM13-AS1
Height 1.02 1 1 2.2 0 1 HM13-AS1
Systolic Blood Pressure 0.75 1 0 0.0 0 1 HM13-AS1
Smoking Status 2.97 1 0 0.0 0 1 HM13-AS1
Cardiovascular Disease 2.21 1 0 0.0 0 1 HM13-AS1
Lung FVC 1.55 1 0 0.0 0 1 HM13-AS1
Hair Pigment 0.33 1 0 0.0 0 1 HM13-AS1
Hearing difficulty/problems: Yes 2.66 1 0 0.0 0 1 HM13-AS1
Townsend deprivation index at recruitment 2.43 1 0 0.0 0 1 HM13-AS1
Maternal smoking around birth 5.75 2 0 0.0 0 1 HM13-AS1 ITM2C
Frequency of unenthusiasm / disinterest in last 2 weeks 3.39 1 0 0.0 0 1 ITM2C
Heel bone mineral density (BMD) T-score, automated (left) 3.67 1 0 0.0 0 1 HM13-AS1
Tinnitus: Yes, but not now, but have in the past 3.12 1 0 0.0 0 1 ITM2C
High blood pressure 3.26 1 0 0.0 0 1 HM13-AS1
Diverticular disease/diverticulitis (self-reported) 2.35 1 0 0.0 0 1 ITM2C
Sitting height 4.89 1 1 2.2 0 1 HM13-AS1
Body mass index (BMI) 0.88 1 0 0.0 0 1 HM13-AS1
Hearing difficulty/problems with background noise 2.26 1 0 0.0 0 1 ITM2C
Heel bone mineral density (BMD) T-score, automated (right) 4.00 1 0 0.0 0 1 HM13-AS1
Medication: Simvastatin 2.68 1 0 0.0 0 1 HM13-AS1
Impedance of arm (right) 0.56 1 0 0.0 0 1 ITM2C
Arm fat percentage (right) 1.13 1 0 0.0 0 1 HM13-AS1
Standing height 1.42 1 1 2.2 0 1 HM13-AS1
Tense / 'highly strung' 4.28 1 0 0.0 0 1 ITM2C
Loud music exposure frequency 3.75 1 0 0.0 0 1 ITM2C
Headache pain in last month 2.36 1 0 0.0 0 1 ITM2C
Medication for cholesterol, blood pressure or diabetes 2.75 1 0 0.0 0 1 HM13-AS1
Glaucoma (self-reported) 3.62 1 0 0.0 0 1 ITM2C
Comparative body size at age 10 1.02 1 0 0.0 0 1 ITM2C
Seen a psychiatrist for nerves, anxiety, tension or depression 6.01 2 0 0.0 0 1 HM13-AS1 ITM2C
Medication for pain relief, constipation, heartburn 2.45 1 0 0.0 0 1 HM13-AS1
Medication: Blood pressure 4.88 1 0 0.0 0 1 HM13-AS1
Pulse rate, automated reading 1.39 1 0 0.0 0 1 HM13-AS1
Comparative height size at age 10 0.68 1 0 0.0 0 1 HM13-AS1
Suffer from 'nerves' 2.01 1 0 0.0 0 1 ITM2C
Commuting to job workplace: Car/motor vehicle 9.02 2 0 0.0 0 1 HM13-AS1 ITM2C
Hypertension (Self-reported) 3.24 1 0 0.0 0 1 HM13-AS1
Arm fat percentage (left) 0.97 1 0 0.0 0 1 HM13-AS1
Average weekly red wine intake 3.15 1 0 0.0 0 1 HM13-AS1
Commuting to job workplace: Walk 4.02 1 0 0.0 0 1 ITM2C
Back pain experienced in last month 3.05 1 0 0.0 0 1 HM13-AS1
Osteoarthritis (self-reported) 2.52 1 0 0.0 0 1 ITM2C
Medication: Gliclazide 3.38 1 0 0.0 0 1 HM13-AS1
Illnesses of father: None of the above (group 1) 3.14 1 0 0.0 0 1 HM13-AS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.50 1 0 0.0 0 1 HM13-AS1
Mother's age at death 3.58 1 0 0.0 0 1 HM13-AS1
Tinnitus: Yes, now most or all of the time 2.48 1 0 0.0 0 1 ITM2C
Supplements: Fish oil (including cod liver oil) 2.62 1 0 0.0 0 1 ITM2C
High cholesterol (Self-reported) 1.74 1 0 0.0 0 1 HM13-AS1
Fractured/broken bones in last 5 years 2.88 1 0 0.0 0 1 HM13-AS1
Diastolic blood pressure, automated reading 2.82 1 0 0.0 0 1 HM13-AS1
Vascular/heart problems diagnosed by doctor 3.63 1 0 0.0 0 1 HM13-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 1 0.023 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 1 0.027 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2