Hub : Genes

ZNF595

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.1530	0.0600	0.00093	0.045	NA	-0.002	NA	0.030	0.0190	NA	0.36000	NA	0.0460
2	GTEx	Brain Cerebellum	0.1340	0.0640	0.00610	0.049	NA	0.098	NA	0.093	0.0150	NA	0.00078	NA	0.0011
3	GTEx	Muscle Skeletal	0.0764	0.0370	0.00072	-0.003	NA	0.010	NA	-0.002	0.9700	NA	0.03300	NA	0.6500
4	NTR	Blood	0.0153	0.0091	0.00410	0.009	0.004	0.001	0.002	0.004	0.0006	0.0180	0.14000	0.058	0.0180
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0473	0.0283	0.00320	-0.002	0.011	0.012	NA	-0.001	0.9800	0.0180	0.01400	NA	0.4000
6	TCGA	Brain Lower Grade Glioma	0.0206	0.0132	0.00940	0.019	0.014	0.009	NA	0.013	0.0029	0.0081	0.02700	NA	0.0110

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	2.5	-1.6	-0.8	-1.3	-0.7	0.0	0.0
Bipolar Disorder or Schizophrenia	1.1	2.6	4.7	-1.8	-1.2	-1.7	-2.2	0.6	1.8
Depressed Affect (Nagel 2018)	0.5	1.0	3.3	0.7	-0.9	1.8	0.5	-0.3	-0.9
Depression (Nagel 2018)	1.2	1.8	3.1	0.3	-1.4	0.6	-1.8	1.6	1.7
Intelligence (Savage-Jansen 2018)	1.2	3.7	11.6	0.8	3.4	2.9	0.7	-0.5	-0.9
Neuroticism (Nagel 2018)	0.3	0.7	2.5	-0.1	-1.1	1.6	-0.0	-0.7	-0.3
Schizophrenia (2018)	1.1	2.4	5.9	-0.9	-0.9	-1.3	-2.2	-0.5	2.4
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.7	0.5	0.9	-0.7	0.0	0.0
Worry (Nagel 2018)	0.8	1.7	6.6	-1.3	-2.6	-0.3	-0.0	1.3	0.3
Alzheimer’s Disease (in mother)	1.8	2.1	7.5	2.7	1.4	1.6	0.2	0.9	0.0
Alzheimer’s Disease (in father)	0.7	0.7	4.3	-0.2	-2.1	-0.1	0.2	0.3	0.1
Alzheimer’s Disease (including proxy)	1.2	1.7	6.4	2.5	0.2	1.4	-1.0	-0.1	0.8
Crohns Disease (2017)	1.0	2.2	4.7	-1.3	0.6	-1.4	1.6	1.5	-2.2
Irritable Bowel Disease (IBD)	0.5	1.1	3.1	-0.1	0.8	-1.0	1.3	0.2	-1.8
Ulcerative Colitis (UC)	0.5	0.9	1.4	1.2	1.1	0.1	0.6	-1.1	-1.1
Major Depression (MDD)	1.9	2.3	7.8	-1.9	-2.8	-1.1	0.5	0.9	-0.2
Reaction Time	0.6	1.2	3.2	-0.6	-1.8	-1.7	-0.5	0.4	0.4
Verbal and Numeric Reasoning (VNR)	1.5	3.5	10.9	1.1	2.9	3.3	-0.6	-0.7	0.1
Breast Cancer	0.6	1.4	6.1	-2.5	-0.2	-0.3	1.2	0.5	-0.6
Ovarian Cancer	2.2	2.8	4.8	-2.2	-1.3	-1.8	-1.8	-0.7	1.9
Prostate Cancer	0.6	0.9	1.6	1.2	0.1	0.1	1.3	-1.1	-1.0
Age at First Birth	1.7	2.5	5.7	1.2	1.2	2.4	-0.9	-2.1	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	0.4	-0.7	-1.4	-0.5	-0.3	0.7
Coronary Artery Disease (CAD)	0.1	0.1	0.5	0.7	0.1	0.1	0.0	-0.1	-0.1
Crohns Disease (2012)	0.7	1.2	2.6	-1.5	0.3	-1.6	-0.2	1.5	0.2
Mean Putamen Volume	0.3	0.4	1.0	0.8	-0.3	0.4	-0.3	-0.5	1.0
Fasting Glucose	2.5	3.0	13.3	0.9	0.8	0.8	1.2	3.6	-1.1
HbA1C	7.3	8.1	26.9	0.3	1.9	1.3	3.2	5.2	-2.5
HDL Cholesterol	0.1	0.2	0.8	-0.2	0.9	0.1	0.6	-0.3	-0.4
LDL Cholesterol	0.8	1.2	3.0	0.8	1.7	0.8	1.3	0.1	-1.0
Lupus	0.1	0.2	0.6	-0.2	0.2	-0.2	0.8	-0.5	-0.4
Neuroticism (2016)	0.3	0.4	1.6	-0.6	-1.3	0.2	-0.2	-0.7	-0.0
Primary Biliary Cirrhosis	0.9	1.2	2.9	1.7	-0.6	0.2	-1.3	-1.2	1.1
Rheumatoid Arthritis	0.6	0.8	1.6	0.7	-1.1	-0.9	-1.0	-1.3	-0.0
Schizophrenia (2014)	0.2	0.3	1.7	-0.4	-0.2	-0.3	-1.3	0.0	0.0
Triglycerides	1.0	1.7	4.1	0.4	0.7	0.5	2.0	1.2	-2.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.9	1.5	1.5	0.8	0.2	-0.7	-1.7
Ulcerative Colitis	0.7	1.0	2.4	1.2	1.5	1.0	0.6	-0.4	-0.9
Blood Eosinophil Count	0.2	1.6	5.3	2.3	0.5	1.2	0.4	1.0	-1.1
Blood Platelet Count	0.1	1.0	2.6	1.6	0.4	-0.1	-0.9	-1.4	0.7
Blood Red Count	0.3	2.5	8.4	1.3	2.9	2.2	0.0	-0.5	-0.0
Blood White Count	0.4	2.7	6.4	1.1	-1.4	-1.3	-1.9	-1.1	2.5
Heel T-Score	0.6	4.6	11.4	-0.1	-3.4	-3.4	0.2	2.0	-1.1
BMI	1.1	6.6	16.4	4.0	4.1	2.4	0.1	-1.1	-0.4
Height	0.3	6.3	13.0	1.4	3.6	1.6	3.3	1.8	-2.5
Waist Hip Ratio (WHR)	0.3	1.5	4.5	0.7	1.5	2.1	-0.3	1.2	0.6
Systolic Blood Pressure	0.1	0.3	1.1	-0.2	0.2	-0.0	1.0	-0.3	-0.5
Smoking Status	0.4	0.9	4.0	2.0	-0.3	-0.4	-0.7	-0.5	0.7
Allergy or Eczema	0.4	0.9	2.6	0.2	0.0	1.3	1.1	0.3	-1.6
Cardiovascular Disease	0.4	1.4	6.5	-0.7	-0.3	1.0	0.3	2.5	0.0
Hypothyroidism (self reported)	0.5	1.2	3.0	1.7	-1.6	-0.1	-0.1	-1.2	-0.8
Respiratory disease	0.4	0.8	4.0	-0.3	-0.7	-0.7	0.0	-2.0	0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.4	-0.0	-1.2	-0.6	-0.9	-0.5	0.4
Lung FEV1/FVC ratio	0.1	0.5	1.7	-0.0	0.0	0.5	1.3	0.1	-1.0
Lung FVC	0.4	1.8	7.1	-0.4	-2.7	-1.6	-0.4	-0.9	0.3
Neuroticism	0.3	0.7	3.4	-0.7	-1.8	0.6	0.0	-0.2	-0.5
Chronotype (morning person)	0.8	1.8	3.2	-1.8	-1.6	-1.7	-0.9	-0.8	0.8
Hair Pigment	0.0	0.6	1.6	0.6	-0.8	-0.8	1.2	0.5	-0.7
Tanning	0.2	2.5	10.6	-3.2	-1.6	-1.4	-0.3	0.2	-0.0
Hand grip strength (left)	0.6	1.5	4.7	-0.1	-2.2	-1.3	0.7	-1.3	-0.8
Number of treatments/medications taken	0.6	1.0	3.2	-0.3	-1.8	-0.5	1.1	0.5	-1.0
Average weekly spirits intake	0.2	0.3	0.8	-0.2	0.3	0.9	-0.4	0.6	0.5
Sensitivity / hurt feelings	0.1	0.2	0.8	-0.4	-0.1	0.9	0.3	-0.6	-0.2
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.7	0.2	-1.8	0.5	-2.2	-0.5	1.4
Hearing difficulty/problems: Yes	0.6	0.9	2.1	-1.0	-0.6	-0.1	-1.5	-0.6	1.2
Relative age of first facial hair	1.3	2.6	4.1	-2.0	-2.0	-1.8	0.8	-0.4	-1.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.4	-1.2	-0.9	0.1	1.1	0.6	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.3	-0.2	-1.0	0.6	0.8	-0.6
Ever had hysterectomy (womb removed)	2.3	2.6	7.4	2.1	2.7	1.9	0.3	-0.5	-0.0
Systolic blood pressure, automated reading	0.4	1.1	3.2	1.2	1.8	1.4	0.5	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.9	-0.8	-0.8	-0.2	0.5	0.2
Angina	0.5	0.7	2.2	-1.1	-1.5	-0.2	-0.0	-0.8	0.1
Medication for hormone replacement therapy	0.4	0.4	1.3	-0.1	-1.0	0.1	0.4	1.1	-0.2
Vitamin and mineral supplements	0.4	0.6	3.0	0.1	1.7	0.2	-0.1	-0.6	0.2
Supplements: Zinc	1.5	1.6	3.6	-1.0	-0.1	-1.9	-1.2	1.0	1.6
Medication: Co-codamol	1.1	1.3	4.4	-0.2	1.0	0.1	2.1	0.8	-1.2
Medication: Metformin	0.2	0.3	0.7	0.7	-0.8	-0.2	-0.0	0.1	-0.6
Diabetes (father)	0.7	0.9	2.2	0.6	-0.2	1.5	0.5	1.0	-1.3
Diabetes (mother)	1.0	1.3	6.0	0.1	0.6	2.4	0.9	-0.2	-0.9
Severe depression (siblings)	0.6	0.7	1.7	0.2	-0.3	-0.4	-1.3	-0.7	1.3
Pack years adult smoking proportion	0.5	0.7	3.3	1.8	0.6	0.3	0.3	0.5	-0.2
Impedance of leg (right)	0.2	0.9	1.9	-1.1	-1.4	-0.2	-1.0	-0.1	1.1
Leg fat-free mass (left)	0.5	2.7	6.6	2.2	2.6	1.4	1.4	-0.6	-0.9
Trunk fat percentage	0.4	1.7	4.3	1.6	2.1	1.7	-0.5	-0.3	0.5
Hand grip strength (right)	0.7	2.0	5.7	0.3	-2.4	-1.1	-0.0	-2.2	0.1
Townsend deprivation index at recruitment	1.2	1.7	4.0	2.0	1.2	0.1	-1.1	-1.7	0.8
Current tobacco smoking	0.2	0.3	0.7	0.7	0.9	0.5	-0.0	-0.5	-0.1
Average weekly fortified wine intake	0.8	0.9	1.6	0.1	1.0	0.9	0.8	1.3	-1.1
Maternal smoking around birth	0.2	0.2	0.8	0.4	0.2	-0.0	-0.4	0.5	0.9
Fed-up feelings	0.9	1.6	5.9	1.0	-1.2	2.4	0.1	-0.9	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	-0.2	0.1	0.9	-1.2	-1.1	1.0
Relative age voice broke	0.6	1.0	2.1	0.1	-0.7	-1.4	0.7	0.9	-1.5
Taking other prescription medications	0.8	1.3	3.6	-1.2	-1.9	-1.4	0.5	0.1	-0.7
Age when periods started (menarche)	2.8	6.7	17.8	-4.2	-2.8	-3.6	1.0	0.6	-0.3
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	7.0	2.2	-0.2	-0.3	-2.6	1.2	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	0.2	-0.4	-0.4	-0.2	0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.8	0.0	0.7	0.6	1.3	0.8	-1.2
Qualifications: CSEs or equivalent	0.2	0.3	1.2	0.1	-1.1	-0.2	0.3	-0.7	-0.3
Serious illness, injury or assault to yourself	2.7	3.3	6.2	-2.4	-2.5	-2.5	1.1	-0.4	-0.5
High blood pressure	0.2	0.5	2.2	-0.4	-0.3	0.6	0.2	1.5	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.2	0.7	0.5	1.5	0.6	-0.2	-1.0
Multivitamins +/- minerals	0.9	1.2	3.2	0.3	-1.3	-0.5	1.0	1.8	-0.7
Stomach or abdominal pain in last month	1.8	2.2	4.5	-2.1	-2.1	-1.6	-0.6	-1.2	0.3
Supplements: Glucosamine	1.9	2.5	6.1	2.5	1.6	1.1	1.9	-0.5	-1.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.3	0.7	-1.8	-1.2	0.4	0.4	0.5
Medication: Atenolol	1.7	2.2	3.7	1.1	1.4	1.6	1.6	1.9	-1.0
Medication: Levothyroxine sodium	1.0	1.7	4.0	1.3	-1.8	0.4	0.5	-2.0	-1.1
Sitting height	0.2	1.4	3.0	1.0	1.0	0.7	1.7	0.7	-1.6
Chronic bronchitis/emphysema (father)	0.9	1.1	2.1	-0.4	-0.2	-1.3	-1.4	-0.8	1.4
High blood pressure (mother)	0.8	1.2	2.5	0.3	-0.4	0.2	1.4	1.5	-1.6
Body mass index (BMI)	0.5	2.2	6.2	2.3	2.5	1.1	0.3	-0.3	-0.4
Impedance of leg (left)	0.3	1.2	3.8	-1.3	-1.9	-0.5	-1.1	0.2	0.7
Leg predicted mass (left)	0.5	2.5	6.2	2.0	2.5	1.4	1.3	-0.7	-0.8
Trunk fat mass	0.6	2.4	6.4	2.1	2.5	1.8	-0.0	-0.6	0.1
Waist circumference	0.7	2.7	7.0	2.4	2.7	1.7	-0.1	-0.6	0.2
Number of incorrect matches in round	2.7	4.4	8.8	-1.0	-2.7	-0.6	-3.0	-1.4	2.7
Past tobacco smoking	0.8	1.5	3.9	0.1	1.6	2.0	1.4	0.2	-0.6
Alcohol usually taken with meals	1.6	2.6	4.6	-0.5	-1.6	-1.8	-2.1	-1.7	1.5
Nervous feelings	1.0	1.8	4.0	-1.0	-2.0	0.3	-1.5	0.1	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	6.6	0.6	-0.6	0.9	-2.6	-0.8	1.8
Hearing difficulty/problems with background noise	0.9	1.4	3.6	-0.2	-0.1	0.1	-1.9	-1.2	1.8
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	0.3	0.3	0.5	0.7	-0.0	0.3
Had menopause	0.5	0.6	1.9	-0.4	0.0	-1.4	-0.8	0.9	0.5
Had other major operations	0.8	0.9	3.3	-0.2	-0.0	0.1	-1.2	-0.8	1.8
Forced vital capacity (FVC)	0.1	0.6	1.1	0.6	-1.0	-0.5	-0.3	-1.0	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	0.7	0.0	-0.0	-1.1	0.7	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.8	0.4	1.1	0.2	0.3	-0.9
Qualifications: None of the above	0.5	1.1	1.5	-0.9	-0.7	-1.2	1.1	1.2	-1.0
Financial difficulties in last 2 years	0.4	0.6	2.0	-1.4	0.1	-0.4	-0.2	1.2	0.1
Mouth/teeth dental problems	0.1	0.1	0.3	-0.5	0.2	0.3	-0.1	0.3	-0.5
Heart attack	1.9	2.4	3.3	-1.8	-1.7	-1.1	-1.5	-1.8	1.3
Allergy	0.1	0.2	0.7	0.2	-0.0	-0.4	-0.1	0.8	0.1
Pain all over the body in last month	1.0	1.1	3.2	0.6	-0.7	0.1	-1.8	-0.8	1.3
Diabetes (self-reported)	0.3	0.5	1.2	-0.5	-1.0	-1.1	-0.3	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	-0.4	0.9	0.9	0.8	0.8	-0.1
Medication: Ramipril	1.1	1.4	3.0	-1.2	-1.7	-1.6	-0.2	-1.1	0.3
Medication: Simvastatin	1.4	2.1	8.3	0.2	0.6	1.8	0.7	2.9	-0.6
Fluid intelligence score	0.9	2.0	6.9	0.9	2.0	2.6	-0.1	0.1	-0.2
Illnesses of siblings	0.9	1.2	2.2	-0.3	-1.3	-1.5	-1.1	0.2	1.5
Neuroticism score	0.6	1.2	3.6	-1.6	-1.9	0.1	0.5	-0.0	-0.9
Weight	0.7	3.6	9.6	2.8	3.1	1.7	0.9	-0.4	-0.7
Impedance of arm (right)	0.3	1.5	3.0	-1.7	-1.6	-0.0	-1.2	-0.2	1.5
Arm fat percentage (right)	0.5	2.0	5.3	2.0	2.3	1.6	0.2	-0.3	-0.1
Trunk fat-free mass	0.5	3.1	5.6	2.4	2.4	1.0	1.8	-1.1	-1.4
Hip circumference	0.7	2.9	7.6	2.4	2.8	1.2	1.1	-0.9	-0.8
Time employed in main current job	0.5	0.6	1.8	-0.5	0.6	-0.2	-0.9	-0.5	1.3
Alcohol intake versus 10 years previously	0.5	0.7	2.4	1.6	0.2	0.6	0.6	0.1	-0.9
Father’s age at death	0.7	1.0	1.9	-1.0	-0.3	-0.6	0.9	1.3	-1.4
Worrier / anxious feelings	0.7	1.3	4.0	-1.8	-2.0	-0.5	0.3	0.0	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.0	-1.2	-1.7	-1.0	0.3	-0.7	-1.0
Falls in the last year	1.3	1.7	3.6	-0.9	-0.3	-0.7	1.6	1.7	-1.9
Hair/balding pattern: Pattern 3	0.7	1.1	3.0	-0.8	1.7	0.8	0.7	1.2	-0.8
Number of live births	0.5	0.7	1.3	1.1	-0.6	-1.1	-0.4	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.3	0.5	-1.1	-0.2	0.4	-0.7	0.0
Pulse rate	0.9	1.6	5.6	0.0	0.7	0.3	-0.9	-2.4	1.5
Happiness	0.2	0.3	1.1	-0.0	-0.3	0.6	-0.4	-1.0	-0.3
Noisy workplace	0.7	0.9	2.0	-1.4	-0.6	-1.0	-0.1	1.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.9	2.0	5.9	1.7	1.8	2.4	-0.5	-0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	3.8	1.1	-1.0	0.8	-1.9	-1.8	1.7
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	-0.1	-0.4	-0.6	1.0	0.8	-0.8
Asthma	0.2	0.4	0.8	-0.2	-0.8	-0.6	-0.3	-0.9	0.3
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	10.5	-0.4	-2.1	-1.2	-2.2	-3.2	2.7
Medication: Cholesterol lowering	0.5	0.8	1.6	-0.8	-1.1	-0.3	0.6	1.3	-0.9
Depression (self-reported)	1.0	1.1	2.2	0.3	-0.1	1.4	1.0	1.5	-1.3
Medication: Lansoprazole	1.2	1.4	3.3	1.0	0.7	0.6	1.5	-0.9	-1.8
Prospective memory result	2.5	3.1	9.3	-1.4	-1.9	-3.0	-1.1	-0.1	1.7
Lung cancer (father)	1.0	1.2	3.0	0.8	0.7	0.4	-0.9	1.7	1.4
Illnesses of mother	2.1	2.6	5.7	-0.1	0.3	-0.7	-2.4	-2.3	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.5	0.6	-1.6	0.7	0.7	-1.3	0.3
Pulse wave Arterial Stiffness index	1.5	1.7	4.7	0.9	2.0	2.2	0.5	0.3	-0.6
Impedance of arm (left)	0.4	1.7	3.0	-1.6	-1.2	0.7	-1.5	-0.1	1.7
Arm fat mass (right)	0.7	2.8	7.3	2.5	2.7	1.6	0.5	-0.5	-0.4
Trunk predicted mass	0.6	3.2	5.7	2.4	2.4	1.0	1.9	-1.0	-1.5
Standing height	0.1	1.5	2.8	1.3	1.7	1.5	1.2	-0.4	-0.7
Length of working week for main job	0.4	0.4	0.8	-0.8	0.3	-0.3	0.9	-0.8	-0.5
Exposure to tobacco smoke at home	0.7	0.8	2.1	0.0	-0.3	-0.9	1.1	1.4	-0.6
Breastfed as a baby	0.3	0.4	1.4	-1.2	-0.1	-0.9	0.3	0.1	-0.1
Tense / ‘highly strung’	0.6	1.1	2.3	-1.2	-1.5	-1.1	-0.7	0.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	5.8	-1.2	-2.4	0.4	-0.7	-0.2	-0.3
Hair/balding pattern: Pattern 4	0.5	1.2	2.4	-0.7	-0.6	0.7	1.2	1.3	-1.6
Birth weight of first child	0.2	0.4	0.8	-0.0	0.9	0.9	-0.1	-0.6	0.5
Peak expiratory flow (PEF)	0.1	0.2	0.7	-0.2	-0.5	-0.0	0.8	-0.1	-0.5
Pulse wave reflection index	1.9	2.4	5.5	1.6	1.7	2.3	1.0	1.0	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.6	-0.2	0.0	-0.2	0.4	0.8	-1.3
Loud music exposure frequency	1.3	1.5	3.6	-1.2	-1.5	-1.9	-0.7	-1.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.5	1.6	1.2	1.1	0.4	-0.3	-0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.0	0.4	-0.5	0.0	-1.4	-0.4	1.3
Blood clot in the leg (DVT)	1.4	1.9	5.5	0.9	-1.0	-1.6	-0.5	-2.3	1.0
Medication: Paracetamol	0.1	0.2	0.3	0.6	-0.2	0.0	-0.5	-0.6	0.3
Headache pain in last month	0.8	1.4	6.4	0.3	-2.5	-0.3	-0.8	-0.9	0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.4	1.1	0.6	0.3	-1.4	-1.6	1.5
Glaucoma (self-reported)	0.8	1.0	2.5	0.7	-0.2	-0.1	-1.4	-0.9	1.6
Gout (self-reported)	0.6	0.8	3.6	0.4	-0.2	-0.0	1.0	1.9	-0.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.5	1.9	-1.6	-0.5	0.5	-2.1	-1.4
Medication: Amlodipine	0.2	0.3	1.4	0.3	0.1	-0.2	0.5	1.2	0.1
Medication: Ventolin 100micrograms inhaler	1.4	1.8	7.1	-0.1	-1.2	-1.0	-0.9	-2.7	0.5
Birth weight	0.0	0.1	0.2	0.3	0.1	0.5	-0.2	-0.4	0.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.3	1.2	1.6	1.7	1.0	-1.8	-0.7
High blood pressure (siblings)	0.6	0.9	2.1	-0.8	0.7	0.2	1.4	0.6	-1.4
Forced vital capacity (FVC), Best measure	0.2	0.9	2.7	0.3	-1.6	0.2	-0.0	-1.2	0.9
Body fat percentage	0.4	1.7	4.8	1.8	2.2	1.5	-0.4	-0.3	0.3
Leg fat percentage (right)	0.5	1.7	4.2	2.0	2.0	1.4	-0.1	-0.5	0.3
Arm fat-free mass (right)	0.8	4.0	8.9	2.8	3.0	1.4	1.6	-0.7	-1.5
Exposure to tobacco smoke outside home	0.4	0.6	1.5	-0.4	1.2	-0.9	-0.2	0.9	0.3
Comparative body size at age 10	0.2	0.5	2.1	0.6	0.2	0.7	0.1	-1.4	-0.2
Number of full brothers	2.3	3.0	5.0	-2.0	-1.3	-1.8	2.2	0.8	-1.8
Worry too long after embarrassment	0.4	0.6	1.8	-0.5	0.5	0.8	0.8	-0.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.3	-1.0	0.0	-0.7	-0.3	0.4
Wheeze or whistling in the chest in last year	0.9	1.7	3.1	-0.4	-1.3	-1.4	-1.8	-1.1	1.4
Number of children fathered	1.4	1.6	3.1	-1.1	-1.8	-0.9	-1.8	0.5	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	1.8	0.2	0.1	-1.3	-0.7	1.3
Age at first live birth	0.8	1.4	4.1	-2.0	0.7	-0.8	-0.2	1.8	-0.2
Pulse wave peak to peak time	1.4	1.6	4.5	-0.9	-2.0	-2.1	-0.4	-0.2	0.5
Health satisfaction	0.3	0.3	0.9	-0.4	-0.9	-0.5	-0.1	0.6	-0.6
Shortness of breath walking on level ground	0.6	0.7	2.3	0.3	-0.4	-0.1	-1.2	0.1	1.5
Qualifications: College or University degree	0.2	0.6	2.1	0.2	1.4	0.9	-0.5	0.4	0.3
Eye problems/disorders: None of the above	1.8	2.1	3.4	1.7	0.8	1.9	1.5	1.1	-1.4
Mouth/teeth dental problems: Loose teeth	1.8	2.2	6.1	-1.4	-2.5	-2.1	0.5	-0.3	-0.6
Emphysema/chronic bronchitis	0.3	0.3	0.8	-0.8	-0.7	0.1	0.1	0.9	0.0
Medication for pain relief, constipation, heartburn	0.5	0.9	2.9	0.2	1.4	0.7	-0.2	1.7	-0.1
Neck or shoulder pain in last month	1.7	2.4	4.7	-1.5	-1.5	-1.6	-2.2	0.6	1.5
Medication: Blood pressure	0.7	1.3	2.1	-1.5	-0.2	-0.1	1.4	1.2	-1.4
Angina (self-reported)	0.6	0.8	2.6	-1.2	-1.6	-0.4	-0.2	-0.7	0.1
Migraine (self-reported)	1.1	1.4	5.3	0.2	-0.7	1.1	-1.0	-2.3	0.7
Medication: Ibuprofen	1.4	1.7	4.8	-0.0	-1.2	-0.5	-1.2	-2.2	1.5
Medication: Allopurinol	1.3	1.7	5.0	-1.1	-0.8	-2.2	-0.2	1.8	0.4
Medication: Omeprazole	0.7	0.8	1.8	-0.4	-0.2	-0.7	-1.3	-0.7	1.3
Medication: Seretide 50 evohaler	1.1	1.2	3.1	-0.3	-1.0	-1.3	-1.8	-0.7	1.0
Mean time to correctly identify matches	0.7	1.3	4.9	-0.6	-1.5	-2.2	-0.1	0.6	-0.1
Heart disease (mother)	4.0	4.9	11.8	-2.2	-3.4	-2.0	-2.1	0.6	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.2	-0.3	-1.1	-0.5	0.0	0.1	-0.2
Whole body fat mass	0.6	2.7	7.8	2.2	2.8	1.7	0.3	-0.6	-0.1
Leg fat mass (right)	0.6	2.3	5.8	2.3	2.4	1.5	0.4	-0.5	-0.2
Arm predicted mass (right)	0.8	3.9	9.1	2.7	3.0	1.4	1.5	-0.9	-1.4
Pulse rate, automated reading	0.3	1.0	2.0	0.6	0.8	-0.4	-1.0	-1.4	1.4
Alcohol intake frequency.	0.8	1.9	5.5	-0.8	-2.3	-1.6	0.9	-1.1	-0.9
Comparative height size at age 10	0.8	4.2	9.1	3.0	2.7	2.5	0.9	-1.0	-0.6
Number of full sisters	0.8	1.0	2.9	1.1	1.0	0.4	-0.4	-1.7	-0.8
Suffer from ‘nerves’	0.3	0.5	1.6	-1.0	-1.3	-0.1	0.3	0.3	-0.6
Overall health rating	0.2	0.3	0.6	0.3	-0.6	-0.2	-0.7	-0.7	0.8
Chest pain or discomfort	0.5	0.7	2.0	1.4	0.7	1.0	-0.2	-0.8	0.4
Had major operations	1.0	1.1	3.8	0.7	-0.4	0.1	-1.9	-0.3	1.5
Age at last live birth	0.5	0.7	2.7	-0.7	1.6	0.3	0.3	0.6	-0.7
Family relationship satisfaction	0.7	0.8	3.8	-0.2	-0.2	-0.4	-0.8	-1.9	0.6
Leg pain on walking	0.6	0.8	1.3	-1.2	-0.5	-1.1	0.9	0.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.0	0.6	-0.7	0.4	-0.2	-1.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	0.8	0.3	0.3	-1.5	0.5	1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	0.6	0.8	0.9	0.8	0.1	-0.5
Medication: Aspirin	0.7	0.9	1.6	-1.2	-0.6	-0.6	1.3	0.4	-1.2
Supplements: Vitamin C	0.1	0.1	0.3	0.1	0.4	-0.3	-0.6	-0.1	0.2
Knee pain experienced in last month	0.4	0.7	2.2	0.7	0.4	0.1	-1.5	-0.8	0.7
Hypertension (Self-reported)	0.2	0.6	2.8	-0.4	-0.3	0.7	0.4	1.7	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	4.2	0.5	1.0	0.9	2.0	-0.1	-1.7
Illnesses of father: Heart disease	0.4	0.5	2.2	-0.5	-1.5	0.1	-0.3	0.4	0.7
Illnesses of siblings: Diabetes	0.6	0.7	1.1	0.8	0.3	0.9	1.1	0.9	-1.0
Smoking status: Previous	0.8	1.2	3.5	0.3	-1.9	-1.3	-1.2	0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.3	0.5	-0.5	-0.1	0.0	-0.1	0.1
Whole body fat-free mass	0.6	3.2	6.6	2.4	2.6	1.2	1.7	-0.9	-1.3
Leg fat-free mass (right)	0.4	2.3	5.2	1.9	2.3	1.2	1.4	-0.4	-1.1
Arm fat percentage (left)	0.6	2.4	6.6	2.0	2.6	2.0	0.3	-0.2	-0.3
Average weekly red wine intake	0.2	0.3	1.0	-0.7	0.1	-1.0	-0.6	0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.5	0.2	-1.1	-1.6	-0.7	0.4	1.3
Mood swings	0.5	1.0	3.3	0.5	-0.9	1.8	-0.6	-1.0	-0.3
Loneliness, isolation	1.6	2.2	5.6	-0.7	1.0	1.1	2.3	0.0	-2.4
Long-standing illness, disability or infirmity	1.0	1.6	5.8	0.1	-2.4	-0.8	0.4	-1.7	-0.2
Ever had bowel cancer screening	0.0	0.0	0.1	0.1	0.1	-0.3	0.3	0.1	-0.0
Diabetes diagnosed by doctor	0.4	0.7	2.2	-0.7	-1.5	-1.2	-0.3	0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.7	0.2	1.3	0.5	0.7	0.7	-1.2
Friendships satisfaction	0.1	0.1	0.3	0.1	0.4	0.5	0.1	-0.1	-0.5
Qualifications: nursing, teaching	0.3	0.5	1.6	-0.2	1.3	0.3	-0.4	0.6	0.8
Commuting to job workplace: Walk	0.7	0.8	1.7	-0.9	0.7	-0.1	-0.9	-1.3	0.9
Eye problems/disorders: Cataract	1.2	1.4	4.2	-2.1	-0.5	-1.7	-0.8	0.0	0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.3	-0.6	-0.0	-0.9	1.2	2.1	-0.6
Medication for cholesterol	1.3	2.0	8.0	0.0	0.0	-1.7	-0.5	-2.8	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	3.2	-1.2	-1.8	-1.5	1.1	1.1	-0.9
Back pain experienced in last month	0.4	0.5	1.0	0.5	-0.6	-1.0	0.5	-0.8	-0.9
Mineral and other dietary supplements	0.4	0.6	1.4	-1.2	0.1	-1.1	-0.9	0.3	0.5
Breast cancer (self-reported)	1.9	2.3	7.0	-1.2	-0.3	-0.2	-2.6	0.0	2.3
Asthma (self-reported)	0.2	0.4	1.0	-0.4	-1.0	-0.7	-0.3	-0.8	0.2
Osteoporosis (self-reported)	1.7	2.1	5.2	-1.2	-0.3	0.1	1.5	2.3	-1.9
Osteoarthritis (self-reported)	1.5	1.9	4.8	-0.1	-1.4	-0.8	-2.2	-0.6	1.9
Medication: Aspirin	0.5	0.6	1.3	-1.2	-0.5	-0.9	0.9	-0.1	-0.6
Medication: Gliclazide	0.4	0.5	1.6	0.1	-0.3	-1.3	0.7	-0.5	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	1.8	0.4	1.3	0.0	0.3	-0.4	0.0
Smoking status: Current	0.1	0.2	0.7	0.4	0.8	0.0	0.2	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.5	-0.1	-1.6	0.2	0.6	-0.8	-0.3
Whole body water mass	0.6	3.3	7.0	2.4	2.6	1.3	1.7	-0.8	-1.3
Leg predicted mass (right)	0.4	2.1	4.8	1.9	2.2	1.1	1.3	-0.5	-1.1
Arm fat mass (left)	0.7	3.0	8.2	2.4	2.9	1.8	0.8	-0.1	-0.6
Number of self-reported non-cancer illnesses	0.7	1.2	3.6	0.1	0.0	0.4	1.9	0.0	-1.9
Average weekly champagne plus white wine intake	0.2	0.2	0.7	0.7	0.3	-0.1	0.8	0.0	0.2
Miserableness	1.1	1.8	8.2	1.5	0.4	2.9	-0.4	0.1	0.5
Guilty feelings	0.5	0.8	4.5	-2.1	-0.6	-0.0	0.1	0.2	-0.1
Wears glasses or contact lenses	1.5	1.7	2.7	0.8	1.1	1.4	1.6	1.3	-1.3
Ever taken oral contraceptive pill	1.7	1.9	4.1	1.8	2.0	1.7	-0.0	-1.1	-0.2
Hearing aid user	0.2	0.2	0.8	0.1	-0.3	-0.2	0.4	0.9	0.0
Mother’s age at death	1.8	2.3	4.9	-1.5	-1.9	-2.2	-1.4	-0.7	0.5
Financial situation satisfaction	0.4	0.6	1.8	-0.3	-0.7	-1.3	-0.9	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.6	-1.0	-1.3	-0.1	-0.4	0.3	0.5
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.4	0.6	0.8	0.3	1.2	-0.2
Eye problems/disorders: Glaucoma	1.2	1.4	3.2	0.8	0.0	-0.2	-1.6	-1.4	1.8
Medication: Blood pressure	0.5	1.0	4.1	-0.1	0.2	1.1	0.5	2.0	-0.5
Pain type(s) experienced in last month: Hip pain	2.2	2.7	5.7	0.7	-1.6	-1.1	-2.4	-1.1	2.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	0.9	-1.6	-0.4	-0.7	-0.4	0.7
High cholesterol (Self-reported)	1.5	2.7	10.8	-1.2	-1.1	1.2	0.5	3.3	-0.9
Medication: Bendroflumethiazide	0.4	0.6	3.2	-0.4	0.3	0.1	0.2	1.8	-0.3
Medication: Paracetamol	0.2	0.2	0.5	0.7	0.1	0.1	-0.7	-0.7	0.2
Medication: Lisinopril	0.4	0.5	1.0	-0.9	0.4	-1.0	-0.0	0.3	-1.0
Medication: Atorvastatin	1.6	2.0	5.7	-1.3	-2.4	-1.8	-0.9	-0.5	0.5
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.6	0.5	0.3	-0.2	-0.6	-0.3
Alcohol drinker status: Never	0.2	0.2	0.5	0.6	-0.7	0.2	-0.1	-0.5	-0.1
Ever smoked	0.6	1.0	4.2	-0.3	-1.0	-2.0	-0.6	0.2	-0.5
Basal metabolic rate	0.6	3.5	7.8	2.5	2.8	1.4	1.7	-0.8	-1.3
Leg fat percentage (left)	0.4	1.5	3.9	2.0	1.8	1.2	-0.1	-0.5	0.1
Arm fat-free mass (left)	0.7	3.7	8.6	2.9	2.6	1.4	1.5	-0.7	-1.3
Number of operations (self-reported)	0.5	0.8	2.5	-0.3	-0.6	-0.1	-1.6	0.0	1.4
Average weekly beer plus cider intake	0.3	0.4	1.5	1.2	0.0	0.5	0.1	-0.6	0.6
Irritability	0.3	0.5	1.4	-0.0	-0.3	1.2	0.9	-0.2	-0.9
Risk taking	0.5	0.7	1.7	-0.7	1.0	0.3	0.6	-0.7	-1.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.4	-0.3	0.6	-0.0	-0.6	-0.1
Fractured/broken bones in last 5 years	0.1	0.2	0.8	-0.3	0.0	-0.2	0.0	-0.9	-0.2
Age started oral contraceptive pill	0.7	0.9	2.2	-1.5	-0.1	-1.4	-0.5	0.9	0.3
Diastolic blood pressure, automated reading	0.5	1.6	2.1	1.5	1.2	0.9	-1.3	-1.2	1.4
Ever depressed for a whole week	1.1	1.3	4.4	-1.3	-2.1	-0.7	-0.0	-1.0	-0.4
Unable to work because of sickness or disability	0.4	0.5	1.3	0.8	-0.7	-0.3	-0.4	-1.2	0.6
Commuting to job workplace: Cycle	1.2	1.5	5.0	-0.6	-1.5	-2.2	0.2	-0.7	-0.8
Myopia	0.6	0.8	2.5	-0.9	-1.6	-0.1	0.4	1.2	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.3	0.6	0.8	-0.3	-0.4	-1.5	0.2
Cholesterol lowering medication	0.6	0.9	2.7	-0.2	-0.2	1.1	-1.1	1.6	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.6	-0.4	-1.0	-0.7	-0.8	0.4
Pain experienced in last month	1.3	2.1	4.3	-0.5	2.1	1.8	0.9	2.0	-0.3
Supplements: Calcium	0.9	1.0	1.8	-1.3	-0.2	0.9	1.2	1.2	-0.8
Basal cell carcinoma (self-reported)	2.5	3.0	10.0	-3.2	-1.3	-2.3	0.4	-0.6	-0.7
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.5	-1.5	-1.5	-0.8	-1.3	-1.6	1.1
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.9	0.7	-1.0	-1.9	-0.4	-2.2	1.0
Heart disease (siblings)	0.3	0.3	0.8	-0.5	-0.3	0.6	-0.9	-0.3	0.7
Alcohol drinker status: Previous	1.6	1.8	7.2	-0.4	-1.3	-2.7	0.5	-1.1	-0.4
Pack years of smoking	0.5	0.7	3.1	1.8	0.6	0.4	0.4	0.6	-0.3
Impedance of whole body	0.4	1.9	3.4	-1.6	-1.9	0.2	-1.7	0.2	1.6
Leg fat mass (left)	0.6	2.2	5.6	2.3	2.4	1.4	0.3	-0.4	-0.2
Arm predicted mass (left)	0.7	3.7	8.2	2.9	2.7	1.2	1.6	-0.9	-1.4