Hub : Traits :

Age at last live birth

161 significantly associated models · 19 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	48702606	51043528	18	1	1.6e-15	2.1e-14	0.029	92	RBM6
2	18	32870015	34346308	1	1	2.2e-07	5.2e-07	0.596	99	RPRD1A

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Age at first live birth	24.8	2	1	2.2	1	RBM6 RPRD1A
Qualifications: College or University degree	21.1	2	1	2.2	1	RBM6 RPRD1A
Age at First Birth	20.4	1	1	2.2	1	RBM6
Body mass index (BMI)	18.6	1	1	2.2	1	RBM6
Qualifications: A levels/AS levels or equivalent	17.4	1	1	2.2	1	RBM6
BMI	16.6	1	1	2.2	1	RBM6
Qualifications: None of the above	15.8	1	1	2.2	1	RBM6
Leg fat mass (left)	14.6	1	1	2.2	1	RBM6
Leg fat mass (right)	14.4	1	1	2.2	1	RBM6
Intelligence (Savage-Jansen 2018)	14.3	1	1	2.2	1	RBM6
Impedance of arm (left)	14.3	1	1	2.2	1	RBM6
Leg fat percentage (left)	14.3	1	1	2.2	1	RBM6
Impedance of arm (right)	14.2	1	1	2.2	1	RBM6
Leg fat percentage (right)	14.2	1	1	2.2	1	RBM6
Impedance of whole body	13.0	1	1	2.2	1	RBM6
Fluid intelligence score	12.7	1	1	2.2	1	RBM6
Arm fat mass (right)	12.6	1	1	2.2	1	RBM6
Arm fat mass (left)	12.4	1	1	2.2	1	RBM6
Verbal and Numeric Reasoning (VNR)	11.6	1	1	2.2	1	RBM6
Ever highly irritable/argumentative for 2 days	11.4	1	1	2.2	1	RBM6
Medication: Co-codamol	10.6	1	0	0.0	1	RBM6
Whole body fat mass	10.4	1	1	2.2	1	RBM6
Miserableness	10.4	1	1	2.2	1	RBM6
Arm fat percentage (right)	10.1	1	1	2.2	1	RBM6
Arm fat percentage (left)	10.1	1	1	2.2	1	RBM6
Mouth/teeth dental problems: Dentures	9.9	1	1	2.2	1	RBM6
Ulcerative Colitis (UC)	9.4	1	1	2.2	1	RBM6
Overall health rating	8.9	1	1	2.2	1	RBM6
Average weekly beer plus cider intake	8.8	1	0	0.0	1	RBM6
Body fat percentage	8.7	1	1	2.2	1	RBM6
Weight	8.6	1	1	2.2	1	RBM6
Waist circumference	8.4	1	1	2.2	1	RBM6
Wheeze or whistling in the chest in last year	8.1	1	1	2.2	1	RBM6
Impedance of leg (left)	7.8	1	1	2.2	1	RBM6
Hip circumference	7.7	1	1	2.2	1	RBM6
Taking other prescription medications	7.3	1	0	0.0	1	RBM6
Impedance of leg (right)	7.1	1	1	2.2	1	RBM6
Number of treatments/medications taken	7.0	1	0	0.0	1	RBM6
Trunk fat mass	7.0	1	1	2.2	1	RBM6
Arm predicted mass (left)	7.0	1	1	2.2	1	RBM6
Exposure to tobacco smoke at home	6.9	1	0	0.0	1	RBM6
Chronic bronchitis/emphysema (mother)	6.9	1	0	0.0	1	RBM6
Number of full brothers	6.9	1	0	0.0	1	RBM6
Arm fat-free mass (left)	6.9	1	1	2.2	1	RBM6
Number of live births	6.8	1	0	0.0	1	RBM6
Exposure to tobacco smoke outside home	6.8	1	0	0.0	1	RBM6
Number of operations (self-reported)	6.6	1	0	0.0	1	RBM6
Irritable Bowel Disease (IBD)	6.5	1	0	0.0	1	RBM6
Arm predicted mass (right)	6.4	1	1	2.2	1	RBM6
Ulcerative Colitis	6.3	1	0	0.0	1	RBM6
Arm fat-free mass (right)	6.0	1	1	2.2	1	RBM6
Fed-up feelings	5.9	1	0	0.0	1	RBM6
Trunk fat percentage	5.8	1	1	2.2	1	RBM6
Qualifications: O levels/GCSEs or equivalent	5.8	1	0	0.0	1	RBM6
Depressed Affect (Nagel 2018)	5.7	1	0	0.0	1	RBM6
Mood swings	5.7	1	0	0.0	1	RBM6
Average weekly red wine intake	5.6	1	0	0.0	1	RBM6
Basal metabolic rate	5.5	1	1	2.2	1	RBM6
Pain experienced in last month	5.5	1	0	0.0	1	RBM6
Schizophrenia vs Biploar Disorder	5.0	1	0	0.0	1	RBM6
Alcohol intake frequency.	4.9	1	0	0.0	1	RBM6
Leg fat-free mass (left)	4.8	1	1	2.2	1	RBM6
Leg predicted mass (left)	4.8	1	1	2.2	1	RBM6
Whole body water mass	4.5	1	1	2.2	1	RBM6
Guilty feelings	4.5	1	0	0.0	1	RBM6
Smoking Status	4.4	1	0	0.0	1	RBM6
Alcohol intake versus 10 years previously	4.4	1	0	0.0	1	RBM6
Whole body fat-free mass	4.3	1	1	2.2	1	RBM6
Respiratory disease	4.1	1	0	0.0	1	RBM6
Comparative body size at age 10	4.0	1	0	0.0	1	RBM6
Leg fat-free mass (right)	3.9	1	1	2.2	1	RBM6
Leg predicted mass (right)	3.9	1	1	2.2	1	RBM6
Trunk fat-free mass	3.8	1	1	2.2	1	RBM6
Trunk predicted mass	3.7	1	1	2.2	1	RBM6
Blood White Count	3.2	1	1	2.2	1	RBM6
Neuroticism	3.1	1	0	0.0	1	RBM6
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	1	0	0.0	1	RBM6
Forced expiratory volume in 1-second (FEV1)	3.0	1	0	0.0	1	RBM6
Forced vital capacity (FVC), Best measure	3.0	1	0	0.0	1	RBM6
Forced vital capacity (FVC)	2.8	1	0	0.0	1	RBM6
Comparative height size at age 10	2.6	1	0	0.0	1	RBM6
Standing height	2.0	1	1	2.2	1	RBM6
Height	1.8	2	1	2.2	1	RBM6 RPRD1A

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	1	0.217	1.8
GTEx	Brain Putamen basal ganglia	1	0.160	1.7
GTEx	Colon Sigmoid	3	0.205	1.7
GTEx	Adipose Visceral Omentum	3	0.147	1.6
GTEx	Brain Caudate basal ganglia	2	0.217	1.6
GTEx	Brain Cortex	2	0.193	1.6
GTEx	Brain Frontal Cortex BA9	3	0.325	1.6
GTEx	Brain Hippocampus	0	0.000	1.6
GTEx	Breast Mammary Tissue	2	0.101	1.6
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.6
GTEx	Esophagus Gastroesophageal Junction	3	0.208	1.6
GTEx	Heart Atrial Appendage	3	0.190	1.6
GTEx	Liver	1	0.139	1.6
GTEx	Ovary	1	0.110	1.6
GTEx	Pituitary	2	0.179	1.6
GTEx	Prostate	1	0.120	1.6
GTEx	Spleen	3	0.213	1.6
GTEx	Uterus	0	0.000	1.6
GTEx	Vagina	1	0.157	1.6
GTEx	Adipose Subcutaneous	2	0.057	1.5
GTEx	Adrenal Gland	1	0.069	1.5
GTEx	Artery Coronary	1	0.085	1.5
GTEx	Artery Tibial	5	0.133	1.5
GTEx	Brain Cerebellar Hemisphere	3	0.201	1.5
GTEx	Brain Cerebellum	5	0.252	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.5
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.5
GTEx	Cells Transformed fibroblasts	4	0.095	1.5
GTEx	Colon Transverse	2	0.097	1.5
GTEx	Esophagus Mucosa	4	0.120	1.5
GTEx	Esophagus Muscularis	4	0.124	1.5
GTEx	Heart Left Ventricle	2	0.131	1.5
GTEx	Lung	4	0.139	1.5
GTEx	Muscle Skeletal	2	0.069	1.5
GTEx	Nerve Tibial	3	0.069	1.5
GTEx	Pancreas	1	0.061	1.5
GTEx	Skin Not Sun Exposed Suprapubic	4	0.163	1.5
GTEx	Skin Sun Exposed Lower leg	5	0.137	1.5
GTEx	Stomach	2	0.138	1.5
GTEx	Testis	2	0.063	1.5
GTEx	Thyroid	4	0.100	1.5
GTEx	Whole Blood	2	0.100	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.5
GTEx	Artery Aorta	3	0.101	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
METSIM	Adipose	3	0.065	1.4
NTR	Blood	2	0.083	1.4
ROSMAP	Brain Pre-frontal Cortex	5	0.114	1.4
CommonMind	Brain Pre-frontal Cortex	3	0.056	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.091	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	3	0.073	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	5	0.116	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	3	0.102	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	3	0.181	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	2	0.151	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	4	0.087	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	5	0.097	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
YFS	Blood	2	0.043	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3