Hub : Traits :

Hair/balding pattern: Pattern 3

432 significantly associated models · 36 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 222826088 223412813 1 1 1.2e-07 6.6e-12 6.5e-10 19 PAX3
2 3 138380069 139954262 2 3 3.2e-17 4.5e-51 1.4e-25 52 RBP1 RP11-219D15.3
3 4 80407869 82578407 3 3 8.2e-14 1.3e-13 1.0e+00 100 C4orf22 FGF5 PRDM8
4 6 125970401 127355237 1 1 8.3e-10 1.5e-12 3.7e-04 75 CENPW
5 6 133319409 134100937 1 1 1.1e-08 9.6e-09 3.0e-01 97 EYA4
6 7 18364750 19854141 1 1 5.7e-20 3.8e-30 7.2e-12 64 TWIST1
7 12 26099201 26643931 1 1 4.4e-11 2.5e-12 1.1e-03 78 SSPN
8 13 100044673 101879559 1 1 9.0e-11 5.1e-11 7.2e-03 83 PCCA
9 17 42607368 45796313 22 2 3.7e-24 1.5e-22 1.0e+00 100 FMNL1 WNT3
10 20 21043102 22430527 1 1 1.8e-39 1.4e-92 2.9e-55 41 RPL41P1
11 20 39567774 40193393 1 1 2.5e-07 1.7e-08 1.0e+00 100 ZHX3
12 21 36163513 36656310 1 1 1.3e-07 4.1e-09 5.4e-03 78 C21orf96

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 4.65 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Depression (Nagel 2018) 2.20 1 0 0.0 0.00 1.00000 WNT3
Intelligence (Savage-Jansen 2018) 1.44 2 1 2.2 0.00 1.00000 CENPW WNT3
Neuroticism (Nagel 2018) 5.56 3 3 6.7 0.00 1.00000 CENPW FMNL1 WNT3
Worry (Nagel 2018) 3.89 3 3 6.7 0.00 1.00000 CENPW FMNL1 WNT3
Crohns Disease (2017) 1.50 1 0 0.0 0.00 1.00000 ZHX3
Irritable Bowel Disease (IBD) 1.42 1 0 0.0 0.00 1.00000 ZHX3
Ulcerative Colitis (UC) 1.09 1 0 0.0 0.00 1.00000 ZHX3
Verbal and Numeric Reasoning (VNR) 1.31 1 0 0.0 0.00 1.00000 CENPW
Breast Cancer 2.40 2 1 2.2 0.00 1.00000 FMNL1 WNT3
Ovarian Cancer 3.15 1 1 2.2 0.00 1.00000 WNT3
Crohns Disease (2012) 1.64 1 0 0.0 0.00 1.00000 WNT3
Mean Putamen Volume 1.74 1 0 0.0 0.00 1.00000 WNT3
Neuroticism (2016) 3.27 2 1 2.2 0.00 1.00000 FMNL1 WNT3
Primary Biliary Cirrhosis 2.17 2 0 0.0 0.00 1.00000 FMNL1 WNT3
Schizophrenia (2014) 1.17 1 0 0.0 0.00 1.00000 WNT3
Type 2 Diabetes (T2D) (2012) 2.35 1 0 0.0 0.00 1.00000 ZHX3
Blood Eosinophil Count 2.57 3 3 6.7 0.00 1.00000 C21orf96 FMNL1 WNT3
Blood Platelet Count 0.79 3 2 4.4 0.00 1.00000 C21orf96 WNT3 ZHX3
Blood Red Count 4.54 5 3 6.7 -0.79 0.11480 C4orf22 CENPW FGF5 FMNL1 WNT3
Blood White Count 1.40 6 2 4.4 -0.13 0.80512 CENPW EYA4 FMNL1 SSPN WNT3 ZHX3
Heel T-Score 5.04 6 6 13.3 0.38 0.45954 EYA4 FMNL1 SSPN TWIST1 WNT3 ZHX3
BMI 0.65 2 0 0.0 0.00 1.00000 C4orf22 FGF5
Height 2.99 5 3 6.7 -0.11 0.85848 CENPW EYA4 PAX3 RPL41P1 WNT3
Waist Hip Ratio (WHR) 2.81 3 3 6.7 0.00 1.00000 CENPW SSPN WNT3
Systolic Blood Pressure 5.32 5 4 8.9 0.24 0.69316 C4orf22 FGF5 FMNL1 PRDM8 SSPN
Smoking Status 1.91 1 0 0.0 0.00 1.00000 WNT3
Cardiovascular Disease 4.28 4 2 4.4 0.65 0.35149 C4orf22 FGF5 FMNL1 PRDM8
Type 2 Diabetes (T2D) (2018) 2.14 1 0 0.0 0.00 1.00000 CENPW
Lung FEV1/FVC ratio 1.07 2 1 2.2 0.00 1.00000 CENPW EYA4
Lung FVC 5.26 4 4 8.9 0.68 0.32205 CENPW FMNL1 TWIST1 WNT3
Neuroticism 5.52 3 2 4.4 0.00 1.00000 CENPW FMNL1 WNT3
Hair Pigment 0.90 6 5 11.1 0.66 0.15199 C4orf22 FGF5 PAX3 RPL41P1 TWIST1 WNT3
Hand grip strength (left) 2.32 1 1 2.2 0.00 1.00000 WNT3
Sensitivity / hurt feelings 5.48 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Frequency of depressed mood in last 2 weeks 2.03 1 0 0.0 0.00 1.00000 WNT3
Relative age of first facial hair 7.89 5 3 6.7 -0.98 0.00280 C4orf22 FGF5 FMNL1 TWIST1 WNT3
Systolic blood pressure, automated reading 4.42 4 3 6.7 1.00 0.00393 C4orf22 FGF5 FMNL1 WNT3
Diabetes (mother) 2.30 1 0 0.0 0.00 1.00000 ZHX3
Impedance of leg (right) 1.17 3 0 0.0 0.00 1.00000 CENPW FMNL1 ZHX3
Leg fat-free mass (left) 1.48 1 1 2.2 0.00 1.00000 CENPW
Trunk fat percentage 2.15 4 3 6.7 0.72 0.27511 CENPW FMNL1 WNT3 ZHX3
Hand grip strength (right) 1.67 1 1 2.2 0.00 1.00000 WNT3
Fed-up feelings 2.86 2 1 2.2 0.00 1.00000 FMNL1 WNT3
Relative age voice broke 4.55 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Age when periods started (menarche) 2.22 1 1 2.2 0.00 1.00000 CENPW
Heel bone mineral density (BMD) T-score, automated (left) 3.34 2 2 4.4 0.00 1.00000 EYA4 ZHX3
Qualifications: CSEs or equivalent 2.14 1 0 0.0 0.00 1.00000 WNT3
High blood pressure 4.98 4 2 4.4 0.72 0.27604 C4orf22 FGF5 FMNL1 PRDM8
Medication: Atenolol 1.91 1 0 0.0 0.00 1.00000 C4orf22
Sitting height 4.37 4 3 6.7 0.02 0.97869 CENPW EYA4 TWIST1 WNT3
High blood pressure (mother) 2.20 1 0 0.0 0.00 1.00000 C4orf22
Impedance of leg (left) 1.18 4 0 0.0 0.79 0.21200 CENPW FMNL1 WNT3 ZHX3
Leg predicted mass (left) 1.49 1 1 2.2 0.00 1.00000 CENPW
Trunk fat mass 1.33 2 2 4.4 0.00 1.00000 WNT3 ZHX3
Past tobacco smoking 2.50 2 0 0.0 0.00 1.00000 PCCA WNT3
Nervous feelings 3.69 3 2 4.4 0.00 1.00000 CENPW FMNL1 WNT3
Frequency of tenseness / restlessness in last 2 weeks 4.17 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Hearing difficulty/problems with background noise 2.61 1 0 0.0 0.00 1.00000 WNT3
Hair/balding pattern: Pattern 2 35.76 13 10 22.2 -0.86 0.00016 C21orf96 C4orf22 CENPW EYA4 FGF5 FMNL1 PAX3 PCCA PRDM8 RPL41P1 SSPN TWIST1 WNT3
Forced vital capacity (FVC) 5.55 3 3 6.7 0.00 1.00000 CENPW FMNL1 WNT3
Heel bone mineral density (BMD) T-score, automated (right) 3.26 2 2 4.4 0.00 1.00000 EYA4 ZHX3
Ever unenthusiastic/disinterested for a whole week 2.23 1 0 0.0 0.00 1.00000 WNT3
Mouth/teeth dental problems 1.84 1 0 0.0 0.00 1.00000 WNT3
Diabetes (self-reported) 1.62 1 0 0.0 0.00 1.00000 CENPW
Neuroticism score 4.93 3 2 4.4 0.00 1.00000 CENPW FMNL1 WNT3
Weight 0.97 1 1 2.2 0.00 1.00000 CENPW
Impedance of arm (right) 1.89 3 3 6.7 0.00 1.00000 CENPW FMNL1 WNT3
Arm fat percentage (right) 1.31 1 1 2.2 0.00 1.00000 CENPW
Trunk fat-free mass 3.11 2 2 4.4 0.00 1.00000 CENPW FMNL1
Hip circumference 1.38 3 1 2.2 0.00 1.00000 CENPW EYA4 ZHX3
Time employed in main current job 2.60 1 1 2.2 0.00 1.00000 WNT3
Worrier / anxious feelings 2.79 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Number of live births 1.75 1 0 0.0 0.00 1.00000 WNT3
Forced expiratory volume in 1-second (FEV1) 4.79 3 3 6.7 0.00 1.00000 CENPW FMNL1 WNT3
Medication: Ibuprofen (e.g. Nurofen) 2.66 1 0 0.0 0.00 1.00000 FMNL1
Forced expiratory volume in 1-second (FEV1), Best measure 4.53 3 2 4.4 0.00 1.00000 CENPW FMNL1 WNT3
Impedance of arm (left) 2.02 3 3 6.7 0.00 1.00000 CENPW FMNL1 WNT3
Trunk predicted mass 3.08 2 2 4.4 0.00 1.00000 CENPW FMNL1
Standing height 3.09 3 3 6.7 0.00 1.00000 CENPW EYA4 WNT3
Hair/balding pattern: Pattern 4 38.78 12 11 24.4 0.72 0.00516 C4orf22 CENPW FGF5 FMNL1 PRDM8 RBP1 RP11-219D15.3 RPL41P1 SSPN TWIST1 WNT3 ZHX3
Peak expiratory flow (PEF) 2.41 1 1 2.2 0.00 1.00000 WNT3
Medication: Paracetamol 2.65 1 1 2.2 0.00 1.00000 WNT3
Headache pain in last month 4.39 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Medication for cholesterol, blood pressure or diabetes 1.98 1 0 0.0 0.00 1.00000 C4orf22
Birth weight 1.21 1 0 0.0 0.00 1.00000 CENPW
Forced vital capacity (FVC), Best measure 5.77 4 3 6.7 0.62 0.37877 CENPW FMNL1 TWIST1 WNT3
Body fat percentage 2.02 4 2 4.4 0.69 0.31243 CENPW FMNL1 WNT3 ZHX3
Leg fat percentage (right) 1.79 2 2 4.4 0.00 1.00000 CENPW ZHX3
Arm fat-free mass (right) 2.33 2 1 2.2 0.00 1.00000 CENPW FMNL1
Number of full brothers 1.35 1 0 0.0 0.00 1.00000 WNT3
Worry too long after embarrassment 2.08 1 0 0.0 0.00 1.00000 WNT3
Qualifications: College or University degree 2.08 2 1 2.2 0.00 1.00000 PCCA WNT3
Emphysema/chronic bronchitis 2.08 1 0 0.0 0.00 1.00000 WNT3
Medication for pain relief, constipation, heartburn 2.66 1 1 2.2 0.00 1.00000 WNT3
Medication: Blood pressure 2.98 3 1 2.2 0.00 1.00000 C4orf22 FGF5 PRDM8
Medication: Ibuprofen 2.47 1 0 0.0 0.00 1.00000 FMNL1
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.42 1 0 0.0 0.00 1.00000 FMNL1
Whole body fat mass 1.05 1 1 2.2 0.00 1.00000 ZHX3
Leg fat mass (right) 0.98 1 1 2.2 0.00 1.00000 ZHX3
Arm predicted mass (right) 2.30 2 1 2.2 0.00 1.00000 CENPW FMNL1
Pulse rate, automated reading 1.50 2 0 0.0 0.00 1.00000 C4orf22 ZHX3
Alcohol intake frequency. 2.29 1 1 2.2 0.00 1.00000 WNT3
Comparative height size at age 10 5.09 2 2 4.4 0.00 1.00000 CENPW WNT3
Suffer from 'nerves' 2.07 1 0 0.0 0.00 1.00000 WNT3
Leg pain on walking 1.92 1 0 0.0 0.00 1.00000 WNT3
Supplements: Vitamin C 1.94 1 0 0.0 0.00 1.00000 WNT3
Hypertension (Self-reported) 4.91 4 2 4.4 0.72 0.28381 C4orf22 FGF5 FMNL1 PRDM8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.89 1 0 0.0 0.00 1.00000 FMNL1
Illnesses of father: Heart disease 1.92 1 0 0.0 0.00 1.00000 WNT3
Smoking status: Previous 3.14 1 0 0.0 0.00 1.00000 PCCA
Forced expiratory volume in 1-second (FEV1), predicted 1.49 1 1 2.2 0.00 1.00000 CENPW
Whole body fat-free mass 2.42 2 1 2.2 0.00 1.00000 CENPW FMNL1
Leg fat-free mass (right) 1.59 1 1 2.2 0.00 1.00000 CENPW
Arm fat percentage (left) 1.40 2 1 2.2 0.00 1.00000 CENPW ZHX3
Handedness (chirality/laterality): Left-handed 3.25 1 1 2.2 0.00 1.00000 WNT3
Mood swings 4.50 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Loneliness, isolation 1.99 1 0 0.0 0.00 1.00000 WNT3
Diabetes diagnosed by doctor 2.30 2 0 0.0 0.00 1.00000 CENPW SSPN
Mouth/teeth dental problems: Mouth ulcers 2.78 1 1 2.2 0.00 1.00000 WNT3
Medication for cholesterol 3.66 2 0 0.0 0.00 1.00000 C4orf22 FGF5
Medication: Gliclazide 1.80 1 0 0.0 0.00 1.00000 SSPN
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.28 2 2 4.4 0.00 1.00000 FMNL1 WNT3
Whole body water mass 2.37 2 1 2.2 0.00 1.00000 CENPW FMNL1
Leg predicted mass (right) 1.58 1 1 2.2 0.00 1.00000 CENPW
Average weekly champagne plus white wine intake 1.74 1 0 0.0 0.00 1.00000 WNT3
Miserableness 2.48 1 1 2.2 0.00 1.00000 WNT3
Guilty feelings 2.72 1 0 0.0 0.00 1.00000 WNT3
Medication: Blood pressure 4.94 3 3 6.7 0.00 1.00000 C4orf22 FGF5 FMNL1
Medication: Paracetamol 2.77 1 1 2.2 0.00 1.00000 WNT3
Illnesses of father: High blood pressure 2.93 1 0 0.0 0.00 1.00000 C4orf22
Basal metabolic rate 1.97 1 1 2.2 0.00 1.00000 CENPW
Leg fat percentage (left) 1.66 2 2 4.4 0.00 1.00000 CENPW ZHX3
Arm fat-free mass (left) 2.25 2 1 2.2 0.00 1.00000 CENPW FMNL1
Irritability 2.39 1 1 2.2 0.00 1.00000 WNT3
Fractured/broken bones in last 5 years 2.41 1 0 0.0 0.00 1.00000 WNT3
Diastolic blood pressure, automated reading 2.57 4 2 4.4 0.98 0.02126 C4orf22 FGF5 FMNL1 ZHX3
Ever depressed for a whole week 1.66 1 0 0.0 0.00 1.00000 WNT3
Myopia 1.67 1 0 0.0 0.00 1.00000 PCCA
Vascular/heart problems diagnosed by doctor 4.43 4 2 4.4 -0.72 0.27888 C4orf22 FGF5 FMNL1 PRDM8
Pain experienced in last month 2.36 2 0 0.0 0.00 1.00000 CENPW WNT3
Impedance of whole body 1.85 3 3 6.7 0.00 1.00000 CENPW FMNL1 WNT3
Leg fat mass (left) 0.92 1 1 2.2 0.00 1.00000 ZHX3
Arm predicted mass (left) 2.07 2 1 2.2 0.00 1.00000 CENPW FMNL1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 7 0.201 1.5
GTEx Adipose Visceral Omentum 7 0.344 1.6
GTEx Adrenal Gland 5 0.343 1.6
GTEx Artery Aorta 8 0.269 1.6
GTEx Artery Coronary 9 0.761 1.9
GTEx Artery Tibial 5 0.133 1.4
GTEx Brain Caudate basal ganglia 5 0.543 1.6
GTEx Brain Cerebellar Hemisphere 8 0.537 1.7
GTEx Brain Cerebellum 6 0.303 1.6
GTEx Brain Cortex 8 0.773 1.8
GTEx Brain Frontal Cortex BA9 6 0.649 1.7
GTEx Brain Hippocampus 5 0.954 2.0
GTEx Brain Hypothalamus 6 1.017 2.0
GTEx Brain Nucleus accumbens basal ganglia 7 0.809 1.8
GTEx Brain Putamen basal ganglia 6 0.962 2.0
GTEx Breast Mammary Tissue 9 0.456 1.6
GTEx Breast Mammary Tissue (Male) 7 0.587 1.8
GTEx Breast Mammary Tissue (Female) 10 0.608 1.6
GTEx Cells EBV-transformed lymphocytes 10 0.703 1.8
GTEx Cells Transformed fibroblasts 9 0.214 1.4
GTEx Colon Sigmoid 7 0.479 1.7
GTEx Colon Transverse 8 0.388 1.6
GTEx Esophagus Gastroesophageal Junction 8 0.554 1.8
GTEx Esophagus Mucosa 10 0.301 1.5
GTEx Esophagus Muscularis 10 0.309 1.6
GTEx Heart Atrial Appendage 7 0.443 1.7
GTEx Heart Left Ventricle 7 0.458 1.7
GTEx Liver 5 0.697 1.8
GTEx Lung 9 0.313 1.6
GTEx Muscle Skeletal 8 0.277 1.5
GTEx Nerve Tibial 9 0.208 1.5
GTEx Ovary 7 0.771 1.8
GTEx Pancreas 9 0.551 1.7
GTEx Pituitary 5 0.448 1.7
GTEx Prostate 5 0.599 1.8
GTEx Skin Not Sun Exposed Suprapubic 8 0.325 1.6
GTEx Skin Sun Exposed Lower leg 9 0.247 1.5
GTEx Small Intestine Terminal Ileum 4 0.868 2.0
GTEx Spleen 6 0.425 1.6
GTEx Stomach 9 0.619 1.8
GTEx Testis 11 0.349 1.5
GTEx Thyroid 10 0.250 1.5
GTEx Uterus 6 1.058 2.1
GTEx Vagina 6 0.945 2.2
GTEx Whole Blood 6 0.301 1.6
METSIM Adipose 1 0.022 1.3
NTR Blood 3 0.125 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 1 0.022 1.2
CommonMind Brain Pre-frontal Cortex 5 0.093 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 8 0.182 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 4 0.365 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.4
The Cancer Genome Atlas Esophageal Carcinoma 3 0.438 1.6
The Cancer Genome Atlas Glioblastoma Multiforme 4 0.391 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 8 0.195 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 5 0.116 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 2 0.181 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 4 0.136 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 5 0.200 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 5 0.314 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 3 0.181 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 4 0.301 1.5
The Cancer Genome Atlas Prostate Adenocarcinoma 7 0.151 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 2 0.289 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 4 0.375 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 5 0.297 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.156 1.4
The Cancer Genome Atlas Thyroid Carcinoma 5 0.097 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 2 0.394 1.5