Hub : Traits :

Pulse wave peak to peak time

1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	12	111645043	113036817	1	1	1.3e-08	7.5e-05	0.033	71	ADAM1A

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Blood Platelet Count	79.71	1	1	2.2	1	ADAM1A
Blood Eosinophil Count	43.01	1	1	2.2	1	ADAM1A
Hypothyroidism (self reported)	32.51	1	1	2.2	1	ADAM1A
Medication: Levothyroxine sodium	30.85	1	1	2.2	1	ADAM1A
Pulse wave Arterial Stiffness index	28.92	1	1	2.2	1	ADAM1A
Hypothyroidism/myxoedema (self-reported)	27.23	1	1	2.2	1	ADAM1A
Blood White Count	21.42	1	1	2.2	1	ADAM1A
Blood Red Count	19.92	1	1	2.2	1	ADAM1A
HbA1C	18.40	1	0	0.0	1	ADAM1A
Birth weight	15.40	1	1	2.2	1	ADAM1A
Medication: Ramipril	14.35	1	0	0.0	1	ADAM1A
Allergy or Eczema	13.63	1	1	2.2	1	ADAM1A
Diastolic blood pressure, automated reading	13.26	1	1	2.2	1	ADAM1A
Hayfever, allergic rhinitis or eczema	13.06	1	1	2.2	1	ADAM1A
Illnesses of siblings	12.27	1	0	0.0	1	ADAM1A
Taking other prescription medications	11.99	1	0	0.0	1	ADAM1A
Medication: Blood pressure	11.87	1	0	0.0	1	ADAM1A
Past tobacco smoking	11.14	1	0	0.0	1	ADAM1A
Vascular/heart problems diagnosed by doctor	10.76	1	1	2.2	1	ADAM1A
Heart attack	10.47	1	0	0.0	1	ADAM1A
Friendships satisfaction	10.40	1	0	0.0	1	ADAM1A
Number of treatments/medications taken	10.28	1	0	0.0	1	ADAM1A
Relative age voice broke	10.28	1	0	0.0	1	ADAM1A
Heart attack/myocardial infarction (self-reported)	10.15	1	0	0.0	1	ADAM1A
Smoking Status	9.86	1	0	0.0	1	ADAM1A
Smoking status: Previous	9.66	1	0	0.0	1	ADAM1A
Hayfever/allergic rhinitis (self-reported)	9.56	1	0	0.0	1	ADAM1A
Medication for cholesterol, blood pressure or diabetes	9.01	1	0	0.0	1	ADAM1A
Systolic Blood Pressure	8.89	1	1	2.2	1	ADAM1A
Illnesses of siblings: Diabetes	8.88	1	0	0.0	1	ADAM1A
Type 2 Diabetes (T2D) (2018)	8.81	1	0	0.0	1	ADAM1A
Birth weight of first child	8.75	1	0	0.0	1	ADAM1A
Hypertension (Self-reported)	8.72	1	0	0.0	1	ADAM1A
Alzheimer’s Disease (in mother)	8.53	1	0	0.0	1	ADAM1A
Cardiovascular Disease	7.99	1	1	2.2	1	ADAM1A
Medication: Atenolol	7.82	1	0	0.0	1	ADAM1A
High blood pressure	7.62	1	0	0.0	1	ADAM1A
Allergy	7.31	1	0	0.0	1	ADAM1A
Illnesses of father: None of the above (group 1)	6.90	1	0	0.0	1	ADAM1A
Mouth/teeth dental problems: Dentures	6.79	1	0	0.0	1	ADAM1A
Long-standing illness, disability or infirmity	6.78	1	0	0.0	1	ADAM1A
Waist Hip Ratio (WHR)	6.65	1	1	2.2	1	ADAM1A
Maternal smoking around birth	6.53	1	0	0.0	1	ADAM1A
Ever taken oral contraceptive pill	6.42	1	0	0.0	1	ADAM1A
Cholesterol lowering medication	6.11	1	0	0.0	1	ADAM1A
Alzheimer’s Disease (including proxy)	6.00	1	0	0.0	1	ADAM1A
Number of self-reported non-cancer illnesses	5.96	1	0	0.0	1	ADAM1A
Ever smoked	5.55	1	0	0.0	1	ADAM1A
Primary Biliary Cirrhosis	5.40	1	0	0.0	1	ADAM1A
High blood pressure (siblings)	5.32	1	0	0.0	1	ADAM1A
Lupus	5.22	1	0	0.0	1	ADAM1A
Illnesses of father: Heart disease	5.16	1	0	0.0	1	ADAM1A
Coronary Artery Disease (CAD)	5.10	1	0	0.0	1	ADAM1A
Medication: Simvastatin	5.04	1	0	0.0	1	ADAM1A
Medication: Cholesterol lowering	4.97	1	0	0.0	1	ADAM1A
Had major operations	4.95	1	0	0.0	1	ADAM1A
Number of full brothers	4.80	1	0	0.0	1	ADAM1A
Schizophrenia vs Biploar Disorder	4.79	1	0	0.0	1	ADAM1A
Angina	4.70	1	0	0.0	1	ADAM1A
Medication: Ibuprofen (e.g. Nurofen)	4.70	1	0	0.0	1	ADAM1A
Systolic blood pressure, automated reading	4.59	1	0	0.0	1	ADAM1A
Medication: Bendroflumethiazide	4.54	1	0	0.0	1	ADAM1A
Diabetes (self-reported)	4.52	1	0	0.0	1	ADAM1A
Medication: Aspirin	4.49	1	0	0.0	1	ADAM1A
Alcohol intake versus 10 years previously	4.37	1	0	0.0	1	ADAM1A
Ulcerative Colitis	4.22	1	0	0.0	1	ADAM1A
Fractured/broken bones in last 5 years	4.21	1	0	0.0	1	ADAM1A
Ulcerative Colitis (UC)	4.15	1	0	0.0	1	ADAM1A
Irritable Bowel Disease (IBD)	4.12	1	0	0.0	1	ADAM1A
Diabetes (father)	4.08	1	0	0.0	1	ADAM1A
Heart disease (siblings)	4.01	1	0	0.0	1	ADAM1A
High blood pressure (mother)	4.00	1	0	0.0	1	ADAM1A
Diabetes diagnosed by doctor	3.90	1	0	0.0	1	ADAM1A
Medication: Blood pressure	3.88	1	0	0.0	1	ADAM1A
Exposure to tobacco smoke at home	3.86	1	0	0.0	1	ADAM1A
Triglycerides	3.80	1	0	0.0	1	ADAM1A
Blood clot in the leg (DVT)	3.75	1	0	0.0	1	ADAM1A
Bilateral oophorectomy (both ovaries removed)	3.74	1	0	0.0	1	ADAM1A
Medication: Aspirin	3.73	1	0	0.0	1	ADAM1A
Medication: Omeprazole (e.g. Zanprol)	3.66	1	0	0.0	1	ADAM1A
Emphysema/chronic bronchitis	3.63	1	0	0.0	1	ADAM1A
Pulse rate	3.44	1	0	0.0	1	ADAM1A
Risk taking	3.39	1	0	0.0	1	ADAM1A
Angina (self-reported)	3.38	1	0	0.0	1	ADAM1A
Rheumatoid Arthritis	3.36	1	0	0.0	1	ADAM1A
Deep venous thrombosis (DVT) (self-reported)	3.24	1	0	0.0	1	ADAM1A
Medication for cholesterol	3.20	1	0	0.0	1	ADAM1A
Impedance of whole body	3.13	1	0	0.0	1	ADAM1A
Asthma (self-reported)	3.03	1	0	0.0	1	ADAM1A
Mean time to correctly identify matches	3.01	1	0	0.0	1	ADAM1A
Impedance of arm (left)	2.99	1	0	0.0	1	ADAM1A
HDL Cholesterol	2.98	1	0	0.0	1	ADAM1A
Trunk fat percentage	2.90	1	0	0.0	1	ADAM1A
Impedance of arm (right)	2.90	1	0	0.0	1	ADAM1A
Number of operations (self-reported)	2.87	1	0	0.0	1	ADAM1A
Neck or shoulder pain in last month	2.77	1	0	0.0	1	ADAM1A
Asthma	2.73	1	0	0.0	1	ADAM1A
Overall health rating	2.70	1	0	0.0	1	ADAM1A
Qualifications: A levels/AS levels or equivalent	2.69	1	0	0.0	1	ADAM1A
Knee pain experienced in last month	2.54	1	0	0.0	1	ADAM1A
Impedance of leg (right)	2.51	1	0	0.0	1	ADAM1A
Tense / 'highly strung'	2.43	1	0	0.0	1	ADAM1A
Body fat percentage	2.28	1	0	0.0	1	ADAM1A
Reaction Time	2.07	1	0	0.0	1	ADAM1A
Qualifications: College or University degree	2.02	1	0	0.0	1	ADAM1A
Impedance of leg (left)	1.97	1	0	0.0	1	ADAM1A
Respiratory disease	1.96	1	0	0.0	1	ADAM1A
Qualifications: None of the above	1.91	1	0	0.0	1	ADAM1A
Heel bone mineral density (BMD) T-score, automated (right)	1.89	1	0	0.0	1	ADAM1A
Arm fat percentage (right)	1.59	1	0	0.0	1	ADAM1A
Trunk fat-free mass	1.34	1	0	0.0	1	ADAM1A
Arm fat percentage (left)	1.34	1	0	0.0	1	ADAM1A
Trunk predicted mass	1.33	1	0	0.0	1	ADAM1A
Trunk fat mass	1.16	1	0	0.0	1	ADAM1A
Whole body fat-free mass	1.15	1	0	0.0	1	ADAM1A
Arm predicted mass (right)	1.13	1	0	0.0	1	ADAM1A
Whole body water mass	1.11	1	0	0.0	1	ADAM1A
Leg fat percentage (right)	1.09	1	0	0.0	1	ADAM1A
Arm fat-free mass (right)	1.06	1	0	0.0	1	ADAM1A
Leg predicted mass (right)	1.05	1	0	0.0	1	ADAM1A
Leg fat-free mass (right)	1.02	1	0	0.0	1	ADAM1A
Arm fat-free mass (left)	1.00	1	0	0.0	1	ADAM1A
Arm predicted mass (left)	0.88	1	0	0.0	1	ADAM1A
Tanning	0.82	1	0	0.0	1	ADAM1A
Basal metabolic rate	0.69	1	0	0.0	1	ADAM1A

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Ovary	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Pancreas	0	0.000	1.1
GTEx	Spleen	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1