Hub : Traits :

Knee pain experienced in last month

71 significantly associated models · 16 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 57995734 58815558 1 1 4.6e-08 7.6e-09 0.00514 76 ALDH1A2
2 19 10516198 11004833 1 1 8.9e-08 1.2e-08 0.04630 88 LOC147727
3 20 32865844 34980465 14 1 4.5e-16 4.0e-18 0.00076 85 GDF5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 6.22 1 0 0.0 0 1 LOC147727
Schizophrenia vs Biploar Disorder 3.41 1 0 0.0 0 1 LOC147727
Reaction Time 4.72 1 0 0.0 0 1 LOC147727
Coronary Artery Disease (CAD) 3.47 1 0 0.0 0 1 LOC147727
LDL Cholesterol 7.47 1 0 0.0 0 1 LOC147727
Blood Platelet Count 1.26 1 1 2.2 0 1 LOC147727
Heel T-Score 0.56 1 0 0.0 0 1 GDF5
Height 38.26 2 2 4.4 0 1 GDF5 LOC147727
Waist Hip Ratio (WHR) 5.53 2 1 2.2 0 1 GDF5 LOC147727
Systolic Blood Pressure 2.55 1 1 2.2 0 1 GDF5
Lung FEV1/FVC ratio 2.10 1 1 2.2 0 1 GDF5
Lung FVC 10.43 2 1 2.2 0 1 ALDH1A2 GDF5
Chronotype (morning person) 3.73 1 0 0.0 0 1 LOC147727
Hair Pigment 11.71 2 2 4.4 0 1 GDF5 LOC147727
Tanning 25.05 1 1 2.2 0 1 GDF5
Hand grip strength (left) 13.51 2 1 2.2 0 1 ALDH1A2 GDF5
Relative age of first facial hair 2.02 1 0 0.0 0 1 GDF5
Impedance of leg (right) 4.96 1 1 2.2 0 1 GDF5
Leg fat-free mass (left) 26.00 2 2 4.4 0 1 GDF5 LOC147727
Hand grip strength (right) 18.26 2 1 2.2 0 1 ALDH1A2 GDF5
Relative age voice broke 4.15 1 0 0.0 0 1 GDF5
Sitting height 46.56 2 2 4.4 0 1 GDF5 LOC147727
Impedance of leg (left) 4.91 2 1 2.2 0 1 GDF5 LOC147727
Leg predicted mass (left) 26.02 2 2 4.4 0 1 GDF5 LOC147727
Trunk fat mass 4.26 2 1 2.2 0 1 GDF5 LOC147727
Alcohol usually taken with meals 3.30 1 0 0.0 0 1 GDF5
Forced vital capacity (FVC) 7.05 2 2 4.4 0 1 GDF5 LOC147727
Medication: Simvastatin 3.02 1 0 0.0 0 1 LOC147727
Weight 15.65 2 2 4.4 0 1 GDF5 LOC147727
Impedance of arm (right) 1.67 1 0 0.0 0 1 GDF5
Trunk fat-free mass 34.78 2 2 4.4 0 1 GDF5 LOC147727
Hip circumference 10.69 2 2 4.4 0 1 GDF5 LOC147727
Forced expiratory volume in 1-second (FEV1) 7.29 2 2 4.4 0 1 GDF5 LOC147727
Qualifications: A levels/AS levels or equivalent 3.32 1 0 0.0 0 1 GDF5
Medication: Cholesterol lowering 4.78 1 0 0.0 0 1 LOC147727
Medication: Lansoprazole 3.74 1 0 0.0 0 1 GDF5
Forced expiratory volume in 1-second (FEV1), Best measure 8.53 2 2 4.4 0 1 GDF5 LOC147727
Impedance of arm (left) 1.36 1 0 0.0 0 1 GDF5
Arm fat mass (right) 2.26 1 0 0.0 0 1 GDF5
Trunk predicted mass 34.98 2 2 4.4 0 1 GDF5 LOC147727
Standing height 39.74 2 2 4.4 0 1 GDF5 LOC147727
Birth weight of first child 3.72 1 0 0.0 0 1 LOC147727
Peak expiratory flow (PEF) 13.64 2 1 2.2 0 1 GDF5 LOC147727
Blood clot in the leg (DVT) 6.48 2 0 0.0 0 1 GDF5 LOC147727
Birth weight 3.58 1 0 0.0 0 1 GDF5
Forced vital capacity (FVC), Best measure 8.73 2 2 4.4 0 1 GDF5 LOC147727
Leg fat percentage (right) 2.69 1 1 2.2 0 1 GDF5
Arm fat-free mass (right) 29.31 2 2 4.4 0 1 GDF5 LOC147727
Qualifications: College or University degree 2.35 1 0 0.0 0 1 GDF5
Neck or shoulder pain in last month 5.05 1 0 0.0 0 1 LOC147727
Mean time to correctly identify matches 3.89 1 0 0.0 0 1 LOC147727
Whole body fat mass 2.92 1 1 2.2 0 1 GDF5
Arm predicted mass (right) 29.35 2 2 4.4 0 1 GDF5 LOC147727
Comparative height size at age 10 33.97 2 2 4.4 0 1 GDF5 LOC147727
Forced expiratory volume in 1-second (FEV1), predicted 19.76 2 1 2.2 0 1 GDF5 LOC147727
Whole body fat-free mass 32.24 2 2 4.4 0 1 GDF5 LOC147727
Leg fat-free mass (right) 27.33 2 2 4.4 0 1 GDF5 LOC147727
Osteoarthritis (self-reported) 7.19 1 0 0.0 0 1 LOC147727
Whole body water mass 31.46 2 2 4.4 0 1 GDF5 LOC147727
Leg predicted mass (right) 27.40 2 2 4.4 0 1 GDF5 LOC147727
Arm fat mass (left) 2.61 2 0 0.0 0 1 GDF5 LOC147727
High cholesterol (Self-reported) 4.38 1 0 0.0 0 1 LOC147727
Basal metabolic rate 28.56 2 2 4.4 0 1 GDF5 LOC147727
Leg fat percentage (left) 2.35 1 0 0.0 0 1 GDF5
Arm fat-free mass (left) 28.21 2 2 4.4 0 1 GDF5 LOC147727
Pain experienced in last month 4.57 1 0 0.0 0 1 LOC147727
Deep venous thrombosis (DVT) (self-reported) 6.33 1 0 0.0 0 1 GDF5
Heart disease (siblings) 3.66 1 0 0.0 0 1 LOC147727
Impedance of whole body 2.89 1 1 2.2 0 1 GDF5
Arm predicted mass (left) 28.67 2 2 4.4 0 1 GDF5 LOC147727

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.6
GTEx Adipose Visceral Omentum 1 0.049 1.6
GTEx Adrenal Gland 1 0.069 1.7
GTEx Artery Aorta 0 0.000 1.6
GTEx Artery Coronary 0 0.000 1.5
GTEx Artery Tibial 0 0.000 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 2 0.134 1.7
GTEx Brain Cerebellum 2 0.101 1.7
GTEx Brain Cortex 2 0.193 1.6
GTEx Brain Frontal Cortex BA9 2 0.216 1.8
GTEx Brain Hippocampus 0 0.000 1.6
GTEx Brain Hypothalamus 1 0.169 1.6
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.6
GTEx Brain Putamen basal ganglia 0 0.000 1.6
GTEx Breast Mammary Tissue 0 0.000 1.6
GTEx Breast Mammary Tissue (Male) 1 0.084 1.6
GTEx Breast Mammary Tissue (Female) 0 0.000 1.5
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.5
GTEx Cells Transformed fibroblasts 2 0.048 1.6
GTEx Colon Sigmoid 0 0.000 1.6
GTEx Colon Transverse 0 0.000 1.6
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.6
GTEx Esophagus Mucosa 2 0.060 1.6
GTEx Esophagus Muscularis 0 0.000 1.6
GTEx Heart Atrial Appendage 0 0.000 1.6
GTEx Heart Left Ventricle 0 0.000 1.6
GTEx Liver 0 0.000 1.6
GTEx Lung 1 0.035 1.6
GTEx Muscle Skeletal 3 0.104 1.6
GTEx Nerve Tibial 1 0.023 1.6
GTEx Ovary 0 0.000 1.6
GTEx Pancreas 1 0.061 1.7
GTEx Pituitary 0 0.000 1.6
GTEx Prostate 0 0.000 1.7
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.6
GTEx Skin Sun Exposed Lower leg 1 0.027 1.6
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.6
GTEx Stomach 1 0.069 1.5
GTEx Testis 0 0.000 1.5
GTEx Thyroid 0 0.000 1.6
GTEx Uterus 0 0.000 1.7
GTEx Vagina 0 0.000 1.6
GTEx Whole Blood 0 0.000 1.6
METSIM Adipose 2 0.043 1.5
NTR Blood 1 0.042 1.5
ROSMAP Brain Pre-frontal Cortex 3 0.068 1.6
YFS Blood 3 0.065 1.4
CommonMind Brain Pre-frontal Cortex 1 0.019 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 3 0.068 1.5
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.5
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.7
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.7
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.6
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.073 1.5
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.6
The Cancer Genome Atlas Brain Lower Grade Glioma 3 0.070 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.6
The Cancer Genome Atlas Lung Adenocarcinoma 3 0.102 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.6
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.6
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 4 0.087 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.6
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.6
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.6
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.197 1.6