Hub : Traits :

Qualifications: CSEs or equivalent

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 150008790 151435941 2 2 4e-08 1.1e-05 0.89 100 CTSS LYSMD1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 5.97 2 0 0.0 0 1 CTSS LYSMD1
Bipolar Disorder or Schizophrenia 6.60 2 0 0.0 0 1 CTSS LYSMD1
Schizophrenia (2018) 3.32 2 0 0.0 0 1 CTSS LYSMD1
Crohns Disease (2017) 1.72 1 0 0.0 0 1 CTSS
Breast Cancer 1.75 1 0 0.0 0 1 CTSS
Body Mass Index (BMI) (2010) 8.10 2 0 0.0 0 1 CTSS LYSMD1
Coronary Artery Disease (CAD) 3.35 1 0 0.0 0 1 CTSS
Crohns Disease (2012) 3.16 1 0 0.0 0 1 CTSS
Fasting Glucose 3.84 1 0 0.0 0 1 LYSMD1
LDL Cholesterol 3.18 1 0 0.0 0 1 LYSMD1
Lupus 2.85 1 0 0.0 0 1 CTSS
Schizophrenia (2014) 4.89 2 0 0.0 0 1 CTSS LYSMD1
Blood Eosinophil Count 1.08 2 0 0.0 0 1 CTSS LYSMD1
Blood Platelet Count 3.09 2 1 2.2 0 1 CTSS LYSMD1
Heel T-Score 2.18 2 0 0.0 0 1 CTSS LYSMD1
BMI 1.47 1 0 0.0 0 1 CTSS
Height 0.48 1 0 0.0 0 1 CTSS
Allergy or Eczema 7.06 2 0 0.0 0 1 CTSS LYSMD1
Hypothyroidism (self reported) 2.41 1 0 0.0 0 1 LYSMD1
Lung FEV1/FVC ratio 1.21 2 0 0.0 0 1 CTSS LYSMD1
Lung FVC 6.72 2 1 2.2 0 1 CTSS LYSMD1
Chronotype (morning person) 2.19 1 0 0.0 0 1 LYSMD1
Hair Pigment 0.29 2 0 0.0 0 1 CTSS LYSMD1
Tanning 0.89 2 0 0.0 0 1 CTSS LYSMD1
Hand grip strength (left) 1.97 1 0 0.0 0 1 LYSMD1
Ever used hormone-replacement therapy (HRT) 2.73 1 0 0.0 0 1 LYSMD1
Eye problems/disorders: Diabetes related eye disease 4.84 1 0 0.0 0 1 LYSMD1
Impedance of leg (right) 3.65 2 0 0.0 0 1 CTSS LYSMD1
Trunk fat percentage 3.43 2 0 0.0 0 1 CTSS LYSMD1
Age when periods started (menarche) 3.38 2 0 0.0 0 1 CTSS LYSMD1
Tinnitus: Yes, but not now, but have in the past 3.03 1 0 0.0 0 1 LYSMD1
Serious illness, injury or assault to yourself 4.41 1 0 0.0 0 1 CTSS
Hayfever, allergic rhinitis or eczema 4.88 2 0 0.0 0 1 CTSS LYSMD1
Medication: Levothyroxine sodium 4.02 1 0 0.0 0 1 LYSMD1
Body mass index (BMI) 1.11 1 0 0.0 0 1 CTSS
Impedance of leg (left) 3.21 2 0 0.0 0 1 CTSS LYSMD1
Trunk fat mass 2.16 2 0 0.0 0 1 CTSS LYSMD1
Alcohol usually taken with meals 6.29 2 0 0.0 0 1 CTSS LYSMD1
Frequency of tenseness / restlessness in last 2 weeks 1.85 1 0 0.0 0 1 CTSS
Forced vital capacity (FVC) 5.06 2 1 2.2 0 1 CTSS LYSMD1
Allergy 2.04 1 0 0.0 0 1 LYSMD1
Arm fat percentage (right) 2.36 2 0 0.0 0 1 CTSS LYSMD1
Hip circumference 0.93 1 0 0.0 0 1 CTSS
Forced expiratory volume in 1-second (FEV1) 3.49 1 0 0.0 0 1 CTSS
Pulse rate 2.12 1 0 0.0 0 1 LYSMD1
Noisy workplace 5.36 2 0 0.0 0 1 CTSS LYSMD1
Medication: Cholesterol lowering 2.82 1 0 0.0 0 1 CTSS
Lung cancer (father) 3.21 1 0 0.0 0 1 CTSS
Forced expiratory volume in 1-second (FEV1), Best measure 2.65 1 0 0.0 0 1 CTSS
Pulse wave Arterial Stiffness index 4.04 1 0 0.0 0 1 CTSS
Arm fat mass (right) 1.37 1 0 0.0 0 1 CTSS
Standing height 0.40 1 0 0.0 0 1 CTSS
Length of working week for main job 3.88 1 0 0.0 0 1 LYSMD1
Birth weight of first child 2.68 1 0 0.0 0 1 CTSS
Peak expiratory flow (PEF) 1.97 1 0 0.0 0 1 CTSS
Hypothyroidism/myxoedema (self-reported) 2.43 1 0 0.0 0 1 LYSMD1
Forced vital capacity (FVC), Best measure 4.77 2 1 2.2 0 1 CTSS LYSMD1
Body fat percentage 4.42 2 0 0.0 0 1 CTSS LYSMD1
Leg fat percentage (right) 5.90 2 0 0.0 0 1 CTSS LYSMD1
Exposure to tobacco smoke outside home 2.68 1 0 0.0 0 1 CTSS
Qualifications: College or University degree 2.60 1 0 0.0 0 1 CTSS
Medication: Blood pressure 2.82 1 0 0.0 0 1 CTSS
Medication: Allopurinol 4.30 1 0 0.0 0 1 CTSS
Whole body fat mass 2.27 2 0 0.0 0 1 CTSS LYSMD1
Leg fat mass (right) 3.17 2 0 0.0 0 1 CTSS LYSMD1
Illness, injury, bereavement, stress in last 2 years 3.57 1 0 0.0 0 1 LYSMD1
Arm fat percentage (left) 2.51 2 0 0.0 0 1 CTSS LYSMD1
Handedness (chirality/laterality): Left-handed 2.65 1 0 0.0 0 1 LYSMD1
Commuting to job workplace: Walk 3.79 1 0 0.0 0 1 LYSMD1
Mouth/teeth dental problems: Mouth ulcers 3.49 1 0 0.0 0 1 CTSS
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.70 1 0 0.0 0 1 CTSS
Arm fat mass (left) 1.33 1 0 0.0 0 1 CTSS
Average weekly champagne plus white wine intake 3.83 1 0 0.0 0 1 CTSS
Miserableness 3.66 1 0 0.0 0 1 LYSMD1
Guilty feelings 1.95 1 0 0.0 0 1 CTSS
Mother's age at death 3.55 1 0 0.0 0 1 LYSMD1
Pain type(s) experienced in last month: Hip pain 2.72 1 0 0.0 0 1 CTSS
Leg fat percentage (left) 5.00 2 0 0.0 0 1 CTSS LYSMD1
Age started oral contraceptive pill 3.53 1 0 0.0 0 1 LYSMD1
Myopia 5.84 1 0 0.0 0 1 CTSS
Basal cell carcinoma (self-reported) 3.12 1 0 0.0 0 1 CTSS
Impedance of whole body 1.68 1 0 0.0 0 1 LYSMD1
Leg fat mass (left) 2.58 2 0 0.0 0 1 CTSS LYSMD1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 1 0.022 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4