Hub : Traits :

Pulse wave Arterial Stiffness index

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 111645043 113036817 1 1 6.2e-09 4e-05 0.025 70 ADAM1A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Schizophrenia vs Biploar Disorder 4.79 1 0 0.0 0 1 ADAM1A
Alzheimer’s Disease (in mother) 8.53 1 0 0.0 0 1 ADAM1A
Alzheimer’s Disease (including proxy) 6.00 1 0 0.0 0 1 ADAM1A
Irritable Bowel Disease (IBD) 4.12 1 0 0.0 0 1 ADAM1A
Ulcerative Colitis (UC) 4.15 1 0 0.0 0 1 ADAM1A
Reaction Time 2.07 1 0 0.0 0 1 ADAM1A
Coronary Artery Disease (CAD) 5.10 1 0 0.0 0 1 ADAM1A
HbA1C 18.40 1 0 0.0 0 1 ADAM1A
HDL Cholesterol 2.98 1 0 0.0 0 1 ADAM1A
Lupus 5.22 1 0 0.0 0 1 ADAM1A
Primary Biliary Cirrhosis 5.40 1 0 0.0 0 1 ADAM1A
Rheumatoid Arthritis 3.36 1 0 0.0 0 1 ADAM1A
Triglycerides 3.80 1 0 0.0 0 1 ADAM1A
Ulcerative Colitis 4.22 1 0 0.0 0 1 ADAM1A
Blood Eosinophil Count 43.01 1 1 2.2 0 1 ADAM1A
Blood Platelet Count 79.71 1 1 2.2 0 1 ADAM1A
Blood Red Count 19.92 1 1 2.2 0 1 ADAM1A
Blood White Count 21.42 1 1 2.2 0 1 ADAM1A
Waist Hip Ratio (WHR) 6.65 1 1 2.2 0 1 ADAM1A
Systolic Blood Pressure 8.89 1 1 2.2 0 1 ADAM1A
Smoking Status 9.86 1 0 0.0 0 1 ADAM1A
Allergy or Eczema 13.63 1 1 2.2 0 1 ADAM1A
Cardiovascular Disease 7.99 1 1 2.2 0 1 ADAM1A
Hypothyroidism (self reported) 32.51 1 1 2.2 0 1 ADAM1A
Respiratory disease 1.96 1 0 0.0 0 1 ADAM1A
Type 2 Diabetes (T2D) (2018) 8.81 1 0 0.0 0 1 ADAM1A
Tanning 0.82 1 0 0.0 0 1 ADAM1A
Number of treatments/medications taken 10.28 1 0 0.0 0 1 ADAM1A
Systolic blood pressure, automated reading 4.59 1 0 0.0 0 1 ADAM1A
Angina 4.70 1 0 0.0 0 1 ADAM1A
Diabetes (father) 4.08 1 0 0.0 0 1 ADAM1A
Impedance of leg (right) 2.51 1 0 0.0 0 1 ADAM1A
Trunk fat percentage 2.90 1 0 0.0 0 1 ADAM1A
Maternal smoking around birth 6.53 1 0 0.0 0 1 ADAM1A
Relative age voice broke 10.28 1 0 0.0 0 1 ADAM1A
Taking other prescription medications 11.99 1 0 0.0 0 1 ADAM1A
Bilateral oophorectomy (both ovaries removed) 3.74 1 0 0.0 0 1 ADAM1A
High blood pressure 7.62 1 0 0.0 0 1 ADAM1A
Hayfever, allergic rhinitis or eczema 13.06 1 1 2.2 0 1 ADAM1A
Medication: Atenolol 7.82 1 0 0.0 0 1 ADAM1A
Medication: Levothyroxine sodium 30.85 1 1 2.2 0 1 ADAM1A
High blood pressure (mother) 4.00 1 0 0.0 0 1 ADAM1A
Impedance of leg (left) 1.97 1 0 0.0 0 1 ADAM1A
Trunk fat mass 1.16 1 0 0.0 0 1 ADAM1A
Past tobacco smoking 11.14 1 0 0.0 0 1 ADAM1A
Heel bone mineral density (BMD) T-score, automated (right) 1.89 1 0 0.0 0 1 ADAM1A
Qualifications: None of the above 1.91 1 0 0.0 0 1 ADAM1A
Heart attack 10.47 1 0 0.0 0 1 ADAM1A
Allergy 7.31 1 0 0.0 0 1 ADAM1A
Diabetes (self-reported) 4.52 1 0 0.0 0 1 ADAM1A
Hayfever/allergic rhinitis (self-reported) 9.56 1 0 0.0 0 1 ADAM1A
Medication: Ramipril 14.35 1 0 0.0 0 1 ADAM1A
Medication: Simvastatin 5.04 1 0 0.0 0 1 ADAM1A
Illnesses of siblings 12.27 1 0 0.0 0 1 ADAM1A
Impedance of arm (right) 2.90 1 0 0.0 0 1 ADAM1A
Arm fat percentage (right) 1.59 1 0 0.0 0 1 ADAM1A
Trunk fat-free mass 1.34 1 0 0.0 0 1 ADAM1A
Alcohol intake versus 10 years previously 4.37 1 0 0.0 0 1 ADAM1A
Pulse rate 3.44 1 0 0.0 0 1 ADAM1A
Qualifications: A levels/AS levels or equivalent 2.69 1 0 0.0 0 1 ADAM1A
Mouth/teeth dental problems: Dentures 6.79 1 0 0.0 0 1 ADAM1A
Asthma 2.73 1 0 0.0 0 1 ADAM1A
Medication: Ibuprofen (e.g. Nurofen) 4.70 1 0 0.0 0 1 ADAM1A
Medication: Cholesterol lowering 4.97 1 0 0.0 0 1 ADAM1A
Impedance of arm (left) 2.99 1 0 0.0 0 1 ADAM1A
Trunk predicted mass 1.33 1 0 0.0 0 1 ADAM1A
Exposure to tobacco smoke at home 3.86 1 0 0.0 0 1 ADAM1A
Tense / 'highly strung' 2.43 1 0 0.0 0 1 ADAM1A
Birth weight of first child 8.75 1 0 0.0 0 1 ADAM1A
Blood clot in the leg (DVT) 3.75 1 0 0.0 0 1 ADAM1A
Medication for cholesterol, blood pressure or diabetes 9.01 1 0 0.0 0 1 ADAM1A
Hypothyroidism/myxoedema (self-reported) 27.23 1 1 2.2 0 1 ADAM1A
Birth weight 15.40 1 1 2.2 0 1 ADAM1A
High blood pressure (siblings) 5.32 1 0 0.0 0 1 ADAM1A
Body fat percentage 2.28 1 0 0.0 0 1 ADAM1A
Leg fat percentage (right) 1.09 1 0 0.0 0 1 ADAM1A
Arm fat-free mass (right) 1.06 1 0 0.0 0 1 ADAM1A
Number of full brothers 4.80 1 0 0.0 0 1 ADAM1A
Pulse wave peak to peak time 27.51 1 1 2.2 0 1 ADAM1A
Qualifications: College or University degree 2.02 1 0 0.0 0 1 ADAM1A
Emphysema/chronic bronchitis 3.63 1 0 0.0 0 1 ADAM1A
Neck or shoulder pain in last month 2.77 1 0 0.0 0 1 ADAM1A
Medication: Blood pressure 11.87 1 0 0.0 0 1 ADAM1A
Angina (self-reported) 3.38 1 0 0.0 0 1 ADAM1A
Mean time to correctly identify matches 3.01 1 0 0.0 0 1 ADAM1A
Arm predicted mass (right) 1.13 1 0 0.0 0 1 ADAM1A
Overall health rating 2.70 1 0 0.0 0 1 ADAM1A
Had major operations 4.95 1 0 0.0 0 1 ADAM1A
Medication: Aspirin 3.73 1 0 0.0 0 1 ADAM1A
Knee pain experienced in last month 2.54 1 0 0.0 0 1 ADAM1A
Hypertension (Self-reported) 8.72 1 0 0.0 0 1 ADAM1A
Illnesses of father: Heart disease 5.16 1 0 0.0 0 1 ADAM1A
Illnesses of siblings: Diabetes 8.88 1 0 0.0 0 1 ADAM1A
Smoking status: Previous 9.66 1 0 0.0 0 1 ADAM1A
Whole body fat-free mass 1.15 1 0 0.0 0 1 ADAM1A
Leg fat-free mass (right) 1.02 1 0 0.0 0 1 ADAM1A
Arm fat percentage (left) 1.34 1 0 0.0 0 1 ADAM1A
Long-standing illness, disability or infirmity 6.78 1 0 0.0 0 1 ADAM1A
Diabetes diagnosed by doctor 3.90 1 0 0.0 0 1 ADAM1A
Friendships satisfaction 10.40 1 0 0.0 0 1 ADAM1A
Medication for cholesterol 3.20 1 0 0.0 0 1 ADAM1A
Asthma (self-reported) 3.03 1 0 0.0 0 1 ADAM1A
Medication: Aspirin 4.49 1 0 0.0 0 1 ADAM1A
Illnesses of father: None of the above (group 1) 6.90 1 0 0.0 0 1 ADAM1A
Whole body water mass 1.11 1 0 0.0 0 1 ADAM1A
Leg predicted mass (right) 1.05 1 0 0.0 0 1 ADAM1A
Number of self-reported non-cancer illnesses 5.96 1 0 0.0 0 1 ADAM1A
Ever taken oral contraceptive pill 6.42 1 0 0.0 0 1 ADAM1A
Medication: Blood pressure 3.88 1 0 0.0 0 1 ADAM1A
Medication: Bendroflumethiazide 4.54 1 0 0.0 0 1 ADAM1A
Ever smoked 5.55 1 0 0.0 0 1 ADAM1A
Basal metabolic rate 0.69 1 0 0.0 0 1 ADAM1A
Arm fat-free mass (left) 1.00 1 0 0.0 0 1 ADAM1A
Number of operations (self-reported) 2.87 1 0 0.0 0 1 ADAM1A
Risk taking 3.39 1 0 0.0 0 1 ADAM1A
Fractured/broken bones in last 5 years 4.21 1 0 0.0 0 1 ADAM1A
Diastolic blood pressure, automated reading 13.26 1 1 2.2 0 1 ADAM1A
Vascular/heart problems diagnosed by doctor 10.76 1 1 2.2 0 1 ADAM1A
Cholesterol lowering medication 6.11 1 0 0.0 0 1 ADAM1A
Medication: Omeprazole (e.g. Zanprol) 3.66 1 0 0.0 0 1 ADAM1A
Heart attack/myocardial infarction (self-reported) 10.15 1 0 0.0 0 1 ADAM1A
Deep venous thrombosis (DVT) (self-reported) 3.24 1 0 0.0 0 1 ADAM1A
Heart disease (siblings) 4.01 1 0 0.0 0 1 ADAM1A
Impedance of whole body 3.13 1 0 0.0 0 1 ADAM1A
Arm predicted mass (left) 0.88 1 0 0.0 0 1 ADAM1A

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 1 0.067 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.1
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.1
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.1
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.1
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.0
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2