Hub : Traits :

Bilateral oophorectomy (both ovaries removed)

4 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	29646947	31048683	2	1	3.4e-09	3.9e-09	0.28	97	ARL14EP

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Ever had hysterectomy (womb removed)	23.5	1	1	2.2	1	ARL14EP
Age at last live birth	15.4	1	0	0.0	1	ARL14EP
Number of operations (self-reported)	15.1	1	0	0.0	1	ARL14EP
Ever used hormone-replacement therapy (HRT)	14.5	1	0	0.0	1	ARL14EP
Age at first live birth	12.6	1	0	0.0	1	ARL14EP
Age when periods started (menarche)	10.4	1	0	0.0	1	ARL14EP
Heel bone mineral density (BMD) T-score, automated (right)	8.2	1	0	0.0	1	ARL14EP
Heel bone mineral density (BMD) T-score, automated (left)	7.2	1	0	0.0	1	ARL14EP
Had menopause	7.1	1	0	0.0	1	ARL14EP
Qualifications: NVQ or HND or HNC or equivalent	6.7	1	0	0.0	1	ARL14EP
Average weekly red wine intake	6.4	1	0	0.0	1	ARL14EP
Ever taken oral contraceptive pill	6.1	1	0	0.0	1	ARL14EP
Frequency of unenthusiasm / disinterest in last 2 weeks	5.7	1	0	0.0	1	ARL14EP
Forced vital capacity (FVC), Best measure	5.7	1	0	0.0	1	ARL14EP
Heel T-Score	5.6	1	1	2.2	1	ARL14EP
Triglycerides	5.4	1	0	0.0	1	ARL14EP
Lung FEV1/FVC ratio	5.3	1	1	2.2	1	ARL14EP
Vascular/heart problems diagnosed by doctor	5.3	1	0	0.0	1	ARL14EP
Hypertension (Self-reported)	5.2	1	0	0.0	1	ARL14EP
Depression (Nagel 2018)	5.1	1	0	0.0	1	ARL14EP
Chest pain or discomfort	5.1	1	0	0.0	1	ARL14EP
Forced vital capacity (FVC)	4.8	1	0	0.0	1	ARL14EP
Medication: Simvastatin	4.8	1	0	0.0	1	ARL14EP
High blood pressure	4.6	1	0	0.0	1	ARL14EP
Age at First Birth	4.4	1	0	0.0	1	ARL14EP
Medication for cholesterol	4.4	1	0	0.0	1	ARL14EP
Pulse rate	4.1	1	0	0.0	1	ARL14EP
Type 2 Diabetes (T2D) (2018)	3.6	1	0	0.0	1	ARL14EP
Peak expiratory flow (PEF)	3.6	1	0	0.0	1	ARL14EP
Cardiovascular Disease	3.3	1	0	0.0	1	ARL14EP
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	1	0	0.0	1	ARL14EP
Height	3.0	1	1	2.2	1	ARL14EP
Sitting height	2.6	1	0	0.0	1	ARL14EP
Forced expiratory volume in 1-second (FEV1)	2.5	1	0	0.0	1	ARL14EP
Standing height	2.5	1	0	0.0	1	ARL14EP
Lung FVC	2.1	1	0	0.0	1	ARL14EP
Waist Hip Ratio (WHR)	1.9	1	0	0.0	1	ARL14EP
Systolic Blood Pressure	1.7	1	0	0.0	1	ARL14EP
Leg fat-free mass (right)	1.3	1	0	0.0	1	ARL14EP
Blood Red Count	1.2	1	0	0.0	1	ARL14EP
Leg predicted mass (left)	1.2	1	0	0.0	1	ARL14EP
Leg predicted mass (right)	1.2	1	0	0.0	1	ARL14EP

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Testis	1	0.032	1.2
GTEx	Thyroid	1	0.025	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Artery Coronary	0	0.000	1.1
GTEx	Artery Tibial	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Breast Mammary Tissue	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.1
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.1
GTEx	Heart Atrial Appendage	0	0.000	1.1
GTEx	Liver	0	0.000	1.1
GTEx	Muscle Skeletal	0	0.000	1.1
GTEx	Nerve Tibial	0	0.000	1.1
GTEx	Stomach	0	0.000	1.1
GTEx	Uterus	0	0.000	1.1
GTEx	Vagina	0	0.000	1.1
GTEx	Whole Blood	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1