Hub : Traits :

Ever had hysterectomy (womb removed)

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 48072855 49519654 1 1 7.7e-09 5.9e-05 0.0018 39 STON1
2 11 29646947 31048683 1 1 2.7e-07 1.6e-06 1.0000 100 ARL14EP

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 1.26 1 0 0.0 0 1 STON1
Depression (Nagel 2018) 3.28 1 0 0.0 0 1 ARL14EP
Schizophrenia (2018) 1.98 1 0 0.0 0 1 STON1
Alzheimer’s Disease (in father) 3.70 1 0 0.0 0 1 STON1
Age at First Birth 3.56 1 0 0.0 0 1 ARL14EP
Schizophrenia (2014) 2.22 1 0 0.0 0 1 STON1
Triglycerides 4.56 2 0 0.0 0 1 ARL14EP STON1
Blood Platelet Count 1.41 1 1 2.2 0 1 STON1
Blood Red Count 0.63 1 0 0.0 0 1 ARL14EP
Blood White Count 1.50 1 0 0.0 0 1 STON1
Heel T-Score 3.03 1 1 2.2 0 1 ARL14EP
BMI 1.22 1 0 0.0 0 1 STON1
Height 2.08 2 1 2.2 0 1 ARL14EP STON1
Waist Hip Ratio (WHR) 1.58 2 0 0.0 0 1 ARL14EP STON1
Systolic Blood Pressure 1.01 1 0 0.0 0 1 ARL14EP
Cardiovascular Disease 3.09 2 0 0.0 0 1 ARL14EP STON1
Type 2 Diabetes (T2D) (2018) 2.46 1 0 0.0 0 1 ARL14EP
Lung FEV1/FVC ratio 3.79 2 1 2.2 0 1 ARL14EP STON1
Lung FVC 1.28 1 0 0.0 0 1 ARL14EP
Relative age of first facial hair 1.73 1 0 0.0 0 1 STON1
Other serious medical condition/disability diagnosed by doctor 2.16 1 0 0.0 0 1 ARL14EP
Ever used hormone-replacement therapy (HRT) 7.55 1 0 0.0 0 1 ARL14EP
Leg fat-free mass (left) 0.89 1 0 0.0 0 1 ARL14EP
Frequency of unenthusiasm / disinterest in last 2 weeks 3.81 1 0 0.0 0 1 ARL14EP
Age when periods started (menarche) 5.92 1 0 0.0 0 1 ARL14EP
Bilateral oophorectomy (both ovaries removed) 20.33 2 1 2.2 0 1 ARL14EP STON1
Heel bone mineral density (BMD) T-score, automated (left) 4.79 2 0 0.0 0 1 ARL14EP STON1
High blood pressure 2.54 1 0 0.0 0 1 ARL14EP
Stomach or abdominal pain in last month 4.50 1 0 0.0 0 1 STON1
Sitting height 1.35 1 0 0.0 0 1 ARL14EP
High blood pressure (mother) 2.10 1 0 0.0 0 1 ARL14EP
Body mass index (BMI) 0.78 1 0 0.0 0 1 STON1
Leg predicted mass (left) 0.92 1 0 0.0 0 1 ARL14EP
Had menopause 4.61 1 0 0.0 0 1 ARL14EP
Had other major operations 5.43 1 0 0.0 0 1 STON1
Forced vital capacity (FVC) 2.58 1 0 0.0 0 1 ARL14EP
Heel bone mineral density (BMD) T-score, automated (right) 5.12 1 0 0.0 0 1 ARL14EP
Medication: Simvastatin 5.84 2 0 0.0 0 1 ARL14EP STON1
Impedance of arm (right) 0.86 1 0 0.0 0 1 STON1
Trunk fat-free mass 0.58 1 0 0.0 0 1 ARL14EP
Time employed in main current job 3.32 1 0 0.0 0 1 STON1
Alcohol intake versus 10 years previously 1.71 1 0 0.0 0 1 ARL14EP
Worrier / anxious feelings 2.78 1 0 0.0 0 1 STON1
Forced expiratory volume in 1-second (FEV1) 1.24 1 0 0.0 0 1 ARL14EP
Pulse rate 4.53 2 0 0.0 0 1 ARL14EP STON1
Happiness 4.33 1 0 0.0 0 1 STON1
Noisy workplace 2.47 1 0 0.0 0 1 STON1
Forced expiratory volume in 1-second (FEV1), Best measure 1.56 1 0 0.0 0 1 ARL14EP
Pulse wave Arterial Stiffness index 3.42 1 0 0.0 0 1 STON1
Impedance of arm (left) 1.10 1 0 0.0 0 1 STON1
Trunk predicted mass 0.58 1 0 0.0 0 1 ARL14EP
Standing height 1.31 1 0 0.0 0 1 ARL14EP
Peak expiratory flow (PEF) 1.85 1 0 0.0 0 1 ARL14EP
Ever highly irritable/argumentative for 2 days 2.40 1 0 0.0 0 1 ARL14EP
Medication: Paracetamol 1.73 1 0 0.0 0 1 STON1
Headache pain in last month 3.12 1 0 0.0 0 1 ARL14EP
Forced vital capacity (FVC), Best measure 2.98 1 0 0.0 0 1 ARL14EP
Number of children fathered 3.36 1 0 0.0 0 1 STON1
Age at first live birth 7.78 2 0 0.0 0 1 ARL14EP STON1
Pulse wave peak to peak time 4.03 1 0 0.0 0 1 STON1
Medication: Blood pressure 1.67 1 0 0.0 0 1 ARL14EP
Angina (self-reported) 3.49 1 0 0.0 0 1 ARL14EP
Pulse rate, automated reading 2.05 1 0 0.0 0 1 STON1
Chest pain or discomfort 3.05 1 0 0.0 0 1 ARL14EP
Age at last live birth 9.48 2 0 0.0 0 1 ARL14EP STON1
Qualifications: NVQ or HND or HNC or equivalent 3.36 1 0 0.0 0 1 ARL14EP
Hypertension (Self-reported) 2.89 1 0 0.0 0 1 ARL14EP
Whole body fat-free mass 0.74 1 0 0.0 0 1 ARL14EP
Leg fat-free mass (right) 0.97 1 0 0.0 0 1 ARL14EP
Average weekly red wine intake 3.71 1 0 0.0 0 1 ARL14EP
Ever had bowel cancer screening 2.59 1 0 0.0 0 1 ARL14EP
Diabetes diagnosed by doctor 2.24 1 0 0.0 0 1 ARL14EP
Medication for cholesterol 2.24 1 0 0.0 0 1 ARL14EP
Osteoporosis (self-reported) 2.63 1 0 0.0 0 1 STON1
Leg predicted mass (right) 0.92 1 0 0.0 0 1 ARL14EP
Ever taken oral contraceptive pill 3.40 1 0 0.0 0 1 ARL14EP
Number of operations (self-reported) 8.64 1 0 0.0 0 1 ARL14EP
Age started oral contraceptive pill 3.14 1 0 0.0 0 1 STON1
Vascular/heart problems diagnosed by doctor 3.20 1 0 0.0 0 1 ARL14EP
Impedance of whole body 0.67 1 0 0.0 0 1 STON1
Leg fat mass (left) 0.74 1 0 0.0 0 1 STON1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.1
GTEx Adipose Visceral Omentum 0 0.000 1.1
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.1
GTEx Artery Coronary 0 0.000 1.1
GTEx Artery Tibial 0 0.000 1.1
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.1
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.1
GTEx Brain Hippocampus 0 0.000 1.1
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.1
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.1
GTEx Cells Transformed fibroblasts 0 0.000 1.1
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.1
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.1
GTEx Esophagus Mucosa 0 0.000 1.1
GTEx Esophagus Muscularis 0 0.000 1.1
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.1
GTEx Muscle Skeletal 0 0.000 1.1
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 0 0.000 1.1
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.1
GTEx Skin Sun Exposed Lower leg 0 0.000 1.1
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.1
GTEx Testis 1 0.032 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.1
METSIM Adipose 1 0.022 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1