Hub : Traits :

Frequency of unenthusiasm / disinterest in last 2 weeks

2 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	10	64531160	65911294	1	1	3.5e-09	4.0e-06	0.3200	95	JMJD1C-AS1
2	13	66643767	68053176	1	1	1.6e-07	1.6e-06	0.0039	64	PCDH9

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Depression (Nagel 2018)	22.21	2	2	4.4	1	JMJD1C-AS1 PCDH9
Loneliness, isolation	17.57	2	0	0.0	1	JMJD1C-AS1 PCDH9
Frequency of depressed mood in last 2 weeks	16.25	2	1	2.2	1	JMJD1C-AS1 PCDH9
Depressed Affect (Nagel 2018)	11.82	2	1	2.2	1	JMJD1C-AS1 PCDH9
Neuroticism score	11.39	2	1	2.2	1	JMJD1C-AS1 PCDH9
Pack years adult smoking proportion	10.66	1	1	2.2	1	JMJD1C-AS1
Frequency of tiredness / lethargy in last 2 weeks	10.40	2	0	0.0	1	JMJD1C-AS1 PCDH9
Fed-up feelings	9.53	2	0	0.0	1	JMJD1C-AS1 PCDH9
Pack years of smoking	9.53	1	1	2.2	1	JMJD1C-AS1
Frequency of tenseness / restlessness in last 2 weeks	9.48	2	0	0.0	1	JMJD1C-AS1 PCDH9
Qualifications: None of the above	9.35	1	1	2.2	1	JMJD1C-AS1
Medication for pain relief, constipation, heartburn	9.11	2	0	0.0	1	JMJD1C-AS1 PCDH9
Miserableness	9.06	2	0	0.0	1	JMJD1C-AS1 PCDH9
Stomach or abdominal pain in last month	8.44	2	0	0.0	1	JMJD1C-AS1 PCDH9
Neuroticism (Nagel 2018)	8.22	2	1	2.2	1	JMJD1C-AS1 PCDH9
Health satisfaction	8.00	1	0	0.0	1	PCDH9
Alzheimer’s Disease (in father)	7.91	2	0	0.0	1	JMJD1C-AS1 PCDH9
Ever highly irritable/argumentative for 2 days	7.40	2	0	0.0	1	JMJD1C-AS1 PCDH9
Qualifications: nursing, teaching	7.32	1	0	0.0	1	JMJD1C-AS1
Neuroticism (2016)	7.22	1	0	0.0	1	PCDH9
Neuroticism	7.22	1	1	2.2	1	PCDH9
Qualifications: College or University degree	6.84	1	1	2.2	1	JMJD1C-AS1
Medication: Paracetamol	6.84	2	0	0.0	1	JMJD1C-AS1 PCDH9
Qualifications: CSEs or equivalent	6.60	1	0	0.0	1	JMJD1C-AS1
Medication: Paracetamol	6.09	2	0	0.0	1	JMJD1C-AS1 PCDH9
Exposure to tobacco smoke outside home	5.98	1	0	0.0	1	JMJD1C-AS1
Mood swings	5.97	2	0	0.0	1	JMJD1C-AS1 PCDH9
Age at first live birth	5.69	2	0	0.0	1	JMJD1C-AS1 PCDH9
Pain type(s) experienced in last month: Hip pain	5.65	2	0	0.0	1	JMJD1C-AS1 PCDH9
Tinnitus: Yes, but not now, but have in the past	5.64	1	0	0.0	1	PCDH9
Verbal and Numeric Reasoning (VNR)	5.42	1	0	0.0	1	JMJD1C-AS1
Seen doctor (GP) for nerves, anxiety, tension or depression	5.31	1	0	0.0	1	PCDH9
Loud music exposure frequency	5.24	1	0	0.0	1	JMJD1C-AS1
Financial difficulties in last 2 years	5.03	1	0	0.0	1	JMJD1C-AS1
Impedance of arm (left)	4.89	1	1	2.2	1	JMJD1C-AS1
Back pain experienced in last month	4.79	2	0	0.0	1	JMJD1C-AS1 PCDH9
Fluid intelligence score	4.76	1	0	0.0	1	JMJD1C-AS1
Overall health rating	4.67	2	0	0.0	1	JMJD1C-AS1 PCDH9
Eye problems/disorders: Cataract	4.67	1	0	0.0	1	JMJD1C-AS1
Guilty feelings	4.62	1	0	0.0	1	PCDH9
Intelligence (Savage-Jansen 2018)	4.58	1	1	2.2	1	JMJD1C-AS1
Ever unenthusiastic/disinterested for a whole week	4.58	1	0	0.0	1	PCDH9
Ever depressed for a whole week	4.46	1	0	0.0	1	PCDH9
Illness, injury, bereavement, stress in last 2 years	4.37	1	0	0.0	1	JMJD1C-AS1
Average weekly champagne plus white wine intake	4.34	1	0	0.0	1	PCDH9
Smoking status: Current	4.23	1	0	0.0	1	JMJD1C-AS1
Impedance of arm (right)	4.22	1	1	2.2	1	JMJD1C-AS1
Leg pain on walking	4.16	1	0	0.0	1	PCDH9
Qualifications: A levels/AS levels or equivalent	4.15	1	0	0.0	1	JMJD1C-AS1
Triglycerides	4.12	1	0	0.0	1	JMJD1C-AS1
Neck or shoulder pain in last month	4.08	1	0	0.0	1	PCDH9
Current tobacco smoking	4.05	1	0	0.0	1	JMJD1C-AS1
Worry too long after embarrassment	4.03	1	0	0.0	1	PCDH9
Shortness of breath walking on level ground	3.99	1	0	0.0	1	PCDH9
Blood White Count	3.87	1	1	2.2	1	JMJD1C-AS1
Worry (Nagel 2018)	3.68	1	0	0.0	1	PCDH9
Irritability	3.66	1	0	0.0	1	PCDH9
Sensitivity / hurt feelings	3.62	2	0	0.0	1	JMJD1C-AS1 PCDH9
Impedance of whole body	3.53	1	1	2.2	1	JMJD1C-AS1
Unable to work because of sickness or disability	3.52	1	0	0.0	1	JMJD1C-AS1
Nervous feelings	3.51	1	0	0.0	1	PCDH9
Worrier / anxious feelings	3.47	1	0	0.0	1	PCDH9
Financial situation satisfaction	3.42	1	0	0.0	1	PCDH9
Pain experienced in last month	3.42	1	0	0.0	1	PCDH9
Suffer from 'nerves'	3.33	1	0	0.0	1	PCDH9
Hearing aid user	3.26	1	0	0.0	1	PCDH9
Medication: Co-codamol	3.21	1	0	0.0	1	PCDH9
Pulse wave peak to peak time	3.20	1	0	0.0	1	JMJD1C-AS1
Mean time to correctly identify matches	3.16	1	0	0.0	1	PCDH9
Ever used hormone-replacement therapy (HRT)	3.15	1	0	0.0	1	JMJD1C-AS1
Eye problems/disorders: None of the above	3.13	1	0	0.0	1	JMJD1C-AS1
Number of treatments/medications taken	3.04	1	0	0.0	1	PCDH9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.02	1	0	0.0	1	JMJD1C-AS1
Reaction Time	2.89	1	0	0.0	1	PCDH9
Vitamin and mineral supplements	2.86	1	0	0.0	1	JMJD1C-AS1
Schizophrenia vs Biploar Disorder	2.83	1	0	0.0	1	PCDH9
Other serious medical condition/disability diagnosed by doctor	2.81	1	0	0.0	1	PCDH9
Taking other prescription medications	2.79	1	0	0.0	1	PCDH9
Pulse wave Arterial Stiffness index	2.78	1	0	0.0	1	JMJD1C-AS1
Coronary Artery Disease (CAD)	2.72	1	0	0.0	1	PCDH9
Smoking Status	2.70	2	0	0.0	1	JMJD1C-AS1 PCDH9
Noisy workplace	2.70	1	0	0.0	1	PCDH9
Qualifications: O levels/GCSEs or equivalent	2.69	1	0	0.0	1	JMJD1C-AS1
Reason for reducing amount of alcohol drunk: Health precaution	2.58	1	0	0.0	1	PCDH9
Breast Cancer	2.57	1	0	0.0	1	JMJD1C-AS1
Wheeze or whistling in the chest in last year	2.51	1	0	0.0	1	PCDH9
Medication: Omeprazole	2.38	1	0	0.0	1	PCDH9
Lung FEV1/FVC ratio	2.36	1	0	0.0	1	JMJD1C-AS1
Average weekly red wine intake	2.34	1	0	0.0	1	JMJD1C-AS1
Townsend deprivation index at recruitment	2.33	1	0	0.0	1	JMJD1C-AS1
Alcohol intake frequency.	2.28	1	0	0.0	1	PCDH9
Blood Platelet Count	2.27	1	1	2.2	1	JMJD1C-AS1
Medication: Atorvastatin	2.24	1	0	0.0	1	JMJD1C-AS1
HDL Cholesterol	2.23	1	0	0.0	1	JMJD1C-AS1
Alcohol usually taken with meals	2.11	1	0	0.0	1	JMJD1C-AS1
Knee pain experienced in last month	2.02	1	0	0.0	1	JMJD1C-AS1
Average weekly beer plus cider intake	2.01	1	0	0.0	1	JMJD1C-AS1
Body mass index (BMI)	2.00	1	0	0.0	1	JMJD1C-AS1
Lung FVC	1.98	1	0	0.0	1	JMJD1C-AS1
Hayfever, allergic rhinitis or eczema	1.96	1	0	0.0	1	PCDH9
Number of incorrect matches in round	1.96	1	0	0.0	1	JMJD1C-AS1
BMI	1.92	2	0	0.0	1	JMJD1C-AS1 PCDH9
Tense / 'highly strung'	1.90	1	0	0.0	1	JMJD1C-AS1
Impedance of leg (right)	1.62	1	0	0.0	1	JMJD1C-AS1
Comparative body size at age 10	1.61	1	0	0.0	1	PCDH9
Arm fat-free mass (left)	1.53	1	0	0.0	1	JMJD1C-AS1
Waist Hip Ratio (WHR)	1.47	1	0	0.0	1	JMJD1C-AS1
Arm predicted mass (left)	1.47	1	0	0.0	1	JMJD1C-AS1
Allergy or Eczema	1.46	1	0	0.0	1	PCDH9
Impedance of leg (left)	1.45	1	0	0.0	1	JMJD1C-AS1
Waist circumference	1.34	1	0	0.0	1	JMJD1C-AS1
Arm fat-free mass (right)	1.23	1	0	0.0	1	JMJD1C-AS1
Allergy	1.12	1	0	0.0	1	PCDH9
Systolic Blood Pressure	1.07	1	0	0.0	1	PCDH9
Arm predicted mass (right)	1.01	1	0	0.0	1	JMJD1C-AS1
Forced expiratory volume in 1-second (FEV1), Best measure	0.84	1	0	0.0	1	JMJD1C-AS1
Whole body water mass	0.73	1	0	0.0	1	JMJD1C-AS1
Blood Red Count	0.72	1	0	0.0	1	JMJD1C-AS1
Whole body fat-free mass	0.70	1	0	0.0	1	JMJD1C-AS1
Basal metabolic rate	0.70	1	0	0.0	1	JMJD1C-AS1
Trunk fat-free mass	0.69	1	0	0.0	1	JMJD1C-AS1
Trunk predicted mass	0.69	1	0	0.0	1	JMJD1C-AS1
Standing height	0.64	1	0	0.0	1	JMJD1C-AS1
Comparative height size at age 10	0.57	1	0	0.0	1	PCDH9
Height	0.49	1	0	0.0	1	JMJD1C-AS1
Hair Pigment	0.37	1	0	0.0	1	JMJD1C-AS1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Artery Aorta	0	0.000	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Lung	0	0.000	1.4
GTEx	Muscle Skeletal	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Testis	1	0.032	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
NTR	Blood	0	0.000	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2