TWAS hub - Ever had stillbirth, spontaneous miscarriage or termination

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	10	18221643	19074958	1	1	2.5e-07	2.3e-07	9e-04	59	CACNB2

Trait	chisq ratio	# genes⁺	corr P	genes
Medication: Atenolol	10.40	1	1	CACNB2
Schizophrenia (2014)	9.69	1	1	CACNB2
Schizophrenia (2018)	9.39	1	1	CACNB2
Bipolar Disorder or Schizophrenia	9.09	1	1	CACNB2
Supplements: Calcium	8.06	1	1	CACNB2
Alzheimer’s Disease (in father)	7.99	1	1	CACNB2
LDL Cholesterol	6.00	1	1	CACNB2
Major Depression (MDD)	5.43	1	1	CACNB2
Average weekly beer plus cider intake	5.43	1	1	CACNB2
Coronary Artery Disease (CAD)	5.19	1	1	CACNB2
Alcohol intake versus 10 years previously	4.64	1	1	CACNB2
Age at last live birth	4.28	1	1	CACNB2
Eye problems/disorders: Diabetes related eye disease	3.84	1	1	CACNB2
Mineral and other dietary supplements	3.77	1	1	CACNB2
Supplements: Glucosamine	3.32	1	1	CACNB2
Average weekly spirits intake	3.13	1	1	CACNB2
Medication: Blood pressure	2.92	1	1	CACNB2
Type 2 Diabetes (T2D) (2018)	2.88	1	1	CACNB2
Risk taking	2.77	1	1	CACNB2
Respiratory disease	2.70	1	1	CACNB2
Bipolar Disorder (2018)	2.59	1	1	CACNB2
Asthma (self-reported)	2.51	1	1	CACNB2
Hand grip strength (right)	2.50	1	1	CACNB2
Ever smoked	2.19	1	1	CACNB2
High blood pressure	1.80	1	1	CACNB2
Cardiovascular Disease	1.79	1	1	CACNB2
Hypertension (Self-reported)	1.79	1	1	CACNB2
Heel bone mineral density (BMD) T-score, automated (right)	1.72	1	1	CACNB2
Hand grip strength (left)	1.71	1	1	CACNB2
Pulse rate, automated reading	1.65	1	1	CACNB2
Impedance of arm (right)	1.16	1	1	CACNB2
Sitting height	1.15	1	1	CACNB2
Systolic Blood Pressure	0.81	1	1	CACNB2
Blood Red Count	0.45	1	1	CACNB2
Blood Platelet Count	0.33	1	1	CACNB2

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Nucleus accumbens basal ganglia	0	0.00	1.14
GTEx	Breast Mammary Tissue (Female)	0	0.00	1.13
GTEx	Esophagus Gastroesophageal Junction	0	0.00	1.13
GTEx	Liver	0	0.00	1.13
GTEx	Whole Blood	0	0.00	1.13
GTEx	Brain Cerebellum	0	0.00	1.12
GTEx	Brain Frontal Cortex BA9	0	0.00	1.12
GTEx	Brain Hippocampus	0	0.00	1.12
GTEx	Brain Putamen basal ganglia	0	0.00	1.12
GTEx	Cells Transformed fibroblasts	0	0.00	1.12
GTEx	Skin Sun Exposed Lower leg	0	0.00	1.12
GTEx	Brain Caudate basal ganglia	0	0.00	1.11
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.00	1.11
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.00	1.11
GTEx	Heart Atrial Appendage	0	0.00	1.10
GTEx	Pancreas	0	0.00	1.10
GTEx	Thyroid	0	0.00	1.10
GTEx	Vagina	0	0.00	1.10
CommonMind	Brain Pre-frontal Cortex	0	0.00	1.10
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.00	1.10
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.00	1.10
GTEx	Adipose Subcutaneous	0	0.00	1.09
GTEx	Brain Cortex	0	0.00	1.09
GTEx	Esophagus Muscularis	0	0.00	1.09
GTEx	Muscle Skeletal	0	0.00	1.09
GTEx	Nerve Tibial	0	0.00	1.09
NTR	Blood	0	0.00	1.09
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.00	1.09
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.00	1.09
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.04	1.09
GTEx	Adrenal Gland	0	0.00	1.08
GTEx	Breast Mammary Tissue (Male)	0	0.00	1.08
GTEx	Esophagus Mucosa	0	0.00	1.08
GTEx	Skin Not Sun Exposed Suprapubic	0	0.00	1.08
GTEx	Testis	0	0.00	1.08
ROSMAP	Brain Pre-frontal Cortex	0	0.00	1.08
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.00	1.08
GTEx	Artery Tibial	0	0.00	1.07
GTEx	Breast Mammary Tissue	0	0.00	1.07
GTEx	Cells EBV-transformed lymphocytes	0	0.00	1.07
GTEx	Heart Left Ventricle	0	0.00	1.07
GTEx	Lung	0	0.00	1.07
METSIM	Adipose	0	0.00	1.07
YFS	Blood	0	0.00	1.07
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.00	1.07
GTEx	Adipose Visceral Omentum	0	0.00	1.06
GTEx	Brain Hypothalamus	0	0.00	1.06
GTEx	Pituitary	0	0.00	1.06
GTEx	Small Intestine Terminal Ileum	0	0.00	1.06
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.00	1.06
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.00	1.06
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.00	1.06
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.00	1.06
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.00	1.05
GTEx	Artery Aorta	0	0.00	1.04
GTEx	Brain Cerebellar Hemisphere	0	0.00	1.04
GTEx	Colon Transverse	0	0.00	1.04
GTEx	Uterus	0	0.00	1.04
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.00	1.04
GTEx	Ovary	0	0.00	1.03
GTEx	Stomach	0	0.00	1.03
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.00	1.03
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.00	1.03
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.00	1.03
GTEx	Artery Coronary	0	0.00	1.02
GTEx	Colon Sigmoid	0	0.00	1.02
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.00	1.02
GTEx	Spleen	0	0.00	1.01
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.00	1.01
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.00	1.00
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.00	0.98
GTEx	Prostate	0	0.00	0.97
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.00	0.97
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.00	0.94

Hub : Traits :

Ever had stillbirth, spontaneous miscarriage or termination

Significant Loci

Pleiotropic Associations

Associations by panel