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Supplements: Glucosamine

9 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	9	32275256	33721935	2	1	4.8e-08	1.3e-07	0.40300	98	APTX
2	10	64195778	65606229	1	1	2.1e-07	1.6e-08	0.00017	56	NRBF2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Blood Platelet Count	25.38	2	1	2.2	1	APTX NRBF2
Diastolic blood pressure, automated reading	14.69	1	1	2.2	1	NRBF2
High blood pressure (siblings)	12.77	1	1	2.2	1	NRBF2
Cardiovascular Disease	10.34	1	1	2.2	1	NRBF2
Number of full sisters	10.18	1	0	0.0	1	NRBF2
Medication: Lisinopril	9.83	1	0	0.0	1	NRBF2
High blood pressure	9.44	1	1	2.2	1	NRBF2
Mineral and other dietary supplements	9.31	1	0	0.0	1	NRBF2
Systolic blood pressure, automated reading	9.03	1	1	2.2	1	NRBF2
Vascular/heart problems diagnosed by doctor	8.99	1	1	2.2	1	NRBF2
Hypertension (Self-reported)	8.62	1	1	2.2	1	NRBF2
Lung FEV1/FVC ratio	8.20	1	1	2.2	1	NRBF2
Systolic Blood Pressure	8.14	1	1	2.2	1	NRBF2
Had other major operations	7.71	1	0	0.0	1	NRBF2
Triglycerides	7.41	1	0	0.0	1	NRBF2
Medication: Bendroflumethiazide	7.40	1	0	0.0	1	NRBF2
Medication: Blood pressure	7.13	1	0	0.0	1	NRBF2
Illnesses of siblings	6.32	1	0	0.0	1	NRBF2
Multivitamins +/- minerals	6.28	1	0	0.0	1	NRBF2
Average weekly red wine intake	6.24	2	0	0.0	1	APTX NRBF2
High blood pressure (mother)	6.10	1	0	0.0	1	NRBF2
Supplements: Fish oil (including cod liver oil)	5.42	1	0	0.0	1	NRBF2
Gout (self-reported)	5.34	1	0	0.0	1	NRBF2
Qualifications: None of the above	4.96	2	0	0.0	1	APTX NRBF2
Forced expiratory volume in 1-second (FEV1), Best measure	4.96	1	1	2.2	1	NRBF2
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.95	1	0	0.0	1	NRBF2
Medication for cholesterol	4.94	1	0	0.0	1	NRBF2
Schizophrenia vs Biploar Disorder	4.91	1	0	0.0	1	NRBF2
Overall health rating	4.34	2	0	0.0	1	APTX NRBF2
Medication: Ventolin 100micrograms inhaler	4.25	1	0	0.0	1	NRBF2
Allergy or Eczema	4.20	1	0	0.0	1	NRBF2
Qualifications: A levels/AS levels or equivalent	4.05	2	0	0.0	1	APTX NRBF2
Illnesses of father: High blood pressure	3.98	1	0	0.0	1	NRBF2
Medication: Amlodipine	3.97	1	0	0.0	1	NRBF2
Blood White Count	3.84	1	1	2.2	1	NRBF2
HDL Cholesterol	3.57	1	0	0.0	1	NRBF2
Number of operations (self-reported)	3.53	1	0	0.0	1	NRBF2
Forced expiratory volume in 1-second (FEV1)	3.52	1	0	0.0	1	NRBF2
Number of live births	3.34	1	0	0.0	1	NRBF2
Age at first live birth	3.10	1	0	0.0	1	NRBF2
Pulse rate	2.97	1	0	0.0	1	APTX
Waist circumference	2.84	1	0	0.0	1	NRBF2
Cholesterol lowering medication	2.80	1	0	0.0	1	NRBF2
Hayfever, allergic rhinitis or eczema	2.78	1	0	0.0	1	NRBF2
Bipolar Disorder (2018)	2.65	1	0	0.0	1	NRBF2
Medication: Blood pressure	2.58	1	0	0.0	1	NRBF2
Leg fat percentage (left)	2.40	1	0	0.0	1	NRBF2
Leg fat mass (left)	2.32	1	0	0.0	1	NRBF2
Impedance of arm (right)	2.29	1	0	0.0	1	NRBF2
Impedance of arm (left)	2.29	1	0	0.0	1	NRBF2
Allergy	2.28	1	0	0.0	1	NRBF2
Tanning	2.26	1	1	2.2	1	NRBF2
Leg fat mass (right)	2.25	1	0	0.0	1	NRBF2
Leg fat percentage (right)	2.16	1	0	0.0	1	NRBF2
Body mass index (BMI)	2.09	1	0	0.0	1	NRBF2
Comparative body size at age 10	1.99	1	0	0.0	1	NRBF2
Hip circumference	1.98	1	0	0.0	1	NRBF2
Lung FVC	1.97	1	0	0.0	1	NRBF2
Heel bone mineral density (BMD) T-score, automated (left)	1.97	1	0	0.0	1	NRBF2
Forced vital capacity (FVC), Best measure	1.87	1	0	0.0	1	NRBF2
BMI	1.75	1	0	0.0	1	NRBF2
Arm fat-free mass (left)	1.70	1	0	0.0	1	NRBF2
Weight	1.68	1	0	0.0	1	NRBF2
Arm predicted mass (left)	1.63	1	0	0.0	1	NRBF2
Arm fat mass (right)	1.57	1	0	0.0	1	NRBF2
Arm fat-free mass (right)	1.51	1	0	0.0	1	NRBF2
Qualifications: College or University degree	1.49	1	0	0.0	1	APTX
Impedance of whole body	1.47	1	0	0.0	1	NRBF2
Arm predicted mass (right)	1.46	1	0	0.0	1	NRBF2
Arm fat mass (left)	1.45	1	0	0.0	1	NRBF2
Whole body fat mass	1.37	1	0	0.0	1	NRBF2
Basal metabolic rate	1.16	1	0	0.0	1	NRBF2
Trunk fat-free mass	1.04	1	0	0.0	1	NRBF2
Trunk predicted mass	1.01	1	0	0.0	1	NRBF2
Whole body fat-free mass	0.95	1	0	0.0	1	NRBF2
Whole body water mass	0.93	1	0	0.0	1	NRBF2
Leg predicted mass (left)	0.79	1	0	0.0	1	NRBF2
Leg fat-free mass (left)	0.78	1	0	0.0	1	NRBF2
Heel T-Score	0.75	1	0	0.0	1	NRBF2
Blood Red Count	0.74	1	0	0.0	1	APTX
Height	0.30	1	0	0.0	1	APTX
Hair Pigment	0.29	1	0	0.0	1	APTX

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Vagina	1	0.157	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Colon Sigmoid	1	0.068	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	1	0.061	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
NTR	Blood	0	0.000	1.2