Hub : Traits :

Supplements: Calcium

6 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 19 3268722 5153606 2 1 9.3e-09 6.9e-09 0.15 94 UBXN6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Neuroticism (Nagel 2018) 4.9 1 0 0.0 0 1 UBXN6
Worry (Nagel 2018) 3.3 1 0 0.0 0 1 UBXN6
Breast Cancer 3.1 1 0 0.0 0 1 UBXN6
Blood Red Count 8.5 1 1 2.2 0 1 UBXN6
BMI 5.2 1 1 2.2 0 1 UBXN6
Systolic Blood Pressure 2.5 1 0 0.0 0 1 UBXN6
Cardiovascular Disease 2.6 1 0 0.0 0 1 UBXN6
Type 2 Diabetes (T2D) (2018) 6.2 1 0 0.0 0 1 UBXN6
Lung FEV1/FVC ratio 2.0 1 0 0.0 0 1 UBXN6
Lung FVC 2.8 1 0 0.0 0 1 UBXN6
Neuroticism 6.5 1 0 0.0 0 1 UBXN6
Chronotype (morning person) 4.6 1 0 0.0 0 1 UBXN6
Hair Pigment 0.7 1 0 0.0 0 1 UBXN6
Supplements: Zinc 7.7 1 0 0.0 0 1 UBXN6
Impedance of leg (right) 9.4 1 1 2.2 0 1 UBXN6
Leg fat-free mass (left) 5.6 1 1 2.2 0 1 UBXN6
High blood pressure 2.6 1 0 0.0 0 1 UBXN6
Body mass index (BMI) 3.4 1 0 0.0 0 1 UBXN6
Impedance of leg (left) 9.0 1 1 2.2 0 1 UBXN6
Leg predicted mass (left) 5.6 1 1 2.2 0 1 UBXN6
Waist circumference 3.3 1 0 0.0 0 1 UBXN6
Forced vital capacity (FVC) 2.1 1 0 0.0 0 1 UBXN6
Neuroticism score 3.4 1 0 0.0 0 1 UBXN6
Weight 3.7 1 0 0.0 0 1 UBXN6
Impedance of arm (right) 10.2 1 1 2.2 0 1 UBXN6
Trunk fat-free mass 4.5 1 0 0.0 0 1 UBXN6
Hip circumference 2.9 1 0 0.0 0 1 UBXN6
Hair/balding pattern: Pattern 3 5.2 1 0 0.0 0 1 UBXN6
Impedance of arm (left) 9.2 1 1 2.2 0 1 UBXN6
Arm fat mass (right) 1.9 1 0 0.0 0 1 UBXN6
Trunk predicted mass 4.5 1 0 0.0 0 1 UBXN6
Peak expiratory flow (PEF) 4.6 1 0 0.0 0 1 UBXN6
Forced vital capacity (FVC), Best measure 1.9 1 0 0.0 0 1 UBXN6
Arm fat-free mass (right) 7.1 1 1 2.2 0 1 UBXN6
Worry too long after embarrassment 4.3 1 0 0.0 0 1 UBXN6
Leg fat mass (right) 2.1 1 0 0.0 0 1 UBXN6
Arm predicted mass (right) 7.3 1 1 2.2 0 1 UBXN6
Whole body fat-free mass 5.6 1 1 2.2 0 1 UBXN6
Leg fat-free mass (right) 5.7 1 1 2.2 0 1 UBXN6
Qualifications: nursing, teaching 4.5 1 0 0.0 0 1 UBXN6
Whole body water mass 5.7 1 1 2.2 0 1 UBXN6
Leg predicted mass (right) 5.8 1 1 2.2 0 1 UBXN6
Arm fat mass (left) 1.9 1 0 0.0 0 1 UBXN6
Guilty feelings 5.7 1 0 0.0 0 1 UBXN6
Basal metabolic rate 5.1 1 1 2.2 0 1 UBXN6
Arm fat-free mass (left) 6.3 1 1 2.2 0 1 UBXN6
Impedance of whole body 9.6 1 1 2.2 0 1 UBXN6
Leg fat mass (left) 2.1 1 0 0.0 0 1 UBXN6
Arm predicted mass (left) 6.1 1 1 2.2 0 1 UBXN6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.1
GTEx Adipose Visceral Omentum 0 0.000 1.1
GTEx Adrenal Gland 0 0.000 1.0
GTEx Artery Aorta 0 0.000 1.1
GTEx Artery Coronary 0 0.000 1.0
GTEx Artery Tibial 0 0.000 1.1
GTEx Brain Caudate basal ganglia 0 0.000 1.0
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.1
GTEx Brain Hippocampus 0 0.000 1.0
GTEx Brain Hypothalamus 0 0.000 1.1
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.1
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.0
GTEx Cells Transformed fibroblasts 1 0.024 1.1
GTEx Colon Sigmoid 0 0.000 1.1
GTEx Colon Transverse 0 0.000 1.1
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.0
GTEx Esophagus Mucosa 0 0.000 1.1
GTEx Esophagus Muscularis 0 0.000 1.1
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 1 0.065 1.1
GTEx Liver 0 0.000 1.0
GTEx Lung 0 0.000 1.1
GTEx Muscle Skeletal 0 0.000 1.1
GTEx Nerve Tibial 0 0.000 1.1
GTEx Ovary 0 0.000 1.0
GTEx Pancreas 0 0.000 1.1
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 1 0.120 1.1
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.1
GTEx Skin Sun Exposed Lower leg 0 0.000 1.1
GTEx Small Intestine Terminal Ileum 0 0.000 1.1
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.1
GTEx Testis 0 0.000 1.1
GTEx Thyroid 0 0.000 1.1
GTEx Uterus 0 0.000 1.1
GTEx Vagina 0 0.000 1.1
GTEx Whole Blood 1 0.050 1.1
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.1
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1