Hub : Traits :

Pulse wave reflection index

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 8 143671615 145059425 1 1 4.0e-07 1.4e-05 6.9e-01 99 RP13-582O9.5
2 20 36139650 37586842 1 1 1.5e-07 3.1e-12 4.8e-08 39 KIAA1755

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Lupus 2.47 1 0 0 0 1 KIAA1755
Rheumatoid Arthritis 2.67 1 0 0 0 1 RP13-582O9.5
Type 2 Diabetes (T2D) 2.40 1 0 0 0 1 KIAA1755
Blood Platelet Count 0.47 1 0 0 0 1 KIAA1755
Blood Red Count 0.76 2 0 0 0 1 KIAA1755 RP13-582O9.5
Blood White Count 0.63 1 0 0 0 1 RP13-582O9.5
BMI 0.83 1 0 0 0 1 RP13-582O9.5
Height 1.12 2 1 3 0 1 KIAA1755 RP13-582O9.5
Smoking Status 2.79 1 0 0 0 1 KIAA1755
Type 2 Diabetes (T2D) 1.59 1 0 0 0 1 KIAA1755
Lung FEV1/FVC ratio 1.00 1 0 0 0 1 RP13-582O9.5
Hair Pigment 0.13 1 0 0 0 1 KIAA1755
Impedance of leg (right) 1.24 1 0 0 0 1 KIAA1755
Leg fat-free mass (left) 0.87 1 0 0 0 1 KIAA1755
Hand grip strength (right) 1.27 1 0 0 0 1 RP13-582O9.5
Current tobacco smoking 2.21 1 0 0 0 1 RP13-582O9.5
Age when periods started (menarche) 2.71 1 0 0 0 1 RP13-582O9.5
Diverticular disease/diverticulitis (self-reported) 3.06 1 0 0 0 1 RP13-582O9.5
Sitting height 1.62 1 0 0 0 1 KIAA1755
Body mass index (BMI) 0.84 1 0 0 0 1 RP13-582O9.5
Impedance of leg (left) 0.99 1 0 0 0 1 KIAA1755
Leg predicted mass (left) 0.97 1 0 0 0 1 KIAA1755
Number of incorrect matches in round 4.15 1 0 0 0 1 RP13-582O9.5
Hearing difficulty/problems with background noise 3.25 1 0 0 0 1 RP13-582O9.5
Had menopause 3.31 1 0 0 0 1 RP13-582O9.5
Forced vital capacity (FVC) 1.25 1 0 0 0 1 RP13-582O9.5
Diabetes (self-reported) 2.01 1 0 0 0 1 KIAA1755
Impedance of arm (right) 1.45 1 0 0 0 1 RP13-582O9.5
Trunk fat-free mass 0.65 1 0 0 0 1 KIAA1755
Frequency of tiredness / lethargy in last 2 weeks 1.86 1 0 0 0 1 RP13-582O9.5
Number of live births 3.23 1 0 0 0 1 RP13-582O9.5
Forced expiratory volume in 1-second (FEV1) 2.34 1 0 0 0 1 RP13-582O9.5
Pulse rate 26.79 1 1 3 0 1 KIAA1755
Medication: Ibuprofen (e.g. Nurofen) 3.15 1 0 0 0 1 RP13-582O9.5
Forced expiratory volume in 1-second (FEV1), Best measure 3.32 1 0 0 0 1 RP13-582O9.5
Pulse wave Arterial Stiffness index 8.13 1 0 0 0 1 RP13-582O9.5
Impedance of arm (left) 1.27 1 0 0 0 1 RP13-582O9.5
Trunk predicted mass 0.63 1 0 0 0 1 KIAA1755
Standing height 1.15 2 0 0 0 1 KIAA1755 RP13-582O9.5
Birth weight of first child 1.74 1 0 0 0 1 KIAA1755
Peak expiratory flow (PEF) 4.50 2 0 0 0 1 KIAA1755 RP13-582O9.5
Mouth/teeth dental problems: Bleeding gums 4.42 1 0 0 0 1 RP13-582O9.5
Medication: Paracetamol 2.01 1 0 0 0 1 KIAA1755
Gout (self-reported) 3.87 1 0 0 0 1 KIAA1755
Forced vital capacity (FVC), Best measure 1.79 1 0 0 0 1 RP13-582O9.5
Leg fat percentage (right) 2.22 2 0 0 0 1 KIAA1755 RP13-582O9.5
Arm fat-free mass (right) 0.51 1 0 0 0 1 KIAA1755
Comparative body size at age 10 1.21 1 0 0 0 1 RP13-582O9.5
Pulse wave peak to peak time 8.57 1 0 0 0 1 RP13-582O9.5
Medication for pain relief, constipation, heartburn 3.04 1 0 0 0 1 KIAA1755
Medication: Ibuprofen 2.75 1 0 0 0 1 RP13-582O9.5
Mean time to correctly identify matches 2.81 1 0 0 0 1 RP13-582O9.5
Heart disease (mother) 3.00 1 0 0 0 1 RP13-582O9.5
Pulse rate, automated reading 31.76 2 1 3 0 1 KIAA1755 RP13-582O9.5
Alcohol intake frequency. 2.35 1 0 0 0 1 KIAA1755
Comparative height size at age 10 0.66 1 0 0 0 1 RP13-582O9.5
Number of full sisters 2.10 1 0 0 0 1 RP13-582O9.5
Smoking status: Previous 2.01 1 0 0 0 1 KIAA1755
Forced expiratory volume in 1-second (FEV1), predicted 3.69 1 0 0 0 1 RP13-582O9.5
Whole body fat-free mass 0.78 1 0 0 0 1 KIAA1755
Leg fat-free mass (right) 1.18 1 0 0 0 1 KIAA1755
Osteoarthritis (self-reported) 5.34 2 0 0 0 1 KIAA1755 RP13-582O9.5
Smoking status: Current 2.68 1 0 0 0 1 RP13-582O9.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.91 1 0 0 0 1 RP13-582O9.5
Whole body water mass 0.79 1 0 0 0 1 KIAA1755
Leg predicted mass (right) 1.13 1 0 0 0 1 KIAA1755
Basal metabolic rate 0.56 1 0 0 0 1 KIAA1755
Leg fat percentage (left) 2.10 1 0 0 0 1 RP13-582O9.5
Arm fat-free mass (left) 0.56 1 0 0 0 1 KIAA1755
Number of operations (self-reported) 1.91 1 0 0 0 1 RP13-582O9.5
Irritability 1.94 1 0 0 0 1 RP13-582O9.5
Diastolic blood pressure, automated reading 2.39 1 0 0 0 1 KIAA1755
Commuting to job workplace: Cycle 5.89 1 0 0 0 1 RP13-582O9.5
Medication: Omeprazole (e.g. Zanprol) 2.18 1 0 0 0 1 RP13-582O9.5
Impedance of whole body 1.02 1 0 0 0 1 RP13-582O9.5
Arm predicted mass (left) 0.62 1 0 0 0 1 KIAA1755

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.26
GTEx Adipose Visceral Omentum 0 0.0000 1.30
GTEx Adrenal Gland 0 0.0000 1.21
GTEx Artery Aorta 0 0.0000 1.25
GTEx Artery Coronary 0 0.0000 1.23
GTEx Artery Tibial 0 0.0000 1.25
GTEx Brain Caudate basal ganglia 0 0.0000 1.20
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.27
GTEx Brain Cerebellum 0 0.0000 1.31
GTEx Brain Cortex 0 0.0000 1.20
GTEx Brain Frontal Cortex BA9 0 0.0000 1.28
GTEx Brain Hippocampus 0 0.0000 1.23
GTEx Brain Hypothalamus 0 0.0000 1.25
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.28
GTEx Brain Putamen basal ganglia 0 0.0000 1.33
GTEx Breast Mammary Tissue 0 0.0000 1.18
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.23
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.24
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.29
GTEx Cells Transformed fibroblasts 0 0.0000 1.23
GTEx Colon Sigmoid 0 0.0000 1.26
GTEx Colon Transverse 0 0.0000 1.28
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.21
GTEx Esophagus Mucosa 0 0.0000 1.27
GTEx Esophagus Muscularis 0 0.0000 1.22
GTEx Heart Atrial Appendage 0 0.0000 1.26
GTEx Heart Left Ventricle 0 0.0000 1.25
GTEx Liver 0 0.0000 1.27
GTEx Lung 0 0.0000 1.24
GTEx Muscle Skeletal 0 0.0000 1.20
GTEx Nerve Tibial 0 0.0000 1.22
GTEx Ovary 0 0.0000 1.25
GTEx Pancreas 0 0.0000 1.23
GTEx Pituitary 0 0.0000 1.19
GTEx Prostate 0 0.0000 1.21
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.21
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.23
GTEx Small Intestine Terminal Ileum 0 0.0000 1.31
GTEx Spleen 0 0.0000 1.24
GTEx Stomach 0 0.0000 1.23
GTEx Testis 1 0.0317 1.28
GTEx Thyroid 0 0.0000 1.22
GTEx Uterus 0 0.0000 1.19
GTEx Vagina 1 0.1575 1.20
GTEx Whole Blood 0 0.0000 1.22
METSIM Adipose 0 0.0000 1.23
NTR Blood 0 0.0000 1.30
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.28
YFS Blood 0 0.0000 1.24
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.27
TCGA Breast Tumor 0 0.0000 1.24
TCGA Breast Normal 0 0.0000 1.22
TCGA Ovarian Tumor 0 0.0000 1.23
TCGA Prostate Tumor 0 0.0000 1.22