Hub : Traits :

Bipolar Disorder (2018)

36 significantly associated models · 23 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 96675166 98024837 1 1 1.8e-07 2.2e-07 1.0e+00 100 LMAN2L
2 3 36055389 37914922 2 2 1.9e-08 3.7e-12 4.3e-06 56 DCLK3 LRRFIP2
3 3 52047421 53545622 2 1 5.5e-08 6.4e-07 4.0e-01 97 NEK4
4 6 84017921 84666980 1 1 7.5e-08 3.3e-07 6.7e-01 99 SNAP91
5 7 24040297 25508637 1 1 2.7e-07 3.6e-07 1.9e-01 93 DFNA5
6 10 111062431 112588355 1 1 9.6e-08 4.5e-08 1.0e+00 100 ADD3
7 12 1204676 2724022 1 1 2.0e-08 1.2e-08 1.7e-01 94 CACNA2D4
8 19 10516198 11004833 1 1 1.0e-07 1.2e-07 5.8e-02 87 LOC147727
9 19 18674057 20432930 5 1 1.2e-08 7.2e-09 1.0e-01 92 YJEFN3
10 21 47049185 48090629 4 1 8.8e-10 2.0e-07 1.6e-01 93 MCM3APAS
11 22 21798199 23032448 1 1 2.1e-07 1.3e-07 1.0e+00 100 TOP3B
12 22 40388308 41777913 2 1 9.0e-09 1.4e-08 1.0e+00 100 XPNPEP3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 14.15 13 9 20.0 0.97 7.0e-08 ADD3 CACNA2D4 DCLK3 DFNA5 LMAN2L LOC147727 LRRFIP2 MCM3APAS NEK4 SNAP91 TOP3B XPNPEP3 YJEFN3
Depression (Nagel 2018) 1.14 1 0 0.0 0.00 1.0e+00 NEK4
Intelligence (Savage-Jansen 2018) 1.02 1 0 0.0 0.00 1.0e+00 NEK4
Neuroticism (Nagel 2018) 1.28 1 0 0.0 0.00 1.0e+00 NEK4
Schizophrenia (2018) 5.71 5 1 2.2 0.99 5.5e-04 CACNA2D4 LMAN2L LRRFIP2 NEK4 SNAP91
Schizophrenia vs Biploar Disorder 3.39 2 0 0.0 0.00 1.0e+00 LOC147727 MCM3APAS
Worry (Nagel 2018) 3.22 2 1 2.2 0.00 1.0e+00 CACNA2D4 NEK4
Major Depression (MDD) 1.46 1 0 0.0 0.00 1.0e+00 NEK4
Reaction Time 1.83 2 0 0.0 0.00 1.0e+00 LOC147727 SNAP91
Verbal and Numeric Reasoning (VNR) 1.16 1 0 0.0 0.00 1.0e+00 NEK4
Bipolar Disorder (2011) 13.50 9 0 0.0 0.99 2.2e-07 CACNA2D4 DCLK3 DFNA5 LMAN2L LRRFIP2 MCM3APAS NEK4 SNAP91 YJEFN3
Coronary Artery Disease (CAD) 2.11 1 0 0.0 0.00 1.0e+00 LOC147727
Rheumatoid Arthritis 3.15 2 0 0.0 0.00 1.0e+00 XPNPEP3 YJEFN3
Schizophrenia (2014) 7.33 6 3 6.7 0.97 9.5e-04 CACNA2D4 DFNA5 LMAN2L LRRFIP2 NEK4 SNAP91
Blood Eosinophil Count 2.69 4 3 6.7 -0.64 3.6e-01 ADD3 LMAN2L NEK4 YJEFN3
Blood Platelet Count 1.38 7 3 6.7 -0.60 1.6e-01 ADD3 DFNA5 LMAN2L LOC147727 NEK4 SNAP91 YJEFN3
Blood Red Count 0.94 3 3 6.7 0.00 1.0e+00 NEK4 TOP3B YJEFN3
Blood White Count 0.54 2 0 0.0 0.00 1.0e+00 ADD3 MCM3APAS
Heel T-Score 0.49 2 0 0.0 0.00 1.0e+00 ADD3 MCM3APAS
BMI 2.20 4 2 4.4 -0.94 5.6e-02 NEK4 SNAP91 XPNPEP3 YJEFN3
Height 2.71 9 4 8.9 0.19 6.3e-01 DCLK3 DFNA5 LMAN2L LOC147727 MCM3APAS NEK4 TOP3B XPNPEP3 YJEFN3
Waist Hip Ratio (WHR) 1.93 4 1 2.2 0.18 8.2e-01 CACNA2D4 NEK4 SNAP91 YJEFN3
Systolic Blood Pressure 1.14 2 1 2.2 0.00 1.0e+00 DFNA5 YJEFN3
Smoking Status 1.50 2 0 0.0 0.00 1.0e+00 NEK4 SNAP91
Hypothyroidism (self reported) 1.68 2 0 0.0 0.00 1.0e+00 LRRFIP2 TOP3B
Lung FEV1/FVC ratio 1.45 3 1 2.2 0.00 1.0e+00 ADD3 NEK4 YJEFN3
Neuroticism 1.49 1 0 0.0 0.00 1.0e+00 NEK4
Hair Pigment 0.21 2 1 2.2 0.00 1.0e+00 ADD3 LOC147727
Tanning 0.26 1 0 0.0 0.00 1.0e+00 NEK4
Hand grip strength (left) 0.76 1 0 0.0 0.00 1.0e+00 SNAP91
Hearing difficulty/problems: Yes 1.89 1 0 0.0 0.00 1.0e+00 YJEFN3
Systolic blood pressure, automated reading 1.36 1 0 0.0 0.00 1.0e+00 DFNA5
Impedance of leg (right) 1.79 4 1 2.2 0.98 2.5e-02 CACNA2D4 NEK4 TOP3B YJEFN3
Leg fat-free mass (left) 1.04 2 0 0.0 0.00 1.0e+00 LOC147727 NEK4
Hand grip strength (right) 0.62 1 0 0.0 0.00 1.0e+00 SNAP91
Townsend deprivation index at recruitment 0.97 1 0 0.0 0.00 1.0e+00 YJEFN3
Fed-up feelings 1.21 1 0 0.0 0.00 1.0e+00 SNAP91
Taking other prescription medications 0.82 1 0 0.0 0.00 1.0e+00 ADD3
Age when periods started (menarche) 3.03 3 0 0.0 0.00 1.0e+00 NEK4 TOP3B XPNPEP3
Serious illness, injury or assault to yourself 1.66 1 0 0.0 0.00 1.0e+00 LMAN2L
Medication: Levothyroxine sodium 1.85 1 0 0.0 0.00 1.0e+00 DCLK3
Sitting height 2.02 3 2 4.4 0.00 1.0e+00 LOC147727 XPNPEP3 YJEFN3
Body mass index (BMI) 1.92 3 2 4.4 0.00 1.0e+00 CACNA2D4 NEK4 YJEFN3
Impedance of leg (left) 1.79 3 1 2.2 0.00 1.0e+00 CACNA2D4 NEK4 YJEFN3
Leg predicted mass (left) 1.04 2 0 0.0 0.00 1.0e+00 LOC147727 NEK4
Waist circumference 1.11 2 0 0.0 0.00 1.0e+00 SNAP91 YJEFN3
Number of incorrect matches in round 1.32 1 0 0.0 0.00 1.0e+00 NEK4
Nervous feelings 2.51 1 1 2.2 0.00 1.0e+00 NEK4
Frequency of tenseness / restlessness in last 2 weeks 1.64 1 0 0.0 0.00 1.0e+00 NEK4
Hearing difficulty/problems with background noise 1.41 1 0 0.0 0.00 1.0e+00 SNAP91
Forced vital capacity (FVC) 1.06 2 0 0.0 0.00 1.0e+00 LOC147727 YJEFN3
Ever unenthusiastic/disinterested for a whole week 2.60 1 0 0.0 0.00 1.0e+00 LMAN2L
Qualifications: None of the above 1.15 1 0 0.0 0.00 1.0e+00 DFNA5
Mouth/teeth dental problems 1.52 1 0 0.0 0.00 1.0e+00 YJEFN3
Fluid intelligence score 1.18 1 0 0.0 0.00 1.0e+00 NEK4
Weight 0.90 2 0 0.0 0.00 1.0e+00 LOC147727 NEK4
Impedance of arm (right) 3.07 4 2 4.4 0.95 5.3e-02 CACNA2D4 NEK4 SNAP91 YJEFN3
Trunk fat-free mass 1.27 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Hip circumference 0.77 1 0 0.0 0.00 1.0e+00 NEK4
Time employed in main current job 1.56 1 0 0.0 0.00 1.0e+00 CACNA2D4
Worrier / anxious feelings 1.97 2 0 0.0 0.00 1.0e+00 CACNA2D4 NEK4
Forced expiratory volume in 1-second (FEV1) 0.75 1 0 0.0 0.00 1.0e+00 LOC147727
Pulse rate 1.80 1 0 0.0 0.00 1.0e+00 NEK4
Qualifications: A levels/AS levels or equivalent 1.50 1 0 0.0 0.00 1.0e+00 DFNA5
Medication: Cholesterol lowering 2.00 1 0 0.0 0.00 1.0e+00 LOC147727
Prospective memory result 2.14 1 0 0.0 0.00 1.0e+00 NEK4
Forced expiratory volume in 1-second (FEV1), Best measure 0.93 1 0 0.0 0.00 1.0e+00 LOC147727
Impedance of arm (left) 2.85 4 2 4.4 0.95 5.3e-02 CACNA2D4 NEK4 SNAP91 YJEFN3
Trunk predicted mass 1.29 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Standing height 2.54 6 2 4.4 0.19 7.2e-01 DCLK3 DFNA5 LOC147727 NEK4 XPNPEP3 YJEFN3
Breastfed as a baby 1.41 1 0 0.0 0.00 1.0e+00 DFNA5
Tense / 'highly strung' 2.29 2 0 0.0 0.00 1.0e+00 CACNA2D4 NEK4
Peak expiratory flow (PEF) 0.73 1 0 0.0 0.00 1.0e+00 LOC147727
Pulse wave reflection index 1.88 1 0 0.0 0.00 1.0e+00 YJEFN3
Qualifications: O levels/GCSEs or equivalent 1.72 1 0 0.0 0.00 1.0e+00 DFNA5
Mouth/teeth dental problems: Bleeding gums 2.19 1 0 0.0 0.00 1.0e+00 YJEFN3
Headache pain in last month 1.78 2 0 0.0 0.00 1.0e+00 NEK4 TOP3B
Medication for cholesterol, blood pressure or diabetes 1.97 1 0 0.0 0.00 1.0e+00 LMAN2L
Hypothyroidism/myxoedema (self-reported) 1.91 2 0 0.0 0.00 1.0e+00 DCLK3 LRRFIP2
Forced vital capacity (FVC), Best measure 1.30 2 0 0.0 0.00 1.0e+00 LOC147727 YJEFN3
Body fat percentage 0.76 1 0 0.0 0.00 1.0e+00 DFNA5
Leg fat percentage (right) 1.72 3 0 0.0 0.00 1.0e+00 DFNA5 LOC147727 YJEFN3
Arm fat-free mass (right) 1.20 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Comparative body size at age 10 2.16 3 0 0.0 0.00 1.0e+00 CACNA2D4 TOP3B YJEFN3
Qualifications: College or University degree 1.47 2 0 0.0 0.00 1.0e+00 ADD3 DFNA5
Mean time to correctly identify matches 2.19 1 0 0.0 0.00 1.0e+00 SNAP91
Leg fat mass (right) 1.16 1 0 0.0 0.00 1.0e+00 YJEFN3
Arm predicted mass (right) 1.23 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Pulse rate, automated reading 1.49 2 0 0.0 0.00 1.0e+00 NEK4 SNAP91
Comparative height size at age 10 2.22 4 1 2.2 0.15 8.5e-01 LOC147727 NEK4 TOP3B YJEFN3
Suffer from 'nerves' 1.50 1 0 0.0 0.00 1.0e+00 NEK4
Chest pain or discomfort 2.02 1 0 0.0 0.00 1.0e+00 NEK4
Hypertension (Self-reported) 1.16 1 0 0.0 0.00 1.0e+00 DFNA5
Forced expiratory volume in 1-second (FEV1), predicted 2.72 2 1 2.2 0.00 1.0e+00 LOC147727 YJEFN3
Whole body fat-free mass 1.20 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Leg fat-free mass (right) 1.12 3 1 2.2 0.00 1.0e+00 LOC147727 NEK4 TOP3B
Whole body water mass 1.20 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Leg predicted mass (right) 1.14 3 1 2.2 0.00 1.0e+00 LOC147727 NEK4 TOP3B
Guilty feelings 2.35 2 0 0.0 0.00 1.0e+00 NEK4 YJEFN3
Tinnitus: Yes, now most or all of the time 2.18 1 0 0.0 0.00 1.0e+00 SNAP91
Ever smoked 1.60 1 0 0.0 0.00 1.0e+00 NEK4
Basal metabolic rate 1.10 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Leg fat percentage (left) 1.78 2 0 0.0 0.00 1.0e+00 DFNA5 YJEFN3
Arm fat-free mass (left) 1.14 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4
Number of operations (self-reported) 1.65 1 0 0.0 0.00 1.0e+00 ADD3
Irritability 1.67 1 0 0.0 0.00 1.0e+00 CACNA2D4
Risk taking 2.05 1 0 0.0 0.00 1.0e+00 DCLK3
Diastolic blood pressure, automated reading 1.40 2 0 0.0 0.00 1.0e+00 CACNA2D4 LMAN2L
Myopia 2.33 2 0 0.0 0.00 1.0e+00 ADD3 YJEFN3
Impedance of whole body 2.51 3 2 4.4 0.00 1.0e+00 CACNA2D4 NEK4 YJEFN3
Leg fat mass (left) 1.19 1 0 0.0 0.00 1.0e+00 YJEFN3
Arm predicted mass (left) 1.14 2 1 2.2 0.00 1.0e+00 LOC147727 NEK4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.7
GTEx Adipose Visceral Omentum 1 0.051 1.7
GTEx Adrenal Gland 0 0.000 1.6
GTEx Artery Aorta 0 0.000 1.7
GTEx Artery Coronary 0 0.000 1.6
GTEx Artery Tibial 1 0.028 1.6
GTEx Brain Caudate basal ganglia 0 0.000 1.6
GTEx Brain Cerebellar Hemisphere 0 0.000 1.6
GTEx Brain Cerebellum 0 0.000 1.7
GTEx Brain Cortex 0 0.000 1.6
GTEx Brain Frontal Cortex BA9 0 0.000 1.6
GTEx Brain Hippocampus 0 0.000 1.8
GTEx Brain Hypothalamus 0 0.000 1.6
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.7
GTEx Brain Putamen basal ganglia 0 0.000 1.5
GTEx Breast Mammary Tissue 0 0.000 1.7
GTEx Breast Mammary Tissue (Male) 0 0.000 1.7
GTEx Breast Mammary Tissue (Female) 0 0.000 1.6
GTEx Cells EBV-transformed lymphocytes 2 0.146 1.7
GTEx Cells Transformed fibroblasts 0 0.000 1.7
GTEx Colon Sigmoid 0 0.000 1.7
GTEx Colon Transverse 1 0.050 1.8
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.7
GTEx Esophagus Mucosa 0 0.000 1.7
GTEx Esophagus Muscularis 1 0.032 1.7
GTEx Heart Atrial Appendage 0 0.000 1.8
GTEx Heart Left Ventricle 1 0.068 1.8
GTEx Liver 0 0.000 1.5
GTEx Lung 0 0.000 1.7
GTEx Muscle Skeletal 1 0.036 1.7
GTEx Nerve Tibial 0 0.000 1.7
GTEx Ovary 0 0.000 1.7
GTEx Pancreas 0 0.000 1.8
GTEx Pituitary 0 0.000 1.7
GTEx Prostate 0 0.000 1.7
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.7
GTEx Skin Sun Exposed Lower leg 1 0.029 1.6
GTEx Small Intestine Terminal Ileum 0 0.000 1.7
GTEx Spleen 3 0.219 1.8
GTEx Stomach 0 0.000 1.6
GTEx Testis 2 0.065 1.7
GTEx Thyroid 1 0.026 1.7
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.7
GTEx Whole Blood 1 0.052 1.7
METSIM Adipose 0 0.000 1.6
NTR Blood 0 0.000 1.6
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.7
YFS Blood 1 0.022 1.6
CommonMind Brain Pre-frontal Cortex 3 0.057 1.6
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.064 1.7
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.024 1.7
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.103 1.7
The Cancer Genome Atlas Esophageal Carcinoma 1 0.154 1.7
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.104 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.7
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 2 0.052 1.6
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.049 1.7
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.036 1.6
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.7
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.7
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.7
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.080 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.023 1.6
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.6
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.6
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.7
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.7
The Cancer Genome Atlas Thyroid Carcinoma 3 0.061 1.7
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.6