Hub : Traits :

Age at last live birth

161 significantly associated models · 19 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48702606 51043528 18 1 1.6e-15 2.1e-14 0.029 92 RBM6
2 18 32870015 34346308 1 1 2.2e-07 5.2e-07 0.596 99 RPRD1A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 5.7 1 0 0.0 0 1 RBM6
Intelligence (Savage-Jansen 2018) 14.3 1 1 2.2 0 1 RBM6
Schizophrenia vs Biploar Disorder 5.0 1 0 0.0 0 1 RBM6
Irritable Bowel Disease (IBD) 6.5 1 0 0.0 0 1 RBM6
Ulcerative Colitis (UC) 9.4 1 1 2.2 0 1 RBM6
Verbal and Numeric Reasoning (VNR) 11.6 1 1 2.2 0 1 RBM6
Age at First Birth 20.4 1 1 2.2 0 1 RBM6
Ulcerative Colitis 6.3 1 0 0.0 0 1 RBM6
Blood White Count 3.2 1 1 2.2 0 1 RBM6
BMI 16.6 1 1 2.2 0 1 RBM6
Height 1.8 2 1 2.2 0 1 RBM6 RPRD1A
Smoking Status 4.4 1 0 0.0 0 1 RBM6
Respiratory disease 4.1 1 0 0.0 0 1 RBM6
Neuroticism 3.1 1 0 0.0 0 1 RBM6
Number of treatments/medications taken 7.0 1 0 0.0 0 1 RBM6
Medication: Co-codamol 10.6 1 0 0.0 0 1 RBM6
Impedance of leg (right) 7.1 1 1 2.2 0 1 RBM6
Leg fat-free mass (left) 4.8 1 1 2.2 0 1 RBM6
Trunk fat percentage 5.8 1 1 2.2 0 1 RBM6
Fed-up feelings 5.9 1 0 0.0 0 1 RBM6
Taking other prescription medications 7.3 1 0 0.0 0 1 RBM6
Body mass index (BMI) 18.6 1 1 2.2 0 1 RBM6
Impedance of leg (left) 7.8 1 1 2.2 0 1 RBM6
Leg predicted mass (left) 4.8 1 1 2.2 0 1 RBM6
Trunk fat mass 7.0 1 1 2.2 0 1 RBM6
Waist circumference 8.4 1 1 2.2 0 1 RBM6
Forced vital capacity (FVC) 2.8 1 0 0.0 0 1 RBM6
Qualifications: None of the above 15.8 1 1 2.2 0 1 RBM6
Fluid intelligence score 12.7 1 1 2.2 0 1 RBM6
Weight 8.6 1 1 2.2 0 1 RBM6
Impedance of arm (right) 14.2 1 1 2.2 0 1 RBM6
Arm fat percentage (right) 10.1 1 1 2.2 0 1 RBM6
Trunk fat-free mass 3.8 1 1 2.2 0 1 RBM6
Hip circumference 7.7 1 1 2.2 0 1 RBM6
Alcohol intake versus 10 years previously 4.4 1 0 0.0 0 1 RBM6
Number of live births 6.8 1 0 0.0 0 1 RBM6
Forced expiratory volume in 1-second (FEV1) 3.0 1 0 0.0 0 1 RBM6
Qualifications: A levels/AS levels or equivalent 17.4 1 1 2.2 0 1 RBM6
Mouth/teeth dental problems: Dentures 9.9 1 1 2.2 0 1 RBM6
Forced expiratory volume in 1-second (FEV1), Best measure 3.1 1 0 0.0 0 1 RBM6
Impedance of arm (left) 14.3 1 1 2.2 0 1 RBM6
Arm fat mass (right) 12.6 1 1 2.2 0 1 RBM6
Trunk predicted mass 3.7 1 1 2.2 0 1 RBM6
Standing height 2.0 1 1 2.2 0 1 RBM6
Exposure to tobacco smoke at home 6.9 1 0 0.0 0 1 RBM6
Ever highly irritable/argumentative for 2 days 11.4 1 1 2.2 0 1 RBM6
Qualifications: O levels/GCSEs or equivalent 5.8 1 0 0.0 0 1 RBM6
Chronic bronchitis/emphysema (mother) 6.9 1 0 0.0 0 1 RBM6
Forced vital capacity (FVC), Best measure 3.0 1 0 0.0 0 1 RBM6
Body fat percentage 8.7 1 1 2.2 0 1 RBM6
Leg fat percentage (right) 14.2 1 1 2.2 0 1 RBM6
Arm fat-free mass (right) 6.0 1 1 2.2 0 1 RBM6
Exposure to tobacco smoke outside home 6.8 1 0 0.0 0 1 RBM6
Comparative body size at age 10 4.0 1 0 0.0 0 1 RBM6
Number of full brothers 6.9 1 0 0.0 0 1 RBM6
Wheeze or whistling in the chest in last year 8.1 1 1 2.2 0 1 RBM6
Age at first live birth 24.8 2 1 2.2 0 1 RBM6 RPRD1A
Qualifications: College or University degree 21.1 2 1 2.2 0 1 RBM6 RPRD1A
Whole body fat mass 10.4 1 1 2.2 0 1 RBM6
Leg fat mass (right) 14.4 1 1 2.2 0 1 RBM6
Arm predicted mass (right) 6.4 1 1 2.2 0 1 RBM6
Alcohol intake frequency. 4.9 1 0 0.0 0 1 RBM6
Comparative height size at age 10 2.6 1 0 0.0 0 1 RBM6
Overall health rating 8.9 1 1 2.2 0 1 RBM6
Whole body fat-free mass 4.3 1 1 2.2 0 1 RBM6
Leg fat-free mass (right) 3.9 1 1 2.2 0 1 RBM6
Arm fat percentage (left) 10.1 1 1 2.2 0 1 RBM6
Average weekly red wine intake 5.6 1 0 0.0 0 1 RBM6
Mood swings 5.7 1 0 0.0 0 1 RBM6
Whole body water mass 4.5 1 1 2.2 0 1 RBM6
Leg predicted mass (right) 3.9 1 1 2.2 0 1 RBM6
Arm fat mass (left) 12.4 1 1 2.2 0 1 RBM6
Miserableness 10.4 1 1 2.2 0 1 RBM6
Guilty feelings 4.5 1 0 0.0 0 1 RBM6
Basal metabolic rate 5.5 1 1 2.2 0 1 RBM6
Leg fat percentage (left) 14.3 1 1 2.2 0 1 RBM6
Arm fat-free mass (left) 6.9 1 1 2.2 0 1 RBM6
Number of operations (self-reported) 6.6 1 0 0.0 0 1 RBM6
Average weekly beer plus cider intake 8.8 1 0 0.0 0 1 RBM6
Pain experienced in last month 5.5 1 0 0.0 0 1 RBM6
Impedance of whole body 13.0 1 1 2.2 0 1 RBM6
Leg fat mass (left) 14.6 1 1 2.2 0 1 RBM6
Arm predicted mass (left) 7.0 1 1 2.2 0 1 RBM6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.057 1.5
GTEx Adipose Visceral Omentum 3 0.147 1.6
GTEx Adrenal Gland 1 0.069 1.5
GTEx Artery Aorta 3 0.101 1.4
GTEx Artery Coronary 1 0.085 1.5
GTEx Artery Tibial 5 0.133 1.5
GTEx Brain Caudate basal ganglia 2 0.217 1.6
GTEx Brain Cerebellar Hemisphere 3 0.201 1.5
GTEx Brain Cerebellum 5 0.252 1.5
GTEx Brain Cortex 2 0.193 1.6
GTEx Brain Frontal Cortex BA9 3 0.325 1.6
GTEx Brain Hippocampus 0 0.000 1.6
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.5
GTEx Brain Putamen basal ganglia 1 0.160 1.7
GTEx Breast Mammary Tissue 2 0.101 1.6
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 1 0.061 1.5
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.6
GTEx Cells Transformed fibroblasts 4 0.095 1.5
GTEx Colon Sigmoid 3 0.205 1.7
GTEx Colon Transverse 2 0.097 1.5
GTEx Esophagus Gastroesophageal Junction 3 0.208 1.6
GTEx Esophagus Mucosa 4 0.120 1.5
GTEx Esophagus Muscularis 4 0.124 1.5
GTEx Heart Atrial Appendage 3 0.190 1.6
GTEx Heart Left Ventricle 2 0.131 1.5
GTEx Liver 1 0.139 1.6
GTEx Lung 4 0.139 1.5
GTEx Muscle Skeletal 2 0.069 1.5
GTEx Nerve Tibial 3 0.069 1.5
GTEx Ovary 1 0.110 1.6
GTEx Pancreas 1 0.061 1.5
GTEx Pituitary 2 0.179 1.6
GTEx Prostate 1 0.120 1.6
GTEx Skin Not Sun Exposed Suprapubic 4 0.163 1.5
GTEx Skin Sun Exposed Lower leg 5 0.137 1.5
GTEx Small Intestine Terminal Ileum 1 0.217 1.8
GTEx Spleen 3 0.213 1.6
GTEx Stomach 2 0.138 1.5
GTEx Testis 2 0.063 1.5
GTEx Thyroid 4 0.100 1.5
GTEx Uterus 0 0.000 1.6
GTEx Vagina 1 0.157 1.6
GTEx Whole Blood 2 0.100 1.5
METSIM Adipose 3 0.065 1.4
NTR Blood 2 0.083 1.4
ROSMAP Brain Pre-frontal Cortex 5 0.114 1.4
YFS Blood 2 0.043 1.3
CommonMind Brain Pre-frontal Cortex 3 0.056 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 4 0.091 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.073 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 5 0.116 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 3 0.102 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 3 0.120 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 3 0.181 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 2 0.151 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 4 0.087 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.5
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.5
The Cancer Genome Atlas Thyroid Carcinoma 5 0.097 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4