Hub : Traits :

Supplements: Calcium

5 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 19 3268722 5153606 2 1 1.4e-08 6.9e-09 0.057 89 UBXN6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Blood Platelet Count 0.57 1 0 0 0 1 UBXN6
Blood Red Count 6.78 1 1 3 0 1 UBXN6
BMI 3.26 1 0 0 0 1 UBXN6
Systolic Blood Pressure 2.03 1 0 0 0 1 UBXN6
Cardiovascular Disease 2.29 1 0 0 0 1 UBXN6
Respiratory disease 3.48 1 0 0 0 1 UBXN6
Type 2 Diabetes (T2D) 6.55 1 0 0 0 1 UBXN6
Lung FEV1/FVC ratio 1.76 1 0 0 0 1 UBXN6
Lung FVC 1.29 1 0 0 0 1 UBXN6
Neuroticism 3.87 1 0 0 0 1 UBXN6
Chronotype (morning person) 6.39 1 0 0 0 1 UBXN6
Hair Pigment 0.57 1 0 0 0 1 UBXN6
Number of treatments/medications taken 4.35 1 0 0 0 1 UBXN6
Systolic blood pressure, automated reading 2.40 1 0 0 0 1 UBXN6
Impedance of leg (right) 6.85 1 1 3 0 1 UBXN6
Leg fat-free mass (left) 3.97 1 0 0 0 1 UBXN6
Body mass index (BMI) 3.33 1 0 0 0 1 UBXN6
Impedance of leg (left) 7.15 1 1 3 0 1 UBXN6
Leg predicted mass (left) 3.92 1 0 0 0 1 UBXN6
Waist circumference 3.84 1 0 0 0 1 UBXN6
Weight 2.94 1 0 0 0 1 UBXN6
Impedance of arm (right) 6.82 1 1 3 0 1 UBXN6
Trunk fat-free mass 2.93 1 0 0 0 1 UBXN6
Hip circumference 2.55 1 0 0 0 1 UBXN6
Medication: Ibuprofen (e.g. Nurofen) 5.40 1 0 0 0 1 UBXN6
Impedance of arm (left) 6.57 1 1 3 0 1 UBXN6
Arm fat mass (right) 1.94 1 0 0 0 1 UBXN6
Trunk predicted mass 2.97 1 0 0 0 1 UBXN6
Peak expiratory flow (PEF) 3.05 1 0 0 0 1 UBXN6
Arm fat-free mass (right) 4.48 1 0 0 0 1 UBXN6
Medication: Ibuprofen 8.49 1 0 0 0 1 UBXN6
Leg fat mass (right) 2.07 1 0 0 0 1 UBXN6
Arm predicted mass (right) 4.77 1 0 0 0 1 UBXN6
Whole body fat-free mass 3.67 1 0 0 0 1 UBXN6
Leg fat-free mass (right) 3.75 1 0 0 0 1 UBXN6
Qualifications: nursing, teaching 5.21 1 0 0 0 1 UBXN6
Mineral and other dietary supplements 6.48 1 0 0 0 1 UBXN6
Whole body water mass 3.80 1 0 0 0 1 UBXN6
Leg predicted mass (right) 3.82 1 0 0 0 1 UBXN6
Arm fat mass (left) 1.99 1 0 0 0 1 UBXN6
Basal metabolic rate 3.44 1 0 0 0 1 UBXN6
Arm fat-free mass (left) 4.14 1 0 0 0 1 UBXN6
Impedance of whole body 7.19 1 1 3 0 1 UBXN6
Leg fat mass (left) 1.95 1 0 0 0 1 UBXN6
Arm predicted mass (left) 4.10 1 0 0 0 1 UBXN6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.10
GTEx Adipose Visceral Omentum 0 0.0000 1.12
GTEx Adrenal Gland 0 0.0000 1.05
GTEx Artery Aorta 0 0.0000 1.12
GTEx Artery Coronary 0 0.0000 1.04
GTEx Artery Tibial 0 0.0000 1.10
GTEx Brain Caudate basal ganglia 0 0.0000 1.02
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.09
GTEx Brain Cerebellum 0 0.0000 1.16
GTEx Brain Cortex 0 0.0000 1.16
GTEx Brain Frontal Cortex BA9 0 0.0000 1.11
GTEx Brain Hippocampus 0 0.0000 1.04
GTEx Brain Hypothalamus 0 0.0000 1.11
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.07
GTEx Brain Putamen basal ganglia 0 0.0000 1.20
GTEx Breast Mammary Tissue 0 0.0000 1.10
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.13
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.09
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.03
GTEx Cells Transformed fibroblasts 1 0.0238 1.11
GTEx Colon Sigmoid 0 0.0000 1.11
GTEx Colon Transverse 0 0.0000 1.11
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.04
GTEx Esophagus Mucosa 0 0.0000 1.13
GTEx Esophagus Muscularis 0 0.0000 1.11
GTEx Heart Atrial Appendage 0 0.0000 1.10
GTEx Heart Left Ventricle 1 0.0654 1.14
GTEx Liver 0 0.0000 1.04
GTEx Lung 0 0.0000 1.13
GTEx Muscle Skeletal 0 0.0000 1.09
GTEx Nerve Tibial 0 0.0000 1.12
GTEx Ovary 0 0.0000 1.05
GTEx Pancreas 0 0.0000 1.12
GTEx Pituitary 0 0.0000 1.11
GTEx Prostate 1 0.1198 1.07
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.15
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.12
GTEx Small Intestine Terminal Ileum 0 0.0000 1.06
GTEx Spleen 0 0.0000 1.09
GTEx Stomach 0 0.0000 1.14
GTEx Testis 0 0.0000 1.10
GTEx Thyroid 0 0.0000 1.08
GTEx Uterus 0 0.0000 1.05
GTEx Vagina 0 0.0000 1.05
GTEx Whole Blood 1 0.0502 1.11
METSIM Adipose 0 0.0000 1.13
NTR Blood 0 0.0000 1.12
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.18
YFS Blood 0 0.0000 1.14
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.12
TCGA Breast Tumor 0 0.0000 1.12
TCGA Breast Normal 0 0.0000 1.07
TCGA Ovarian Tumor 0 0.0000 1.08
TCGA Prostate Tumor 0 0.0000 1.15