Hub : Traits :

Age at First Birth

193 significantly associated models · 31 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	153220716	154640423	7	1	7.4e-10	2.6e-09	1.000	100	SLC39A1
2	2	99468341	101456989	1	1	5.3e-09	1.0e-08	0.260	96	AFF3
3	3	48702606	51009435	18	1	3.9e-17	3.8e-15	0.069	95	RNF123
4	5	44048891	45516364	2	1	3.7e-10	4.8e-10	0.083	92	RP11-53O19.3
5	5	133164490	134612693	1	1	1.4e-07	1.6e-07	0.017	79	PHF15
6	16	89052565	90172696	1	1	5.5e-10	6.8e-05	0.286	93	RP11-368I7.4

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Depressed Affect (Nagel 2018)	4.02	1	1	2.2	0.00	1.0000	RNF123
Intelligence (Savage-Jansen 2018)	11.02	3	3	6.7	0.00	1.0000	AFF3 RNF123 SLC39A1
Neuroticism (Nagel 2018)	2.61	1	0	0.0	0.00	1.0000	RP11-53O19.3
Crohns Disease (2017)	5.77	1	1	2.2	0.00	1.0000	RNF123
Irritable Bowel Disease (IBD)	6.05	1	1	2.2	0.00	1.0000	RNF123
Ulcerative Colitis (UC)	4.05	1	1	2.2	0.00	1.0000	RNF123
Major Depression (MDD)	4.41	1	0	0.0	0.00	1.0000	SLC39A1
Reaction Time	2.02	1	0	0.0	0.00	1.0000	RNF123
Verbal and Numeric Reasoning (VNR)	9.23	3	2	4.4	0.00	1.0000	AFF3 RNF123 SLC39A1
Prostate Cancer	5.74	1	1	2.2	0.00	1.0000	SLC39A1
Coronary Artery Disease (CAD)	2.60	1	0	0.0	0.00	1.0000	RNF123
Crohns Disease (2012)	5.49	1	1	2.2	0.00	1.0000	RNF123
Rheumatoid Arthritis	3.99	1	0	0.0	0.00	1.0000	AFF3
Ulcerative Colitis	4.60	1	1	2.2	0.00	1.0000	RNF123
Blood Eosinophil Count	0.94	2	0	0.0	0.00	1.0000	PHF15 RNF123
Blood Platelet Count	1.43	3	2	4.4	0.00	1.0000	PHF15 RP11-368I7.4 SLC39A1
Blood Red Count	3.20	3	3	6.7	0.00	1.0000	AFF3 RNF123 RP11-368I7.4
Blood White Count	1.97	2	2	4.4	0.00	1.0000	RNF123 RP11-368I7.4
Heel T-Score	2.27	2	1	2.2	0.00	1.0000	AFF3 RNF123
BMI	7.77	3	3	6.7	0.00	1.0000	AFF3 PHF15 RNF123
Height	0.77	2	1	2.2	0.00	1.0000	RNF123 RP11-53O19.3
Systolic Blood Pressure	1.81	1	1	2.2	0.00	1.0000	RNF123
Smoking Status	2.63	1	0	0.0	0.00	1.0000	RP11-53O19.3
Cardiovascular Disease	1.88	1	0	0.0	0.00	1.0000	RNF123
Hypothyroidism (self reported)	2.46	1	0	0.0	0.00	1.0000	AFF3
Type 2 Diabetes (T2D) (2018)	4.09	1	1	2.2	0.00	1.0000	RNF123
Neuroticism	2.66	1	0	0.0	0.00	1.0000	RNF123
Hair Pigment	161.13	1	1	2.2	0.00	1.0000	RP11-368I7.4
Tanning	171.53	1	1	2.2	0.00	1.0000	RP11-368I7.4
Hand grip strength (left)	2.17	1	0	0.0	0.00	1.0000	RP11-53O19.3
Number of treatments/medications taken	3.57	1	1	2.2	0.00	1.0000	RNF123
Relative age of first facial hair	5.28	1	1	2.2	0.00	1.0000	RP11-368I7.4
Systolic blood pressure, automated reading	1.86	1	0	0.0	0.00	1.0000	RNF123
Medication: Co-codamol	4.84	1	0	0.0	0.00	1.0000	RNF123
Medication: Metformin	2.23	1	0	0.0	0.00	1.0000	RNF123
Impedance of leg (right)	2.46	2	2	4.4	0.00	1.0000	PHF15 RNF123
Leg fat-free mass (left)	2.37	1	1	2.2	0.00	1.0000	RNF123
Trunk fat percentage	5.69	2	2	4.4	0.00	1.0000	RNF123 RP11-368I7.4
Hand grip strength (right)	1.83	1	0	0.0	0.00	1.0000	RP11-53O19.3
Maternal smoking around birth	5.42	2	0	0.0	0.00	1.0000	RNF123 RP11-53O19.3
Fed-up feelings	5.95	1	1	2.2	0.00	1.0000	RNF123
Relative age voice broke	4.30	1	0	0.0	0.00	1.0000	PHF15
Taking other prescription medications	4.34	1	1	2.2	0.00	1.0000	RNF123
Age when periods started (menarche)	6.57	1	1	2.2	0.00	1.0000	PHF15
Bilateral oophorectomy (both ovaries removed)	3.92	1	0	0.0	0.00	1.0000	PHF15
Heel bone mineral density (BMD) T-score, automated (left)	3.53	1	1	2.2	0.00	1.0000	RNF123
Qualifications: CSEs or equivalent	4.37	1	0	0.0	0.00	1.0000	RNF123
Body mass index (BMI)	9.82	3	3	6.7	0.00	1.0000	AFF3 PHF15 RNF123
Impedance of leg (left)	2.40	2	2	4.4	0.00	1.0000	PHF15 RNF123
Leg predicted mass (left)	2.34	1	1	2.2	0.00	1.0000	RNF123
Trunk fat mass	5.55	2	1	2.2	0.00	1.0000	RNF123 RP11-368I7.4
Waist circumference	5.90	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Alcohol usually taken with meals	3.86	1	0	0.0	0.00	1.0000	AFF3
Nervous feelings	1.81	1	0	0.0	0.00	1.0000	SLC39A1
Forced vital capacity (FVC)	1.90	2	0	0.0	0.00	1.0000	RNF123 RP11-53O19.3
Heel bone mineral density (BMD) T-score, automated (right)	3.08	1	1	2.2	0.00	1.0000	RNF123
Qualifications: None of the above	8.46	4	1	2.2	-0.99	0.0050	AFF3 RNF123 RP11-368I7.4 RP11-53O19.3
Heart attack	4.12	1	0	0.0	0.00	1.0000	RNF123
Allergy	2.16	1	0	0.0	0.00	1.0000	SLC39A1
Diabetes (self-reported)	4.31	1	1	2.2	0.00	1.0000	RNF123
Fluid intelligence score	9.10	3	2	4.4	0.00	1.0000	AFF3 RNF123 SLC39A1
Neuroticism score	2.51	1	0	0.0	0.00	1.0000	RNF123
Weight	5.03	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Impedance of arm (right)	5.72	3	2	4.4	0.00	1.0000	AFF3 PHF15 RNF123
Arm fat percentage (right)	6.80	4	1	2.2	-1.00	0.0018	AFF3 PHF15 RNF123 RP11-368I7.4
Trunk fat-free mass	1.74	2	1	2.2	0.00	1.0000	RNF123 RP11-368I7.4
Hip circumference	3.99	2	1	2.2	0.00	1.0000	PHF15 RNF123
Alcohol intake versus 10 years previously	5.80	1	1	2.2	0.00	1.0000	RNF123
Father's age at death	3.10	1	0	0.0	0.00	1.0000	RNF123
Number of live births	5.59	2	0	0.0	0.00	1.0000	RNF123 RP11-368I7.4
Forced expiratory volume in 1-second (FEV1)	1.43	1	0	0.0	0.00	1.0000	RNF123
Noisy workplace	3.57	1	0	0.0	0.00	1.0000	SLC39A1
Qualifications: A levels/AS levels or equivalent	10.46	1	1	2.2	0.00	1.0000	RNF123
Mouth/teeth dental problems: Dentures	4.22	1	0	0.0	0.00	1.0000	RNF123
Asthma	3.00	1	0	0.0	0.00	1.0000	AFF3
Medication: Cholesterol lowering	2.52	1	0	0.0	0.00	1.0000	RNF123
Forced expiratory volume in 1-second (FEV1), Best measure	1.72	1	0	0.0	0.00	1.0000	RNF123
Impedance of arm (left)	6.10	4	2	4.4	0.75	0.2492	AFF3 PHF15 RNF123 RP11-368I7.4
Arm fat mass (right)	7.33	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Trunk predicted mass	1.72	2	1	2.2	0.00	1.0000	RNF123 RP11-368I7.4
Standing height	1.33	3	0	0.0	0.00	1.0000	PHF15 RP11-368I7.4 RP11-53O19.3
Exposure to tobacco smoke at home	4.08	1	0	0.0	0.00	1.0000	RNF123
Hair/balding pattern: Pattern 4	2.09	1	0	0.0	0.00	1.0000	SLC39A1
Ever highly irritable/argumentative for 2 days	2.69	1	0	0.0	0.00	1.0000	RNF123
Qualifications: O levels/GCSEs or equivalent	2.25	1	0	0.0	0.00	1.0000	RNF123
Medication for cholesterol, blood pressure or diabetes	3.13	1	0	0.0	0.00	1.0000	RNF123
Hypothyroidism/myxoedema (self-reported)	3.15	1	0	0.0	0.00	1.0000	AFF3
Medication: Ventolin 100micrograms inhaler	6.11	2	0	0.0	0.00	1.0000	AFF3 SLC39A1
Chronic bronchitis/emphysema (mother)	3.75	1	0	0.0	0.00	1.0000	RNF123
Forced vital capacity (FVC), Best measure	2.09	2	0	0.0	0.00	1.0000	RNF123 RP11-53O19.3
Body fat percentage	6.87	3	1	2.2	0.00	1.0000	AFF3 RNF123 RP11-368I7.4
Leg fat percentage (right)	8.54	2	1	2.2	0.00	1.0000	AFF3 RNF123
Arm fat-free mass (right)	3.05	1	1	2.2	0.00	1.0000	RNF123
Wheeze or whistling in the chest in last year	6.64	2	1	2.2	0.00	1.0000	AFF3 RNF123
Age at first live birth	12.24	4	1	2.2	0.97	0.0289	RNF123 RP11-368I7.4 RP11-53O19.3 SLC39A1
Qualifications: College or University degree	13.60	4	2	4.4	0.98	0.0166	AFF3 PHF15 RNF123 RP11-368I7.4
Neck or shoulder pain in last month	3.47	1	0	0.0	0.00	1.0000	RP11-368I7.4
Medication: Blood pressure	2.42	1	0	0.0	0.00	1.0000	RNF123
Medication: Seretide 50 evohaler	2.78	1	0	0.0	0.00	1.0000	RNF123
Mean time to correctly identify matches	2.54	1	0	0.0	0.00	1.0000	RNF123
Whole body fat mass	6.85	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Leg fat mass (right)	8.49	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Arm predicted mass (right)	2.95	1	1	2.2	0.00	1.0000	RNF123
Pulse rate, automated reading	3.67	1	1	2.2	0.00	1.0000	RNF123
Alcohol intake frequency.	4.31	1	1	2.2	0.00	1.0000	RNF123
Comparative height size at age 10	2.00	1	1	2.2	0.00	1.0000	RP11-368I7.4
Overall health rating	5.24	1	1	2.2	0.00	1.0000	RNF123
Age at last live birth	9.36	1	1	2.2	0.00	1.0000	RNF123
Leg pain on walking	6.29	1	1	2.2	0.00	1.0000	RNF123
Qualifications: NVQ or HND or HNC or equivalent	3.86	1	0	0.0	0.00	1.0000	RNF123
Whole body fat-free mass	2.05	1	1	2.2	0.00	1.0000	RNF123
Leg fat-free mass (right)	2.05	2	1	2.2	0.00	1.0000	PHF15 RNF123
Arm fat percentage (left)	7.33	4	2	4.4	-1.00	0.0017	AFF3 PHF15 RNF123 RP11-368I7.4
Mood swings	4.23	1	1	2.2	0.00	1.0000	RNF123
Ever had bowel cancer screening	3.25	1	0	0.0	0.00	1.0000	RNF123
Diabetes diagnosed by doctor	3.27	1	0	0.0	0.00	1.0000	RNF123
Qualifications: nursing, teaching	4.84	1	1	2.2	0.00	1.0000	RNF123
Mouth/teeth dental problems: Mouth ulcers	2.40	1	0	0.0	0.00	1.0000	AFF3
Asthma (self-reported)	3.11	1	0	0.0	0.00	1.0000	AFF3
Whole body water mass	2.12	1	1	2.2	0.00	1.0000	RNF123
Leg predicted mass (right)	2.03	2	1	2.2	0.00	1.0000	PHF15 RNF123
Arm fat mass (left)	7.54	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Miserableness	3.30	1	1	2.2	0.00	1.0000	RNF123
Financial situation satisfaction	3.02	1	0	0.0	0.00	1.0000	RNF123
Medication: Lisinopril	2.21	1	0	0.0	0.00	1.0000	RP11-368I7.4
Basal metabolic rate	2.73	1	1	2.2	0.00	1.0000	RNF123
Leg fat percentage (left)	8.94	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Arm fat-free mass (left)	3.51	2	1	2.2	0.00	1.0000	PHF15 RNF123
Average weekly beer plus cider intake	3.29	1	0	0.0	0.00	1.0000	RNF123
Irritability	1.85	1	0	0.0	0.00	1.0000	RP11-53O19.3
Age started oral contraceptive pill	8.63	2	0	0.0	0.00	1.0000	RNF123 RP11-53O19.3
Diastolic blood pressure, automated reading	4.21	1	1	2.2	0.00	1.0000	RNF123
Vascular/heart problems diagnosed by doctor	2.09	1	0	0.0	0.00	1.0000	SLC39A1
Pain experienced in last month	4.77	2	0	0.0	0.00	1.0000	RNF123 SLC39A1
Basal cell carcinoma (self-reported)	8.56	1	1	2.2	0.00	1.0000	RP11-368I7.4
Impedance of whole body	4.56	2	2	4.4	0.00	1.0000	PHF15 RNF123
Leg fat mass (left)	8.85	3	1	2.2	0.00	1.0000	AFF3 PHF15 RNF123
Arm predicted mass (left)	3.51	1	1	2.2	0.00	1.0000	RNF123

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	2	0.058	1.5
GTEx	Adipose Visceral Omentum	2	0.099	1.5
GTEx	Adrenal Gland	1	0.069	1.5
GTEx	Artery Aorta	3	0.102	1.5
GTEx	Artery Coronary	1	0.085	1.4
GTEx	Artery Tibial	7	0.188	1.5
GTEx	Brain Caudate basal ganglia	2	0.219	1.6
GTEx	Brain Cerebellar Hemisphere	4	0.271	1.6
GTEx	Brain Cerebellum	5	0.254	1.5
GTEx	Brain Cortex	2	0.194	1.7
GTEx	Brain Frontal Cortex BA9	3	0.328	1.7
GTEx	Brain Hippocampus	0	0.000	1.6
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.5
GTEx	Brain Putamen basal ganglia	1	0.161	1.6
GTEx	Breast Mammary Tissue	2	0.102	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	2	0.124	1.5
GTEx	Cells EBV-transformed lymphocytes	1	0.071	1.6
GTEx	Cells Transformed fibroblasts	6	0.144	1.5
GTEx	Colon Sigmoid	3	0.206	1.6
GTEx	Colon Transverse	3	0.147	1.6
GTEx	Esophagus Gastroesophageal Junction	4	0.279	1.6
GTEx	Esophagus Mucosa	4	0.122	1.5
GTEx	Esophagus Muscularis	4	0.125	1.5
GTEx	Heart Atrial Appendage	3	0.191	1.5
GTEx	Heart Left Ventricle	2	0.131	1.6
GTEx	Liver	1	0.141	1.5
GTEx	Lung	5	0.176	1.6
GTEx	Muscle Skeletal	5	0.174	1.4
GTEx	Nerve Tibial	2	0.047	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Pancreas	1	0.062	1.6
GTEx	Pituitary	1	0.090	1.5
GTEx	Prostate	1	0.121	1.5
GTEx	Skin Not Sun Exposed Suprapubic	5	0.205	1.6
GTEx	Skin Sun Exposed Lower leg	5	0.139	1.5
GTEx	Small Intestine Terminal Ileum	1	0.219	1.7
GTEx	Spleen	3	0.214	1.7
GTEx	Stomach	2	0.138	1.5
GTEx	Testis	3	0.096	1.5
GTEx	Thyroid	5	0.126	1.5
GTEx	Uterus	0	0.000	1.5
GTEx	Vagina	1	0.159	1.5
GTEx	Whole Blood	2	0.101	1.6
METSIM	Adipose	6	0.131	1.4
NTR	Blood	3	0.125	1.4
ROSMAP	Brain Pre-frontal Cortex	5	0.115	1.5
YFS	Blood	3	0.065	1.4
CommonMind	Brain Pre-frontal Cortex	3	0.056	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.124	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	5	0.116	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.093	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.050	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	2	0.201	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.112	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.100	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	3	0.149	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	7	0.167	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.093	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	5	0.175	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	4	0.163	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.065	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	3	0.184	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	2	0.155	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	5	0.110	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	2	0.387	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	3	0.182	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.081	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	7	0.139	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5