Hub : Traits :

Townsend deprivation index at recruitment

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 127035761 128592201 1 1 7.2e-08 9.9e-05 0.058 76 SCAI

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Age at First Birth 5.28 1 0 0.0 0 1 SCAI
LDL Cholesterol 4.04 1 0 0.0 0 1 SCAI
Primary Biliary Cirrhosis 3.23 1 0 0.0 0 1 SCAI
Blood Red Count 1.07 1 0 0.0 0 1 SCAI
Blood White Count 0.57 1 0 0.0 0 1 SCAI
Heel T-Score 2.53 1 0 0.0 0 1 SCAI
BMI 0.77 1 0 0.0 0 1 SCAI
Height 1.21 1 0 0.0 0 1 SCAI
Waist Hip Ratio (WHR) 5.65 1 0 0.0 0 1 SCAI
Systolic Blood Pressure 1.70 1 0 0.0 0 1 SCAI
Smoking Status 17.53 1 1 2.2 0 1 SCAI
Tanning 2.06 1 0 0.0 0 1 SCAI
Hand grip strength (left) 7.96 1 0 0.0 0 1 SCAI
Number of treatments/medications taken 3.15 1 0 0.0 0 1 SCAI
Sensitivity / hurt feelings 5.57 1 0 0.0 0 1 SCAI
Relative age of first facial hair 2.20 1 0 0.0 0 1 SCAI
Vitamin and mineral supplements 3.41 1 0 0.0 0 1 SCAI
Pack years adult smoking proportion 9.25 1 0 0.0 0 1 SCAI
Leg fat-free mass (left) 0.73 1 0 0.0 0 1 SCAI
Trunk fat percentage 1.74 1 0 0.0 0 1 SCAI
Hand grip strength (right) 9.26 1 0 0.0 0 1 SCAI
Current tobacco smoking 19.41 1 1 2.2 0 1 SCAI
Relative age voice broke 3.15 1 0 0.0 0 1 SCAI
Age when periods started (menarche) 9.56 1 0 0.0 0 1 SCAI
Tinnitus: Yes, but not now, but have in the past 4.07 1 0 0.0 0 1 SCAI
Serious illness, injury or assault to yourself 5.07 1 0 0.0 0 1 SCAI
Stomach or abdominal pain in last month 3.96 1 0 0.0 0 1 SCAI
Sitting height 1.71 1 0 0.0 0 1 SCAI
Leg predicted mass (left) 0.73 1 0 0.0 0 1 SCAI
Waist circumference 2.48 1 0 0.0 0 1 SCAI
Past tobacco smoking 9.38 1 0 0.0 0 1 SCAI
Alcohol usually taken with meals 7.89 1 0 0.0 0 1 SCAI
Forced vital capacity (FVC) 2.54 1 0 0.0 0 1 SCAI
Qualifications: None of the above 6.56 1 0 0.0 0 1 SCAI
Mouth/teeth dental problems 10.87 1 0 0.0 0 1 SCAI
Heart attack 7.93 1 0 0.0 0 1 SCAI
Allergy 2.24 1 0 0.0 0 1 SCAI
Arm fat percentage (right) 1.53 1 0 0.0 0 1 SCAI
Trunk fat-free mass 1.72 1 0 0.0 0 1 SCAI
Forced expiratory volume in 1-second (FEV1) 4.92 1 0 0.0 0 1 SCAI
Pulse rate 8.48 1 0 0.0 0 1 SCAI
Noisy workplace 3.69 1 0 0.0 0 1 SCAI
Qualifications: A levels/AS levels or equivalent 5.09 1 0 0.0 0 1 SCAI
Mouth/teeth dental problems: Dentures 14.32 1 0 0.0 0 1 SCAI
Forced expiratory volume in 1-second (FEV1), Best measure 2.96 1 0 0.0 0 1 SCAI
Trunk predicted mass 1.75 1 0 0.0 0 1 SCAI
Standing height 1.80 1 0 0.0 0 1 SCAI
Seen doctor (GP) for nerves, anxiety, tension or depression 2.88 1 0 0.0 0 1 SCAI
Peak expiratory flow (PEF) 7.83 1 0 0.0 0 1 SCAI
Pulse wave reflection index 8.65 1 0 0.0 0 1 SCAI
Ever highly irritable/argumentative for 2 days 3.30 1 0 0.0 0 1 SCAI
Qualifications: O levels/GCSEs or equivalent 7.02 1 0 0.0 0 1 SCAI
Blood clot in the leg (DVT) 3.90 1 0 0.0 0 1 SCAI
Medication: Paracetamol 2.64 1 0 0.0 0 1 SCAI
Medication: Amlodipine 3.27 1 0 0.0 0 1 SCAI
Medication: Ventolin 100micrograms inhaler 6.52 1 0 0.0 0 1 SCAI
Forced vital capacity (FVC), Best measure 2.05 1 0 0.0 0 1 SCAI
Body fat percentage 1.99 1 0 0.0 0 1 SCAI
Leg fat percentage (right) 2.12 1 0 0.0 0 1 SCAI
Exposure to tobacco smoke outside home 12.62 1 0 0.0 0 1 SCAI
Seen a psychiatrist for nerves, anxiety, tension or depression 4.01 1 0 0.0 0 1 SCAI
Age at first live birth 2.27 1 0 0.0 0 1 SCAI
Health satisfaction 5.39 1 0 0.0 0 1 SCAI
Qualifications: College or University degree 5.42 1 0 0.0 0 1 SCAI
Mouth/teeth dental problems: Loose teeth 8.20 1 0 0.0 0 1 SCAI
Emphysema/chronic bronchitis 14.53 1 0 0.0 0 1 SCAI
Medication for pain relief, constipation, heartburn 3.18 1 0 0.0 0 1 SCAI
Medication: Allopurinol 4.85 1 0 0.0 0 1 SCAI
Pulse rate, automated reading 9.03 1 1 2.2 0 1 SCAI
Comparative height size at age 10 2.38 1 0 0.0 0 1 SCAI
Overall health rating 9.45 1 0 0.0 0 1 SCAI
Age at last live birth 5.17 1 0 0.0 0 1 SCAI
Qualifications: NVQ or HND or HNC or equivalent 5.99 1 0 0.0 0 1 SCAI
Knee pain experienced in last month 15.52 1 0 0.0 0 1 SCAI
Whole body fat-free mass 1.34 1 0 0.0 0 1 SCAI
Arm fat percentage (left) 1.91 1 0 0.0 0 1 SCAI
Average weekly red wine intake 5.65 1 0 0.0 0 1 SCAI
Long-standing illness, disability or infirmity 2.81 1 0 0.0 0 1 SCAI
Qualifications: nursing, teaching 7.09 1 0 0.0 0 1 SCAI
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.70 1 0 0.0 0 1 SCAI
Back pain experienced in last month 5.37 1 0 0.0 0 1 SCAI
Mineral and other dietary supplements 3.53 1 0 0.0 0 1 SCAI
Osteoarthritis (self-reported) 10.04 1 0 0.0 0 1 SCAI
Smoking status: Current 22.48 1 1 2.2 0 1 SCAI
Whole body water mass 1.28 1 0 0.0 0 1 SCAI
Number of self-reported non-cancer illnesses 4.02 1 0 0.0 0 1 SCAI
Average weekly champagne plus white wine intake 6.12 1 0 0.0 0 1 SCAI
Wears glasses or contact lenses 3.33 1 0 0.0 0 1 SCAI
Mother's age at death 11.97 1 0 0.0 0 1 SCAI
Financial situation satisfaction 9.88 1 0 0.0 0 1 SCAI
Supplements: Fish oil (including cod liver oil) 3.12 1 0 0.0 0 1 SCAI
Ever smoked 10.20 1 0 0.0 0 1 SCAI
Basal metabolic rate 0.89 1 0 0.0 0 1 SCAI
Leg fat percentage (left) 2.92 1 0 0.0 0 1 SCAI
Arm fat-free mass (left) 0.83 1 0 0.0 0 1 SCAI
Number of operations (self-reported) 3.39 1 0 0.0 0 1 SCAI
Age started oral contraceptive pill 6.08 1 0 0.0 0 1 SCAI
Diastolic blood pressure, automated reading 2.61 1 0 0.0 0 1 SCAI
Ever depressed for a whole week 4.52 1 0 0.0 0 1 SCAI
Unable to work because of sickness or disability 6.86 1 0 0.0 0 1 SCAI
Myopia 8.99 1 0 0.0 0 1 SCAI
Pain experienced in last month 10.87 1 0 0.0 0 1 SCAI
Heart attack/myocardial infarction (self-reported) 7.93 1 0 0.0 0 1 SCAI
Deep venous thrombosis (DVT) (self-reported) 3.91 1 0 0.0 0 1 SCAI
Pack years of smoking 8.40 1 0 0.0 0 1 SCAI
Arm predicted mass (left) 1.00 1 0 0.0 0 1 SCAI

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 0 0.000 1.5
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.5
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.5
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.5
GTEx Lung 0 0.000 1.5
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.5
GTEx Skin Sun Exposed Lower leg 0 0.000 1.5
GTEx Small Intestine Terminal Ileum 0 0.000 1.6
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.5
GTEx Testis 0 0.000 1.5
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.5
METSIM Adipose 0 0.000 1.4
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.5
YFS Blood 0 0.000 1.4
CommonMind Brain Pre-frontal Cortex 0 0.000 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.5
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4