Hub : Traits :

Hearing aid user

8 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 53989244 55590761 1 1 3.2e-08 3.8e-07 6.2e-02 86 SPTBN1
2 5 72162264 73576479 1 1 7.5e-09 7.5e-11 3.8e-07 39 UTP15

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Neuroticism 4.42 1 0 0 0 1 UTP15
Heel T-Score 1.81 1 0 0 0 1 SPTBN1
BMI 0.87 1 0 0 0 1 UTP15
Height 0.31 1 0 0 0 1 SPTBN1
Lung FEV1/FVC ratio 2.27 2 0 0 0 1 SPTBN1 UTP15
Hair Pigment 0.59 2 0 0 0 1 SPTBN1 UTP15
Hearing difficulty/problems: Yes 18.99 2 1 3 0 1 SPTBN1 UTP15
Hearing difficulty/problems with background noise 9.81 2 0 0 0 1 SPTBN1 UTP15
Hair/balding pattern: Pattern 2 2.97 1 0 0 0 1 SPTBN1
Had menopause 3.11 1 0 0 0 1 UTP15
Number of live births 3.08 1 0 0 0 1 SPTBN1
Forced expiratory volume in 1-second (FEV1), Best measure 1.71 1 0 0 0 1 SPTBN1
Birth weight of first child 5.13 1 0 0 0 1 UTP15
Comparative height size at age 10 1.20 1 0 0 0 1 SPTBN1
Had major operations 4.42 1 0 0 0 1 SPTBN1
Commuting to job workplace: Cycle 5.58 1 0 0 0 1 SPTBN1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.16
GTEx Adipose Visceral Omentum 0 0.0000 1.13
GTEx Adrenal Gland 0 0.0000 1.11
GTEx Artery Aorta 1 0.0336 1.15
GTEx Artery Coronary 0 0.0000 1.12
GTEx Artery Tibial 2 0.0532 1.15
GTEx Brain Caudate basal ganglia 0 0.0000 1.16
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.12
GTEx Brain Cerebellum 0 0.0000 1.14
GTEx Brain Cortex 0 0.0000 1.16
GTEx Brain Frontal Cortex BA9 0 0.0000 1.16
GTEx Brain Hippocampus 0 0.0000 1.19
GTEx Brain Hypothalamus 0 0.0000 1.15
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.12
GTEx Brain Putamen basal ganglia 0 0.0000 1.19
GTEx Breast Mammary Tissue 0 0.0000 1.17
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.10
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.11
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.22
GTEx Cells Transformed fibroblasts 0 0.0000 1.18
GTEx Colon Sigmoid 0 0.0000 1.20
GTEx Colon Transverse 0 0.0000 1.14
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.15
GTEx Esophagus Mucosa 0 0.0000 1.15
GTEx Esophagus Muscularis 0 0.0000 1.15
GTEx Heart Atrial Appendage 0 0.0000 1.08
GTEx Heart Left Ventricle 0 0.0000 1.11
GTEx Liver 0 0.0000 1.05
GTEx Lung 0 0.0000 1.15
GTEx Muscle Skeletal 0 0.0000 1.09
GTEx Nerve Tibial 0 0.0000 1.12
GTEx Ovary 0 0.0000 1.16
GTEx Pancreas 0 0.0000 1.15
GTEx Pituitary 0 0.0000 1.10
GTEx Prostate 0 0.0000 1.19
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.13
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.11
GTEx Small Intestine Terminal Ileum 0 0.0000 1.17
GTEx Spleen 0 0.0000 1.09
GTEx Stomach 0 0.0000 1.08
GTEx Testis 0 0.0000 1.16
GTEx Thyroid 0 0.0000 1.13
GTEx Uterus 0 0.0000 1.23
GTEx Vagina 0 0.0000 1.15
GTEx Whole Blood 0 0.0000 1.16
METSIM Adipose 1 0.0217 1.12
NTR Blood 0 0.0000 1.16
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.15
YFS Blood 1 0.0217 1.15
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.14
TCGA Breast Tumor 0 0.0000 1.10
TCGA Breast Normal 0 0.0000 1.06
TCGA Ovarian Tumor 0 0.0000 1.10
TCGA Prostate Tumor 0 0.0000 1.12