Hub : Traits :

Hair/balding pattern: Pattern 3

432 significantly associated models · 36 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	222826088	223412813	1	1	1.2e-07	6.6e-12	6.5e-10	19	PAX3
2	3	138380069	139954262	2	3	3.2e-17	4.5e-51	1.4e-25	52	RBP1 RP11-219D15.3
3	4	80407869	82578407	3	3	8.2e-14	1.3e-13	1.0e+00	100	C4orf22 FGF5 PRDM8
4	6	125970401	127355237	1	1	8.3e-10	1.5e-12	3.7e-04	75	CENPW
5	6	133319409	134100937	1	1	1.1e-08	9.6e-09	3.0e-01	97	EYA4
6	7	18364750	19854141	1	1	5.7e-20	3.8e-30	7.2e-12	64	TWIST1
7	12	26099201	26643931	1	1	4.4e-11	2.5e-12	1.1e-03	78	SSPN
8	13	100044673	101879559	1	1	9.0e-11	5.1e-11	7.2e-03	83	PCCA
9	17	42607368	45796313	22	2	3.7e-24	1.5e-22	1.0e+00	100	FMNL1 WNT3
10	20	21043102	22430527	1	1	1.8e-39	1.4e-92	2.9e-55	41	RPL41P1
11	20	39567774	40193393	1	1	2.5e-07	1.7e-08	1.0e+00	100	ZHX3
12	21	36163513	36656310	1	1	1.3e-07	4.1e-09	5.4e-03	78	C21orf96

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hair/balding pattern: Pattern 4	38.78	12	11	24.4	0.72	0.00516	C4orf22 CENPW FGF5 FMNL1 PRDM8 RBP1 RP11-219D15.3 RPL41P1 SSPN TWIST1 WNT3 ZHX3
Hair/balding pattern: Pattern 2	35.76	13	10	22.2	-0.86	0.00016	C21orf96 C4orf22 CENPW EYA4 FGF5 FMNL1 PAX3 PCCA PRDM8 RPL41P1 SSPN TWIST1 WNT3
Relative age of first facial hair	7.89	5	3	6.7	-0.98	0.00280	C4orf22 FGF5 FMNL1 TWIST1 WNT3
Forced vital capacity (FVC), Best measure	5.77	4	3	6.7	0.62	0.37877	CENPW FMNL1 TWIST1 WNT3
Neuroticism (Nagel 2018)	5.56	3	3	6.7	0.00	1.00000	CENPW FMNL1 WNT3
Forced vital capacity (FVC)	5.55	3	3	6.7	0.00	1.00000	CENPW FMNL1 WNT3
Neuroticism	5.52	3	2	4.4	0.00	1.00000	CENPW FMNL1 WNT3
Sensitivity / hurt feelings	5.48	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Systolic Blood Pressure	5.32	5	4	8.9	0.24	0.69316	C4orf22 FGF5 FMNL1 PRDM8 SSPN
Lung FVC	5.26	4	4	8.9	0.68	0.32205	CENPW FMNL1 TWIST1 WNT3
Comparative height size at age 10	5.09	2	2	4.4	0.00	1.00000	CENPW WNT3
Heel T-Score	5.04	6	6	13.3	0.38	0.45954	EYA4 FMNL1 SSPN TWIST1 WNT3 ZHX3
High blood pressure	4.98	4	2	4.4	0.72	0.27604	C4orf22 FGF5 FMNL1 PRDM8
Medication: Blood pressure	4.94	3	3	6.7	0.00	1.00000	C4orf22 FGF5 FMNL1
Neuroticism score	4.93	3	2	4.4	0.00	1.00000	CENPW FMNL1 WNT3
Hypertension (Self-reported)	4.91	4	2	4.4	0.72	0.28381	C4orf22 FGF5 FMNL1 PRDM8
Forced expiratory volume in 1-second (FEV1)	4.79	3	3	6.7	0.00	1.00000	CENPW FMNL1 WNT3
Depressed Affect (Nagel 2018)	4.65	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Relative age voice broke	4.55	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Blood Red Count	4.54	5	3	6.7	-0.79	0.11480	C4orf22 CENPW FGF5 FMNL1 WNT3
Forced expiratory volume in 1-second (FEV1), Best measure	4.53	3	2	4.4	0.00	1.00000	CENPW FMNL1 WNT3
Mood swings	4.50	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Vascular/heart problems diagnosed by doctor	4.43	4	2	4.4	-0.72	0.27888	C4orf22 FGF5 FMNL1 PRDM8
Systolic blood pressure, automated reading	4.42	4	3	6.7	1.00	0.00393	C4orf22 FGF5 FMNL1 WNT3
Headache pain in last month	4.39	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Sitting height	4.37	4	3	6.7	0.02	0.97869	CENPW EYA4 TWIST1 WNT3
Cardiovascular Disease	4.28	4	2	4.4	0.65	0.35149	C4orf22 FGF5 FMNL1 PRDM8
Frequency of tenseness / restlessness in last 2 weeks	4.17	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Worry (Nagel 2018)	3.89	3	3	6.7	0.00	1.00000	CENPW FMNL1 WNT3
Nervous feelings	3.69	3	2	4.4	0.00	1.00000	CENPW FMNL1 WNT3
Medication for cholesterol	3.66	2	0	0.0	0.00	1.00000	C4orf22 FGF5
Heel bone mineral density (BMD) T-score, automated (left)	3.34	2	2	4.4	0.00	1.00000	EYA4 ZHX3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.28	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Neuroticism (2016)	3.27	2	1	2.2	0.00	1.00000	FMNL1 WNT3
Heel bone mineral density (BMD) T-score, automated (right)	3.26	2	2	4.4	0.00	1.00000	EYA4 ZHX3
Handedness (chirality/laterality): Left-handed	3.25	1	1	2.2	0.00	1.00000	WNT3
Ovarian Cancer	3.15	1	1	2.2	0.00	1.00000	WNT3
Smoking status: Previous	3.14	1	0	0.0	0.00	1.00000	PCCA
Trunk fat-free mass	3.11	2	2	4.4	0.00	1.00000	CENPW FMNL1
Standing height	3.09	3	3	6.7	0.00	1.00000	CENPW EYA4 WNT3
Trunk predicted mass	3.08	2	2	4.4	0.00	1.00000	CENPW FMNL1
Height	2.99	5	3	6.7	-0.11	0.85848	CENPW EYA4 PAX3 RPL41P1 WNT3
Medication: Blood pressure	2.98	3	1	2.2	0.00	1.00000	C4orf22 FGF5 PRDM8
Illnesses of father: High blood pressure	2.93	1	0	0.0	0.00	1.00000	C4orf22
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.89	1	0	0.0	0.00	1.00000	FMNL1
Fed-up feelings	2.86	2	1	2.2	0.00	1.00000	FMNL1 WNT3
Waist Hip Ratio (WHR)	2.81	3	3	6.7	0.00	1.00000	CENPW SSPN WNT3
Worrier / anxious feelings	2.79	2	2	4.4	0.00	1.00000	FMNL1 WNT3
Mouth/teeth dental problems: Mouth ulcers	2.78	1	1	2.2	0.00	1.00000	WNT3
Medication: Paracetamol	2.77	1	1	2.2	0.00	1.00000	WNT3
Guilty feelings	2.72	1	0	0.0	0.00	1.00000	WNT3
Medication: Ibuprofen (e.g. Nurofen)	2.66	1	0	0.0	0.00	1.00000	FMNL1
Medication for pain relief, constipation, heartburn	2.66	1	1	2.2	0.00	1.00000	WNT3
Medication: Paracetamol	2.65	1	1	2.2	0.00	1.00000	WNT3
Hearing difficulty/problems with background noise	2.61	1	0	0.0	0.00	1.00000	WNT3
Time employed in main current job	2.60	1	1	2.2	0.00	1.00000	WNT3
Blood Eosinophil Count	2.57	3	3	6.7	0.00	1.00000	C21orf96 FMNL1 WNT3
Diastolic blood pressure, automated reading	2.57	4	2	4.4	0.98	0.02126	C4orf22 FGF5 FMNL1 ZHX3
Past tobacco smoking	2.50	2	0	0.0	0.00	1.00000	PCCA WNT3
Miserableness	2.48	1	1	2.2	0.00	1.00000	WNT3
Medication: Ibuprofen	2.47	1	0	0.0	0.00	1.00000	FMNL1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.42	1	0	0.0	0.00	1.00000	FMNL1
Whole body fat-free mass	2.42	2	1	2.2	0.00	1.00000	CENPW FMNL1
Peak expiratory flow (PEF)	2.41	1	1	2.2	0.00	1.00000	WNT3
Fractured/broken bones in last 5 years	2.41	1	0	0.0	0.00	1.00000	WNT3
Breast Cancer	2.40	2	1	2.2	0.00	1.00000	FMNL1 WNT3
Irritability	2.39	1	1	2.2	0.00	1.00000	WNT3
Whole body water mass	2.37	2	1	2.2	0.00	1.00000	CENPW FMNL1
Pain experienced in last month	2.36	2	0	0.0	0.00	1.00000	CENPW WNT3
Type 2 Diabetes (T2D) (2012)	2.35	1	0	0.0	0.00	1.00000	ZHX3
Arm fat-free mass (right)	2.33	2	1	2.2	0.00	1.00000	CENPW FMNL1
Hand grip strength (left)	2.32	1	1	2.2	0.00	1.00000	WNT3
Diabetes (mother)	2.30	1	0	0.0	0.00	1.00000	ZHX3
Arm predicted mass (right)	2.30	2	1	2.2	0.00	1.00000	CENPW FMNL1
Diabetes diagnosed by doctor	2.30	2	0	0.0	0.00	1.00000	CENPW SSPN
Alcohol intake frequency.	2.29	1	1	2.2	0.00	1.00000	WNT3
Arm fat-free mass (left)	2.25	2	1	2.2	0.00	1.00000	CENPW FMNL1
Ever unenthusiastic/disinterested for a whole week	2.23	1	0	0.0	0.00	1.00000	WNT3
Age when periods started (menarche)	2.22	1	1	2.2	0.00	1.00000	CENPW
Depression (Nagel 2018)	2.20	1	0	0.0	0.00	1.00000	WNT3
High blood pressure (mother)	2.20	1	0	0.0	0.00	1.00000	C4orf22
Primary Biliary Cirrhosis	2.17	2	0	0.0	0.00	1.00000	FMNL1 WNT3
Trunk fat percentage	2.15	4	3	6.7	0.72	0.27511	CENPW FMNL1 WNT3 ZHX3
Type 2 Diabetes (T2D) (2018)	2.14	1	0	0.0	0.00	1.00000	CENPW
Qualifications: CSEs or equivalent	2.14	1	0	0.0	0.00	1.00000	WNT3
Worry too long after embarrassment	2.08	1	0	0.0	0.00	1.00000	WNT3
Qualifications: College or University degree	2.08	2	1	2.2	0.00	1.00000	PCCA WNT3
Emphysema/chronic bronchitis	2.08	1	0	0.0	0.00	1.00000	WNT3
Suffer from 'nerves'	2.07	1	0	0.0	0.00	1.00000	WNT3
Arm predicted mass (left)	2.07	2	1	2.2	0.00	1.00000	CENPW FMNL1
Frequency of depressed mood in last 2 weeks	2.03	1	0	0.0	0.00	1.00000	WNT3
Impedance of arm (left)	2.02	3	3	6.7	0.00	1.00000	CENPW FMNL1 WNT3
Body fat percentage	2.02	4	2	4.4	0.69	0.31243	CENPW FMNL1 WNT3 ZHX3
Loneliness, isolation	1.99	1	0	0.0	0.00	1.00000	WNT3
Medication for cholesterol, blood pressure or diabetes	1.98	1	0	0.0	0.00	1.00000	C4orf22
Basal metabolic rate	1.97	1	1	2.2	0.00	1.00000	CENPW
Supplements: Vitamin C	1.94	1	0	0.0	0.00	1.00000	WNT3
Leg pain on walking	1.92	1	0	0.0	0.00	1.00000	WNT3
Illnesses of father: Heart disease	1.92	1	0	0.0	0.00	1.00000	WNT3
Smoking Status	1.91	1	0	0.0	0.00	1.00000	WNT3
Medication: Atenolol	1.91	1	0	0.0	0.00	1.00000	C4orf22
Impedance of arm (right)	1.89	3	3	6.7	0.00	1.00000	CENPW FMNL1 WNT3
Impedance of whole body	1.85	3	3	6.7	0.00	1.00000	CENPW FMNL1 WNT3
Mouth/teeth dental problems	1.84	1	0	0.0	0.00	1.00000	WNT3
Medication: Gliclazide	1.80	1	0	0.0	0.00	1.00000	SSPN
Leg fat percentage (right)	1.79	2	2	4.4	0.00	1.00000	CENPW ZHX3
Number of live births	1.75	1	0	0.0	0.00	1.00000	WNT3
Mean Putamen Volume	1.74	1	0	0.0	0.00	1.00000	WNT3
Average weekly champagne plus white wine intake	1.74	1	0	0.0	0.00	1.00000	WNT3
Hand grip strength (right)	1.67	1	1	2.2	0.00	1.00000	WNT3
Myopia	1.67	1	0	0.0	0.00	1.00000	PCCA
Leg fat percentage (left)	1.66	2	2	4.4	0.00	1.00000	CENPW ZHX3
Ever depressed for a whole week	1.66	1	0	0.0	0.00	1.00000	WNT3
Crohns Disease (2012)	1.64	1	0	0.0	0.00	1.00000	WNT3
Diabetes (self-reported)	1.62	1	0	0.0	0.00	1.00000	CENPW
Leg fat-free mass (right)	1.59	1	1	2.2	0.00	1.00000	CENPW
Leg predicted mass (right)	1.58	1	1	2.2	0.00	1.00000	CENPW
Crohns Disease (2017)	1.50	1	0	0.0	0.00	1.00000	ZHX3
Pulse rate, automated reading	1.50	2	0	0.0	0.00	1.00000	C4orf22 ZHX3
Leg predicted mass (left)	1.49	1	1	2.2	0.00	1.00000	CENPW
Forced expiratory volume in 1-second (FEV1), predicted	1.49	1	1	2.2	0.00	1.00000	CENPW
Leg fat-free mass (left)	1.48	1	1	2.2	0.00	1.00000	CENPW
Intelligence (Savage-Jansen 2018)	1.44	2	1	2.2	0.00	1.00000	CENPW WNT3
Irritable Bowel Disease (IBD)	1.42	1	0	0.0	0.00	1.00000	ZHX3
Blood White Count	1.40	6	2	4.4	-0.13	0.80512	CENPW EYA4 FMNL1 SSPN WNT3 ZHX3
Arm fat percentage (left)	1.40	2	1	2.2	0.00	1.00000	CENPW ZHX3
Hip circumference	1.38	3	1	2.2	0.00	1.00000	CENPW EYA4 ZHX3
Number of full brothers	1.35	1	0	0.0	0.00	1.00000	WNT3
Trunk fat mass	1.33	2	2	4.4	0.00	1.00000	WNT3 ZHX3
Verbal and Numeric Reasoning (VNR)	1.31	1	0	0.0	0.00	1.00000	CENPW
Arm fat percentage (right)	1.31	1	1	2.2	0.00	1.00000	CENPW
Birth weight	1.21	1	0	0.0	0.00	1.00000	CENPW
Impedance of leg (left)	1.18	4	0	0.0	0.79	0.21200	CENPW FMNL1 WNT3 ZHX3
Schizophrenia (2014)	1.17	1	0	0.0	0.00	1.00000	WNT3
Impedance of leg (right)	1.17	3	0	0.0	0.00	1.00000	CENPW FMNL1 ZHX3
Ulcerative Colitis (UC)	1.09	1	0	0.0	0.00	1.00000	ZHX3
Lung FEV1/FVC ratio	1.07	2	1	2.2	0.00	1.00000	CENPW EYA4
Whole body fat mass	1.05	1	1	2.2	0.00	1.00000	ZHX3
Leg fat mass (right)	0.98	1	1	2.2	0.00	1.00000	ZHX3
Weight	0.97	1	1	2.2	0.00	1.00000	CENPW
Leg fat mass (left)	0.92	1	1	2.2	0.00	1.00000	ZHX3
Hair Pigment	0.90	6	5	11.1	0.66	0.15199	C4orf22 FGF5 PAX3 RPL41P1 TWIST1 WNT3
Blood Platelet Count	0.79	3	2	4.4	0.00	1.00000	C21orf96 WNT3 ZHX3
BMI	0.65	2	0	0.0	0.00	1.00000	C4orf22 FGF5

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Vagina	6	0.945	2.2
GTEx	Uterus	6	1.058	2.1
GTEx	Brain Hippocampus	5	0.954	2.0
GTEx	Brain Hypothalamus	6	1.017	2.0
GTEx	Brain Putamen basal ganglia	6	0.962	2.0
GTEx	Small Intestine Terminal Ileum	4	0.868	2.0
GTEx	Artery Coronary	9	0.761	1.9
GTEx	Brain Cortex	8	0.773	1.8
GTEx	Brain Nucleus accumbens basal ganglia	7	0.809	1.8
GTEx	Breast Mammary Tissue (Male)	7	0.587	1.8
GTEx	Cells EBV-transformed lymphocytes	10	0.703	1.8
GTEx	Esophagus Gastroesophageal Junction	8	0.554	1.8
GTEx	Liver	5	0.697	1.8
GTEx	Ovary	7	0.771	1.8
GTEx	Prostate	5	0.599	1.8
GTEx	Stomach	9	0.619	1.8
GTEx	Brain Cerebellar Hemisphere	8	0.537	1.7
GTEx	Brain Frontal Cortex BA9	6	0.649	1.7
GTEx	Colon Sigmoid	7	0.479	1.7
GTEx	Heart Atrial Appendage	7	0.443	1.7
GTEx	Heart Left Ventricle	7	0.458	1.7
GTEx	Pancreas	9	0.551	1.7
GTEx	Pituitary	5	0.448	1.7
GTEx	Adipose Visceral Omentum	7	0.344	1.6
GTEx	Adrenal Gland	5	0.343	1.6
GTEx	Artery Aorta	8	0.269	1.6
GTEx	Brain Caudate basal ganglia	5	0.543	1.6
GTEx	Brain Cerebellum	6	0.303	1.6
GTEx	Breast Mammary Tissue	9	0.456	1.6
GTEx	Breast Mammary Tissue (Female)	10	0.608	1.6
GTEx	Colon Transverse	8	0.388	1.6
GTEx	Esophagus Muscularis	10	0.309	1.6
GTEx	Lung	9	0.313	1.6
GTEx	Skin Not Sun Exposed Suprapubic	8	0.325	1.6
GTEx	Spleen	6	0.425	1.6
GTEx	Whole Blood	6	0.301	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	3	0.438	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	4	0.391	1.6
GTEx	Adipose Subcutaneous	7	0.201	1.5
GTEx	Esophagus Mucosa	10	0.301	1.5
GTEx	Muscle Skeletal	8	0.277	1.5
GTEx	Nerve Tibial	9	0.208	1.5
GTEx	Skin Sun Exposed Lower leg	9	0.247	1.5
GTEx	Testis	11	0.349	1.5
GTEx	Thyroid	10	0.250	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.365	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	4	0.301	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	4	0.375	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.394	1.5
GTEx	Artery Tibial	5	0.133	1.4
GTEx	Cells Transformed fibroblasts	9	0.214	1.4
CommonMind	Brain Pre-frontal Cortex	5	0.093	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	8	0.182	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	8	0.195	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	5	0.116	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	4	0.136	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	5	0.200	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	5	0.314	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	3	0.181	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	7	0.151	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	2	0.289	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	5	0.297	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.156	1.4
METSIM	Adipose	1	0.022	1.3
NTR	Blood	3	0.125	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	5	0.097	1.3
YFS	Blood	1	0.022	1.2