Hub : Traits :

Bipolar Disorder (2018)

36 significantly associated models · 23 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	96675166	98024837	1	1	1.8e-07	2.2e-07	1.0e+00	100	LMAN2L
2	3	36055389	37914922	2	2	1.9e-08	3.7e-12	4.3e-06	56	DCLK3 LRRFIP2
3	3	52047421	53545622	2	1	5.5e-08	6.4e-07	4.0e-01	97	NEK4
4	6	84017921	84666980	1	1	7.5e-08	3.3e-07	6.7e-01	99	SNAP91
5	7	24040297	25508637	1	1	2.7e-07	3.6e-07	1.9e-01	93	DFNA5
6	10	111062431	112588355	1	1	9.6e-08	4.5e-08	1.0e+00	100	ADD3
7	12	1204676	2724022	1	1	2.0e-08	1.2e-08	1.7e-01	94	CACNA2D4
8	19	10516198	11004833	1	1	1.0e-07	1.2e-07	5.8e-02	87	LOC147727
9	19	18674057	20432930	5	1	1.2e-08	7.2e-09	1.0e-01	92	YJEFN3
10	21	47049185	48090629	4	1	8.8e-10	2.0e-07	1.6e-01	93	MCM3APAS
11	22	21798199	23032448	1	1	2.1e-07	1.3e-07	1.0e+00	100	TOP3B
12	22	40388308	41777913	2	1	9.0e-09	1.4e-08	1.0e+00	100	XPNPEP3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	14.15	13	9	20.0	0.97	7.0e-08	ADD3 CACNA2D4 DCLK3 DFNA5 LMAN2L LOC147727 LRRFIP2 MCM3APAS NEK4 SNAP91 TOP3B XPNPEP3 YJEFN3
Bipolar Disorder (2011)	13.50	9	0	0.0	0.99	2.2e-07	CACNA2D4 DCLK3 DFNA5 LMAN2L LRRFIP2 MCM3APAS NEK4 SNAP91 YJEFN3
Schizophrenia (2014)	7.33	6	3	6.7	0.97	9.5e-04	CACNA2D4 DFNA5 LMAN2L LRRFIP2 NEK4 SNAP91
Schizophrenia (2018)	5.71	5	1	2.2	0.99	5.5e-04	CACNA2D4 LMAN2L LRRFIP2 NEK4 SNAP91
Schizophrenia vs Biploar Disorder	3.39	2	0	0.0	0.00	1.0e+00	LOC147727 MCM3APAS
Worry (Nagel 2018)	3.22	2	1	2.2	0.00	1.0e+00	CACNA2D4 NEK4
Rheumatoid Arthritis	3.15	2	0	0.0	0.00	1.0e+00	XPNPEP3 YJEFN3
Impedance of arm (right)	3.07	4	2	4.4	0.95	5.3e-02	CACNA2D4 NEK4 SNAP91 YJEFN3
Age when periods started (menarche)	3.03	3	0	0.0	0.00	1.0e+00	NEK4 TOP3B XPNPEP3
Impedance of arm (left)	2.85	4	2	4.4	0.95	5.3e-02	CACNA2D4 NEK4 SNAP91 YJEFN3
Forced expiratory volume in 1-second (FEV1), predicted	2.72	2	1	2.2	0.00	1.0e+00	LOC147727 YJEFN3
Height	2.71	9	4	8.9	0.19	6.3e-01	DCLK3 DFNA5 LMAN2L LOC147727 MCM3APAS NEK4 TOP3B XPNPEP3 YJEFN3
Blood Eosinophil Count	2.69	4	3	6.7	-0.64	3.6e-01	ADD3 LMAN2L NEK4 YJEFN3
Ever unenthusiastic/disinterested for a whole week	2.60	1	0	0.0	0.00	1.0e+00	LMAN2L
Standing height	2.54	6	2	4.4	0.19	7.2e-01	DCLK3 DFNA5 LOC147727 NEK4 XPNPEP3 YJEFN3
Nervous feelings	2.51	1	1	2.2	0.00	1.0e+00	NEK4
Impedance of whole body	2.51	3	2	4.4	0.00	1.0e+00	CACNA2D4 NEK4 YJEFN3
Guilty feelings	2.35	2	0	0.0	0.00	1.0e+00	NEK4 YJEFN3
Myopia	2.33	2	0	0.0	0.00	1.0e+00	ADD3 YJEFN3
Tense / 'highly strung'	2.29	2	0	0.0	0.00	1.0e+00	CACNA2D4 NEK4
Comparative height size at age 10	2.22	4	1	2.2	0.15	8.5e-01	LOC147727 NEK4 TOP3B YJEFN3
BMI	2.20	4	2	4.4	-0.94	5.6e-02	NEK4 SNAP91 XPNPEP3 YJEFN3
Mouth/teeth dental problems: Bleeding gums	2.19	1	0	0.0	0.00	1.0e+00	YJEFN3
Mean time to correctly identify matches	2.19	1	0	0.0	0.00	1.0e+00	SNAP91
Tinnitus: Yes, now most or all of the time	2.18	1	0	0.0	0.00	1.0e+00	SNAP91
Comparative body size at age 10	2.16	3	0	0.0	0.00	1.0e+00	CACNA2D4 TOP3B YJEFN3
Prospective memory result	2.14	1	0	0.0	0.00	1.0e+00	NEK4
Coronary Artery Disease (CAD)	2.11	1	0	0.0	0.00	1.0e+00	LOC147727
Risk taking	2.05	1	0	0.0	0.00	1.0e+00	DCLK3
Sitting height	2.02	3	2	4.4	0.00	1.0e+00	LOC147727 XPNPEP3 YJEFN3
Chest pain or discomfort	2.02	1	0	0.0	0.00	1.0e+00	NEK4
Medication: Cholesterol lowering	2.00	1	0	0.0	0.00	1.0e+00	LOC147727
Worrier / anxious feelings	1.97	2	0	0.0	0.00	1.0e+00	CACNA2D4 NEK4
Medication for cholesterol, blood pressure or diabetes	1.97	1	0	0.0	0.00	1.0e+00	LMAN2L
Waist Hip Ratio (WHR)	1.93	4	1	2.2	0.18	8.2e-01	CACNA2D4 NEK4 SNAP91 YJEFN3
Body mass index (BMI)	1.92	3	2	4.4	0.00	1.0e+00	CACNA2D4 NEK4 YJEFN3
Hypothyroidism/myxoedema (self-reported)	1.91	2	0	0.0	0.00	1.0e+00	DCLK3 LRRFIP2
Hearing difficulty/problems: Yes	1.89	1	0	0.0	0.00	1.0e+00	YJEFN3
Pulse wave reflection index	1.88	1	0	0.0	0.00	1.0e+00	YJEFN3
Medication: Levothyroxine sodium	1.85	1	0	0.0	0.00	1.0e+00	DCLK3
Reaction Time	1.83	2	0	0.0	0.00	1.0e+00	LOC147727 SNAP91
Pulse rate	1.80	1	0	0.0	0.00	1.0e+00	NEK4
Impedance of leg (right)	1.79	4	1	2.2	0.98	2.5e-02	CACNA2D4 NEK4 TOP3B YJEFN3
Impedance of leg (left)	1.79	3	1	2.2	0.00	1.0e+00	CACNA2D4 NEK4 YJEFN3
Headache pain in last month	1.78	2	0	0.0	0.00	1.0e+00	NEK4 TOP3B
Leg fat percentage (left)	1.78	2	0	0.0	0.00	1.0e+00	DFNA5 YJEFN3
Qualifications: O levels/GCSEs or equivalent	1.72	1	0	0.0	0.00	1.0e+00	DFNA5
Leg fat percentage (right)	1.72	3	0	0.0	0.00	1.0e+00	DFNA5 LOC147727 YJEFN3
Hypothyroidism (self reported)	1.68	2	0	0.0	0.00	1.0e+00	LRRFIP2 TOP3B
Irritability	1.67	1	0	0.0	0.00	1.0e+00	CACNA2D4
Serious illness, injury or assault to yourself	1.66	1	0	0.0	0.00	1.0e+00	LMAN2L
Number of operations (self-reported)	1.65	1	0	0.0	0.00	1.0e+00	ADD3
Frequency of tenseness / restlessness in last 2 weeks	1.64	1	0	0.0	0.00	1.0e+00	NEK4
Ever smoked	1.60	1	0	0.0	0.00	1.0e+00	NEK4
Time employed in main current job	1.56	1	0	0.0	0.00	1.0e+00	CACNA2D4
Mouth/teeth dental problems	1.52	1	0	0.0	0.00	1.0e+00	YJEFN3
Smoking Status	1.50	2	0	0.0	0.00	1.0e+00	NEK4 SNAP91
Qualifications: A levels/AS levels or equivalent	1.50	1	0	0.0	0.00	1.0e+00	DFNA5
Suffer from 'nerves'	1.50	1	0	0.0	0.00	1.0e+00	NEK4
Neuroticism	1.49	1	0	0.0	0.00	1.0e+00	NEK4
Pulse rate, automated reading	1.49	2	0	0.0	0.00	1.0e+00	NEK4 SNAP91
Qualifications: College or University degree	1.47	2	0	0.0	0.00	1.0e+00	ADD3 DFNA5
Major Depression (MDD)	1.46	1	0	0.0	0.00	1.0e+00	NEK4
Lung FEV1/FVC ratio	1.45	3	1	2.2	0.00	1.0e+00	ADD3 NEK4 YJEFN3
Hearing difficulty/problems with background noise	1.41	1	0	0.0	0.00	1.0e+00	SNAP91
Breastfed as a baby	1.41	1	0	0.0	0.00	1.0e+00	DFNA5
Diastolic blood pressure, automated reading	1.40	2	0	0.0	0.00	1.0e+00	CACNA2D4 LMAN2L
Blood Platelet Count	1.38	7	3	6.7	-0.60	1.6e-01	ADD3 DFNA5 LMAN2L LOC147727 NEK4 SNAP91 YJEFN3
Systolic blood pressure, automated reading	1.36	1	0	0.0	0.00	1.0e+00	DFNA5
Number of incorrect matches in round	1.32	1	0	0.0	0.00	1.0e+00	NEK4
Forced vital capacity (FVC), Best measure	1.30	2	0	0.0	0.00	1.0e+00	LOC147727 YJEFN3
Trunk predicted mass	1.29	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Neuroticism (Nagel 2018)	1.28	1	0	0.0	0.00	1.0e+00	NEK4
Trunk fat-free mass	1.27	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Arm predicted mass (right)	1.23	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Fed-up feelings	1.21	1	0	0.0	0.00	1.0e+00	SNAP91
Arm fat-free mass (right)	1.20	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Whole body fat-free mass	1.20	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Whole body water mass	1.20	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Leg fat mass (left)	1.19	1	0	0.0	0.00	1.0e+00	YJEFN3
Fluid intelligence score	1.18	1	0	0.0	0.00	1.0e+00	NEK4
Verbal and Numeric Reasoning (VNR)	1.16	1	0	0.0	0.00	1.0e+00	NEK4
Leg fat mass (right)	1.16	1	0	0.0	0.00	1.0e+00	YJEFN3
Hypertension (Self-reported)	1.16	1	0	0.0	0.00	1.0e+00	DFNA5
Qualifications: None of the above	1.15	1	0	0.0	0.00	1.0e+00	DFNA5
Depression (Nagel 2018)	1.14	1	0	0.0	0.00	1.0e+00	NEK4
Systolic Blood Pressure	1.14	2	1	2.2	0.00	1.0e+00	DFNA5 YJEFN3
Leg predicted mass (right)	1.14	3	1	2.2	0.00	1.0e+00	LOC147727 NEK4 TOP3B
Arm fat-free mass (left)	1.14	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Arm predicted mass (left)	1.14	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Leg fat-free mass (right)	1.12	3	1	2.2	0.00	1.0e+00	LOC147727 NEK4 TOP3B
Waist circumference	1.11	2	0	0.0	0.00	1.0e+00	SNAP91 YJEFN3
Basal metabolic rate	1.10	2	1	2.2	0.00	1.0e+00	LOC147727 NEK4
Forced vital capacity (FVC)	1.06	2	0	0.0	0.00	1.0e+00	LOC147727 YJEFN3
Leg fat-free mass (left)	1.04	2	0	0.0	0.00	1.0e+00	LOC147727 NEK4
Leg predicted mass (left)	1.04	2	0	0.0	0.00	1.0e+00	LOC147727 NEK4
Intelligence (Savage-Jansen 2018)	1.02	1	0	0.0	0.00	1.0e+00	NEK4
Townsend deprivation index at recruitment	0.97	1	0	0.0	0.00	1.0e+00	YJEFN3
Blood Red Count	0.94	3	3	6.7	0.00	1.0e+00	NEK4 TOP3B YJEFN3
Forced expiratory volume in 1-second (FEV1), Best measure	0.93	1	0	0.0	0.00	1.0e+00	LOC147727
Weight	0.90	2	0	0.0	0.00	1.0e+00	LOC147727 NEK4
Taking other prescription medications	0.82	1	0	0.0	0.00	1.0e+00	ADD3
Hip circumference	0.77	1	0	0.0	0.00	1.0e+00	NEK4
Hand grip strength (left)	0.76	1	0	0.0	0.00	1.0e+00	SNAP91
Body fat percentage	0.76	1	0	0.0	0.00	1.0e+00	DFNA5
Forced expiratory volume in 1-second (FEV1)	0.75	1	0	0.0	0.00	1.0e+00	LOC147727
Peak expiratory flow (PEF)	0.73	1	0	0.0	0.00	1.0e+00	LOC147727
Hand grip strength (right)	0.62	1	0	0.0	0.00	1.0e+00	SNAP91
Blood White Count	0.54	2	0	0.0	0.00	1.0e+00	ADD3 MCM3APAS
Heel T-Score	0.49	2	0	0.0	0.00	1.0e+00	ADD3 MCM3APAS
Tanning	0.26	1	0	0.0	0.00	1.0e+00	NEK4
Hair Pigment	0.21	2	1	2.2	0.00	1.0e+00	ADD3 LOC147727

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Hippocampus	0	0.000	1.8
GTEx	Colon Transverse	1	0.050	1.8
GTEx	Heart Atrial Appendage	0	0.000	1.8
GTEx	Heart Left Ventricle	1	0.068	1.8
GTEx	Pancreas	0	0.000	1.8
GTEx	Spleen	3	0.219	1.8
GTEx	Adipose Subcutaneous	0	0.000	1.7
GTEx	Adipose Visceral Omentum	1	0.051	1.7
GTEx	Artery Aorta	0	0.000	1.7
GTEx	Brain Cerebellum	0	0.000	1.7
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.7
GTEx	Breast Mammary Tissue	0	0.000	1.7
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.7
GTEx	Cells EBV-transformed lymphocytes	2	0.146	1.7
GTEx	Cells Transformed fibroblasts	0	0.000	1.7
GTEx	Colon Sigmoid	0	0.000	1.7
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.7
GTEx	Esophagus Mucosa	0	0.000	1.7
GTEx	Esophagus Muscularis	1	0.032	1.7
GTEx	Lung	0	0.000	1.7
GTEx	Muscle Skeletal	1	0.036	1.7
GTEx	Nerve Tibial	0	0.000	1.7
GTEx	Ovary	0	0.000	1.7
GTEx	Pituitary	0	0.000	1.7
GTEx	Prostate	0	0.000	1.7
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.7
GTEx	Small Intestine Terminal Ileum	0	0.000	1.7
GTEx	Testis	2	0.065	1.7
GTEx	Thyroid	1	0.026	1.7
GTEx	Vagina	0	0.000	1.7
GTEx	Whole Blood	1	0.052	1.7
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.7
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.064	1.7
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.024	1.7
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.103	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.154	1.7
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.7
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.049	1.7
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.7
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.7
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.7
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.7
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.7
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.061	1.7
GTEx	Adrenal Gland	0	0.000	1.6
GTEx	Artery Coronary	0	0.000	1.6
GTEx	Artery Tibial	1	0.028	1.6
GTEx	Brain Caudate basal ganglia	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.6
GTEx	Brain Cortex	0	0.000	1.6
GTEx	Brain Frontal Cortex BA9	0	0.000	1.6
GTEx	Brain Hypothalamus	0	0.000	1.6
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.6
GTEx	Skin Sun Exposed Lower leg	1	0.029	1.6
GTEx	Stomach	0	0.000	1.6
METSIM	Adipose	0	0.000	1.6
NTR	Blood	0	0.000	1.6
YFS	Blood	1	0.022	1.6
CommonMind	Brain Pre-frontal Cortex	3	0.057	1.6
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.104	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	2	0.052	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.036	1.6
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.080	1.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.023	1.6
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.6
GTEx	Brain Putamen basal ganglia	0	0.000	1.5
GTEx	Liver	0	0.000	1.5
GTEx	Uterus	0	0.000	1.5