Hub : Traits :

Osteoarthritis (self-reported)

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 69978290 71471456 1 1 1.1e-08 1.6e-10 0.004 80 TGFA

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Prostate Cancer 3.60 1 0 0.0 0 1 TGFA
Age at First Birth 6.96 1 0 0.0 0 1 TGFA
Blood Platelet Count 0.55 1 0 0.0 0 1 TGFA
Heel T-Score 2.06 1 0 0.0 0 1 TGFA
BMI 2.00 1 0 0.0 0 1 TGFA
Allergy or Eczema 2.06 1 0 0.0 0 1 TGFA
Hand grip strength (left) 23.09 1 1 2.2 0 1 TGFA
Angina 5.65 1 0 0.0 0 1 TGFA
Diabetes (father) 6.17 1 0 0.0 0 1 TGFA
Impedance of leg (right) 1.27 1 0 0.0 0 1 TGFA
Trunk fat percentage 1.21 1 0 0.0 0 1 TGFA
Hand grip strength (right) 26.28 1 1 2.2 0 1 TGFA
Fed-up feelings 2.69 1 0 0.0 0 1 TGFA
Heel bone mineral density (BMD) T-score, automated (left) 4.40 1 0 0.0 0 1 TGFA
Multivitamins +/- minerals 3.48 1 0 0.0 0 1 TGFA
Supplements: Glucosamine 6.01 1 0 0.0 0 1 TGFA
High blood pressure (mother) 2.82 1 0 0.0 0 1 TGFA
Body mass index (BMI) 2.24 1 0 0.0 0 1 TGFA
Impedance of leg (left) 1.34 1 0 0.0 0 1 TGFA
Trunk fat mass 1.09 1 0 0.0 0 1 TGFA
Waist circumference 1.08 1 0 0.0 0 1 TGFA
Heel bone mineral density (BMD) T-score, automated (right) 2.35 1 0 0.0 0 1 TGFA
Allergy 2.32 1 0 0.0 0 1 TGFA
Weight 1.15 1 0 0.0 0 1 TGFA
Arm fat percentage (right) 1.64 1 0 0.0 0 1 TGFA
Hip circumference 1.87 1 0 0.0 0 1 TGFA
Frequency of tiredness / lethargy in last 2 weeks 2.41 1 0 0.0 0 1 TGFA
Asthma 2.87 1 0 0.0 0 1 TGFA
Medication: Ibuprofen (e.g. Nurofen) 6.86 1 0 0.0 0 1 TGFA
Pulse wave Arterial Stiffness index 4.31 1 0 0.0 0 1 TGFA
Arm fat mass (right) 1.34 1 0 0.0 0 1 TGFA
Exposure to tobacco smoke at home 3.60 1 0 0.0 0 1 TGFA
Loud music exposure frequency 9.02 1 0 0.0 0 1 TGFA
Medication: Paracetamol 4.78 1 0 0.0 0 1 TGFA
Body fat percentage 1.15 1 0 0.0 0 1 TGFA
Pulse wave peak to peak time 4.85 1 0 0.0 0 1 TGFA
Medication for pain relief, constipation, heartburn 7.33 1 0 0.0 0 1 TGFA
Angina (self-reported) 6.01 1 0 0.0 0 1 TGFA
Medication: Ibuprofen 8.09 1 0 0.0 0 1 TGFA
Whole body fat mass 1.38 1 0 0.0 0 1 TGFA
Leg fat mass (right) 1.33 1 0 0.0 0 1 TGFA
Overall health rating 3.62 1 0 0.0 0 1 TGFA
Knee pain experienced in last month 5.59 1 0 0.0 0 1 TGFA
Arm fat percentage (left) 1.83 1 0 0.0 0 1 TGFA
Long-standing illness, disability or infirmity 4.39 1 0 0.0 0 1 TGFA
Asthma (self-reported) 2.39 1 0 0.0 0 1 TGFA
Arm fat mass (left) 1.47 1 0 0.0 0 1 TGFA
Number of self-reported non-cancer illnesses 2.59 1 0 0.0 0 1 TGFA
Pain type(s) experienced in last month: Hip pain 3.50 1 0 0.0 0 1 TGFA
Medication: Paracetamol 4.85 1 0 0.0 0 1 TGFA
Medication: Omeprazole (e.g. Zanprol) 3.51 1 0 0.0 0 1 TGFA
Basal cell carcinoma (self-reported) 4.07 1 0 0.0 0 1 TGFA
Leg fat mass (left) 1.22 1 0 0.0 0 1 TGFA

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 1 0.019 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1