Hub : Traits :

Age at First Birth

193 significantly associated models · 31 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 153220716 154640423 7 1 7.4e-10 2.6e-09 1.000 100 SLC39A1
2 2 99468341 101456989 1 1 5.3e-09 1.0e-08 0.260 96 AFF3
3 3 48702606 51009435 18 1 3.9e-17 3.8e-15 0.069 95 RNF123
4 5 44048891 45516364 2 1 3.7e-10 4.8e-10 0.083 92 RP11-53O19.3
5 5 133164490 134612693 1 1 1.4e-07 1.6e-07 0.017 79 PHF15
6 16 89052565 90172696 1 1 5.5e-10 6.8e-05 0.286 93 RP11-368I7.4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 4.02 1 1 2.2 0.00 1.0000 RNF123
Intelligence (Savage-Jansen 2018) 11.02 3 3 6.7 0.00 1.0000 AFF3 RNF123 SLC39A1
Neuroticism (Nagel 2018) 2.61 1 0 0.0 0.00 1.0000 RP11-53O19.3
Crohns Disease (2017) 5.77 1 1 2.2 0.00 1.0000 RNF123
Irritable Bowel Disease (IBD) 6.05 1 1 2.2 0.00 1.0000 RNF123
Ulcerative Colitis (UC) 4.05 1 1 2.2 0.00 1.0000 RNF123
Major Depression (MDD) 4.41 1 0 0.0 0.00 1.0000 SLC39A1
Reaction Time 2.02 1 0 0.0 0.00 1.0000 RNF123
Verbal and Numeric Reasoning (VNR) 9.23 3 2 4.4 0.00 1.0000 AFF3 RNF123 SLC39A1
Prostate Cancer 5.74 1 1 2.2 0.00 1.0000 SLC39A1
Coronary Artery Disease (CAD) 2.60 1 0 0.0 0.00 1.0000 RNF123
Crohns Disease (2012) 5.49 1 1 2.2 0.00 1.0000 RNF123
Rheumatoid Arthritis 3.99 1 0 0.0 0.00 1.0000 AFF3
Ulcerative Colitis 4.60 1 1 2.2 0.00 1.0000 RNF123
Blood Eosinophil Count 0.94 2 0 0.0 0.00 1.0000 PHF15 RNF123
Blood Platelet Count 1.43 3 2 4.4 0.00 1.0000 PHF15 RP11-368I7.4 SLC39A1
Blood Red Count 3.20 3 3 6.7 0.00 1.0000 AFF3 RNF123 RP11-368I7.4
Blood White Count 1.97 2 2 4.4 0.00 1.0000 RNF123 RP11-368I7.4
Heel T-Score 2.27 2 1 2.2 0.00 1.0000 AFF3 RNF123
BMI 7.77 3 3 6.7 0.00 1.0000 AFF3 PHF15 RNF123
Height 0.77 2 1 2.2 0.00 1.0000 RNF123 RP11-53O19.3
Systolic Blood Pressure 1.81 1 1 2.2 0.00 1.0000 RNF123
Smoking Status 2.63 1 0 0.0 0.00 1.0000 RP11-53O19.3
Cardiovascular Disease 1.88 1 0 0.0 0.00 1.0000 RNF123
Hypothyroidism (self reported) 2.46 1 0 0.0 0.00 1.0000 AFF3
Type 2 Diabetes (T2D) (2018) 4.09 1 1 2.2 0.00 1.0000 RNF123
Neuroticism 2.66 1 0 0.0 0.00 1.0000 RNF123
Hair Pigment 161.13 1 1 2.2 0.00 1.0000 RP11-368I7.4
Tanning 171.53 1 1 2.2 0.00 1.0000 RP11-368I7.4
Hand grip strength (left) 2.17 1 0 0.0 0.00 1.0000 RP11-53O19.3
Number of treatments/medications taken 3.57 1 1 2.2 0.00 1.0000 RNF123
Relative age of first facial hair 5.28 1 1 2.2 0.00 1.0000 RP11-368I7.4
Systolic blood pressure, automated reading 1.86 1 0 0.0 0.00 1.0000 RNF123
Medication: Co-codamol 4.84 1 0 0.0 0.00 1.0000 RNF123
Medication: Metformin 2.23 1 0 0.0 0.00 1.0000 RNF123
Impedance of leg (right) 2.46 2 2 4.4 0.00 1.0000 PHF15 RNF123
Leg fat-free mass (left) 2.37 1 1 2.2 0.00 1.0000 RNF123
Trunk fat percentage 5.69 2 2 4.4 0.00 1.0000 RNF123 RP11-368I7.4
Hand grip strength (right) 1.83 1 0 0.0 0.00 1.0000 RP11-53O19.3
Maternal smoking around birth 5.42 2 0 0.0 0.00 1.0000 RNF123 RP11-53O19.3
Fed-up feelings 5.95 1 1 2.2 0.00 1.0000 RNF123
Relative age voice broke 4.30 1 0 0.0 0.00 1.0000 PHF15
Taking other prescription medications 4.34 1 1 2.2 0.00 1.0000 RNF123
Age when periods started (menarche) 6.57 1 1 2.2 0.00 1.0000 PHF15
Bilateral oophorectomy (both ovaries removed) 3.92 1 0 0.0 0.00 1.0000 PHF15
Heel bone mineral density (BMD) T-score, automated (left) 3.53 1 1 2.2 0.00 1.0000 RNF123
Qualifications: CSEs or equivalent 4.37 1 0 0.0 0.00 1.0000 RNF123
Body mass index (BMI) 9.82 3 3 6.7 0.00 1.0000 AFF3 PHF15 RNF123
Impedance of leg (left) 2.40 2 2 4.4 0.00 1.0000 PHF15 RNF123
Leg predicted mass (left) 2.34 1 1 2.2 0.00 1.0000 RNF123
Trunk fat mass 5.55 2 1 2.2 0.00 1.0000 RNF123 RP11-368I7.4
Waist circumference 5.90 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Alcohol usually taken with meals 3.86 1 0 0.0 0.00 1.0000 AFF3
Nervous feelings 1.81 1 0 0.0 0.00 1.0000 SLC39A1
Forced vital capacity (FVC) 1.90 2 0 0.0 0.00 1.0000 RNF123 RP11-53O19.3
Heel bone mineral density (BMD) T-score, automated (right) 3.08 1 1 2.2 0.00 1.0000 RNF123
Qualifications: None of the above 8.46 4 1 2.2 -0.99 0.0050 AFF3 RNF123 RP11-368I7.4 RP11-53O19.3
Heart attack 4.12 1 0 0.0 0.00 1.0000 RNF123
Allergy 2.16 1 0 0.0 0.00 1.0000 SLC39A1
Diabetes (self-reported) 4.31 1 1 2.2 0.00 1.0000 RNF123
Fluid intelligence score 9.10 3 2 4.4 0.00 1.0000 AFF3 RNF123 SLC39A1
Neuroticism score 2.51 1 0 0.0 0.00 1.0000 RNF123
Weight 5.03 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Impedance of arm (right) 5.72 3 2 4.4 0.00 1.0000 AFF3 PHF15 RNF123
Arm fat percentage (right) 6.80 4 1 2.2 -1.00 0.0018 AFF3 PHF15 RNF123 RP11-368I7.4
Trunk fat-free mass 1.74 2 1 2.2 0.00 1.0000 RNF123 RP11-368I7.4
Hip circumference 3.99 2 1 2.2 0.00 1.0000 PHF15 RNF123
Alcohol intake versus 10 years previously 5.80 1 1 2.2 0.00 1.0000 RNF123
Father's age at death 3.10 1 0 0.0 0.00 1.0000 RNF123
Number of live births 5.59 2 0 0.0 0.00 1.0000 RNF123 RP11-368I7.4
Forced expiratory volume in 1-second (FEV1) 1.43 1 0 0.0 0.00 1.0000 RNF123
Noisy workplace 3.57 1 0 0.0 0.00 1.0000 SLC39A1
Qualifications: A levels/AS levels or equivalent 10.46 1 1 2.2 0.00 1.0000 RNF123
Mouth/teeth dental problems: Dentures 4.22 1 0 0.0 0.00 1.0000 RNF123
Asthma 3.00 1 0 0.0 0.00 1.0000 AFF3
Medication: Cholesterol lowering 2.52 1 0 0.0 0.00 1.0000 RNF123
Forced expiratory volume in 1-second (FEV1), Best measure 1.72 1 0 0.0 0.00 1.0000 RNF123
Impedance of arm (left) 6.10 4 2 4.4 0.75 0.2492 AFF3 PHF15 RNF123 RP11-368I7.4
Arm fat mass (right) 7.33 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Trunk predicted mass 1.72 2 1 2.2 0.00 1.0000 RNF123 RP11-368I7.4
Standing height 1.33 3 0 0.0 0.00 1.0000 PHF15 RP11-368I7.4 RP11-53O19.3
Exposure to tobacco smoke at home 4.08 1 0 0.0 0.00 1.0000 RNF123
Hair/balding pattern: Pattern 4 2.09 1 0 0.0 0.00 1.0000 SLC39A1
Ever highly irritable/argumentative for 2 days 2.69 1 0 0.0 0.00 1.0000 RNF123
Qualifications: O levels/GCSEs or equivalent 2.25 1 0 0.0 0.00 1.0000 RNF123
Medication for cholesterol, blood pressure or diabetes 3.13 1 0 0.0 0.00 1.0000 RNF123
Hypothyroidism/myxoedema (self-reported) 3.15 1 0 0.0 0.00 1.0000 AFF3
Medication: Ventolin 100micrograms inhaler 6.11 2 0 0.0 0.00 1.0000 AFF3 SLC39A1
Chronic bronchitis/emphysema (mother) 3.75 1 0 0.0 0.00 1.0000 RNF123
Forced vital capacity (FVC), Best measure 2.09 2 0 0.0 0.00 1.0000 RNF123 RP11-53O19.3
Body fat percentage 6.87 3 1 2.2 0.00 1.0000 AFF3 RNF123 RP11-368I7.4
Leg fat percentage (right) 8.54 2 1 2.2 0.00 1.0000 AFF3 RNF123
Arm fat-free mass (right) 3.05 1 1 2.2 0.00 1.0000 RNF123
Wheeze or whistling in the chest in last year 6.64 2 1 2.2 0.00 1.0000 AFF3 RNF123
Age at first live birth 12.24 4 1 2.2 0.97 0.0289 RNF123 RP11-368I7.4 RP11-53O19.3 SLC39A1
Qualifications: College or University degree 13.60 4 2 4.4 0.98 0.0166 AFF3 PHF15 RNF123 RP11-368I7.4
Neck or shoulder pain in last month 3.47 1 0 0.0 0.00 1.0000 RP11-368I7.4
Medication: Blood pressure 2.42 1 0 0.0 0.00 1.0000 RNF123
Medication: Seretide 50 evohaler 2.78 1 0 0.0 0.00 1.0000 RNF123
Mean time to correctly identify matches 2.54 1 0 0.0 0.00 1.0000 RNF123
Whole body fat mass 6.85 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Leg fat mass (right) 8.49 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Arm predicted mass (right) 2.95 1 1 2.2 0.00 1.0000 RNF123
Pulse rate, automated reading 3.67 1 1 2.2 0.00 1.0000 RNF123
Alcohol intake frequency. 4.31 1 1 2.2 0.00 1.0000 RNF123
Comparative height size at age 10 2.00 1 1 2.2 0.00 1.0000 RP11-368I7.4
Overall health rating 5.24 1 1 2.2 0.00 1.0000 RNF123
Age at last live birth 9.36 1 1 2.2 0.00 1.0000 RNF123
Leg pain on walking 6.29 1 1 2.2 0.00 1.0000 RNF123
Qualifications: NVQ or HND or HNC or equivalent 3.86 1 0 0.0 0.00 1.0000 RNF123
Whole body fat-free mass 2.05 1 1 2.2 0.00 1.0000 RNF123
Leg fat-free mass (right) 2.05 2 1 2.2 0.00 1.0000 PHF15 RNF123
Arm fat percentage (left) 7.33 4 2 4.4 -1.00 0.0017 AFF3 PHF15 RNF123 RP11-368I7.4
Mood swings 4.23 1 1 2.2 0.00 1.0000 RNF123
Ever had bowel cancer screening 3.25 1 0 0.0 0.00 1.0000 RNF123
Diabetes diagnosed by doctor 3.27 1 0 0.0 0.00 1.0000 RNF123
Qualifications: nursing, teaching 4.84 1 1 2.2 0.00 1.0000 RNF123
Mouth/teeth dental problems: Mouth ulcers 2.40 1 0 0.0 0.00 1.0000 AFF3
Asthma (self-reported) 3.11 1 0 0.0 0.00 1.0000 AFF3
Whole body water mass 2.12 1 1 2.2 0.00 1.0000 RNF123
Leg predicted mass (right) 2.03 2 1 2.2 0.00 1.0000 PHF15 RNF123
Arm fat mass (left) 7.54 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Miserableness 3.30 1 1 2.2 0.00 1.0000 RNF123
Financial situation satisfaction 3.02 1 0 0.0 0.00 1.0000 RNF123
Medication: Lisinopril 2.21 1 0 0.0 0.00 1.0000 RP11-368I7.4
Basal metabolic rate 2.73 1 1 2.2 0.00 1.0000 RNF123
Leg fat percentage (left) 8.94 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Arm fat-free mass (left) 3.51 2 1 2.2 0.00 1.0000 PHF15 RNF123
Average weekly beer plus cider intake 3.29 1 0 0.0 0.00 1.0000 RNF123
Irritability 1.85 1 0 0.0 0.00 1.0000 RP11-53O19.3
Age started oral contraceptive pill 8.63 2 0 0.0 0.00 1.0000 RNF123 RP11-53O19.3
Diastolic blood pressure, automated reading 4.21 1 1 2.2 0.00 1.0000 RNF123
Vascular/heart problems diagnosed by doctor 2.09 1 0 0.0 0.00 1.0000 SLC39A1
Pain experienced in last month 4.77 2 0 0.0 0.00 1.0000 RNF123 SLC39A1
Basal cell carcinoma (self-reported) 8.56 1 1 2.2 0.00 1.0000 RP11-368I7.4
Impedance of whole body 4.56 2 2 4.4 0.00 1.0000 PHF15 RNF123
Leg fat mass (left) 8.85 3 1 2.2 0.00 1.0000 AFF3 PHF15 RNF123
Arm predicted mass (left) 3.51 1 1 2.2 0.00 1.0000 RNF123

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.058 1.5
GTEx Adipose Visceral Omentum 2 0.099 1.5
GTEx Adrenal Gland 1 0.069 1.5
GTEx Artery Aorta 3 0.102 1.5
GTEx Artery Coronary 1 0.085 1.4
GTEx Artery Tibial 7 0.188 1.5
GTEx Brain Caudate basal ganglia 2 0.219 1.6
GTEx Brain Cerebellar Hemisphere 4 0.271 1.6
GTEx Brain Cerebellum 5 0.254 1.5
GTEx Brain Cortex 2 0.194 1.7
GTEx Brain Frontal Cortex BA9 3 0.328 1.7
GTEx Brain Hippocampus 0 0.000 1.6
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.5
GTEx Brain Putamen basal ganglia 1 0.161 1.6
GTEx Breast Mammary Tissue 2 0.102 1.5
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 2 0.124 1.5
GTEx Cells EBV-transformed lymphocytes 1 0.071 1.6
GTEx Cells Transformed fibroblasts 6 0.144 1.5
GTEx Colon Sigmoid 3 0.206 1.6
GTEx Colon Transverse 3 0.147 1.6
GTEx Esophagus Gastroesophageal Junction 4 0.279 1.6
GTEx Esophagus Mucosa 4 0.122 1.5
GTEx Esophagus Muscularis 4 0.125 1.5
GTEx Heart Atrial Appendage 3 0.191 1.5
GTEx Heart Left Ventricle 2 0.131 1.6
GTEx Liver 1 0.141 1.5
GTEx Lung 5 0.176 1.6
GTEx Muscle Skeletal 5 0.174 1.4
GTEx Nerve Tibial 2 0.047 1.5
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 1 0.062 1.6
GTEx Pituitary 1 0.090 1.5
GTEx Prostate 1 0.121 1.5
GTEx Skin Not Sun Exposed Suprapubic 5 0.205 1.6
GTEx Skin Sun Exposed Lower leg 5 0.139 1.5
GTEx Small Intestine Terminal Ileum 1 0.219 1.7
GTEx Spleen 3 0.214 1.7
GTEx Stomach 2 0.138 1.5
GTEx Testis 3 0.096 1.5
GTEx Thyroid 5 0.126 1.5
GTEx Uterus 0 0.000 1.5
GTEx Vagina 1 0.159 1.5
GTEx Whole Blood 2 0.101 1.6
METSIM Adipose 6 0.131 1.4
NTR Blood 3 0.125 1.4
ROSMAP Brain Pre-frontal Cortex 5 0.115 1.5
YFS Blood 3 0.065 1.4
CommonMind Brain Pre-frontal Cortex 3 0.056 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.124 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 5 0.116 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.093 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.050 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 2 0.201 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.112 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.100 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 3 0.149 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 7 0.167 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.093 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 5 0.175 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 4 0.163 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.065 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 3 0.184 1.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 2 0.155 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 5 0.110 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 2 0.387 1.5
The Cancer Genome Atlas Stomach Adenocarcinoma 3 0.182 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.081 1.5
The Cancer Genome Atlas Thyroid Carcinoma 7 0.139 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.5