Hub : Traits :

Medication: Seretide 50 evohaler

6 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 130936652 132425049 3 1 1.8e-07 3.3e-07 0.51 98 SLC22A4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 38.1 1 1 3 0 1 SLC22A4
Irritable Bowel Disease (IBD) 22.3 1 1 3 0 1 SLC22A4
Breast Cancer 5.8 1 0 0 0 1 SLC22A4
Crohns Disease (2012) 27.4 1 1 3 0 1 SLC22A4
Triglycerides 6.8 1 0 0 0 1 SLC22A4
Blood Eosinophil Count 122.5 1 1 3 0 1 SLC22A4
Blood Platelet Count 18.4 1 1 3 0 1 SLC22A4
Blood White Count 29.8 1 1 3 0 1 SLC22A4
Height 22.6 1 1 3 0 1 SLC22A4
Allergy or Eczema 6.8 1 0 0 0 1 SLC22A4
Cardiovascular Disease 4.6 1 0 0 0 1 SLC22A4
Respiratory disease 32.4 1 1 3 0 1 SLC22A4
Lung FEV1/FVC ratio 8.8 1 1 3 0 1 SLC22A4
Lung FVC 13.4 1 1 3 0 1 SLC22A4
Hand grip strength (left) 18.0 1 1 3 0 1 SLC22A4
Number of treatments/medications taken 11.2 1 0 0 0 1 SLC22A4
Leg fat-free mass (left) 13.5 1 1 3 0 1 SLC22A4
Hand grip strength (right) 20.0 1 1 3 0 1 SLC22A4
Taking other prescription medications 7.1 1 0 0 0 1 SLC22A4
High blood pressure 10.8 1 1 3 0 1 SLC22A4
Hayfever, allergic rhinitis or eczema 11.9 1 0 0 0 1 SLC22A4
Sitting height 12.8 1 1 3 0 1 SLC22A4
Impedance of leg (left) 2.2 1 0 0 0 1 SLC22A4
Leg predicted mass (left) 13.5 1 1 3 0 1 SLC22A4
Trunk fat mass 1.8 1 0 0 0 1 SLC22A4
Frequency of tenseness / restlessness in last 2 weeks 7.0 1 0 0 0 1 SLC22A4
Allergy 21.0 1 1 3 0 1 SLC22A4
Weight 6.8 1 1 3 0 1 SLC22A4
Trunk fat-free mass 14.6 1 1 3 0 1 SLC22A4
Father's age at death 15.3 1 0 0 0 1 SLC22A4
Hair/balding pattern: Pattern 3 4.9 1 0 0 0 1 SLC22A4
Forced expiratory volume in 1-second (FEV1) 3.4 1 0 0 0 1 SLC22A4
Asthma 34.6 1 1 3 0 1 SLC22A4
Illnesses of mother 6.5 1 0 0 0 1 SLC22A4
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 1 0 0 0 1 SLC22A4
Trunk predicted mass 14.7 1 1 3 0 1 SLC22A4
Standing height 22.8 1 1 3 0 1 SLC22A4
Birth weight of first child 3.9 1 0 0 0 1 SLC22A4
Peak expiratory flow (PEF) 5.3 1 0 0 0 1 SLC22A4
Medication for cholesterol, blood pressure or diabetes 7.1 1 0 0 0 1 SLC22A4
Medication: Amlodipine 5.7 1 0 0 0 1 SLC22A4
Birth weight 5.0 1 0 0 0 1 SLC22A4
High blood pressure (siblings) 6.4 1 0 0 0 1 SLC22A4
Leg fat percentage (right) 2.0 1 0 0 0 1 SLC22A4
Arm fat-free mass (right) 11.5 1 1 3 0 1 SLC22A4
Exposure to tobacco smoke outside home 6.6 1 0 0 0 1 SLC22A4
Comparative body size at age 10 2.7 1 0 0 0 1 SLC22A4
Wheeze or whistling in the chest in last year 4.9 1 0 0 0 1 SLC22A4
Medication: Blood pressure 8.0 1 0 0 0 1 SLC22A4
Arm predicted mass (right) 11.4 1 1 3 0 1 SLC22A4
Comparative height size at age 10 19.2 1 1 3 0 1 SLC22A4
Illness, injury, bereavement, stress in last 2 years 9.3 1 0 0 0 1 SLC22A4
Hypertension (Self-reported) 9.9 1 1 3 0 1 SLC22A4
Forced expiratory volume in 1-second (FEV1), predicted 15.5 1 1 3 0 1 SLC22A4
Whole body fat-free mass 14.2 1 1 3 0 1 SLC22A4
Leg fat-free mass (right) 12.7 1 1 3 0 1 SLC22A4
Medication for cholesterol 6.0 1 0 0 0 1 SLC22A4
Asthma (self-reported) 34.7 1 1 3 0 1 SLC22A4
Osteoarthritis (self-reported) 5.5 1 0 0 0 1 SLC22A4
Whole body water mass 14.4 1 1 3 0 1 SLC22A4
Leg predicted mass (right) 12.8 1 1 3 0 1 SLC22A4
Number of self-reported non-cancer illnesses 10.8 1 0 0 0 1 SLC22A4
Medication: Blood pressure 14.4 1 1 3 0 1 SLC22A4
Medication: Bendroflumethiazide 15.9 1 0 0 0 1 SLC22A4
Basal metabolic rate 12.9 1 1 3 0 1 SLC22A4
Leg fat percentage (left) 2.7 1 0 0 0 1 SLC22A4
Arm fat-free mass (left) 12.4 1 1 3 0 1 SLC22A4
Diastolic blood pressure, automated reading 5.0 1 0 0 0 1 SLC22A4
Vascular/heart problems diagnosed by doctor 13.6 1 1 3 0 1 SLC22A4
Medication: Omeprazole (e.g. Zanprol) 8.0 1 0 0 0 1 SLC22A4
Arm predicted mass (left) 12.5 1 1 3 0 1 SLC22A4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.13
GTEx Adipose Visceral Omentum 0 0.0000 1.18
GTEx Adrenal Gland 0 0.0000 1.17
GTEx Artery Aorta 0 0.0000 1.12
GTEx Artery Coronary 0 0.0000 1.08
GTEx Artery Tibial 0 0.0000 1.17
GTEx Brain Caudate basal ganglia 0 0.0000 1.16
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.19
GTEx Brain Cerebellum 0 0.0000 1.16
GTEx Brain Cortex 0 0.0000 1.24
GTEx Brain Frontal Cortex BA9 0 0.0000 1.24
GTEx Brain Hippocampus 1 0.1908 1.21
GTEx Brain Hypothalamus 0 0.0000 1.30
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.26
GTEx Brain Putamen basal ganglia 0 0.0000 1.21
GTEx Breast Mammary Tissue 0 0.0000 1.23
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.13
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.19
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.11
GTEx Cells Transformed fibroblasts 0 0.0000 1.20
GTEx Colon Sigmoid 0 0.0000 1.13
GTEx Colon Transverse 0 0.0000 1.15
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.13
GTEx Esophagus Mucosa 1 0.0301 1.12
GTEx Esophagus Muscularis 0 0.0000 1.14
GTEx Heart Atrial Appendage 0 0.0000 1.17
GTEx Heart Left Ventricle 0 0.0000 1.10
GTEx Liver 0 0.0000 1.18
GTEx Lung 1 0.0348 1.12
GTEx Muscle Skeletal 0 0.0000 1.15
GTEx Nerve Tibial 0 0.0000 1.16
GTEx Ovary 0 0.0000 1.13
GTEx Pancreas 0 0.0000 1.15
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.13
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.17
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.21
GTEx Small Intestine Terminal Ileum 0 0.0000 1.25
GTEx Spleen 0 0.0000 1.19
GTEx Stomach 0 0.0000 1.14
GTEx Testis 0 0.0000 1.15
GTEx Thyroid 0 0.0000 1.17
GTEx Uterus 0 0.0000 1.14
GTEx Vagina 0 0.0000 1.16
GTEx Whole Blood 1 0.0502 1.21
METSIM Adipose 1 0.0217 1.14
NTR Blood 0 0.0000 1.22
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.21
YFS Blood 0 0.0000 1.16
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.15
TCGA Breast Tumor 0 0.0000 1.18
TCGA Breast Normal 1 0.0238 1.19
TCGA Ovarian Tumor 0 0.0000 1.13
TCGA Prostate Tumor 0 0.0000 1.15