Hub : Traits :

Supplements: Glucosamine

9 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 32275256 33721935 2 1 4.8e-08 1.3e-07 0.40300 98 APTX
2 10 64195778 65606229 1 1 2.1e-07 1.6e-08 0.00017 56 NRBF2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.65 1 0 0.0 0 1 NRBF2
Schizophrenia vs Biploar Disorder 4.91 1 0 0.0 0 1 NRBF2
HDL Cholesterol 3.57 1 0 0.0 0 1 NRBF2
Triglycerides 7.41 1 0 0.0 0 1 NRBF2
Blood Platelet Count 25.38 2 1 2.2 0 1 APTX NRBF2
Blood Red Count 0.74 1 0 0.0 0 1 APTX
Blood White Count 3.84 1 1 2.2 0 1 NRBF2
Heel T-Score 0.75 1 0 0.0 0 1 NRBF2
BMI 1.75 1 0 0.0 0 1 NRBF2
Height 0.30 1 0 0.0 0 1 APTX
Systolic Blood Pressure 8.14 1 1 2.2 0 1 NRBF2
Allergy or Eczema 4.20 1 0 0.0 0 1 NRBF2
Cardiovascular Disease 10.34 1 1 2.2 0 1 NRBF2
Lung FEV1/FVC ratio 8.20 1 1 2.2 0 1 NRBF2
Lung FVC 1.97 1 0 0.0 0 1 NRBF2
Hair Pigment 0.29 1 0 0.0 0 1 APTX
Tanning 2.26 1 1 2.2 0 1 NRBF2
Systolic blood pressure, automated reading 9.03 1 1 2.2 0 1 NRBF2
Leg fat-free mass (left) 0.78 1 0 0.0 0 1 NRBF2
Heel bone mineral density (BMD) T-score, automated (left) 1.97 1 0 0.0 0 1 NRBF2
High blood pressure 9.44 1 1 2.2 0 1 NRBF2
Hayfever, allergic rhinitis or eczema 2.78 1 0 0.0 0 1 NRBF2
Multivitamins +/- minerals 6.28 1 0 0.0 0 1 NRBF2
High blood pressure (mother) 6.10 1 0 0.0 0 1 NRBF2
Body mass index (BMI) 2.09 1 0 0.0 0 1 NRBF2
Leg predicted mass (left) 0.79 1 0 0.0 0 1 NRBF2
Waist circumference 2.84 1 0 0.0 0 1 NRBF2
Had other major operations 7.71 1 0 0.0 0 1 NRBF2
Qualifications: None of the above 4.96 2 0 0.0 0 1 APTX NRBF2
Allergy 2.28 1 0 0.0 0 1 NRBF2
Illnesses of siblings 6.32 1 0 0.0 0 1 NRBF2
Weight 1.68 1 0 0.0 0 1 NRBF2
Impedance of arm (right) 2.29 1 0 0.0 0 1 NRBF2
Trunk fat-free mass 1.04 1 0 0.0 0 1 NRBF2
Hip circumference 1.98 1 0 0.0 0 1 NRBF2
Number of live births 3.34 1 0 0.0 0 1 NRBF2
Forced expiratory volume in 1-second (FEV1) 3.52 1 0 0.0 0 1 NRBF2
Pulse rate 2.97 1 0 0.0 0 1 APTX
Qualifications: A levels/AS levels or equivalent 4.05 2 0 0.0 0 1 APTX NRBF2
Forced expiratory volume in 1-second (FEV1), Best measure 4.96 1 1 2.2 0 1 NRBF2
Impedance of arm (left) 2.29 1 0 0.0 0 1 NRBF2
Arm fat mass (right) 1.57 1 0 0.0 0 1 NRBF2
Trunk predicted mass 1.01 1 0 0.0 0 1 NRBF2
Gout (self-reported) 5.34 1 0 0.0 0 1 NRBF2
Medication: Amlodipine 3.97 1 0 0.0 0 1 NRBF2
Medication: Ventolin 100micrograms inhaler 4.25 1 0 0.0 0 1 NRBF2
High blood pressure (siblings) 12.77 1 1 2.2 0 1 NRBF2
Forced vital capacity (FVC), Best measure 1.87 1 0 0.0 0 1 NRBF2
Leg fat percentage (right) 2.16 1 0 0.0 0 1 NRBF2
Arm fat-free mass (right) 1.51 1 0 0.0 0 1 NRBF2
Comparative body size at age 10 1.99 1 0 0.0 0 1 NRBF2
Age at first live birth 3.10 1 0 0.0 0 1 NRBF2
Qualifications: College or University degree 1.49 1 0 0.0 0 1 APTX
Medication: Blood pressure 2.58 1 0 0.0 0 1 NRBF2
Whole body fat mass 1.37 1 0 0.0 0 1 NRBF2
Leg fat mass (right) 2.25 1 0 0.0 0 1 NRBF2
Arm predicted mass (right) 1.46 1 0 0.0 0 1 NRBF2
Number of full sisters 10.18 1 0 0.0 0 1 NRBF2
Overall health rating 4.34 2 0 0.0 0 1 APTX NRBF2
Hypertension (Self-reported) 8.62 1 1 2.2 0 1 NRBF2
Whole body fat-free mass 0.95 1 0 0.0 0 1 NRBF2
Average weekly red wine intake 6.24 2 0 0.0 0 1 APTX NRBF2
Medication for cholesterol 4.94 1 0 0.0 0 1 NRBF2
Mineral and other dietary supplements 9.31 1 0 0.0 0 1 NRBF2
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.95 1 0 0.0 0 1 NRBF2
Whole body water mass 0.93 1 0 0.0 0 1 NRBF2
Arm fat mass (left) 1.45 1 0 0.0 0 1 NRBF2
Medication: Blood pressure 7.13 1 0 0.0 0 1 NRBF2
Supplements: Fish oil (including cod liver oil) 5.42 1 0 0.0 0 1 NRBF2
Medication: Bendroflumethiazide 7.40 1 0 0.0 0 1 NRBF2
Medication: Lisinopril 9.83 1 0 0.0 0 1 NRBF2
Illnesses of father: High blood pressure 3.98 1 0 0.0 0 1 NRBF2
Basal metabolic rate 1.16 1 0 0.0 0 1 NRBF2
Leg fat percentage (left) 2.40 1 0 0.0 0 1 NRBF2
Arm fat-free mass (left) 1.70 1 0 0.0 0 1 NRBF2
Number of operations (self-reported) 3.53 1 0 0.0 0 1 NRBF2
Diastolic blood pressure, automated reading 14.69 1 1 2.2 0 1 NRBF2
Vascular/heart problems diagnosed by doctor 8.99 1 1 2.2 0 1 NRBF2
Cholesterol lowering medication 2.80 1 0 0.0 0 1 NRBF2
Impedance of whole body 1.47 1 0 0.0 0 1 NRBF2
Leg fat mass (left) 2.32 1 0 0.0 0 1 NRBF2
Arm predicted mass (left) 1.63 1 0 0.0 0 1 NRBF2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 1 0.034 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 1 0.067 1.4
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 1 0.068 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 1 0.061 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 1 0.027 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.4
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 1 0.157 1.4
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3