Hub : Traits :

Depression (Nagel 2018)

34 significantly associated models · 15 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	135273949	137261517	3	1	3.1e-09	1.0e-08	0.11700	92	PCCB
2	5	9999146	11452037	1	1	2.6e-07	9.2e-06	0.05400	81	DAP
3	7	11553163	12967449	1	1	1.2e-07	5.4e-08	1.00000	100	TMEM106B
4	9	95518076	96913764	1	2	3.1e-08	4.7e-08	0.19600	94	FAM120AOS
5	10	64195778	65911294	2	2	3.3e-09	8.4e-07	0.86400	100	JMJD1C-AS1 NRBF2
6	13	66643767	68053176	1	1	1.8e-08	2.0e-07	0.00168	64	PCDH9
7	18	34124783	35844220	1	1	2.3e-07	9.5e-09	0.00014	56	CELF4
8	21	43482926	43983429	1	1	1.7e-07	1.3e-05	0.20500	92	TFF3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Frequency of depressed mood in last 2 weeks	15.89	8	4	8.9	0.99	1.5e-07	CELF4 DAP FAM120AOS JMJD1C-AS1 NRBF2 PCCB PCDH9 TMEM106B
Frequency of unenthusiasm / disinterest in last 2 weeks	15.10	9	2	4.4	0.99	5.4e-09	CELF4 DAP FAM120AOS JMJD1C-AS1 NRBF2 PCCB PCDH9 TFF3 TMEM106B
Loneliness, isolation	12.31	6	1	2.2	0.99	4.7e-05	FAM120AOS JMJD1C-AS1 PCCB PCDH9 TFF3 TMEM106B
Neuroticism score	10.54	6	5	11.1	0.99	2.3e-05	CELF4 FAM120AOS PCCB PCDH9 TFF3 TMEM106B
Depressed Affect (Nagel 2018)	10.41	8	2	4.4	0.99	8.8e-07	CELF4 FAM120AOS JMJD1C-AS1 NRBF2 PCCB PCDH9 TFF3 TMEM106B
Frequency of tenseness / restlessness in last 2 weeks	9.92	7	1	2.2	0.99	1.9e-05	CELF4 FAM120AOS JMJD1C-AS1 NRBF2 PCCB PCDH9 TMEM106B
Neuroticism (Nagel 2018)	9.52	5	5	11.1	1.00	2.1e-05	CELF4 FAM120AOS PCCB PCDH9 TMEM106B
Neuroticism	8.65	6	4	8.9	0.99	1.9e-05	CELF4 FAM120AOS PCCB PCDH9 TFF3 TMEM106B
Frequency of tiredness / lethargy in last 2 weeks	7.92	6	0	0.0	1.00	4.6e-06	FAM120AOS JMJD1C-AS1 NRBF2 PCCB PCDH9 TMEM106B
Fed-up feelings	7.44	5	1	2.2	0.99	2.7e-04	CELF4 FAM120AOS NRBF2 PCCB PCDH9
Miserableness	7.44	5	1	2.2	0.98	2.3e-03	FAM120AOS NRBF2 PCCB PCDH9 TMEM106B
Mood swings	7.18	4	1	2.2	0.97	4.9e-03	CELF4 FAM120AOS JMJD1C-AS1 TMEM106B
Worry (Nagel 2018)	7.01	5	1	2.2	0.99	1.3e-03	CELF4 FAM120AOS PCCB PCDH9 TMEM106B
Tense / 'highly strung'	6.46	4	2	4.4	0.98	2.6e-03	CELF4 FAM120AOS PCCB TMEM106B
Blood Platelet Count	5.71	4	3	6.7	-0.77	2.3e-01	FAM120AOS JMJD1C-AS1 NRBF2 PCCB
Qualifications: None of the above	5.55	3	2	4.4	0.99	6.9e-03	FAM120AOS JMJD1C-AS1 NRBF2
Seen doctor (GP) for nerves, anxiety, tension or depression	5.38	2	1	2.2	0.00	1.0e+00	PCDH9 TMEM106B
Major Depression (MDD)	5.29	2	0	0.0	0.00	1.0e+00	FAM120AOS TMEM106B
Overall health rating	5.12	4	0	0.0	0.98	2.5e-03	CELF4 FAM120AOS NRBF2 PCDH9
Guilty feelings	5.01	3	0	0.0	0.00	1.0e+00	FAM120AOS PCCB PCDH9
Stomach or abdominal pain in last month	4.43	3	0	0.0	0.00	1.0e+00	FAM120AOS PCCB PCDH9
Financial difficulties in last 2 years	4.40	4	0	0.0	0.99	8.7e-03	FAM120AOS JMJD1C-AS1 NRBF2 TMEM106B
Neuroticism (2016)	4.37	2	0	0.0	0.00	1.0e+00	PCCB PCDH9
Irritability	4.34	1	1	2.2	0.00	1.0e+00	TMEM106B
Worrier / anxious feelings	4.30	4	1	2.2	0.99	9.9e-03	FAM120AOS PCCB PCDH9 TMEM106B
Pack years adult smoking proportion	4.27	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Triglycerides	4.07	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Nervous feelings	4.06	3	1	2.2	0.00	1.0e+00	CELF4 PCCB PCDH9
Qualifications: A levels/AS levels or equivalent	4.05	3	1	2.2	-0.99	1.5e-02	FAM120AOS JMJD1C-AS1 NRBF2
Medication for pain relief, constipation, heartburn	3.90	3	0	0.0	0.00	1.0e+00	FAM120AOS JMJD1C-AS1 PCDH9
Qualifications: College or University degree	3.83	4	2	4.4	-0.99	8.7e-04	CELF4 FAM120AOS JMJD1C-AS1 NRBF2
Pain experienced in last month	3.81	1	0	0.0	0.00	1.0e+00	FAM120AOS
Unable to work because of sickness or disability	3.78	1	0	0.0	0.00	1.0e+00	FAM120AOS
Exposure to tobacco smoke outside home	3.75	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Sensitivity / hurt feelings	3.71	2	0	0.0	0.00	1.0e+00	CELF4 PCCB
Comparative body size at age 10	3.61	1	1	2.2	0.00	1.0e+00	FAM120AOS
Pack years of smoking	3.61	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Worry too long after embarrassment	3.58	3	0	0.0	0.00	1.0e+00	CELF4 PCCB PCDH9
Verbal and Numeric Reasoning (VNR)	3.57	3	1	2.2	-0.97	2.6e-02	FAM120AOS JMJD1C-AS1 NRBF2
Qualifications: nursing, teaching	3.49	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Pain type(s) experienced in last month: Hip pain	3.49	1	0	0.0	0.00	1.0e+00	FAM120AOS
Depression (self-reported)	3.27	1	0	0.0	0.00	1.0e+00	TMEM106B
Age at first live birth	3.23	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Blood White Count	3.21	3	2	4.4	0.00	1.0e+00	JMJD1C-AS1 NRBF2 PCCB
Number of operations (self-reported)	3.21	1	0	0.0	0.00	1.0e+00	FAM120AOS
Suffer from 'nerves'	3.19	3	0	0.0	0.00	1.0e+00	CELF4 PCDH9 TMEM106B
Ever highly irritable/argumentative for 2 days	3.18	1	0	0.0	0.00	1.0e+00	FAM120AOS
Intelligence (Savage-Jansen 2018)	3.14	4	1	2.2	-1.00	2.5e-03	FAM120AOS JMJD1C-AS1 NRBF2 PCCB
Average weekly red wine intake	3.11	1	1	2.2	0.00	1.0e+00	NRBF2
Medication: Paracetamol	3.08	1	0	0.0	0.00	1.0e+00	FAM120AOS
Long-standing illness, disability or infirmity	3.08	2	0	0.0	0.00	1.0e+00	FAM120AOS TMEM106B
Risk taking	3.04	3	0	0.0	0.00	1.0e+00	FAM120AOS PCCB TMEM106B
Seen a psychiatrist for nerves, anxiety, tension or depression	2.99	1	0	0.0	0.00	1.0e+00	TMEM106B
Fluid intelligence score	2.98	3	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2 PCCB
Schizophrenia (2018)	2.90	2	0	0.0	0.00	1.0e+00	FAM120AOS PCCB
Headache pain in last month	2.89	2	0	0.0	0.00	1.0e+00	FAM120AOS PCCB
Noisy workplace	2.86	1	0	0.0	0.00	1.0e+00	FAM120AOS
Ever depressed for a whole week	2.84	1	0	0.0	0.00	1.0e+00	TMEM106B
Hearing difficulty/problems: Yes	2.80	2	0	0.0	0.00	1.0e+00	FAM120AOS PCCB
Falls in the last year	2.80	1	0	0.0	0.00	1.0e+00	FAM120AOS
Impedance of arm (left)	2.74	4	2	4.4	-0.97	2.8e-02	FAM120AOS JMJD1C-AS1 NRBF2 TMEM106B
Health satisfaction	2.67	1	0	0.0	0.00	1.0e+00	PCDH9
Schizophrenia vs Biploar Disorder	2.66	1	0	0.0	0.00	1.0e+00	TFF3
Medication: Co-codamol	2.66	1	0	0.0	0.00	1.0e+00	FAM120AOS
Number of self-reported non-cancer illnesses	2.66	1	0	0.0	0.00	1.0e+00	TMEM106B
Impedance of arm (right)	2.63	4	2	4.4	-0.99	1.4e-02	FAM120AOS JMJD1C-AS1 NRBF2 TMEM106B
High blood pressure (siblings)	2.62	2	0	0.0	0.00	1.0e+00	NRBF2 TMEM106B
Pain all over the body in last month	2.60	1	0	0.0	0.00	1.0e+00	TMEM106B
Medication: Paracetamol	2.56	1	0	0.0	0.00	1.0e+00	PCDH9
HDL Cholesterol	2.42	1	0	0.0	0.00	1.0e+00	NRBF2
Townsend deprivation index at recruitment	2.41	1	0	0.0	0.00	1.0e+00	FAM120AOS
Qualifications: O levels/GCSEs or equivalent	2.32	2	0	0.0	0.00	1.0e+00	FAM120AOS NRBF2
Taking other prescription medications	2.30	1	0	0.0	0.00	1.0e+00	TMEM106B
Loud music exposure frequency	2.29	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Schizophrenia (2014)	2.28	2	0	0.0	0.00	1.0e+00	FAM120AOS PCCB
Lung FEV1/FVC ratio	2.27	3	1	2.2	0.00	1.0e+00	FAM120AOS JMJD1C-AS1 NRBF2
Current tobacco smoking	2.25	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Smoking status: Current	2.23	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Medication: Aspirin	2.06	1	0	0.0	0.00	1.0e+00	TMEM106B
Average weekly beer plus cider intake	2.04	1	0	0.0	0.00	1.0e+00	NRBF2
Reaction Time	2.02	1	0	0.0	0.00	1.0e+00	PCCB
Medication: Ibuprofen (e.g. Nurofen)	1.96	1	0	0.0	0.00	1.0e+00	FAM120AOS
Impedance of whole body	1.95	3	2	4.4	0.00	1.0e+00	JMJD1C-AS1 NRBF2 TMEM106B
Qualifications: CSEs or equivalent	1.91	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Average weekly champagne plus white wine intake	1.88	1	0	0.0	0.00	1.0e+00	PCDH9
Had other major operations	1.84	1	0	0.0	0.00	1.0e+00	FAM120AOS
Mouth/teeth dental problems: Dentures	1.83	1	0	0.0	0.00	1.0e+00	PCCB
Wheeze or whistling in the chest in last year	1.83	1	0	0.0	0.00	1.0e+00	FAM120AOS
Mean time to correctly identify matches	1.83	2	0	0.0	0.00	1.0e+00	PCCB PCDH9
Angina (self-reported)	1.81	1	0	0.0	0.00	1.0e+00	TMEM106B
Medication: Aspirin	1.74	1	0	0.0	0.00	1.0e+00	TMEM106B
Medication: Blood pressure	1.66	1	0	0.0	0.00	1.0e+00	PCCB
Rheumatoid Arthritis	1.64	1	0	0.0	0.00	1.0e+00	PCCB
Respiratory disease	1.61	1	0	0.0	0.00	1.0e+00	NRBF2
Body mass index (BMI)	1.58	3	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2 TMEM106B
Waist circumference	1.58	2	0	0.0	0.00	1.0e+00	NRBF2 PCCB
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.57	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Smoking Status	1.55	1	0	0.0	0.00	1.0e+00	NRBF2
Chronotype (morning person)	1.53	2	0	0.0	0.00	1.0e+00	CELF4 FAM120AOS
Bipolar Disorder or Schizophrenia	1.52	1	0	0.0	0.00	1.0e+00	FAM120AOS
Waist Hip Ratio (WHR)	1.51	3	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2 PCCB
Forced expiratory volume in 1-second (FEV1), Best measure	1.40	2	0	0.0	0.00	1.0e+00	FAM120AOS NRBF2
Leg fat percentage (right)	1.38	3	0	0.0	0.00	1.0e+00	CELF4 FAM120AOS NRBF2
BMI	1.37	4	0	0.0	0.50	5.0e-01	FAM120AOS JMJD1C-AS1 NRBF2 TMEM106B
Cardiovascular Disease	1.37	2	0	0.0	0.00	1.0e+00	PCCB TMEM106B
Impedance of leg (left)	1.37	3	0	0.0	0.00	1.0e+00	FAM120AOS JMJD1C-AS1 NRBF2
Supplements: Zinc	1.36	1	0	0.0	0.00	1.0e+00	NRBF2
Age when periods started (menarche)	1.35	1	0	0.0	0.00	1.0e+00	FAM120AOS
Impedance of leg (right)	1.33	3	0	0.0	0.00	1.0e+00	FAM120AOS JMJD1C-AS1 NRBF2
Leg fat percentage (left)	1.32	3	0	0.0	0.00	1.0e+00	CELF4 FAM120AOS NRBF2
Lung FVC	1.28	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Eye problems/disorders: Cataract	1.28	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Vascular/heart problems diagnosed by doctor	1.27	2	0	0.0	0.00	1.0e+00	PCCB TMEM106B
Blood Red Count	1.17	3	2	4.4	0.00	1.0e+00	DAP JMJD1C-AS1 NRBF2
High blood pressure	1.16	1	0	0.0	0.00	1.0e+00	PCCB
Hypertension (Self-reported)	1.15	1	0	0.0	0.00	1.0e+00	PCCB
Breast Cancer	1.10	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Alcohol intake versus 10 years previously	1.07	1	0	0.0	0.00	1.0e+00	TMEM106B
Leg fat mass (right)	1.06	1	0	0.0	0.00	1.0e+00	NRBF2
Comparative height size at age 10	1.05	2	0	0.0	0.00	1.0e+00	PCCB TMEM106B
Heel T-Score	1.04	1	1	2.2	0.00	1.0e+00	FAM120AOS
Arm fat-free mass (left)	0.85	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Arm predicted mass (left)	0.85	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Heel bone mineral density (BMD) T-score, automated (left)	0.80	1	0	0.0	0.00	1.0e+00	FAM120AOS
Diastolic blood pressure, automated reading	0.80	1	0	0.0	0.00	1.0e+00	NRBF2
Heel bone mineral density (BMD) T-score, automated (right)	0.78	1	0	0.0	0.00	1.0e+00	FAM120AOS
Arm fat-free mass (right)	0.75	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 NRBF2
Systolic Blood Pressure	0.73	1	0	0.0	0.00	1.0e+00	PCCB
Standing height	0.72	2	0	0.0	0.00	1.0e+00	NRBF2 TMEM106B
Arm predicted mass (right)	0.70	1	0	0.0	0.00	1.0e+00	NRBF2
Height	0.69	6	2	4.4	-0.62	1.9e-01	DAP FAM120AOS JMJD1C-AS1 NRBF2 PCCB TMEM106B
Body fat percentage	0.69	1	0	0.0	0.00	1.0e+00	CELF4
Hair Pigment	0.10	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	1	0.085	1.7
GTEx	Breast Mammary Tissue	0	0.000	1.7
GTEx	Liver	0	0.000	1.7
GTEx	Small Intestine Terminal Ileum	0	0.000	1.7
GTEx	Uterus	0	0.000	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.147	1.7
GTEx	Adipose Visceral Omentum	0	0.000	1.6
GTEx	Brain Cortex	0	0.000	1.6
GTEx	Brain Hippocampus	0	0.000	1.6
GTEx	Brain Hypothalamus	0	0.000	1.6
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.6
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.6
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.6
GTEx	Cells Transformed fibroblasts	0	0.000	1.6
GTEx	Colon Sigmoid	0	0.000	1.6
GTEx	Colon Transverse	0	0.000	1.6
GTEx	Esophagus Muscularis	0	0.000	1.6
GTEx	Heart Atrial Appendage	1	0.063	1.6
GTEx	Heart Left Ventricle	0	0.000	1.6
GTEx	Lung	1	0.035	1.6
GTEx	Ovary	0	0.000	1.6
GTEx	Pituitary	0	0.000	1.6
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.6
GTEx	Spleen	0	0.000	1.6
GTEx	Stomach	0	0.000	1.6
GTEx	Whole Blood	0	0.000	1.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	2	0.189	1.6
GTEx	Adipose Subcutaneous	0	0.000	1.5
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Artery Tibial	0	0.000	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.5
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.5
GTEx	Brain Cerebellum	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.5
GTEx	Esophagus Mucosa	1	0.030	1.5
GTEx	Muscle Skeletal	0	0.000	1.5
GTEx	Nerve Tibial	0	0.000	1.5
GTEx	Pancreas	1	0.061	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.5
GTEx	Testis	2	0.064	1.5
GTEx	Thyroid	1	0.025	1.5
GTEx	Vagina	0	0.000	1.5
NTR	Blood	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.5
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.049	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.074	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.020	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
METSIM	Adipose	1	0.022	1.4
YFS	Blood	4	0.087	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.060	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4