Hub : Traits :

Noisy workplace

1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	135874930	137261517	1	1	8.1e-08	3.4e-06	0.22	93	RP11-85F14.5

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Impedance of arm (right)	17.92	1	1	2.2	1	RP11-85F14.5
Impedance of arm (left)	16.01	1	1	2.2	1	RP11-85F14.5
Body mass index (BMI)	15.02	1	1	2.2	1	RP11-85F14.5
Falls in the last year	13.78	1	0	0.0	1	RP11-85F14.5
BMI	13.62	1	1	2.2	1	RP11-85F14.5
Cardiovascular Disease	13.10	1	1	2.2	1	RP11-85F14.5
Medication: Ibuprofen	12.79	1	0	0.0	1	RP11-85F14.5
Impedance of whole body	12.61	1	1	2.2	1	RP11-85F14.5
Heart attack	12.52	1	0	0.0	1	RP11-85F14.5
Heart attack/myocardial infarction (self-reported)	12.11	1	0	0.0	1	RP11-85F14.5
Leg fat percentage (right)	12.10	1	1	2.2	1	RP11-85F14.5
Leg fat percentage (left)	12.07	1	1	2.2	1	RP11-85F14.5
Illnesses of father: Heart disease	12.01	1	0	0.0	1	RP11-85F14.5
Age started oral contraceptive pill	11.96	1	0	0.0	1	RP11-85F14.5
Medication: Ibuprofen (e.g. Nurofen)	11.93	1	0	0.0	1	RP11-85F14.5
HDL Cholesterol	11.55	1	0	0.0	1	RP11-85F14.5
Waist circumference	10.78	1	1	2.2	1	RP11-85F14.5
Illnesses of siblings: Diabetes	10.14	1	0	0.0	1	RP11-85F14.5
Triglycerides	9.87	1	0	0.0	1	RP11-85F14.5
Leg fat mass (right)	9.76	1	1	2.2	1	RP11-85F14.5
Average weekly beer plus cider intake	9.41	1	0	0.0	1	RP11-85F14.5
Medication: Cholesterol lowering	9.37	1	0	0.0	1	RP11-85F14.5
Leg fat mass (left)	9.22	1	1	2.2	1	RP11-85F14.5
High cholesterol (Self-reported)	8.95	1	0	0.0	1	RP11-85F14.5
Neck or shoulder pain in last month	8.65	1	0	0.0	1	RP11-85F14.5
Long-standing illness, disability or infirmity	8.40	1	0	0.0	1	RP11-85F14.5
Standing height	8.02	1	1	2.2	1	RP11-85F14.5
Alcohol usually taken with meals	7.91	1	0	0.0	1	RP11-85F14.5
Medication: Simvastatin	7.86	1	0	0.0	1	RP11-85F14.5
Body Mass Index (BMI) (2010)	7.65	1	0	0.0	1	RP11-85F14.5
Medication: Aspirin	7.64	1	0	0.0	1	RP11-85F14.5
Height	7.60	1	1	2.2	1	RP11-85F14.5
Pain experienced in last month	7.44	1	0	0.0	1	RP11-85F14.5
Vascular/heart problems diagnosed by doctor	7.40	1	0	0.0	1	RP11-85F14.5
Medication for pain relief, constipation, heartburn	7.15	1	0	0.0	1	RP11-85F14.5
Handedness (chirality/laterality): Left-handed	7.00	1	0	0.0	1	RP11-85F14.5
Average weekly red wine intake	6.90	1	0	0.0	1	RP11-85F14.5
Medication: Atorvastatin	6.88	1	0	0.0	1	RP11-85F14.5
Impedance of leg (left)	6.86	1	1	2.2	1	RP11-85F14.5
Arm fat percentage (left)	6.82	1	1	2.2	1	RP11-85F14.5
Medication: Aspirin	6.78	1	0	0.0	1	RP11-85F14.5
Cholesterol lowering medication	6.74	1	0	0.0	1	RP11-85F14.5
Angina (self-reported)	6.66	1	0	0.0	1	RP11-85F14.5
Mouth/teeth dental problems: Dentures	6.42	1	0	0.0	1	RP11-85F14.5
Overall health rating	6.38	1	0	0.0	1	RP11-85F14.5
Qualifications: NVQ or HND or HNC or equivalent	6.29	1	0	0.0	1	RP11-85F14.5
Medication: Co-codamol	6.25	1	0	0.0	1	RP11-85F14.5
Illnesses of siblings	6.19	1	0	0.0	1	RP11-85F14.5
Angina	6.14	1	0	0.0	1	RP11-85F14.5
Arm fat mass (left)	6.02	1	0	0.0	1	RP11-85F14.5
Impedance of leg (right)	6.00	1	1	2.2	1	RP11-85F14.5
Arm fat mass (right)	5.98	1	0	0.0	1	RP11-85F14.5
Arm fat percentage (right)	5.74	1	0	0.0	1	RP11-85F14.5
High blood pressure (mother)	5.59	1	0	0.0	1	RP11-85F14.5
Medication for cholesterol, blood pressure or diabetes	5.51	1	0	0.0	1	RP11-85F14.5
Exposure to tobacco smoke outside home	5.33	1	0	0.0	1	RP11-85F14.5
Body fat percentage	5.32	1	0	0.0	1	RP11-85F14.5
Relative age of first facial hair	5.29	1	0	0.0	1	RP11-85F14.5
Whole body fat mass	5.29	1	0	0.0	1	RP11-85F14.5
Fluid intelligence score	5.27	1	0	0.0	1	RP11-85F14.5
Hip circumference	5.22	1	0	0.0	1	RP11-85F14.5
Heart disease (mother)	5.21	1	0	0.0	1	RP11-85F14.5
Mouth/teeth dental problems	5.20	1	0	0.0	1	RP11-85F14.5
Comparative height size at age 10	5.12	1	1	2.2	1	RP11-85F14.5
Intelligence (Savage-Jansen 2018)	5.10	1	0	0.0	1	RP11-85F14.5
Chest pain or discomfort	5.06	1	0	0.0	1	RP11-85F14.5
Seen a psychiatrist for nerves, anxiety, tension or depression	4.81	1	0	0.0	1	RP11-85F14.5
Qualifications: O levels/GCSEs or equivalent	4.75	1	0	0.0	1	RP11-85F14.5
Medication: Paracetamol	4.71	1	0	0.0	1	RP11-85F14.5
Hypertension (Self-reported)	4.65	1	0	0.0	1	RP11-85F14.5
Ever used hormone-replacement therapy (HRT)	4.61	1	0	0.0	1	RP11-85F14.5
Number of incorrect matches in round	4.55	1	0	0.0	1	RP11-85F14.5
Health satisfaction	4.55	1	0	0.0	1	RP11-85F14.5
Diabetes diagnosed by doctor	4.54	1	0	0.0	1	RP11-85F14.5
Illnesses of father: None of the above (group 1)	4.53	1	0	0.0	1	RP11-85F14.5
Number of treatments/medications taken	4.43	1	0	0.0	1	RP11-85F14.5
Relative age voice broke	4.37	1	0	0.0	1	RP11-85F14.5
High blood pressure	4.34	1	0	0.0	1	RP11-85F14.5
Heart disease (siblings)	4.30	1	0	0.0	1	RP11-85F14.5
Type 2 Diabetes (T2D) (2018)	4.28	1	0	0.0	1	RP11-85F14.5
Medication: Paracetamol	4.28	1	0	0.0	1	RP11-85F14.5
Verbal and Numeric Reasoning (VNR)	4.16	1	0	0.0	1	RP11-85F14.5
Average weekly spirits intake	4.14	1	0	0.0	1	RP11-85F14.5
Mother's age at death	4.03	1	0	0.0	1	RP11-85F14.5
Townsend deprivation index at recruitment	3.95	1	0	0.0	1	RP11-85F14.5
Wheeze or whistling in the chest in last year	3.91	1	0	0.0	1	RP11-85F14.5
Commuting to job workplace: Cycle	3.85	1	0	0.0	1	RP11-85F14.5
Birth weight of first child	3.81	1	0	0.0	1	RP11-85F14.5
Qualifications: CSEs or equivalent	3.50	1	0	0.0	1	RP11-85F14.5
Medication: Metformin	3.40	1	0	0.0	1	RP11-85F14.5
Qualifications: None of the above	3.40	1	0	0.0	1	RP11-85F14.5
Risk taking	3.39	1	0	0.0	1	RP11-85F14.5
Pulse wave peak to peak time	3.35	1	0	0.0	1	RP11-85F14.5
Medication for cholesterol	3.31	1	0	0.0	1	RP11-85F14.5
Diabetes (self-reported)	3.26	1	0	0.0	1	RP11-85F14.5
Qualifications: College or University degree	3.15	1	0	0.0	1	RP11-85F14.5
Pack years adult smoking proportion	3.14	1	0	0.0	1	RP11-85F14.5
Blood White Count	3.06	1	0	0.0	1	RP11-85F14.5
Miserableness	3.01	1	0	0.0	1	RP11-85F14.5
Weight	2.97	1	0	0.0	1	RP11-85F14.5
Age at First Birth	2.92	1	0	0.0	1	RP11-85F14.5
Number of live births	2.92	1	0	0.0	1	RP11-85F14.5
Schizophrenia (2014)	2.90	1	0	0.0	1	RP11-85F14.5
Knee pain experienced in last month	2.86	1	0	0.0	1	RP11-85F14.5
Blood Platelet Count	2.72	1	1	2.2	1	RP11-85F14.5
Schizophrenia (2018)	2.70	1	0	0.0	1	RP11-85F14.5
Trunk fat mass	2.69	1	0	0.0	1	RP11-85F14.5
Frequency of tiredness / lethargy in last 2 weeks	2.59	1	0	0.0	1	RP11-85F14.5
Pulse rate, automated reading	2.53	1	0	0.0	1	RP11-85F14.5
Hypothyroidism/myxoedema (self-reported)	2.45	1	0	0.0	1	RP11-85F14.5
Hayfever, allergic rhinitis or eczema	2.37	1	0	0.0	1	RP11-85F14.5
Arm fat-free mass (right)	2.35	1	0	0.0	1	RP11-85F14.5
Arm predicted mass (right)	2.27	1	0	0.0	1	RP11-85F14.5
Forced expiratory volume in 1-second (FEV1), predicted	2.18	1	0	0.0	1	RP11-85F14.5
Nervous feelings	2.15	1	0	0.0	1	RP11-85F14.5
Trunk fat percentage	2.14	1	0	0.0	1	RP11-85F14.5
Bipolar Disorder or Schizophrenia	2.11	1	0	0.0	1	RP11-85F14.5
Irritable Bowel Disease (IBD)	2.11	1	0	0.0	1	RP11-85F14.5
Qualifications: A levels/AS levels or equivalent	2.05	1	0	0.0	1	RP11-85F14.5
Blood Eosinophil Count	1.76	1	0	0.0	1	RP11-85F14.5
Arm predicted mass (left)	1.76	1	0	0.0	1	RP11-85F14.5
Hair/balding pattern: Pattern 4	1.75	1	0	0.0	1	RP11-85F14.5
Arm fat-free mass (left)	1.56	1	0	0.0	1	RP11-85F14.5
Allergy or Eczema	1.53	1	0	0.0	1	RP11-85F14.5
Leg predicted mass (left)	1.49	1	0	0.0	1	RP11-85F14.5
Leg fat-free mass (left)	1.46	1	0	0.0	1	RP11-85F14.5
Basal metabolic rate	1.40	1	0	0.0	1	RP11-85F14.5
Leg fat-free mass (right)	1.16	1	0	0.0	1	RP11-85F14.5
Leg predicted mass (right)	1.11	1	0	0.0	1	RP11-85F14.5
Whole body fat-free mass	0.90	1	0	0.0	1	RP11-85F14.5
Whole body water mass	0.79	1	0	0.0	1	RP11-85F14.5
Blood Red Count	0.55	1	0	0.0	1	RP11-85F14.5

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2