Hub : Traits :

Ever smoked

131 significantly associated models · 40 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	33030461	34592020	2	1	1.4e-07	3.4e-08	1.0e+00	100	PHC2
2	1	66019891	67086881	1	1	1.5e-07	8.7e-06	7.0e-01	99	PDE4B
3	2	44448632	45864710	1	1	4.0e-11	8.5e-11	1.0e+00	100	RP11-89K21.1
4	2	47224927	48727280	1	1	2.9e-09	6.3e-07	7.8e-02	88	MSH6
5	3	84317575	86808226	1	2	2.6e-14	1.7e-14	8.1e-03	88	CADM2
6	4	57587795	58088682	1	1	2.3e-08	3.1e-09	4.4e-02	88	C4orf14
7	5	86867897	88427942	1	1	1.9e-07	1.1e-06	5.0e-01	98	TMEM161B-AS1
8	6	110588546	112501537	3	1	5.1e-12	1.6e-13	3.7e-03	84	REV3L
9	7	2646223	5003373	1	1	1.3e-07	3.2e-09	6.7e-03	79	SDK1
10	7	98244565	99751521	3	1	2.2e-09	3.6e-08	8.1e-01	100	CPSF4
11	7	116660803	118207833	1	1	5.3e-11	5.4e-12	5.2e-04	75	CTTNBP2
12	9	127218258	128824378	2	1	4.3e-08	4.9e-08	2.8e-03	70	PRPS1P2
13	10	103527782	105897979	12	8	3.5e-12	1.4e-10	NaN	NaN	ARL3 AS3MT C10orf32 NT5C2 WBP1L
14	11	58247718	59659006	1	1	8.8e-09	3.6e-09	1.0e-01	92	DTX4
15	11	112135760	113846006	1	1	4.0e-10	8.0e-36	1.3e-27	24	NCAM1
16	13	100942854	101489459	1	1	7.9e-08	1.9e-08	6.6e-02	89	A2LD1
17	14	88594808	90043684	1	1	1.3e-07	8.7e-06	9.2e-01	100	TTC8
18	16	86671	1417408	2	1	2.0e-07	1.6e-07	1.5e-01	92	WDR90
19	17	1508522	2923933	1	1	4.0e-08	1.8e-07	9.8e-01	100	SRR
20	17	7431014	8850460	2	1	7.4e-08	8.4e-08	2.1e-01	94	C17orf68
21	22	46185873	46688208	1	1	2.9e-07	3.0e-07	1.4e-01	92	LOC100271722

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	2.54	2	2	4.4	-0.07	9.2e-01	AS3MT C10orf32
Depressed Affect (Nagel 2018)	1.46	3	0	0.0	0.00	1.0e+00	CTTNBP2 NCAM1 TMEM161B-AS1
Intelligence (Savage-Jansen 2018)	1.14	2	0	0.0	0.00	1.0e+00	C17orf68 CADM2
Neuroticism (Nagel 2018)	2.65	5	1	2.2	-0.21	7.4e-01	C10orf32 C17orf68 CADM2 CTTNBP2 TMEM161B-AS1
Schizophrenia (2018)	3.34	2	2	4.4	-0.03	9.6e-01	AS3MT C10orf32
Worry (Nagel 2018)	5.41	7	3	6.7	-0.66	3.9e-02	ARL3 AS3MT C10orf32 C17orf68 CADM2 PRPS1P2 TMEM161B-AS1
Major Depression (MDD)	1.77	1	0	0.0	0.00	1.0e+00	CTTNBP2
Verbal and Numeric Reasoning (VNR)	1.43	1	0	0.0	0.00	1.0e+00	C17orf68
Prostate Cancer	2.68	1	0	0.0	0.00	1.0e+00	WBP1L
LDL Cholesterol	0.97	1	0	0.0	0.00	1.0e+00	C17orf68
Schizophrenia (2014)	2.76	2	2	4.4	0.01	9.8e-01	AS3MT C10orf32
Blood Eosinophil Count	0.67	3	1	2.2	0.00	1.0e+00	ARL3 C4orf14 PHC2
Blood Platelet Count	1.29	11	6	13.3	0.72	3.9e-03	ARL3 AS3MT C10orf32 C4orf14 CPSF4 DTX4 MSH6 NT5C2 PHC2 WBP1L WDR90
Blood Red Count	0.38	1	0	0.0	0.00	1.0e+00	PHC2
Blood White Count	2.20	9	8	17.8	0.78	2.7e-03	ARL3 AS3MT C10orf32 C17orf68 C4orf14 CPSF4 NT5C2 PDE4B WBP1L
Heel T-Score	1.77	8	4	8.9	-0.01	9.8e-01	AS3MT C10orf32 C4orf14 LOC100271722 MSH6 NCAM1 PHC2 SRR
BMI	2.48	7	5	11.1	0.78	2.3e-02	C10orf32 CADM2 CPSF4 PDE4B PHC2 REV3L SRR
Height	1.82	14	9	20.0	0.44	8.1e-02	A2LD1 ARL3 AS3MT C10orf32 C17orf68 C4orf14 CPSF4 NCAM1 NT5C2 PHC2 PRPS1P2 SRR WBP1L WDR90
Waist Hip Ratio (WHR)	0.93	2	0	0.0	0.00	1.0e+00	MSH6 PRPS1P2
Systolic Blood Pressure	1.73	6	3	6.7	-0.79	6.1e-02	AS3MT C10orf32 C17orf68 CADM2 NCAM1 SRR
Smoking Status	20.91	24	18	40.0	0.98	4.6e-20	A2LD1 ARL3 AS3MT C10orf32 C17orf68 C4orf14 CADM2 CPSF4 CTTNBP2 DTX4 LOC100271722 MSH6 NCAM1 NT5C2 PDE4B PHC2 PRPS1P2 REV3L RP11-89K21.1 SDK1 SRR TMEM161B-AS1 WBP1L WDR90
Allergy or Eczema	2.75	6	1	2.2	-0.83	2.2e-02	ARL3 C10orf32 CPSF4 NT5C2 SRR WBP1L
Cardiovascular Disease	1.15	1	0	0.0	0.00	1.0e+00	WBP1L
Respiratory disease	1.06	1	0	0.0	0.00	1.0e+00	C4orf14
Type 2 Diabetes (T2D) (2018)	1.85	1	0	0.0	0.00	1.0e+00	CPSF4
Lung FEV1/FVC ratio	1.08	2	0	0.0	0.00	1.0e+00	CTTNBP2 MSH6
Lung FVC	1.24	4	2	4.4	0.42	5.8e-01	C4orf14 MSH6 PRPS1P2 WDR90
Neuroticism	2.98	6	1	2.2	-0.07	9.0e-01	C10orf32 C17orf68 CADM2 CTTNBP2 PRPS1P2 TMEM161B-AS1
Chronotype (morning person)	1.81	3	0	0.0	0.00	1.0e+00	CPSF4 NCAM1 TMEM161B-AS1
Hair Pigment	0.14	2	1	2.2	0.00	1.0e+00	C4orf14 MSH6
Tanning	0.93	4	2	4.4	0.92	9.3e-03	AS3MT C10orf32 CADM2 PDE4B
Hand grip strength (left)	3.63	5	1	2.2	0.81	1.5e-02	AS3MT C10orf32 CADM2 PHC2 PRPS1P2
Sensitivity / hurt feelings	1.62	1	0	0.0	0.00	1.0e+00	PRPS1P2
Relative age of first facial hair	1.68	1	0	0.0	0.00	1.0e+00	C10orf32
Other serious medical condition/disability diagnosed by doctor	1.38	1	0	0.0	0.00	1.0e+00	CADM2
Systolic blood pressure, automated reading	1.56	2	1	2.2	0.00	1.0e+00	C10orf32 SRR
Pack years adult smoking proportion	3.03	1	0	0.0	0.00	1.0e+00	C10orf32
Impedance of leg (right)	1.56	7	1	2.2	-0.34	4.6e-01	C10orf32 CADM2 CPSF4 NCAM1 PHC2 PRPS1P2 SRR
Leg fat-free mass (left)	2.66	7	3	6.7	0.80	5.6e-03	AS3MT C10orf32 CADM2 PDE4B PHC2 PRPS1P2 WDR90
Trunk fat percentage	1.34	5	1	2.2	0.61	2.7e-01	CADM2 CPSF4 PDE4B REV3L SRR
Hand grip strength (right)	2.69	3	1	2.2	0.58	4.2e-01	C10orf32 CADM2 PRPS1P2
Townsend deprivation index at recruitment	4.11	3	0	0.0	0.00	1.0e+00	C10orf32 CTTNBP2 PRPS1P2
Current tobacco smoking	8.30	12	4	8.9	0.99	5.2e-12	ARL3 AS3MT C10orf32 CTTNBP2 LOC100271722 NCAM1 NT5C2 PDE4B PRPS1P2 REV3L RP11-89K21.1 WBP1L
Maternal smoking around birth	5.85	5	1	2.2	1.00	6.6e-08	ARL3 AS3MT C10orf32 NT5C2 REV3L
Fed-up feelings	1.35	1	0	0.0	0.00	1.0e+00	CTTNBP2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.04	1	0	0.0	0.00	1.0e+00	CTTNBP2
Age when periods started (menarche)	1.82	2	1	2.2	0.00	1.0e+00	MSH6 PRPS1P2
Heel bone mineral density (BMD) T-score, automated (left)	1.31	1	1	2.2	0.00	1.0e+00	C4orf14
High blood pressure	1.61	2	0	0.0	0.00	1.0e+00	ARL3 SRR
Hayfever, allergic rhinitis or eczema	2.31	4	1	2.2	-0.68	3.2e-01	ARL3 NT5C2 SRR WBP1L
Medication: Atenolol	1.16	1	0	0.0	0.00	1.0e+00	WBP1L
Sitting height	1.63	9	3	6.7	0.33	3.6e-01	ARL3 AS3MT C10orf32 C17orf68 CPSF4 NCAM1 PRPS1P2 WBP1L WDR90
Body mass index (BMI)	2.52	7	3	6.7	0.81	1.5e-02	C10orf32 CADM2 CPSF4 PDE4B PHC2 REV3L SRR
Impedance of leg (left)	1.50	6	1	2.2	-0.20	7.1e-01	CADM2 CPSF4 PHC2 PRPS1P2 SDK1 SRR
Leg predicted mass (left)	2.64	7	3	6.7	0.80	5.6e-03	AS3MT C10orf32 CADM2 PDE4B PHC2 PRPS1P2 WDR90
Trunk fat mass	1.86	6	2	4.4	0.76	4.5e-02	C10orf32 CADM2 CPSF4 PDE4B PHC2 SRR
Waist circumference	2.49	5	3	6.7	0.99	4.0e-05	C10orf32 CADM2 CPSF4 PDE4B PHC2
Number of incorrect matches in round	3.11	3	0	0.0	-0.51	3.7e-01	AS3MT C10orf32 C17orf68
Past tobacco smoking	19.63	25	16	35.6	-0.99	2.0e-26	A2LD1 ARL3 AS3MT C10orf32 C17orf68 C4orf14 CADM2 CPSF4 CTTNBP2 DTX4 LOC100271722 MSH6 NCAM1 NT5C2 PDE4B PHC2 PRPS1P2 REV3L RP11-89K21.1 SDK1 SRR TMEM161B-AS1 TTC8 WBP1L WDR90
Alcohol usually taken with meals	3.66	4	0	0.0	-0.56	4.4e-01	A2LD1 CADM2 CTTNBP2 SRR
Nervous feelings	5.60	6	2	4.4	-0.84	4.6e-03	AS3MT C10orf32 CADM2 PRPS1P2 SRR TMEM161B-AS1
Frequency of tenseness / restlessness in last 2 weeks	1.49	1	0	0.0	0.00	1.0e+00	LOC100271722
Hearing difficulty/problems with background noise	3.44	4	0	0.0	1.00	6.4e-04	ARL3 C10orf32 C4orf14 WBP1L
Hair/balding pattern: Pattern 2	1.67	1	0	0.0	0.00	1.0e+00	A2LD1
Forced vital capacity (FVC)	2.00	6	1	2.2	0.21	6.9e-01	C10orf32 C4orf14 MSH6 PRPS1P2 REV3L WBP1L
Heel bone mineral density (BMD) T-score, automated (right)	1.44	2	1	2.2	0.00	1.0e+00	C4orf14 NCAM1
Qualifications: None of the above	1.91	1	0	0.0	0.00	1.0e+00	WDR90
Mouth/teeth dental problems	2.62	2	0	0.0	0.00	1.0e+00	LOC100271722 PRPS1P2
Heart attack	1.32	1	0	0.0	0.00	1.0e+00	TMEM161B-AS1
Allergy	2.08	2	1	2.2	0.00	1.0e+00	SRR WBP1L
Neuroticism score	2.16	3	0	0.0	0.00	1.0e+00	CTTNBP2 PRPS1P2 TMEM161B-AS1
Weight	2.96	7	4	8.9	0.97	5.2e-07	ARL3 AS3MT C10orf32 CADM2 CPSF4 PDE4B PHC2
Impedance of arm (right)	2.56	5	2	4.4	-0.99	9.7e-05	C10orf32 C4orf14 CADM2 CPSF4 PHC2
Arm fat percentage (right)	1.58	4	3	6.7	0.55	3.4e-01	CADM2 CPSF4 PDE4B SRR
Trunk fat-free mass	3.13	10	5	11.1	0.79	7.9e-04	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PHC2 PRPS1P2 WBP1L WDR90
Hip circumference	2.44	7	3	6.7	0.86	7.5e-04	AS3MT C10orf32 CADM2 CPSF4 PDE4B PHC2 SRR
Alcohol intake versus 10 years previously	2.93	2	0	0.0	0.00	1.0e+00	C10orf32 NT5C2
Worrier / anxious feelings	5.99	6	3	6.7	-0.97	2.1e-06	AS3MT C10orf32 CADM2 NT5C2 REV3L TMEM161B-AS1
Frequency of tiredness / lethargy in last 2 weeks	1.44	1	0	0.0	0.00	1.0e+00	PRPS1P2
Number of live births	2.49	2	1	2.2	0.00	1.0e+00	C17orf68 CADM2
Forced expiratory volume in 1-second (FEV1)	2.13	5	2	4.4	-0.29	6.4e-01	C4orf14 CTTNBP2 PRPS1P2 REV3L RP11-89K21.1
Qualifications: A levels/AS levels or equivalent	2.40	1	1	2.2	0.00	1.0e+00	CADM2
Forced expiratory volume in 1-second (FEV1), Best measure	1.49	2	0	0.0	0.00	1.0e+00	C4orf14 PRPS1P2
Pulse wave Arterial Stiffness index	2.99	1	0	0.0	0.00	1.0e+00	PHC2
Impedance of arm (left)	2.59	5	2	4.4	-0.99	6.5e-05	C10orf32 C4orf14 CADM2 CPSF4 PHC2
Arm fat mass (right)	2.11	6	3	6.7	0.78	3.7e-02	C10orf32 CADM2 CPSF4 PDE4B PHC2 SRR
Trunk predicted mass	3.11	10	5	11.1	0.78	9.0e-04	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PHC2 PRPS1P2 WBP1L WDR90
Standing height	2.09	11	8	17.8	0.40	1.6e-01	A2LD1 ARL3 AS3MT C10orf32 C17orf68 CPSF4 NCAM1 PHC2 PRPS1P2 WBP1L WDR90
Exposure to tobacco smoke at home	1.95	1	0	0.0	0.00	1.0e+00	RP11-89K21.1
Tense / 'highly strung'	1.94	2	0	0.0	0.00	1.0e+00	C17orf68 CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.10	4	0	0.0	-0.16	8.4e-01	CADM2 CTTNBP2 LOC100271722 TMEM161B-AS1
Hair/balding pattern: Pattern 4	1.40	1	1	2.2	0.00	1.0e+00	SRR
Birth weight of first child	2.25	2	0	0.0	0.00	1.0e+00	AS3MT C10orf32
Peak expiratory flow (PEF)	2.90	3	1	2.2	0.86	6.2e-02	C10orf32 CTTNBP2 PRPS1P2
Medication: Paracetamol	1.90	1	0	0.0	0.00	1.0e+00	C17orf68
Birth weight	1.93	4	0	0.0	0.12	8.8e-01	AS3MT C10orf32 LOC100271722 SRR
Forced vital capacity (FVC), Best measure	1.40	3	0	0.0	0.00	1.0e+00	C4orf14 MSH6 PRPS1P2
Body fat percentage	1.60	5	2	4.4	0.64	2.5e-01	CADM2 CPSF4 PDE4B REV3L SRR
Leg fat percentage (right)	2.10	4	2	4.4	1.00	1.5e-04	CADM2 CPSF4 PDE4B REV3L
Arm fat-free mass (right)	3.59	10	4	8.9	0.82	3.2e-04	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PHC2 PRPS1P2 WBP1L WDR90
Exposure to tobacco smoke outside home	4.29	4	0	0.0	0.68	1.4e-01	C10orf32 CTTNBP2 SRR WBP1L
Comparative body size at age 10	2.64	3	2	4.4	0.65	3.5e-01	CADM2 PDE4B SRR
Number of full brothers	2.05	1	0	0.0	0.00	1.0e+00	CADM2
Worry too long after embarrassment	2.41	3	0	0.0	0.00	1.0e+00	CADM2 SRR TMEM161B-AS1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.95	2	0	0.0	0.00	1.0e+00	PRPS1P2 TMEM161B-AS1
Wheeze or whistling in the chest in last year	1.59	1	0	0.0	0.00	1.0e+00	LOC100271722
Number of children fathered	2.47	1	1	2.2	0.00	1.0e+00	CADM2
Pulse wave peak to peak time	3.11	2	0	0.0	0.00	1.0e+00	AS3MT C10orf32
Qualifications: College or University degree	3.28	7	2	4.4	-0.96	1.7e-04	A2LD1 AS3MT C10orf32 CADM2 CTTNBP2 SDK1 WDR90
Medication for pain relief, constipation, heartburn	2.35	2	0	0.0	0.00	1.0e+00	C17orf68 REV3L
Migraine (self-reported)	1.71	1	0	0.0	0.00	1.0e+00	CADM2
Mean time to correctly identify matches	1.81	1	0	0.0	0.00	1.0e+00	TMEM161B-AS1
Heart disease (mother)	1.69	1	0	0.0	0.00	1.0e+00	NCAM1
Whole body fat mass	2.24	7	3	6.7	0.81	1.4e-02	C10orf32 CADM2 CPSF4 PDE4B PHC2 REV3L SRR
Leg fat mass (right)	2.89	6	4	8.9	0.98	3.2e-05	C10orf32 CADM2 CPSF4 PDE4B PHC2 REV3L
Arm predicted mass (right)	3.68	11	4	8.9	0.82	1.8e-04	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PDE4B PHC2 PRPS1P2 WBP1L WDR90
Pulse rate, automated reading	1.59	3	1	2.2	0.00	1.0e+00	CPSF4 MSH6 WDR90
Alcohol intake frequency.	2.28	2	1	2.2	0.00	1.0e+00	CADM2 RP11-89K21.1
Comparative height size at age 10	1.34	5	2	4.4	0.45	4.5e-01	ARL3 PDE4B PHC2 WBP1L WDR90
Number of full sisters	2.98	1	1	2.2	0.00	1.0e+00	CADM2
Suffer from 'nerves'	2.79	1	1	2.2	0.00	1.0e+00	CADM2
Overall health rating	1.64	1	0	0.0	0.00	1.0e+00	PRPS1P2
Qualifications: NVQ or HND or HNC or equivalent	2.26	1	0	0.0	0.00	1.0e+00	SDK1
Illness, injury, bereavement, stress in last 2 years	1.73	1	0	0.0	0.00	1.0e+00	CTTNBP2
Knee pain experienced in last month	1.88	1	0	0.0	0.00	1.0e+00	ARL3
Hypertension (Self-reported)	1.48	1	0	0.0	0.00	1.0e+00	SRR
Smoking status: Previous	12.72	18	3	6.7	0.99	1.4e-20	A2LD1 ARL3 AS3MT C10orf32 C17orf68 C4orf14 CADM2 DTX4 MSH6 NCAM1 NT5C2 PHC2 REV3L RP11-89K21.1 SDK1 SRR WBP1L WDR90
Forced expiratory volume in 1-second (FEV1), predicted	1.95	3	0	0.0	0.00	1.0e+00	C10orf32 SDK1 WBP1L
Whole body fat-free mass	3.00	9	5	11.1	0.78	2.5e-03	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PHC2 PRPS1P2 WDR90
Leg fat-free mass (right)	2.64	7	4	8.9	0.79	6.8e-03	AS3MT C10orf32 CADM2 PDE4B PHC2 PRPS1P2 WDR90
Arm fat percentage (left)	1.58	4	3	6.7	0.55	3.3e-01	CADM2 CPSF4 PDE4B SRR
Mood swings	1.01	1	0	0.0	0.00	1.0e+00	CTTNBP2
Long-standing illness, disability or infirmity	2.42	2	0	0.0	0.00	1.0e+00	REV3L TMEM161B-AS1
Qualifications: nursing, teaching	2.50	2	1	2.2	0.00	1.0e+00	CADM2 SDK1
Mouth/teeth dental problems: Mouth ulcers	1.49	1	0	0.0	0.00	1.0e+00	CADM2
Smoking status: Current	8.77	13	3	6.7	0.99	2.4e-12	ARL3 AS3MT C10orf32 CADM2 CTTNBP2 LOC100271722 NCAM1 NT5C2 PDE4B PRPS1P2 REV3L RP11-89K21.1 WBP1L
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.61	2	0	0.0	0.00	1.0e+00	ARL3 PRPS1P2
Whole body water mass	2.97	9	5	11.1	0.79	2.5e-03	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PHC2 PRPS1P2 WDR90
Leg predicted mass (right)	2.60	7	4	8.9	0.79	6.6e-03	AS3MT C10orf32 CADM2 PDE4B PHC2 PRPS1P2 WDR90
Arm fat mass (left)	2.22	6	3	6.7	0.80	2.9e-02	C10orf32 CADM2 CPSF4 PDE4B PHC2 SRR
Average weekly champagne plus white wine intake	1.66	1	0	0.0	0.00	1.0e+00	WDR90
Miserableness	1.47	2	0	0.0	0.00	1.0e+00	CTTNBP2 NCAM1
Wears glasses or contact lenses	2.35	1	0	0.0	0.00	1.0e+00	CADM2
Commuting to job workplace: Public transport	1.99	1	0	0.0	0.00	1.0e+00	CADM2
Supplements: Fish oil (including cod liver oil)	1.25	1	0	0.0	0.00	1.0e+00	CPSF4
High cholesterol (Self-reported)	1.01	1	0	0.0	0.00	1.0e+00	CADM2
Medication: Bendroflumethiazide	1.66	2	0	0.0	0.00	1.0e+00	ARL3 TTC8
Medication: Paracetamol	1.60	1	0	0.0	0.00	1.0e+00	C17orf68
Medication: Lisinopril	1.34	1	0	0.0	0.00	1.0e+00	C17orf68
Alcohol drinker status: Never	1.83	1	0	0.0	0.00	1.0e+00	CADM2
Basal metabolic rate	3.00	9	4	8.9	0.82	1.2e-03	ARL3 AS3MT C10orf32 C4orf14 CADM2 PDE4B PHC2 PRPS1P2 WDR90
Leg fat percentage (left)	2.22	4	2	4.4	1.00	8.2e-05	CADM2 CPSF4 PDE4B REV3L
Arm fat-free mass (left)	3.32	8	4	8.9	0.88	4.2e-04	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PHC2 PRPS1P2
Average weekly beer plus cider intake	2.80	2	0	0.0	0.00	1.0e+00	CADM2 RP11-89K21.1
Irritability	2.47	2	0	0.0	0.00	1.0e+00	AS3MT C10orf32
Risk taking	6.47	6	1	2.2	0.97	2.8e-04	AS3MT C10orf32 CADM2 LOC100271722 PHC2 RP11-89K21.1
Fractured/broken bones in last 5 years	1.15	1	0	0.0	0.00	1.0e+00	CTTNBP2
Age started oral contraceptive pill	2.18	1	0	0.0	0.00	1.0e+00	CADM2
Diastolic blood pressure, automated reading	1.76	5	1	2.2	0.60	2.8e-01	AS3MT C10orf32 NT5C2 SRR WBP1L
Unable to work because of sickness or disability	2.62	1	0	0.0	0.00	1.0e+00	C17orf68
Myopia	2.04	1	0	0.0	0.00	1.0e+00	A2LD1
Vascular/heart problems diagnosed by doctor	1.66	1	0	0.0	0.00	1.0e+00	SRR
Pain experienced in last month	1.89	1	0	0.0	0.00	1.0e+00	PRPS1P2
Heart attack/myocardial infarction (self-reported)	1.24	1	0	0.0	0.00	1.0e+00	TMEM161B-AS1
Impedance of whole body	2.20	6	2	4.4	-0.88	8.5e-03	C10orf32 C4orf14 CADM2 CPSF4 PHC2 PRPS1P2
Leg fat mass (left)	2.96	6	4	8.9	0.97	2.2e-05	C10orf32 CADM2 CPSF4 PDE4B PHC2 REV3L
Arm predicted mass (left)	3.33	9	4	8.9	0.87	9.6e-05	ARL3 AS3MT C10orf32 C4orf14 CADM2 NT5C2 PDE4B PHC2 PRPS1P2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	2	0.057	1.9
GTEx	Adipose Visceral Omentum	3	0.147	1.9
GTEx	Adrenal Gland	1	0.069	1.8
GTEx	Artery Aorta	2	0.067	1.8
GTEx	Artery Coronary	1	0.085	1.9
GTEx	Artery Tibial	5	0.133	1.8
GTEx	Brain Caudate basal ganglia	0	0.000	1.9
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.9
GTEx	Brain Cerebellum	4	0.202	1.9
GTEx	Brain Cortex	1	0.097	1.9
GTEx	Brain Frontal Cortex BA9	0	0.000	1.8
GTEx	Brain Hippocampus	0	0.000	1.9
GTEx	Brain Hypothalamus	2	0.339	2.0
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.8
GTEx	Brain Putamen basal ganglia	0	0.000	1.7
GTEx	Breast Mammary Tissue	0	0.000	1.9
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.7
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.8
GTEx	Cells EBV-transformed lymphocytes	2	0.141	1.8
GTEx	Cells Transformed fibroblasts	4	0.095	1.8
GTEx	Colon Sigmoid	1	0.068	1.8
GTEx	Colon Transverse	2	0.097	1.8
GTEx	Esophagus Gastroesophageal Junction	2	0.138	1.8
GTEx	Esophagus Mucosa	1	0.030	1.8
GTEx	Esophagus Muscularis	3	0.093	1.8
GTEx	Heart Atrial Appendage	0	0.000	1.8
GTEx	Heart Left Ventricle	1	0.065	1.8
GTEx	Liver	1	0.139	2.0
GTEx	Lung	3	0.104	1.9
GTEx	Muscle Skeletal	3	0.104	1.8
GTEx	Nerve Tibial	1	0.023	1.8
GTEx	Ovary	0	0.000	2.0
GTEx	Pancreas	1	0.061	1.9
GTEx	Pituitary	1	0.090	1.8
GTEx	Prostate	0	0.000	1.8
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.9
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.9
GTEx	Small Intestine Terminal Ileum	0	0.000	1.8
GTEx	Spleen	1	0.071	1.8
GTEx	Stomach	0	0.000	1.8
GTEx	Testis	0	0.000	1.8
GTEx	Thyroid	3	0.075	1.9
GTEx	Uterus	1	0.176	1.9
GTEx	Vagina	0	0.000	1.8
GTEx	Whole Blood	1	0.050	1.8
METSIM	Adipose	7	0.152	1.7
NTR	Blood	3	0.125	1.6
ROSMAP	Brain Pre-frontal Cortex	5	0.114	1.8
YFS	Blood	2	0.043	1.7
CommonMind	Brain Pre-frontal Cortex	6	0.112	1.7
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.6
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.7
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.7
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.7
The Cancer Genome Atlas	Glioblastoma Multiforme	3	0.294	1.7
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	4	0.147	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.7
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.7
The Cancer Genome Atlas	Brain Lower Grade Glioma	4	0.093	1.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.7
The Cancer Genome Atlas	Lung Adenocarcinoma	3	0.102	1.7
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.7
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.7
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.7
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	3	0.226	1.7
The Cancer Genome Atlas	Prostate Adenocarcinoma	4	0.087	1.6
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.7
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.6
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.7
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.6
The Cancer Genome Atlas	Thyroid Carcinoma	7	0.136	1.7
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5