Hub : Traits :

Mineral and other dietary supplements

4 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 64195778 66034105 2 1 2.6e-08 3.4e-08 0.18 94 NRBF2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 2.60 1 0 0.0 0 1 NRBF2
Intelligence (Savage-Jansen 2018) 3.22 1 0 0.0 0 1 NRBF2
Worry (Nagel 2018) 3.55 1 0 0.0 0 1 NRBF2
Body Mass Index (BMI) (2010) 5.53 1 0 0.0 0 1 NRBF2
HDL Cholesterol 5.34 1 0 0.0 0 1 NRBF2
Schizophrenia (2014) 2.97 1 0 0.0 0 1 NRBF2
Triglycerides 10.63 1 0 0.0 0 1 NRBF2
Blood Platelet Count 69.08 1 1 2.2 0 1 NRBF2
Blood Red Count 3.29 1 1 2.2 0 1 NRBF2
Blood White Count 21.77 1 1 2.2 0 1 NRBF2
Heel T-Score 0.93 1 0 0.0 0 1 NRBF2
BMI 5.90 1 1 2.2 0 1 NRBF2
Height 4.17 1 1 2.2 0 1 NRBF2
Systolic Blood Pressure 3.07 1 0 0.0 0 1 NRBF2
Allergy or Eczema 4.23 1 0 0.0 0 1 NRBF2
Cardiovascular Disease 5.57 1 0 0.0 0 1 NRBF2
Respiratory disease 3.78 1 0 0.0 0 1 NRBF2
Type 2 Diabetes (T2D) (2018) 3.70 1 0 0.0 0 1 NRBF2
Lung FEV1/FVC ratio 7.58 1 1 2.2 0 1 NRBF2
Relative age of first facial hair 14.15 1 1 2.2 0 1 NRBF2
Systolic blood pressure, automated reading 3.16 1 0 0.0 0 1 NRBF2
Vitamin and mineral supplements 12.71 1 0 0.0 0 1 NRBF2
Supplements: Zinc 13.28 1 0 0.0 0 1 NRBF2
Relative age voice broke 9.66 1 0 0.0 0 1 NRBF2
Taking other prescription medications 4.08 1 0 0.0 0 1 NRBF2
Age when periods started (menarche) 9.45 1 0 0.0 0 1 NRBF2
High blood pressure 6.66 1 0 0.0 0 1 NRBF2
Hayfever, allergic rhinitis or eczema 5.17 1 0 0.0 0 1 NRBF2
Multivitamins +/- minerals 21.43 1 1 2.2 0 1 NRBF2
Stomach or abdominal pain in last month 6.47 1 0 0.0 0 1 NRBF2
Supplements: Glucosamine 17.74 1 0 0.0 0 1 NRBF2
Sitting height 0.92 1 0 0.0 0 1 NRBF2
High blood pressure (mother) 4.90 1 0 0.0 0 1 NRBF2
Body mass index (BMI) 6.18 1 1 2.2 0 1 NRBF2
Waist circumference 2.51 1 0 0.0 0 1 NRBF2
Alcohol usually taken with meals 9.89 1 0 0.0 0 1 NRBF2
Qualifications: None of the above 6.78 1 0 0.0 0 1 NRBF2
Allergy 5.86 1 0 0.0 0 1 NRBF2
Diabetes (self-reported) 7.89 1 0 0.0 0 1 NRBF2
Hayfever/allergic rhinitis (self-reported) 5.15 1 0 0.0 0 1 NRBF2
Impedance of arm (right) 7.07 1 1 2.2 0 1 NRBF2
Arm fat percentage (right) 2.39 1 0 0.0 0 1 NRBF2
Qualifications: A levels/AS levels or equivalent 6.41 1 0 0.0 0 1 NRBF2
Impedance of arm (left) 7.04 1 1 2.2 0 1 NRBF2
Arm fat mass (right) 2.50 1 0 0.0 0 1 NRBF2
Standing height 3.23 1 1 2.2 0 1 NRBF2
Blood clot in the leg (DVT) 9.48 1 0 0.0 0 1 NRBF2
Gout (self-reported) 5.66 1 0 0.0 0 1 NRBF2
Medication: Ventolin 100micrograms inhaler 5.93 1 0 0.0 0 1 NRBF2
High blood pressure (siblings) 5.56 1 0 0.0 0 1 NRBF2
Body fat percentage 1.79 1 0 0.0 0 1 NRBF2
Leg fat percentage (right) 5.72 1 0 0.0 0 1 NRBF2
Exposure to tobacco smoke outside home 8.21 1 0 0.0 0 1 NRBF2
Comparative body size at age 10 2.90 1 0 0.0 0 1 NRBF2
Age at first live birth 6.41 1 0 0.0 0 1 NRBF2
Qualifications: College or University degree 2.97 1 0 0.0 0 1 NRBF2
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.37 1 0 0.0 0 1 NRBF2
Leg fat mass (right) 3.71 1 0 0.0 0 1 NRBF2
Number of full sisters 7.59 1 0 0.0 0 1 NRBF2
Age at last live birth 10.57 1 0 0.0 0 1 NRBF2
Hypertension (Self-reported) 6.05 1 0 0.0 0 1 NRBF2
Arm fat percentage (left) 2.30 1 0 0.0 0 1 NRBF2
Average weekly red wine intake 8.83 1 0 0.0 0 1 NRBF2
Diabetes diagnosed by doctor 5.55 1 0 0.0 0 1 NRBF2
Medication for cholesterol 5.22 1 0 0.0 0 1 NRBF2
Arm fat mass (left) 2.51 1 0 0.0 0 1 NRBF2
Mother's age at death 6.89 1 0 0.0 0 1 NRBF2
Medication: Blood pressure 9.25 1 0 0.0 0 1 NRBF2
Supplements: Fish oil (including cod liver oil) 15.92 1 0 0.0 0 1 NRBF2
Medication: Bendroflumethiazide 4.26 1 0 0.0 0 1 NRBF2
Leg fat percentage (left) 5.40 1 0 0.0 0 1 NRBF2
Average weekly beer plus cider intake 14.81 1 0 0.0 0 1 NRBF2
Diastolic blood pressure, automated reading 11.45 1 1 2.2 0 1 NRBF2
Vascular/heart problems diagnosed by doctor 6.00 1 0 0.0 0 1 NRBF2
Supplements: Calcium 12.72 1 0 0.0 0 1 NRBF2
Deep venous thrombosis (DVT) (self-reported) 11.20 1 0 0.0 0 1 NRBF2
Impedance of whole body 3.56 1 0 0.0 0 1 NRBF2
Leg fat mass (left) 3.38 1 0 0.0 0 1 NRBF2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.5
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.3
GTEx Stomach 1 0.069 1.4
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.5
YFS Blood 0 0.000 1.4
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4