Hub : Traits :

Medication: Seretide 50 evohaler

2 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 102680184 103216820 1 1 1.2e-08 1.6e-10 0.0015 76 IL1RL1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Intelligence (Savage-Jansen 2018) 1.85 1 0 0.0 0 1 IL1RL1
Neuroticism (Nagel 2018) 2.29 1 0 0.0 0 1 IL1RL1
Schizophrenia (2018) 2.60 1 0 0.0 0 1 IL1RL1
Irritable Bowel Disease (IBD) 2.15 1 0 0.0 0 1 IL1RL1
Verbal and Numeric Reasoning (VNR) 2.36 1 0 0.0 0 1 IL1RL1
Age at First Birth 4.83 1 0 0.0 0 1 IL1RL1
Blood Eosinophil Count 230.12 1 1 2.2 0 1 IL1RL1
Blood Platelet Count 0.57 1 0 0.0 0 1 IL1RL1
Blood White Count 2.16 1 0 0.0 0 1 IL1RL1
Height 0.74 1 0 0.0 0 1 IL1RL1
Allergy or Eczema 132.83 1 1 2.2 0 1 IL1RL1
Respiratory disease 148.83 1 1 2.2 0 1 IL1RL1
Lung FEV1/FVC ratio 12.30 1 1 2.2 0 1 IL1RL1
Number of treatments/medications taken 4.55 1 0 0.0 0 1 IL1RL1
Townsend deprivation index at recruitment 4.63 1 0 0.0 0 1 IL1RL1
Taking other prescription medications 14.95 1 0 0.0 0 1 IL1RL1
Qualifications: CSEs or equivalent 3.83 1 0 0.0 0 1 IL1RL1
Hayfever, allergic rhinitis or eczema 117.93 1 1 2.2 0 1 IL1RL1
Medication: Atenolol 10.24 1 0 0.0 0 1 IL1RL1
Had other major operations 6.33 1 0 0.0 0 1 IL1RL1
Ever unenthusiastic/disinterested for a whole week 5.40 1 0 0.0 0 1 IL1RL1
Allergy 160.29 1 1 2.2 0 1 IL1RL1
Hayfever/allergic rhinitis (self-reported) 67.87 1 1 2.2 0 1 IL1RL1
Fluid intelligence score 2.55 1 0 0.0 0 1 IL1RL1
Noisy workplace 4.87 1 0 0.0 0 1 IL1RL1
Asthma 139.73 1 1 2.2 0 1 IL1RL1
Loud music exposure frequency 5.32 1 0 0.0 0 1 IL1RL1
Medication: Ventolin 100micrograms inhaler 75.34 1 1 2.2 0 1 IL1RL1
Wheeze or whistling in the chest in last year 75.43 1 1 2.2 0 1 IL1RL1
Emphysema/chronic bronchitis 5.15 1 0 0.0 0 1 IL1RL1
Chest pain or discomfort 14.30 1 0 0.0 0 1 IL1RL1
Long-standing illness, disability or infirmity 3.43 1 0 0.0 0 1 IL1RL1
Medication: Laxatives (e.g. Dulcolax, Senokot) 6.71 1 0 0.0 0 1 IL1RL1
Asthma (self-reported) 140.05 1 1 2.2 0 1 IL1RL1
Osteoarthritis (self-reported) 3.88 1 0 0.0 0 1 IL1RL1
Number of self-reported non-cancer illnesses 12.46 1 0 0.0 0 1 IL1RL1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.1
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.1
GTEx Artery Coronary 0 0.000 1.1
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.1
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.1
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.1
GTEx Esophagus Mucosa 0 0.000 1.1
GTEx Esophagus Muscularis 0 0.000 1.1
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.1
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.1
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.1
GTEx Pancreas 0 0.000 1.1
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.1
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.1
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.1
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.0