Hub : Traits :

HbA1C

55 significantly associated models · 10 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 3327407 4763028 1 1 3.8e-09 1.1e-03 1.3e-03 3 PRPF4B
2 10 70332066 71859953 1 1 1.2e-12 3.2e-25 2.1e-14 46 HK1
3 12 111645043 113036817 1 1 1.1e-07 3.8e-06 9.7e-01 100 ADAM1A
4 13 102551035 104030692 1 1 8.8e-11 1.9e-03 1.5e-04 -50 TPP2
5 17 79977970 81051007 6 1 3.1e-25 1.6e-26 8.4e-03 94 FN3K

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Fasting Glucose 7.48 1 1 3.0 0 1 PRPF4B
Blood Eosinophil Count 1.99 1 1 3.0 0 1 ADAM1A
Blood Platelet Count 3.21 3 1 3.0 0 1 ADAM1A FN3K HK1
Blood Red Count 5.45 2 2 6.1 0 1 ADAM1A HK1
Blood White Count 1.98 1 1 3.0 0 1 ADAM1A
Height 0.25 1 0 0.0 0 1 FN3K
Systolic Blood Pressure 1.40 1 1 3.0 0 1 ADAM1A
Smoking Status 2.01 1 0 0.0 0 1 ADAM1A
Allergy or Eczema 2.23 1 0 0.0 0 1 ADAM1A
Cardiovascular Disease 1.83 1 0 0.0 0 1 ADAM1A
High blood pressure 1.85 1 0 0.0 0 1 ADAM1A
Hayfever, allergic rhinitis or eczema 2.41 1 0 0.0 0 1 ADAM1A
Medication: Levothyroxine sodium 2.18 1 0 0.0 0 1 ADAM1A
Past tobacco smoking 2.22 1 0 0.0 0 1 ADAM1A
Allergy 2.50 1 0 0.0 0 1 HK1
Pulse wave Arterial Stiffness index 3.15 1 0 0.0 0 1 ADAM1A
Birth weight of first child 2.33 1 0 0.0 0 1 HK1
Birth weight 2.32 1 0 0.0 0 1 ADAM1A
Wheeze or whistling in the chest in last year 2.64 1 0 0.0 0 1 PRPF4B
Pulse wave peak to peak time 3.21 1 0 0.0 0 1 ADAM1A
Hypertension (Self-reported) 2.08 1 0 0.0 0 1 ADAM1A
Diastolic blood pressure, automated reading 1.16 1 0 0.0 0 1 ADAM1A
Vascular/heart problems diagnosed by doctor 1.71 1 0 0.0 0 1 ADAM1A
Heart attack/myocardial infarction (self-reported) 3.70 1 0 0.0 0 1 HK1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0578 1.11
GTEx Adipose Visceral Omentum 1 0.0495 1.17
GTEx Adrenal Gland 1 0.0691 1.18
GTEx Artery Aorta 1 0.0339 1.09
GTEx Artery Coronary 1 0.0851 1.17
GTEx Artery Tibial 1 0.0268 1.12
GTEx Brain Caudate basal ganglia 0 0.0000 1.17
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.06
GTEx Brain Cerebellum 0 0.0000 1.05
GTEx Brain Cortex 3 0.2921 1.20
GTEx Brain Frontal Cortex BA9 1 0.1093 1.18
GTEx Brain Hippocampus 1 0.1919 1.23
GTEx Brain Hypothalamus 1 0.1701 1.12
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.16
GTEx Brain Putamen basal ganglia 0 0.0000 1.09
GTEx Breast Mammary Tissue 1 0.0509 1.11
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.09
GTEx Breast Mammary Tissue (Female) 1 0.0617 1.12
GTEx Cells EBV-transformed lymphocytes 2 0.1417 1.16
GTEx Cells Transformed fibroblasts 1 0.0240 1.09
GTEx Colon Sigmoid 1 0.0688 1.18
GTEx Colon Transverse 1 0.0489 1.14
GTEx Esophagus Gastroesophageal Junction 1 0.0697 1.21
GTEx Esophagus Mucosa 2 0.0607 1.15
GTEx Esophagus Muscularis 1 0.0312 1.13
GTEx Heart Atrial Appendage 1 0.0638 1.15
GTEx Heart Left Ventricle 0 0.0000 1.21
GTEx Liver 1 0.1403 1.16
GTEx Lung 1 0.0352 1.10
GTEx Muscle Skeletal 1 0.0348 1.12
GTEx Nerve Tibial 2 0.0466 1.14
GTEx Ovary 1 0.1114 1.23
GTEx Pancreas 1 0.0616 1.12
GTEx Pituitary 0 0.0000 1.18
GTEx Prostate 0 0.0000 1.16
GTEx Skin Not Sun Exposed Suprapubic 1 0.0410 1.11
GTEx Skin Sun Exposed Lower leg 1 0.0277 1.13
GTEx Small Intestine Terminal Ileum 0 0.0000 1.14
GTEx Spleen 1 0.0713 1.10
GTEx Stomach 1 0.0692 1.13
GTEx Testis 1 0.0319 1.15
GTEx Thyroid 3 0.0758 1.14
GTEx Uterus 1 0.1783 1.17
GTEx Vagina 1 0.1587 1.24
GTEx Whole Blood 2 0.1011 1.13
METSIM Adipose 1 0.0219 1.09
NTR Blood 2 0.0833 1.18
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.05
YFS Blood 1 0.0217 1.13
CommonMind Brain Pre-frontal Cortex 1 0.0187 1.09
TCGA Breast Tumor 0 0.0000 1.02
TCGA Breast Normal 3 0.0719 1.18
TCGA Ovarian Tumor 1 0.0344 1.09
TCGA Prostate Tumor 2 0.0583 1.09