TWAS hub - Medication: Seretide 50 evohaler

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	102680184	103216820	1	1	1.2e-08	1.6e-10	0.0015	76	IL1RL1

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Blood Eosinophil Count	230.12	1	1	2.2	1	IL1RL1
Allergy	160.29	1	1	2.2	1	IL1RL1
Respiratory disease	148.83	1	1	2.2	1	IL1RL1
Asthma (self-reported)	140.05	1	1	2.2	1	IL1RL1
Asthma	139.73	1	1	2.2	1	IL1RL1
Allergy or Eczema	132.83	1	1	2.2	1	IL1RL1
Hayfever, allergic rhinitis or eczema	117.93	1	1	2.2	1	IL1RL1
Wheeze or whistling in the chest in last year	75.43	1	1	2.2	1	IL1RL1
Medication: Ventolin 100micrograms inhaler	75.34	1	1	2.2	1	IL1RL1
Hayfever/allergic rhinitis (self-reported)	67.87	1	1	2.2	1	IL1RL1
Taking other prescription medications	14.95	1	0	0.0	1	IL1RL1
Chest pain or discomfort	14.30	1	0	0.0	1	IL1RL1
Number of self-reported non-cancer illnesses	12.46	1	0	0.0	1	IL1RL1
Lung FEV1/FVC ratio	12.30	1	1	2.2	1	IL1RL1
Medication: Atenolol	10.24	1	0	0.0	1	IL1RL1
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.71	1	0	0.0	1	IL1RL1
Had other major operations	6.33	1	0	0.0	1	IL1RL1
Ever unenthusiastic/disinterested for a whole week	5.40	1	0	0.0	1	IL1RL1
Loud music exposure frequency	5.32	1	0	0.0	1	IL1RL1
Emphysema/chronic bronchitis	5.15	1	0	0.0	1	IL1RL1
Noisy workplace	4.87	1	0	0.0	1	IL1RL1
Age at First Birth	4.83	1	0	0.0	1	IL1RL1
Townsend deprivation index at recruitment	4.63	1	0	0.0	1	IL1RL1
Number of treatments/medications taken	4.55	1	0	0.0	1	IL1RL1
Osteoarthritis (self-reported)	3.88	1	0	0.0	1	IL1RL1
Qualifications: CSEs or equivalent	3.83	1	0	0.0	1	IL1RL1
Long-standing illness, disability or infirmity	3.43	1	0	0.0	1	IL1RL1
Schizophrenia (2018)	2.60	1	0	0.0	1	IL1RL1
Fluid intelligence score	2.55	1	0	0.0	1	IL1RL1
Verbal and Numeric Reasoning (VNR)	2.36	1	0	0.0	1	IL1RL1
Neuroticism (Nagel 2018)	2.29	1	0	0.0	1	IL1RL1
Blood White Count	2.16	1	0	0.0	1	IL1RL1
Irritable Bowel Disease (IBD)	2.15	1	0	0.0	1	IL1RL1
Intelligence (Savage-Jansen 2018)	1.85	1	0	0.0	1	IL1RL1
Height	0.74	1	0	0.0	1	IL1RL1
Blood Platelet Count	0.57	1	0	0.0	1	IL1RL1

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
GTEx	Adipose Subcutaneous	0	0.000	1.1
GTEx	Artery Aorta	0	0.000	1.1
GTEx	Artery Coronary	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.1
GTEx	Colon Sigmoid	0	0.000	1.1
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.1
GTEx	Esophagus Mucosa	0	0.000	1.1
GTEx	Esophagus Muscularis	0	0.000	1.1
GTEx	Heart Left Ventricle	0	0.000	1.1
GTEx	Lung	0	0.000	1.1
GTEx	Ovary	0	0.000	1.1
GTEx	Pancreas	0	0.000	1.1
GTEx	Prostate	0	0.000	1.1
GTEx	Stomach	0	0.000	1.1
GTEx	Uterus	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.0

Hub : Traits :

Medication: Seretide 50 evohaler

Significant Loci

Pleiotropic Associations

Associations by panel