Hub : Genes

ZNF595

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Caudate basal ganglia 0.1530 0.0600 0.00093 0.045 NA -0.002 NA 0.030 0.0190 NA 0.36000 NA 0.0460
2 GTEx Brain Cerebellum 0.1340 0.0640 0.00610 0.049 NA 0.098 NA 0.093 0.0150 NA 0.00078 NA 0.0011
3 GTEx Muscle Skeletal 0.0764 0.0370 0.00072 -0.003 NA 0.010 NA -0.002 0.9700 NA 0.03300 NA 0.6500
4 NTR Blood 0.0153 0.0091 0.00410 0.009 0.004 0.001 0.002 0.004 0.0006 0.0180 0.14000 0.058 0.0180
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0473 0.0283 0.00320 -0.002 0.011 0.012 NA -0.001 0.9800 0.0180 0.01400 NA 0.4000
6 TCGA Brain Lower Grade Glioma 0.0206 0.0132 0.00940 0.019 0.014 0.009 NA 0.013 0.0029 0.0081 0.02700 NA 0.0110

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 0.9 2.5 -1.6 -0.8 -1.3 -0.7 0.0 0.0
Bipolar Disorder or Schizophrenia 1.1 2.6 4.7 -1.8 -1.2 -1.7 -2.2 0.6 1.8
Depressed Affect (Nagel 2018) 0.5 1.0 3.3 0.7 -0.9 1.8 0.5 -0.3 -0.9
Depression (Nagel 2018) 1.2 1.8 3.1 0.3 -1.4 0.6 -1.8 1.6 1.7
Intelligence (Savage-Jansen 2018) 1.2 3.7 11.6 0.8 3.4 2.9 0.7 -0.5 -0.9
Neuroticism (Nagel 2018) 0.3 0.7 2.5 -0.1 -1.1 1.6 -0.0 -0.7 -0.3
Schizophrenia (2018) 1.1 2.4 5.9 -0.9 -0.9 -1.3 -2.2 -0.5 2.4
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 0.7 0.5 0.9 -0.7 0.0 0.0
Worry (Nagel 2018) 0.8 1.7 6.6 -1.3 -2.6 -0.3 -0.0 1.3 0.3
Alzheimer’s Disease (in mother) 1.8 2.1 7.5 2.7 1.4 1.6 0.2 0.9 0.0
Alzheimer’s Disease (in father) 0.7 0.7 4.3 -0.2 -2.1 -0.1 0.2 0.3 0.1
Alzheimer’s Disease (including proxy) 1.2 1.7 6.4 2.5 0.2 1.4 -1.0 -0.1 0.8
Crohns Disease (2017) 1.0 2.2 4.7 -1.3 0.6 -1.4 1.6 1.5 -2.2
Irritable Bowel Disease (IBD) 0.5 1.1 3.1 -0.1 0.8 -1.0 1.3 0.2 -1.8
Ulcerative Colitis (UC) 0.5 0.9 1.4 1.2 1.1 0.1 0.6 -1.1 -1.1
Major Depression (MDD) 1.9 2.3 7.8 -1.9 -2.8 -1.1 0.5 0.9 -0.2
Reaction Time 0.6 1.2 3.2 -0.6 -1.8 -1.7 -0.5 0.4 0.4
Verbal and Numeric Reasoning (VNR) 1.5 3.5 10.9 1.1 2.9 3.3 -0.6 -0.7 0.1
Breast Cancer 0.6 1.4 6.1 -2.5 -0.2 -0.3 1.2 0.5 -0.6
Ovarian Cancer 2.2 2.8 4.8 -2.2 -1.3 -1.8 -1.8 -0.7 1.9
Prostate Cancer 0.6 0.9 1.6 1.2 0.1 0.1 1.3 -1.1 -1.0
Age at First Birth 1.7 2.5 5.7 1.2 1.2 2.4 -0.9 -2.1 0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.1 -0.2 0.1 -0.1 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.8 0.4 -0.7 -1.4 -0.5 -0.3 0.7
Coronary Artery Disease (CAD) 0.1 0.1 0.5 0.7 0.1 0.1 0.0 -0.1 -0.1
Crohns Disease (2012) 0.7 1.2 2.6 -1.5 0.3 -1.6 -0.2 1.5 0.2
Mean Putamen Volume 0.3 0.4 1.0 0.8 -0.3 0.4 -0.3 -0.5 1.0
Fasting Glucose 2.5 3.0 13.3 0.9 0.8 0.8 1.2 3.6 -1.1
HbA1C 7.3 8.1 26.9 0.3 1.9 1.3 3.2 5.2 -2.5
HDL Cholesterol 0.1 0.2 0.8 -0.2 0.9 0.1 0.6 -0.3 -0.4
LDL Cholesterol 0.8 1.2 3.0 0.8 1.7 0.8 1.3 0.1 -1.0
Lupus 0.1 0.2 0.6 -0.2 0.2 -0.2 0.8 -0.5 -0.4
Neuroticism (2016) 0.3 0.4 1.6 -0.6 -1.3 0.2 -0.2 -0.7 -0.0
Primary Biliary Cirrhosis 0.9 1.2 2.9 1.7 -0.6 0.2 -1.3 -1.2 1.1
Rheumatoid Arthritis 0.6 0.8 1.6 0.7 -1.1 -0.9 -1.0 -1.3 -0.0
Schizophrenia (2014) 0.2 0.3 1.7 -0.4 -0.2 -0.3 -1.3 0.0 0.0
Triglycerides 1.0 1.7 4.1 0.4 0.7 0.5 2.0 1.2 -2.0
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.9 1.5 1.5 0.8 0.2 -0.7 -1.7
Ulcerative Colitis 0.7 1.0 2.4 1.2 1.5 1.0 0.6 -0.4 -0.9
Blood Eosinophil Count 0.2 1.6 5.3 2.3 0.5 1.2 0.4 1.0 -1.1
Blood Platelet Count 0.1 1.0 2.6 1.6 0.4 -0.1 -0.9 -1.4 0.7
Blood Red Count 0.3 2.5 8.4 1.3 2.9 2.2 0.0 -0.5 -0.0
Blood White Count 0.4 2.7 6.4 1.1 -1.4 -1.3 -1.9 -1.1 2.5
Heel T-Score 0.6 4.6 11.4 -0.1 -3.4 -3.4 0.2 2.0 -1.1
BMI 1.1 6.6 16.4 4.0 4.1 2.4 0.1 -1.1 -0.4
Height 0.3 6.3 13.0 1.4 3.6 1.6 3.3 1.8 -2.5
Waist Hip Ratio (WHR) 0.3 1.5 4.5 0.7 1.5 2.1 -0.3 1.2 0.6
Systolic Blood Pressure 0.1 0.3 1.1 -0.2 0.2 -0.0 1.0 -0.3 -0.5
Smoking Status 0.4 0.9 4.0 2.0 -0.3 -0.4 -0.7 -0.5 0.7
Allergy or Eczema 0.4 0.9 2.6 0.2 0.0 1.3 1.1 0.3 -1.6
Cardiovascular Disease 0.4 1.4 6.5 -0.7 -0.3 1.0 0.3 2.5 0.0
Hypothyroidism (self reported) 0.5 1.2 3.0 1.7 -1.6 -0.1 -0.1 -1.2 -0.8
Respiratory disease 0.4 0.8 4.0 -0.3 -0.7 -0.7 0.0 -2.0 0.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.4 -0.0 -1.2 -0.6 -0.9 -0.5 0.4
Lung FEV1/FVC ratio 0.1 0.5 1.7 -0.0 0.0 0.5 1.3 0.1 -1.0
Lung FVC 0.4 1.8 7.1 -0.4 -2.7 -1.6 -0.4 -0.9 0.3
Neuroticism 0.3 0.7 3.4 -0.7 -1.8 0.6 0.0 -0.2 -0.5
Chronotype (morning person) 0.8 1.8 3.2 -1.8 -1.6 -1.7 -0.9 -0.8 0.8
Hair Pigment 0.0 0.6 1.6 0.6 -0.8 -0.8 1.2 0.5 -0.7
Tanning 0.2 2.5 10.6 -3.2 -1.6 -1.4 -0.3 0.2 -0.0
Hand grip strength (left) 0.6 1.5 4.7 -0.1 -2.2 -1.3 0.7 -1.3 -0.8
Number of treatments/medications taken 0.6 1.0 3.2 -0.3 -1.8 -0.5 1.1 0.5 -1.0
Average weekly spirits intake 0.2 0.3 0.8 -0.2 0.3 0.9 -0.4 0.6 0.5
Sensitivity / hurt feelings 0.1 0.2 0.8 -0.4 -0.1 0.9 0.3 -0.6 -0.2
Frequency of depressed mood in last 2 weeks 1.2 1.7 4.7 0.2 -1.8 0.5 -2.2 -0.5 1.4
Hearing difficulty/problems: Yes 0.6 0.9 2.1 -1.0 -0.6 -0.1 -1.5 -0.6 1.2
Relative age of first facial hair 1.3 2.6 4.1 -2.0 -2.0 -1.8 0.8 -0.4 -1.8
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.4 -1.2 -0.9 0.1 1.1 0.6 -0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.0 0.3 -0.2 -1.0 0.6 0.8 -0.6
Ever had hysterectomy (womb removed) 2.3 2.6 7.4 2.1 2.7 1.9 0.3 -0.5 -0.0
Systolic blood pressure, automated reading 0.4 1.1 3.2 1.2 1.8 1.4 0.5 0.2 -0.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.9 -0.9 -0.8 -0.8 -0.2 0.5 0.2
Angina 0.5 0.7 2.2 -1.1 -1.5 -0.2 -0.0 -0.8 0.1
Medication for hormone replacement therapy 0.4 0.4 1.3 -0.1 -1.0 0.1 0.4 1.1 -0.2
Vitamin and mineral supplements 0.4 0.6 3.0 0.1 1.7 0.2 -0.1 -0.6 0.2
Supplements: Zinc 1.5 1.6 3.6 -1.0 -0.1 -1.9 -1.2 1.0 1.6
Medication: Co-codamol 1.1 1.3 4.4 -0.2 1.0 0.1 2.1 0.8 -1.2
Medication: Metformin 0.2 0.3 0.7 0.7 -0.8 -0.2 -0.0 0.1 -0.6
Diabetes (father) 0.7 0.9 2.2 0.6 -0.2 1.5 0.5 1.0 -1.3
Diabetes (mother) 1.0 1.3 6.0 0.1 0.6 2.4 0.9 -0.2 -0.9
Severe depression (siblings) 0.6 0.7 1.7 0.2 -0.3 -0.4 -1.3 -0.7 1.3
Pack years adult smoking proportion 0.5 0.7 3.3 1.8 0.6 0.3 0.3 0.5 -0.2
Impedance of leg (right) 0.2 0.9 1.9 -1.1 -1.4 -0.2 -1.0 -0.1 1.1
Leg fat-free mass (left) 0.5 2.7 6.6 2.2 2.6 1.4 1.4 -0.6 -0.9
Trunk fat percentage 0.4 1.7 4.3 1.6 2.1 1.7 -0.5 -0.3 0.5
Hand grip strength (right) 0.7 2.0 5.7 0.3 -2.4 -1.1 -0.0 -2.2 0.1
Townsend deprivation index at recruitment 1.2 1.7 4.0 2.0 1.2 0.1 -1.1 -1.7 0.8
Current tobacco smoking 0.2 0.3 0.7 0.7 0.9 0.5 -0.0 -0.5 -0.1
Average weekly fortified wine intake 0.8 0.9 1.6 0.1 1.0 0.9 0.8 1.3 -1.1
Maternal smoking around birth 0.2 0.2 0.8 0.4 0.2 -0.0 -0.4 0.5 0.9
Fed-up feelings 0.9 1.6 5.9 1.0 -1.2 2.4 0.1 -0.9 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.5 -0.2 0.1 0.9 -1.2 -1.1 1.0
Relative age voice broke 0.6 1.0 2.1 0.1 -0.7 -1.4 0.7 0.9 -1.5
Taking other prescription medications 0.8 1.3 3.6 -1.2 -1.9 -1.4 0.5 0.1 -0.7
Age when periods started (menarche) 2.8 6.7 17.8 -4.2 -2.8 -3.6 1.0 0.6 -0.3
Bilateral oophorectomy (both ovaries removed) 2.7 3.1 7.0 2.2 -0.2 -0.3 -2.6 1.2 2.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.3 0.2 -0.4 -0.4 -0.2 0.6 -0.2
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.8 0.0 0.7 0.6 1.3 0.8 -1.2
Qualifications: CSEs or equivalent 0.2 0.3 1.2 0.1 -1.1 -0.2 0.3 -0.7 -0.3
Serious illness, injury or assault to yourself 2.7 3.3 6.2 -2.4 -2.5 -2.5 1.1 -0.4 -0.5
High blood pressure 0.2 0.5 2.2 -0.4 -0.3 0.6 0.2 1.5 0.0
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.2 0.7 0.5 1.5 0.6 -0.2 -1.0
Multivitamins +/- minerals 0.9 1.2 3.2 0.3 -1.3 -0.5 1.0 1.8 -0.7
Stomach or abdominal pain in last month 1.8 2.2 4.5 -2.1 -2.1 -1.6 -0.6 -1.2 0.3
Supplements: Glucosamine 1.9 2.5 6.1 2.5 1.6 1.1 1.9 -0.5 -1.2
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.3 0.7 -1.8 -1.2 0.4 0.4 0.5
Medication: Atenolol 1.7 2.2 3.7 1.1 1.4 1.6 1.6 1.9 -1.0
Medication: Levothyroxine sodium 1.0 1.7 4.0 1.3 -1.8 0.4 0.5 -2.0 -1.1
Sitting height 0.2 1.4 3.0 1.0 1.0 0.7 1.7 0.7 -1.6
Chronic bronchitis/emphysema (father) 0.9 1.1 2.1 -0.4 -0.2 -1.3 -1.4 -0.8 1.4
High blood pressure (mother) 0.8 1.2 2.5 0.3 -0.4 0.2 1.4 1.5 -1.6
Body mass index (BMI) 0.5 2.2 6.2 2.3 2.5 1.1 0.3 -0.3 -0.4
Impedance of leg (left) 0.3 1.2 3.8 -1.3 -1.9 -0.5 -1.1 0.2 0.7
Leg predicted mass (left) 0.5 2.5 6.2 2.0 2.5 1.4 1.3 -0.7 -0.8
Trunk fat mass 0.6 2.4 6.4 2.1 2.5 1.8 -0.0 -0.6 0.1
Waist circumference 0.7 2.7 7.0 2.4 2.7 1.7 -0.1 -0.6 0.2
Number of incorrect matches in round 2.7 4.4 8.8 -1.0 -2.7 -0.6 -3.0 -1.4 2.7
Past tobacco smoking 0.8 1.5 3.9 0.1 1.6 2.0 1.4 0.2 -0.6
Alcohol usually taken with meals 1.6 2.6 4.6 -0.5 -1.6 -1.8 -2.1 -1.7 1.5
Nervous feelings 1.0 1.8 4.0 -1.0 -2.0 0.3 -1.5 0.1 1.9
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 6.6 0.6 -0.6 0.9 -2.6 -0.8 1.8
Hearing difficulty/problems with background noise 0.9 1.4 3.6 -0.2 -0.1 0.1 -1.9 -1.2 1.8
Hair/balding pattern: Pattern 2 0.1 0.2 0.6 0.3 0.3 0.5 0.7 -0.0 0.3
Had menopause 0.5 0.6 1.9 -0.4 0.0 -1.4 -0.8 0.9 0.5
Had other major operations 0.8 0.9 3.3 -0.2 -0.0 0.1 -1.2 -0.8 1.8
Forced vital capacity (FVC) 0.1 0.6 1.1 0.6 -1.0 -0.5 -0.3 -1.0 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.2 0.7 0.0 -0.0 -1.1 0.7 0.8
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.3 -0.8 0.4 1.1 0.2 0.3 -0.9
Qualifications: None of the above 0.5 1.1 1.5 -0.9 -0.7 -1.2 1.1 1.2 -1.0
Financial difficulties in last 2 years 0.4 0.6 2.0 -1.4 0.1 -0.4 -0.2 1.2 0.1
Mouth/teeth dental problems 0.1 0.1 0.3 -0.5 0.2 0.3 -0.1 0.3 -0.5
Heart attack 1.9 2.4 3.3 -1.8 -1.7 -1.1 -1.5 -1.8 1.3
Allergy 0.1 0.2 0.7 0.2 -0.0 -0.4 -0.1 0.8 0.1
Pain all over the body in last month 1.0 1.1 3.2 0.6 -0.7 0.1 -1.8 -0.8 1.3
Diabetes (self-reported) 0.3 0.5 1.2 -0.5 -1.0 -1.1 -0.3 0.3 0.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 -0.4 0.9 0.9 0.8 0.8 -0.1
Medication: Ramipril 1.1 1.4 3.0 -1.2 -1.7 -1.6 -0.2 -1.1 0.3
Medication: Simvastatin 1.4 2.1 8.3 0.2 0.6 1.8 0.7 2.9 -0.6
Fluid intelligence score 0.9 2.0 6.9 0.9 2.0 2.6 -0.1 0.1 -0.2
Illnesses of siblings 0.9 1.2 2.2 -0.3 -1.3 -1.5 -1.1 0.2 1.5
Neuroticism score 0.6 1.2 3.6 -1.6 -1.9 0.1 0.5 -0.0 -0.9
Weight 0.7 3.6 9.6 2.8 3.1 1.7 0.9 -0.4 -0.7
Impedance of arm (right) 0.3 1.5 3.0 -1.7 -1.6 -0.0 -1.2 -0.2 1.5
Arm fat percentage (right) 0.5 2.0 5.3 2.0 2.3 1.6 0.2 -0.3 -0.1
Trunk fat-free mass 0.5 3.1 5.6 2.4 2.4 1.0 1.8 -1.1 -1.4
Hip circumference 0.7 2.9 7.6 2.4 2.8 1.2 1.1 -0.9 -0.8
Time employed in main current job 0.5 0.6 1.8 -0.5 0.6 -0.2 -0.9 -0.5 1.3
Alcohol intake versus 10 years previously 0.5 0.7 2.4 1.6 0.2 0.6 0.6 0.1 -0.9
Father’s age at death 0.7 1.0 1.9 -1.0 -0.3 -0.6 0.9 1.3 -1.4
Worrier / anxious feelings 0.7 1.3 4.0 -1.8 -2.0 -0.5 0.3 0.0 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 3.0 -1.2 -1.7 -1.0 0.3 -0.7 -1.0
Falls in the last year 1.3 1.7 3.6 -0.9 -0.3 -0.7 1.6 1.7 -1.9
Hair/balding pattern: Pattern 3 0.7 1.1 3.0 -0.8 1.7 0.8 0.7 1.2 -0.8
Number of live births 0.5 0.7 1.3 1.1 -0.6 -1.1 -0.4 -1.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.3 0.5 -1.1 -0.2 0.4 -0.7 0.0
Pulse rate 0.9 1.6 5.6 0.0 0.7 0.3 -0.9 -2.4 1.5
Happiness 0.2 0.3 1.1 -0.0 -0.3 0.6 -0.4 -1.0 -0.3
Noisy workplace 0.7 0.9 2.0 -1.4 -0.6 -1.0 -0.1 1.4 -0.4
Qualifications: A levels/AS levels or equivalent 0.9 2.0 5.9 1.7 1.8 2.4 -0.5 -0.1 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 3.8 1.1 -1.0 0.8 -1.9 -1.8 1.7
Mouth/teeth dental problems: Dentures 0.3 0.4 0.9 -0.1 -0.4 -0.6 1.0 0.8 -0.8
Asthma 0.2 0.4 0.8 -0.2 -0.8 -0.6 -0.3 -0.9 0.3
Medication: Ibuprofen (e.g. Nurofen) 3.7 4.7 10.5 -0.4 -2.1 -1.2 -2.2 -3.2 2.7
Medication: Cholesterol lowering 0.5 0.8 1.6 -0.8 -1.1 -0.3 0.6 1.3 -0.9
Depression (self-reported) 1.0 1.1 2.2 0.3 -0.1 1.4 1.0 1.5 -1.3
Medication: Lansoprazole 1.2 1.4 3.3 1.0 0.7 0.6 1.5 -0.9 -1.8
Prospective memory result 2.5 3.1 9.3 -1.4 -1.9 -3.0 -1.1 -0.1 1.7
Lung cancer (father) 1.0 1.2 3.0 0.8 0.7 0.4 -0.9 1.7 1.4
Illnesses of mother 2.1 2.6 5.7 -0.1 0.3 -0.7 -2.4 -2.3 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.5 0.6 -1.6 0.7 0.7 -1.3 0.3
Pulse wave Arterial Stiffness index 1.5 1.7 4.7 0.9 2.0 2.2 0.5 0.3 -0.6
Impedance of arm (left) 0.4 1.7 3.0 -1.6 -1.2 0.7 -1.5 -0.1 1.7
Arm fat mass (right) 0.7 2.8 7.3 2.5 2.7 1.6 0.5 -0.5 -0.4
Trunk predicted mass 0.6 3.2 5.7 2.4 2.4 1.0 1.9 -1.0 -1.5
Standing height 0.1 1.5 2.8 1.3 1.7 1.5 1.2 -0.4 -0.7
Length of working week for main job 0.4 0.4 0.8 -0.8 0.3 -0.3 0.9 -0.8 -0.5
Exposure to tobacco smoke at home 0.7 0.8 2.1 0.0 -0.3 -0.9 1.1 1.4 -0.6
Breastfed as a baby 0.3 0.4 1.4 -1.2 -0.1 -0.9 0.3 0.1 -0.1
Tense / ‘highly strung’ 0.6 1.1 2.3 -1.2 -1.5 -1.1 -0.7 0.2 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 5.8 -1.2 -2.4 0.4 -0.7 -0.2 -0.3
Hair/balding pattern: Pattern 4 0.5 1.2 2.4 -0.7 -0.6 0.7 1.2 1.3 -1.6
Birth weight of first child 0.2 0.4 0.8 -0.0 0.9 0.9 -0.1 -0.6 0.5
Peak expiratory flow (PEF) 0.1 0.2 0.7 -0.2 -0.5 -0.0 0.8 -0.1 -0.5
Pulse wave reflection index 1.9 2.4 5.5 1.6 1.7 2.3 1.0 1.0 -1.1
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.6 -0.2 0.0 -0.2 0.4 0.8 -1.3
Loud music exposure frequency 1.3 1.5 3.6 -1.2 -1.5 -1.9 -0.7 -1.0 0.5
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.5 1.6 1.2 1.1 0.4 -0.3 -0.1
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.0 0.4 -0.5 0.0 -1.4 -0.4 1.3
Blood clot in the leg (DVT) 1.4 1.9 5.5 0.9 -1.0 -1.6 -0.5 -2.3 1.0
Medication: Paracetamol 0.1 0.2 0.3 0.6 -0.2 0.0 -0.5 -0.6 0.3
Headache pain in last month 0.8 1.4 6.4 0.3 -2.5 -0.3 -0.8 -0.9 0.3
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 2.4 1.1 0.6 0.3 -1.4 -1.6 1.5
Glaucoma (self-reported) 0.8 1.0 2.5 0.7 -0.2 -0.1 -1.4 -0.9 1.6
Gout (self-reported) 0.6 0.8 3.6 0.4 -0.2 -0.0 1.0 1.9 -0.5
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 4.5 1.9 -1.6 -0.5 0.5 -2.1 -1.4
Medication: Amlodipine 0.2 0.3 1.4 0.3 0.1 -0.2 0.5 1.2 0.1
Medication: Ventolin 100micrograms inhaler 1.4 1.8 7.1 -0.1 -1.2 -1.0 -0.9 -2.7 0.5
Birth weight 0.0 0.1 0.2 0.3 0.1 0.5 -0.2 -0.4 0.0
Chronic bronchitis/emphysema (mother) 1.7 2.0 3.3 1.2 1.6 1.7 1.0 -1.8 -0.7
High blood pressure (siblings) 0.6 0.9 2.1 -0.8 0.7 0.2 1.4 0.6 -1.4
Forced vital capacity (FVC), Best measure 0.2 0.9 2.7 0.3 -1.6 0.2 -0.0 -1.2 0.9
Body fat percentage 0.4 1.7 4.8 1.8 2.2 1.5 -0.4 -0.3 0.3
Leg fat percentage (right) 0.5 1.7 4.2 2.0 2.0 1.4 -0.1 -0.5 0.3
Arm fat-free mass (right) 0.8 4.0 8.9 2.8 3.0 1.4 1.6 -0.7 -1.5
Exposure to tobacco smoke outside home 0.4 0.6 1.5 -0.4 1.2 -0.9 -0.2 0.9 0.3
Comparative body size at age 10 0.2 0.5 2.1 0.6 0.2 0.7 0.1 -1.4 -0.2
Number of full brothers 2.3 3.0 5.0 -2.0 -1.3 -1.8 2.2 0.8 -1.8
Worry too long after embarrassment 0.4 0.6 1.8 -0.5 0.5 0.8 0.8 -0.3 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.1 0.3 -1.0 0.0 -0.7 -0.3 0.4
Wheeze or whistling in the chest in last year 0.9 1.7 3.1 -0.4 -1.3 -1.4 -1.8 -1.1 1.4
Number of children fathered 1.4 1.6 3.1 -1.1 -1.8 -0.9 -1.8 0.5 1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 3.2 1.8 0.2 0.1 -1.3 -0.7 1.3
Age at first live birth 0.8 1.4 4.1 -2.0 0.7 -0.8 -0.2 1.8 -0.2
Pulse wave peak to peak time 1.4 1.6 4.5 -0.9 -2.0 -2.1 -0.4 -0.2 0.5
Health satisfaction 0.3 0.3 0.9 -0.4 -0.9 -0.5 -0.1 0.6 -0.6
Shortness of breath walking on level ground 0.6 0.7 2.3 0.3 -0.4 -0.1 -1.2 0.1 1.5
Qualifications: College or University degree 0.2 0.6 2.1 0.2 1.4 0.9 -0.5 0.4 0.3
Eye problems/disorders: None of the above 1.8 2.1 3.4 1.7 0.8 1.9 1.5 1.1 -1.4
Mouth/teeth dental problems: Loose teeth 1.8 2.2 6.1 -1.4 -2.5 -2.1 0.5 -0.3 -0.6
Emphysema/chronic bronchitis 0.3 0.3 0.8 -0.8 -0.7 0.1 0.1 0.9 0.0
Medication for pain relief, constipation, heartburn 0.5 0.9 2.9 0.2 1.4 0.7 -0.2 1.7 -0.1
Neck or shoulder pain in last month 1.7 2.4 4.7 -1.5 -1.5 -1.6 -2.2 0.6 1.5
Medication: Blood pressure 0.7 1.3 2.1 -1.5 -0.2 -0.1 1.4 1.2 -1.4
Angina (self-reported) 0.6 0.8 2.6 -1.2 -1.6 -0.4 -0.2 -0.7 0.1
Migraine (self-reported) 1.1 1.4 5.3 0.2 -0.7 1.1 -1.0 -2.3 0.7
Medication: Ibuprofen 1.4 1.7 4.8 -0.0 -1.2 -0.5 -1.2 -2.2 1.5
Medication: Allopurinol 1.3 1.7 5.0 -1.1 -0.8 -2.2 -0.2 1.8 0.4
Medication: Omeprazole 0.7 0.8 1.8 -0.4 -0.2 -0.7 -1.3 -0.7 1.3
Medication: Seretide 50 evohaler 1.1 1.2 3.1 -0.3 -1.0 -1.3 -1.8 -0.7 1.0
Mean time to correctly identify matches 0.7 1.3 4.9 -0.6 -1.5 -2.2 -0.1 0.6 -0.1
Heart disease (mother) 4.0 4.9 11.8 -2.2 -3.4 -2.0 -2.1 0.6 2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.2 -0.3 -1.1 -0.5 0.0 0.1 -0.2
Whole body fat mass 0.6 2.7 7.8 2.2 2.8 1.7 0.3 -0.6 -0.1
Leg fat mass (right) 0.6 2.3 5.8 2.3 2.4 1.5 0.4 -0.5 -0.2
Arm predicted mass (right) 0.8 3.9 9.1 2.7 3.0 1.4 1.5 -0.9 -1.4
Pulse rate, automated reading 0.3 1.0 2.0 0.6 0.8 -0.4 -1.0 -1.4 1.4
Alcohol intake frequency. 0.8 1.9 5.5 -0.8 -2.3 -1.6 0.9 -1.1 -0.9
Comparative height size at age 10 0.8 4.2 9.1 3.0 2.7 2.5 0.9 -1.0 -0.6
Number of full sisters 0.8 1.0 2.9 1.1 1.0 0.4 -0.4 -1.7 -0.8
Suffer from ‘nerves’ 0.3 0.5 1.6 -1.0 -1.3 -0.1 0.3 0.3 -0.6
Overall health rating 0.2 0.3 0.6 0.3 -0.6 -0.2 -0.7 -0.7 0.8
Chest pain or discomfort 0.5 0.7 2.0 1.4 0.7 1.0 -0.2 -0.8 0.4
Had major operations 1.0 1.1 3.8 0.7 -0.4 0.1 -1.9 -0.3 1.5
Age at last live birth 0.5 0.7 2.7 -0.7 1.6 0.3 0.3 0.6 -0.7
Family relationship satisfaction 0.7 0.8 3.8 -0.2 -0.2 -0.4 -0.8 -1.9 0.6
Leg pain on walking 0.6 0.8 1.3 -1.2 -0.5 -1.1 0.9 0.3 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 3.0 0.6 -0.7 0.4 -0.2 -1.7 -0.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.2 0.8 0.3 0.3 -1.5 0.5 1.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.7 0.6 0.8 0.9 0.8 0.1 -0.5
Medication: Aspirin 0.7 0.9 1.6 -1.2 -0.6 -0.6 1.3 0.4 -1.2
Supplements: Vitamin C 0.1 0.1 0.3 0.1 0.4 -0.3 -0.6 -0.1 0.2
Knee pain experienced in last month 0.4 0.7 2.2 0.7 0.4 0.1 -1.5 -0.8 0.7
Hypertension (Self-reported) 0.2 0.6 2.8 -0.4 -0.3 0.7 0.4 1.7 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 4.2 0.5 1.0 0.9 2.0 -0.1 -1.7
Illnesses of father: Heart disease 0.4 0.5 2.2 -0.5 -1.5 0.1 -0.3 0.4 0.7
Illnesses of siblings: Diabetes 0.6 0.7 1.1 0.8 0.3 0.9 1.1 0.9 -1.0
Smoking status: Previous 0.8 1.2 3.5 0.3 -1.9 -1.3 -1.2 0.3 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.3 0.5 -0.5 -0.1 0.0 -0.1 0.1
Whole body fat-free mass 0.6 3.2 6.6 2.4 2.6 1.2 1.7 -0.9 -1.3
Leg fat-free mass (right) 0.4 2.3 5.2 1.9 2.3 1.2 1.4 -0.4 -1.1
Arm fat percentage (left) 0.6 2.4 6.6 2.0 2.6 2.0 0.3 -0.2 -0.3
Average weekly red wine intake 0.2 0.3 1.0 -0.7 0.1 -1.0 -0.6 0.3 -0.1
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.5 0.2 -1.1 -1.6 -0.7 0.4 1.3
Mood swings 0.5 1.0 3.3 0.5 -0.9 1.8 -0.6 -1.0 -0.3
Loneliness, isolation 1.6 2.2 5.6 -0.7 1.0 1.1 2.3 0.0 -2.4
Long-standing illness, disability or infirmity 1.0 1.6 5.8 0.1 -2.4 -0.8 0.4 -1.7 -0.2
Ever had bowel cancer screening 0.0 0.0 0.1 0.1 0.1 -0.3 0.3 0.1 -0.0
Diabetes diagnosed by doctor 0.4 0.7 2.2 -0.7 -1.5 -1.2 -0.3 0.1 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.7 0.2 1.3 0.5 0.7 0.7 -1.2
Friendships satisfaction 0.1 0.1 0.3 0.1 0.4 0.5 0.1 -0.1 -0.5
Qualifications: nursing, teaching 0.3 0.5 1.6 -0.2 1.3 0.3 -0.4 0.6 0.8
Commuting to job workplace: Walk 0.7 0.8 1.7 -0.9 0.7 -0.1 -0.9 -1.3 0.9
Eye problems/disorders: Cataract 1.2 1.4 4.2 -2.1 -0.5 -1.7 -0.8 0.0 0.5
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 4.3 -0.6 -0.0 -0.9 1.2 2.1 -0.6
Medication for cholesterol 1.3 2.0 8.0 0.0 0.0 -1.7 -0.5 -2.8 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.7 3.2 -1.2 -1.8 -1.5 1.1 1.1 -0.9
Back pain experienced in last month 0.4 0.5 1.0 0.5 -0.6 -1.0 0.5 -0.8 -0.9
Mineral and other dietary supplements 0.4 0.6 1.4 -1.2 0.1 -1.1 -0.9 0.3 0.5
Breast cancer (self-reported) 1.9 2.3 7.0 -1.2 -0.3 -0.2 -2.6 0.0 2.3
Asthma (self-reported) 0.2 0.4 1.0 -0.4 -1.0 -0.7 -0.3 -0.8 0.2
Osteoporosis (self-reported) 1.7 2.1 5.2 -1.2 -0.3 0.1 1.5 2.3 -1.9
Osteoarthritis (self-reported) 1.5 1.9 4.8 -0.1 -1.4 -0.8 -2.2 -0.6 1.9
Medication: Aspirin 0.5 0.6 1.3 -1.2 -0.5 -0.9 0.9 -0.1 -0.6
Medication: Gliclazide 0.4 0.5 1.6 0.1 -0.3 -1.3 0.7 -0.5 -0.7
Illnesses of father: None of the above (group 1) 0.3 0.4 1.8 0.4 1.3 0.0 0.3 -0.4 0.0
Smoking status: Current 0.1 0.2 0.7 0.4 0.8 0.0 0.2 -0.4 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.5 -0.1 -1.6 0.2 0.6 -0.8 -0.3
Whole body water mass 0.6 3.3 7.0 2.4 2.6 1.3 1.7 -0.8 -1.3
Leg predicted mass (right) 0.4 2.1 4.8 1.9 2.2 1.1 1.3 -0.5 -1.1
Arm fat mass (left) 0.7 3.0 8.2 2.4 2.9 1.8 0.8 -0.1 -0.6
Number of self-reported non-cancer illnesses 0.7 1.2 3.6 0.1 0.0 0.4 1.9 0.0 -1.9
Average weekly champagne plus white wine intake 0.2 0.2 0.7 0.7 0.3 -0.1 0.8 0.0 0.2
Miserableness 1.1 1.8 8.2 1.5 0.4 2.9 -0.4 0.1 0.5
Guilty feelings 0.5 0.8 4.5 -2.1 -0.6 -0.0 0.1 0.2 -0.1
Wears glasses or contact lenses 1.5 1.7 2.7 0.8 1.1 1.4 1.6 1.3 -1.3
Ever taken oral contraceptive pill 1.7 1.9 4.1 1.8 2.0 1.7 -0.0 -1.1 -0.2
Hearing aid user 0.2 0.2 0.8 0.1 -0.3 -0.2 0.4 0.9 0.0
Mother’s age at death 1.8 2.3 4.9 -1.5 -1.9 -2.2 -1.4 -0.7 0.5
Financial situation satisfaction 0.4 0.6 1.8 -0.3 -0.7 -1.3 -0.9 0.3 0.1
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.6 -1.0 -1.3 -0.1 -0.4 0.3 0.5
Commuting to job workplace: Public transport 0.4 0.5 1.5 0.4 0.6 0.8 0.3 1.2 -0.2
Eye problems/disorders: Glaucoma 1.2 1.4 3.2 0.8 0.0 -0.2 -1.6 -1.4 1.8
Medication: Blood pressure 0.5 1.0 4.1 -0.1 0.2 1.1 0.5 2.0 -0.5
Pain type(s) experienced in last month: Hip pain 2.2 2.7 5.7 0.7 -1.6 -1.1 -2.4 -1.1 2.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.6 0.9 -1.6 -0.4 -0.7 -0.4 0.7
High cholesterol (Self-reported) 1.5 2.7 10.8 -1.2 -1.1 1.2 0.5 3.3 -0.9
Medication: Bendroflumethiazide 0.4 0.6 3.2 -0.4 0.3 0.1 0.2 1.8 -0.3
Medication: Paracetamol 0.2 0.2 0.5 0.7 0.1 0.1 -0.7 -0.7 0.2
Medication: Lisinopril 0.4 0.5 1.0 -0.9 0.4 -1.0 -0.0 0.3 -1.0
Medication: Atorvastatin 1.6 2.0 5.7 -1.3 -2.4 -1.8 -0.9 -0.5 0.5
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.6 0.5 0.3 -0.2 -0.6 -0.3
Alcohol drinker status: Never 0.2 0.2 0.5 0.6 -0.7 0.2 -0.1 -0.5 -0.1
Ever smoked 0.6 1.0 4.2 -0.3 -1.0 -2.0 -0.6 0.2 -0.5
Basal metabolic rate 0.6 3.5 7.8 2.5 2.8 1.4 1.7 -0.8 -1.3
Leg fat percentage (left) 0.4 1.5 3.9 2.0 1.8 1.2 -0.1 -0.5 0.1
Arm fat-free mass (left) 0.7 3.7 8.6 2.9 2.6 1.4 1.5 -0.7 -1.3
Number of operations (self-reported) 0.5 0.8 2.5 -0.3 -0.6 -0.1 -1.6 0.0 1.4
Average weekly beer plus cider intake 0.3 0.4 1.5 1.2 0.0 0.5 0.1 -0.6 0.6
Irritability 0.3 0.5 1.4 -0.0 -0.3 1.2 0.9 -0.2 -0.9
Risk taking 0.5 0.7 1.7 -0.7 1.0 0.3 0.6 -0.7 -1.3
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 -0.4 -0.3 0.6 -0.0 -0.6 -0.1
Fractured/broken bones in last 5 years 0.1 0.2 0.8 -0.3 0.0 -0.2 0.0 -0.9 -0.2
Age started oral contraceptive pill 0.7 0.9 2.2 -1.5 -0.1 -1.4 -0.5 0.9 0.3
Diastolic blood pressure, automated reading 0.5 1.6 2.1 1.5 1.2 0.9 -1.3 -1.2 1.4
Ever depressed for a whole week 1.1 1.3 4.4 -1.3 -2.1 -0.7 -0.0 -1.0 -0.4
Unable to work because of sickness or disability 0.4 0.5 1.3 0.8 -0.7 -0.3 -0.4 -1.2 0.6
Commuting to job workplace: Cycle 1.2 1.5 5.0 -0.6 -1.5 -2.2 0.2 -0.7 -0.8
Myopia 0.6 0.8 2.5 -0.9 -1.6 -0.1 0.4 1.2 -0.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 2.3 0.6 0.8 -0.3 -0.4 -1.5 0.2
Cholesterol lowering medication 0.6 0.9 2.7 -0.2 -0.2 1.1 -1.1 1.6 0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 -0.6 -0.4 -1.0 -0.7 -0.8 0.4
Pain experienced in last month 1.3 2.1 4.3 -0.5 2.1 1.8 0.9 2.0 -0.3
Supplements: Calcium 0.9 1.0 1.8 -1.3 -0.2 0.9 1.2 1.2 -0.8
Basal cell carcinoma (self-reported) 2.5 3.0 10.0 -3.2 -1.3 -2.3 0.4 -0.6 -0.7
Heart attack/myocardial infarction (self-reported) 1.3 1.7 2.5 -1.5 -1.5 -0.8 -1.3 -1.6 1.1
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 4.9 0.7 -1.0 -1.9 -0.4 -2.2 1.0
Heart disease (siblings) 0.3 0.3 0.8 -0.5 -0.3 0.6 -0.9 -0.3 0.7
Alcohol drinker status: Previous 1.6 1.8 7.2 -0.4 -1.3 -2.7 0.5 -1.1 -0.4
Pack years of smoking 0.5 0.7 3.1 1.8 0.6 0.4 0.4 0.6 -0.3
Impedance of whole body 0.4 1.9 3.4 -1.6 -1.9 0.2 -1.7 0.2 1.6
Leg fat mass (left) 0.6 2.2 5.6 2.3 2.4 1.4 0.3 -0.4 -0.2
Arm predicted mass (left) 0.7 3.7 8.2 2.9 2.7 1.2 1.6 -0.9 -1.4