Hub : Traits :

Commuting to job workplace: Public transport

2 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	231030554	232441175	1	1	3.9e-08	1.2e-03	0.0059	28	ITM2C
2	20	29833609	30854378	1	1	1.6e-07	1.3e-07	0.0968	90	HM13-AS1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Commuting to job workplace: Car/motor vehicle	9.02	2	0	0.0	1	HM13-AS1 ITM2C
Seen a psychiatrist for nerves, anxiety, tension or depression	6.01	2	0	0.0	1	HM13-AS1 ITM2C
Maternal smoking around birth	5.75	2	0	0.0	1	HM13-AS1 ITM2C
Blood Red Count	5.66	2	1	2.2	1	HM13-AS1 ITM2C
Sitting height	4.89	1	1	2.2	1	HM13-AS1
Mean Putamen Volume	4.88	1	0	0.0	1	HM13-AS1
Medication: Blood pressure	4.88	1	0	0.0	1	HM13-AS1
Tense / 'highly strung'	4.28	1	0	0.0	1	ITM2C
Blood Platelet Count	4.21	1	1	2.2	1	HM13-AS1
Commuting to job workplace: Walk	4.02	1	0	0.0	1	ITM2C
Heel bone mineral density (BMD) T-score, automated (right)	4.00	1	0	0.0	1	HM13-AS1
Type 2 Diabetes (T2D) (2012)	3.83	1	0	0.0	1	ITM2C
Loud music exposure frequency	3.75	1	0	0.0	1	ITM2C
Heel bone mineral density (BMD) T-score, automated (left)	3.67	1	0	0.0	1	HM13-AS1
Vascular/heart problems diagnosed by doctor	3.63	1	0	0.0	1	HM13-AS1
Glaucoma (self-reported)	3.62	1	0	0.0	1	ITM2C
Mother's age at death	3.58	1	0	0.0	1	HM13-AS1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.39	1	0	0.0	1	ITM2C
Medication: Gliclazide	3.38	1	0	0.0	1	HM13-AS1
High blood pressure	3.26	1	0	0.0	1	HM13-AS1
Hypertension (Self-reported)	3.24	1	0	0.0	1	HM13-AS1
Average weekly red wine intake	3.15	1	0	0.0	1	HM13-AS1
Illnesses of father: None of the above (group 1)	3.14	1	0	0.0	1	HM13-AS1
Tinnitus: Yes, but not now, but have in the past	3.12	1	0	0.0	1	ITM2C
Back pain experienced in last month	3.05	1	0	0.0	1	HM13-AS1
Heel T-Score	2.99	1	1	2.2	1	HM13-AS1
Smoking Status	2.97	1	0	0.0	1	HM13-AS1
Fractured/broken bones in last 5 years	2.88	1	0	0.0	1	HM13-AS1
Diastolic blood pressure, automated reading	2.82	1	0	0.0	1	HM13-AS1
Medication for cholesterol, blood pressure or diabetes	2.75	1	0	0.0	1	HM13-AS1
Medication: Simvastatin	2.68	1	0	0.0	1	HM13-AS1
Hearing difficulty/problems: Yes	2.66	1	0	0.0	1	HM13-AS1
Supplements: Fish oil (including cod liver oil)	2.62	1	0	0.0	1	ITM2C
Osteoarthritis (self-reported)	2.52	1	0	0.0	1	ITM2C
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.50	1	0	0.0	1	HM13-AS1
Tinnitus: Yes, now most or all of the time	2.48	1	0	0.0	1	ITM2C
Medication for pain relief, constipation, heartburn	2.45	1	0	0.0	1	HM13-AS1
Townsend deprivation index at recruitment	2.43	1	0	0.0	1	HM13-AS1
Headache pain in last month	2.36	1	0	0.0	1	ITM2C
Diverticular disease/diverticulitis (self-reported)	2.35	1	0	0.0	1	ITM2C
Hearing difficulty/problems with background noise	2.26	1	0	0.0	1	ITM2C
Cardiovascular Disease	2.21	1	0	0.0	1	HM13-AS1
Suffer from 'nerves'	2.01	1	0	0.0	1	ITM2C
BMI	1.78	1	0	0.0	1	HM13-AS1
High cholesterol (Self-reported)	1.74	1	0	0.0	1	HM13-AS1
Lung FVC	1.55	1	0	0.0	1	HM13-AS1
Standing height	1.42	1	1	2.2	1	HM13-AS1
Pulse rate, automated reading	1.39	1	0	0.0	1	HM13-AS1
Blood Eosinophil Count	1.18	1	0	0.0	1	HM13-AS1
Arm fat percentage (right)	1.13	1	0	0.0	1	HM13-AS1
Height	1.02	1	1	2.2	1	HM13-AS1
Comparative body size at age 10	1.02	1	0	0.0	1	ITM2C
Arm fat percentage (left)	0.97	1	0	0.0	1	HM13-AS1
Body mass index (BMI)	0.88	1	0	0.0	1	HM13-AS1
Systolic Blood Pressure	0.75	1	0	0.0	1	HM13-AS1
Comparative height size at age 10	0.68	1	0	0.0	1	HM13-AS1
Impedance of arm (right)	0.56	1	0	0.0	1	ITM2C
Hair Pigment	0.33	1	0	0.0	1	HM13-AS1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	1	0.023	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
YFS	Blood	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1