Hub : Traits :

Bilateral oophorectomy (both ovaries removed)

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 198510 950750 2 1 3.9e-07 1.7e-06 0.24 94 BET1L
2 11 29646947 31048683 1 1 3.4e-09 3.9e-09 0.28 97 ARL14EP

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Age at First Birth 2.35 1 0 0.0 0 1 ARL14EP
Triglycerides 5.38 1 0 0.0 0 1 ARL14EP
Blood Platelet Count 4.04 1 1 3.0 0 1 BET1L
Blood Red Count 1.72 2 0 0.0 0 1 ARL14EP BET1L
Heel T-Score 2.85 1 1 3.0 0 1 ARL14EP
BMI 0.79 1 0 0.0 0 1 BET1L
Height 2.14 2 2 6.1 0 1 ARL14EP BET1L
Waist Hip Ratio (WHR) 1.54 1 0 0.0 0 1 ARL14EP
Systolic Blood Pressure 0.85 1 0 0.0 0 1 ARL14EP
Cardiovascular Disease 1.67 1 0 0.0 0 1 ARL14EP
Type 2 Diabetes (T2D) 2.28 1 0 0.0 0 1 ARL14EP
Lung FEV1/FVC ratio 3.55 2 1 3.0 0 1 ARL14EP BET1L
Lung FVC 1.04 1 0 0.0 0 1 ARL14EP
Ever used hormone-replacement therapy (HRT) 7.65 1 0 0.0 0 1 ARL14EP
Ever had hysterectomy (womb removed) 17.34 2 1 3.0 0 1 ARL14EP BET1L
Frequency of unenthusiasm / disinterest in last 2 weeks 4.96 1 0 0.0 0 1 ARL14EP
Age when periods started (menarche) 6.09 1 0 0.0 0 1 ARL14EP
Heel bone mineral density (BMD) T-score, automated (left) 3.64 1 0 0.0 0 1 ARL14EP
Tinnitus: Yes, but not now, but have in the past 4.06 1 0 0.0 0 1 BET1L
High blood pressure 2.29 1 0 0.0 0 1 ARL14EP
Sitting height 1.42 1 0 0.0 0 1 ARL14EP
Body mass index (BMI) 0.81 1 0 0.0 0 1 BET1L
Leg predicted mass (left) 0.64 1 0 0.0 0 1 ARL14EP
Had menopause 3.98 1 0 0.0 0 1 ARL14EP
Forced vital capacity (FVC) 2.38 1 0 0.0 0 1 ARL14EP
Heel bone mineral density (BMD) T-score, automated (right) 4.07 1 0 0.0 0 1 ARL14EP
Medication: Simvastatin 2.95 1 0 0.0 0 1 ARL14EP
Impedance of arm (right) 2.35 1 0 0.0 0 1 BET1L
Forced expiratory volume in 1-second (FEV1) 1.45 1 0 0.0 0 1 ARL14EP
Pulse rate 2.07 1 0 0.0 0 1 ARL14EP
Qualifications: A levels/AS levels or equivalent 3.73 1 0 0.0 0 1 BET1L
Medication: Lansoprazole 4.58 1 0 0.0 0 1 BET1L
Forced expiratory volume in 1-second (FEV1), Best measure 1.58 1 0 0.0 0 1 ARL14EP
Impedance of arm (left) 2.08 1 0 0.0 0 1 BET1L
Standing height 1.69 2 0 0.0 0 1 ARL14EP BET1L
Peak expiratory flow (PEF) 1.93 1 0 0.0 0 1 ARL14EP
Forced vital capacity (FVC), Best measure 2.80 1 0 0.0 0 1 ARL14EP
Age at first live birth 6.38 1 0 0.0 0 1 ARL14EP
Eye problems/disorders: None of the above 5.75 1 0 0.0 0 1 BET1L
Overall health rating 2.46 1 0 0.0 0 1 BET1L
Chest pain or discomfort 3.35 1 0 0.0 0 1 ARL14EP
Age at last live birth 7.91 1 0 0.0 0 1 ARL14EP
Qualifications: NVQ or HND or HNC or equivalent 3.34 1 0 0.0 0 1 ARL14EP
Hypertension (Self-reported) 2.60 1 0 0.0 0 1 ARL14EP
Leg fat-free mass (right) 0.68 1 0 0.0 0 1 ARL14EP
Average weekly red wine intake 4.16 1 0 0.0 0 1 ARL14EP
Eye problems/disorders: Cataract 4.99 1 0 0.0 0 1 BET1L
Medication for cholesterol 2.20 1 0 0.0 0 1 ARL14EP
Leg predicted mass (right) 0.64 1 0 0.0 0 1 ARL14EP
Ever taken oral contraceptive pill 3.63 1 0 0.0 0 1 ARL14EP
Financial situation satisfaction 2.85 1 0 0.0 0 1 BET1L
Number of operations (self-reported) 9.82 2 0 0.0 0 1 ARL14EP BET1L
Vascular/heart problems diagnosed by doctor 2.63 1 0 0.0 0 1 ARL14EP
Pain experienced in last month 2.94 1 0 0.0 0 1 BET1L
Impedance of whole body 0.97 1 0 0.0 0 1 BET1L

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.15
GTEx Adipose Visceral Omentum 0 0.0000 1.18
GTEx Adrenal Gland 0 0.0000 1.12
GTEx Artery Aorta 0 0.0000 1.17
GTEx Artery Coronary 0 0.0000 1.14
GTEx Artery Tibial 0 0.0000 1.14
GTEx Brain Caudate basal ganglia 0 0.0000 1.19
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.24
GTEx Brain Cerebellum 0 0.0000 1.21
GTEx Brain Cortex 0 0.0000 1.29
GTEx Brain Frontal Cortex BA9 0 0.0000 1.28
GTEx Brain Hippocampus 0 0.0000 1.17
GTEx Brain Hypothalamus 0 0.0000 1.19
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.14
GTEx Brain Putamen basal ganglia 0 0.0000 1.18
GTEx Breast Mammary Tissue 0 0.0000 1.12
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.09
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.10
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.13
GTEx Cells Transformed fibroblasts 0 0.0000 1.15
GTEx Colon Sigmoid 0 0.0000 1.19
GTEx Colon Transverse 0 0.0000 1.18
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.14
GTEx Esophagus Mucosa 0 0.0000 1.18
GTEx Esophagus Muscularis 0 0.0000 1.17
GTEx Heart Atrial Appendage 0 0.0000 1.15
GTEx Heart Left Ventricle 0 0.0000 1.18
GTEx Liver 0 0.0000 1.14
GTEx Lung 0 0.0000 1.18
GTEx Muscle Skeletal 0 0.0000 1.11
GTEx Nerve Tibial 0 0.0000 1.15
GTEx Ovary 0 0.0000 1.20
GTEx Pancreas 0 0.0000 1.20
GTEx Pituitary 0 0.0000 1.17
GTEx Prostate 0 0.0000 1.16
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.16
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.17
GTEx Small Intestine Terminal Ileum 0 0.0000 1.28
GTEx Spleen 0 0.0000 1.19
GTEx Stomach 0 0.0000 1.15
GTEx Testis 1 0.0317 1.18
GTEx Thyroid 1 0.0250 1.19
GTEx Uterus 0 0.0000 1.11
GTEx Vagina 0 0.0000 1.11
GTEx Whole Blood 0 0.0000 1.13
METSIM Adipose 0 0.0000 1.15
NTR Blood 1 0.0416 1.20
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.15
YFS Blood 0 0.0000 1.17
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.20
TCGA Breast Tumor 0 0.0000 1.15
TCGA Breast Normal 0 0.0000 1.12
TCGA Ovarian Tumor 0 0.0000 1.12
TCGA Prostate Tumor 0 0.0000 1.14