Hub : Traits :

Frequency of unenthusiasm / disinterest in last 2 weeks

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 64531160 65911294 1 1 3.5e-09 4.0e-06 0.3200 95 JMJD1C-AS1
2 13 66643767 68053176 1 1 1.6e-07 1.6e-06 0.0039 64 PCDH9

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 11.82 2 1 2.2 0 1 JMJD1C-AS1 PCDH9
Depression (Nagel 2018) 22.21 2 2 4.4 0 1 JMJD1C-AS1 PCDH9
Intelligence (Savage-Jansen 2018) 4.58 1 1 2.2 0 1 JMJD1C-AS1
Neuroticism (Nagel 2018) 8.22 2 1 2.2 0 1 JMJD1C-AS1 PCDH9
Schizophrenia vs Biploar Disorder 2.83 1 0 0.0 0 1 PCDH9
Worry (Nagel 2018) 3.68 1 0 0.0 0 1 PCDH9
Alzheimer’s Disease (in father) 7.91 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Reaction Time 2.89 1 0 0.0 0 1 PCDH9
Verbal and Numeric Reasoning (VNR) 5.42 1 0 0.0 0 1 JMJD1C-AS1
Breast Cancer 2.57 1 0 0.0 0 1 JMJD1C-AS1
Coronary Artery Disease (CAD) 2.72 1 0 0.0 0 1 PCDH9
HDL Cholesterol 2.23 1 0 0.0 0 1 JMJD1C-AS1
Neuroticism (2016) 7.22 1 0 0.0 0 1 PCDH9
Triglycerides 4.12 1 0 0.0 0 1 JMJD1C-AS1
Blood Platelet Count 2.27 1 1 2.2 0 1 JMJD1C-AS1
Blood Red Count 0.72 1 0 0.0 0 1 JMJD1C-AS1
Blood White Count 3.87 1 1 2.2 0 1 JMJD1C-AS1
BMI 1.92 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Height 0.49 1 0 0.0 0 1 JMJD1C-AS1
Waist Hip Ratio (WHR) 1.47 1 0 0.0 0 1 JMJD1C-AS1
Systolic Blood Pressure 1.07 1 0 0.0 0 1 PCDH9
Smoking Status 2.70 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Allergy or Eczema 1.46 1 0 0.0 0 1 PCDH9
Lung FEV1/FVC ratio 2.36 1 0 0.0 0 1 JMJD1C-AS1
Lung FVC 1.98 1 0 0.0 0 1 JMJD1C-AS1
Neuroticism 7.22 1 1 2.2 0 1 PCDH9
Hair Pigment 0.37 1 0 0.0 0 1 JMJD1C-AS1
Number of treatments/medications taken 3.04 1 0 0.0 0 1 PCDH9
Sensitivity / hurt feelings 3.62 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Frequency of depressed mood in last 2 weeks 16.25 2 1 2.2 0 1 JMJD1C-AS1 PCDH9
Other serious medical condition/disability diagnosed by doctor 2.81 1 0 0.0 0 1 PCDH9
Ever used hormone-replacement therapy (HRT) 3.15 1 0 0.0 0 1 JMJD1C-AS1
Vitamin and mineral supplements 2.86 1 0 0.0 0 1 JMJD1C-AS1
Medication: Co-codamol 3.21 1 0 0.0 0 1 PCDH9
Pack years adult smoking proportion 10.66 1 1 2.2 0 1 JMJD1C-AS1
Impedance of leg (right) 1.62 1 0 0.0 0 1 JMJD1C-AS1
Townsend deprivation index at recruitment 2.33 1 0 0.0 0 1 JMJD1C-AS1
Current tobacco smoking 4.05 1 0 0.0 0 1 JMJD1C-AS1
Fed-up feelings 9.53 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Taking other prescription medications 2.79 1 0 0.0 0 1 PCDH9
Tinnitus: Yes, but not now, but have in the past 5.64 1 0 0.0 0 1 PCDH9
Qualifications: CSEs or equivalent 6.60 1 0 0.0 0 1 JMJD1C-AS1
Hayfever, allergic rhinitis or eczema 1.96 1 0 0.0 0 1 PCDH9
Stomach or abdominal pain in last month 8.44 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Body mass index (BMI) 2.00 1 0 0.0 0 1 JMJD1C-AS1
Impedance of leg (left) 1.45 1 0 0.0 0 1 JMJD1C-AS1
Waist circumference 1.34 1 0 0.0 0 1 JMJD1C-AS1
Number of incorrect matches in round 1.96 1 0 0.0 0 1 JMJD1C-AS1
Alcohol usually taken with meals 2.11 1 0 0.0 0 1 JMJD1C-AS1
Nervous feelings 3.51 1 0 0.0 0 1 PCDH9
Frequency of tenseness / restlessness in last 2 weeks 9.48 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Ever unenthusiastic/disinterested for a whole week 4.58 1 0 0.0 0 1 PCDH9
Qualifications: None of the above 9.35 1 1 2.2 0 1 JMJD1C-AS1
Financial difficulties in last 2 years 5.03 1 0 0.0 0 1 JMJD1C-AS1
Allergy 1.12 1 0 0.0 0 1 PCDH9
Fluid intelligence score 4.76 1 0 0.0 0 1 JMJD1C-AS1
Neuroticism score 11.39 2 1 2.2 0 1 JMJD1C-AS1 PCDH9
Impedance of arm (right) 4.22 1 1 2.2 0 1 JMJD1C-AS1
Trunk fat-free mass 0.69 1 0 0.0 0 1 JMJD1C-AS1
Worrier / anxious feelings 3.47 1 0 0.0 0 1 PCDH9
Frequency of tiredness / lethargy in last 2 weeks 10.40 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Noisy workplace 2.70 1 0 0.0 0 1 PCDH9
Qualifications: A levels/AS levels or equivalent 4.15 1 0 0.0 0 1 JMJD1C-AS1
Forced expiratory volume in 1-second (FEV1), Best measure 0.84 1 0 0.0 0 1 JMJD1C-AS1
Pulse wave Arterial Stiffness index 2.78 1 0 0.0 0 1 JMJD1C-AS1
Impedance of arm (left) 4.89 1 1 2.2 0 1 JMJD1C-AS1
Trunk predicted mass 0.69 1 0 0.0 0 1 JMJD1C-AS1
Standing height 0.64 1 0 0.0 0 1 JMJD1C-AS1
Tense / 'highly strung' 1.90 1 0 0.0 0 1 JMJD1C-AS1
Seen doctor (GP) for nerves, anxiety, tension or depression 5.31 1 0 0.0 0 1 PCDH9
Ever highly irritable/argumentative for 2 days 7.40 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Loud music exposure frequency 5.24 1 0 0.0 0 1 JMJD1C-AS1
Qualifications: O levels/GCSEs or equivalent 2.69 1 0 0.0 0 1 JMJD1C-AS1
Medication: Paracetamol 6.09 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Arm fat-free mass (right) 1.23 1 0 0.0 0 1 JMJD1C-AS1
Exposure to tobacco smoke outside home 5.98 1 0 0.0 0 1 JMJD1C-AS1
Comparative body size at age 10 1.61 1 0 0.0 0 1 PCDH9
Worry too long after embarrassment 4.03 1 0 0.0 0 1 PCDH9
Wheeze or whistling in the chest in last year 2.51 1 0 0.0 0 1 PCDH9
Reason for reducing amount of alcohol drunk: Health precaution 2.58 1 0 0.0 0 1 PCDH9
Age at first live birth 5.69 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Pulse wave peak to peak time 3.20 1 0 0.0 0 1 JMJD1C-AS1
Health satisfaction 8.00 1 0 0.0 0 1 PCDH9
Shortness of breath walking on level ground 3.99 1 0 0.0 0 1 PCDH9
Qualifications: College or University degree 6.84 1 1 2.2 0 1 JMJD1C-AS1
Eye problems/disorders: None of the above 3.13 1 0 0.0 0 1 JMJD1C-AS1
Medication for pain relief, constipation, heartburn 9.11 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Neck or shoulder pain in last month 4.08 1 0 0.0 0 1 PCDH9
Medication: Omeprazole 2.38 1 0 0.0 0 1 PCDH9
Mean time to correctly identify matches 3.16 1 0 0.0 0 1 PCDH9
Arm predicted mass (right) 1.01 1 0 0.0 0 1 JMJD1C-AS1
Alcohol intake frequency. 2.28 1 0 0.0 0 1 PCDH9
Comparative height size at age 10 0.57 1 0 0.0 0 1 PCDH9
Suffer from 'nerves' 3.33 1 0 0.0 0 1 PCDH9
Overall health rating 4.67 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Leg pain on walking 4.16 1 0 0.0 0 1 PCDH9
Illness, injury, bereavement, stress in last 2 years 4.37 1 0 0.0 0 1 JMJD1C-AS1
Knee pain experienced in last month 2.02 1 0 0.0 0 1 JMJD1C-AS1
Whole body fat-free mass 0.70 1 0 0.0 0 1 JMJD1C-AS1
Average weekly red wine intake 2.34 1 0 0.0 0 1 JMJD1C-AS1
Mood swings 5.97 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Loneliness, isolation 17.57 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Qualifications: nursing, teaching 7.32 1 0 0.0 0 1 JMJD1C-AS1
Eye problems/disorders: Cataract 4.67 1 0 0.0 0 1 JMJD1C-AS1
Back pain experienced in last month 4.79 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Smoking status: Current 4.23 1 0 0.0 0 1 JMJD1C-AS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.02 1 0 0.0 0 1 JMJD1C-AS1
Whole body water mass 0.73 1 0 0.0 0 1 JMJD1C-AS1
Average weekly champagne plus white wine intake 4.34 1 0 0.0 0 1 PCDH9
Miserableness 9.06 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Guilty feelings 4.62 1 0 0.0 0 1 PCDH9
Hearing aid user 3.26 1 0 0.0 0 1 PCDH9
Financial situation satisfaction 3.42 1 0 0.0 0 1 PCDH9
Pain type(s) experienced in last month: Hip pain 5.65 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Medication: Paracetamol 6.84 2 0 0.0 0 1 JMJD1C-AS1 PCDH9
Medication: Atorvastatin 2.24 1 0 0.0 0 1 JMJD1C-AS1
Basal metabolic rate 0.70 1 0 0.0 0 1 JMJD1C-AS1
Arm fat-free mass (left) 1.53 1 0 0.0 0 1 JMJD1C-AS1
Average weekly beer plus cider intake 2.01 1 0 0.0 0 1 JMJD1C-AS1
Irritability 3.66 1 0 0.0 0 1 PCDH9
Ever depressed for a whole week 4.46 1 0 0.0 0 1 PCDH9
Unable to work because of sickness or disability 3.52 1 0 0.0 0 1 JMJD1C-AS1
Pain experienced in last month 3.42 1 0 0.0 0 1 PCDH9
Pack years of smoking 9.53 1 1 2.2 0 1 JMJD1C-AS1
Impedance of whole body 3.53 1 1 2.2 0 1 JMJD1C-AS1
Arm predicted mass (left) 1.47 1 0 0.0 0 1 JMJD1C-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.4
GTEx Testis 1 0.032 1.4
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.4
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3