TWAS hub - EIF4EBP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0280	0.0150	0.01700	0.000	0.010	0.001	0.010	0.000	3.0e-01	1.7e-02	0.25000	1.7e-02	2.9e-01
2	GTEx	Muscle Skeletal	0.0563	0.0304	0.00880	0.015	NA	0.014	NA	0.015	1.1e-02	NA	0.01500	NA	1.1e-02
3	METSIM	Adipose	0.0786	0.0283	0.00032	0.019	0.035	0.015	0.033	0.015	6.8e-04	4.8e-06	0.00190	9.2e-06	1.9e-03
4	TCGA	Lung Squamous Cell Carcinoma	0.0318	0.0241	0.00010	0.037	0.032	0.028	NA	0.034	4.6e-05	1.2e-04	0.00032	NA	7.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Had menopause	13.9	17.4	33.9	3.6	0.1	4.8	5.8
Ever used hormone-replacement therapy (HRT)	10.1	12.9	29.3	3.8	1.2	2.5	5.4
Medication for hormone replacement therapy	7.1	7.9	10.7	3.3	1.0	3.2	3.1
Risk taking	4.0	5.8	9.7	3.1	2.6	2.4	0.9
Noisy workplace	3.8	4.7	9.0	3.0	-0.1	2.0	2.4
Glaucoma (self-reported)	3.5	4.1	8.3	1.6	0.6	2.3	2.9
Medication: Aspirin	3.0	4.0	7.1	1.9	-1.8	1.4	2.7
Breast Cancer	2.8	6.8	14.2	1.2	-0.1	3.4	3.8
Mother’s age at death	2.7	3.4	8.1	2.0	0.4	1.2	2.8
Ever had prostate specific antigen (PSA) test	2.7	3.2	8.5	0.1	1.2	2.9	1.6
Bipolar Disorder or Schizophrenia	2.6	6.4	24.4	4.9	0.5	1.1	0.0
Diabetes (father)	2.6	3.2	5.9	-1.7	-2.4	-1.9	-0.6
Diabetes (mother)	2.6	3.3	6.3	2.5	0.0	1.0	2.4
Pack years adult smoking proportion	2.5	3.9	6.8	2.3	0.0	2.6	1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	8.6	-0.5	2.9	-1.3	-0.5
Pack years of smoking	2.5	3.7	6.4	2.2	-0.2	2.5	1.9
Medication: Aspirin	2.3	3.1	5.3	1.8	-1.7	0.9	2.3
Ovarian Cancer	2.2	2.9	5.0	1.4	1.1	2.2	1.8
Rheumatoid Arthritis	2.1	2.9	8.3	2.9	-0.0	1.8	0.0
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	4.0	-0.5	1.5	-2.0	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	4.3	-1.7	1.5	-0.6	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.9	-0.5	-0.3	-2.2	-2.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	6.7	-1.2	-0.8	-2.6	-0.6
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	8.3	0.1	-0.2	-2.7	-2.9
Bipolar Disorder (2018)	1.9	3.0	11.6	3.4	0.1	0.8	0.0
Mean Putamen Volume	1.9	2.2	7.3	1.0	2.7	0.7	0.0
Chronotype (morning person)	1.9	4.4	10.8	-2.0	1.3	-1.0	-3.3
Age when periods started (menarche)	1.9	4.6	9.6	0.6	-0.1	3.1	2.9
Had major operations	1.9	2.3	6.8	1.0	-0.2	2.6	1.1
Illnesses of siblings: Diabetes	1.8	2.3	3.5	1.5	-1.3	1.9	1.2
Handedness (chirality/laterality): Left-handed	1.8	2.1	3.0	-1.7	-1.6	-1.7	-0.3
Schizophrenia (2014)	1.7	3.7	14.4	3.8	0.2	0.5	0.0
Heart attack	1.7	2.1	6.6	-0.7	-2.6	-1.0	-0.6
Number of children fathered	1.7	1.9	2.7	1.1	1.7	1.4	1.3
Mouth/teeth dental problems: Loose teeth	1.7	2.0	3.7	-0.1	1.9	1.7	1.1
Illnesses of father: None of the above (group 1)	1.7	2.1	5.3	1.1	2.3	1.4	0.0
Financial situation satisfaction	1.7	2.1	6.0	0.9	-1.0	0.8	2.5
Basal cell carcinoma (self-reported)	1.7	2.1	5.9	-0.4	2.4	1.4	-0.2
Heart attack/myocardial infarction (self-reported)	1.7	2.2	7.1	-0.7	-2.7	-1.0	-0.7
Loud music exposure frequency	1.6	1.7	6.0	0.4	0.6	0.5	2.5
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	7.2	0.5	2.7	1.7	-0.3
Schizophrenia (2018)	1.5	3.1	11.3	3.4	0.5	1.0	0.0
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.1	-1.8	-0.9	-1.4	-0.9
Medication: Ramipril	1.5	1.9	5.0	-1.0	-2.2	-0.9	1.0
Birth weight of first child	1.5	2.8	4.9	-2.2	-0.4	-2.0	-1.4
Worry too long after embarrassment	1.5	2.5	6.8	2.6	0.9	0.4	1.4
Emphysema/chronic bronchitis	1.5	1.7	3.1	-0.8	1.5	-1.0	-1.8
Alcohol intake frequency.	1.5	3.4	7.7	-1.4	-1.5	-2.8	-1.3
Hypothyroidism (self reported)	1.4	3.2	6.4	0.5	-0.7	-2.4	-2.5
Medication: Atenolol	1.4	1.7	2.9	-1.1	-1.7	-1.6	-0.5
Medication: Simvastatin	1.4	2.0	6.8	-0.6	-2.6	-0.9	-0.0
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.8	2.2	0.9	0.1	1.0
Cardiovascular Disease	1.3	4.2	7.6	-2.2	-2.8	-1.9	-0.8
Lung FVC	1.3	6.6	16.3	-3.1	-4.0	0.1	0.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.9	1.7	1.5	0.9	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.4	-1.3	-1.5	-1.2	-1.2
Medication: Blood pressure	1.3	2.3	5.3	-1.2	-2.3	-1.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.9	0.1	2.4	-0.1	0.1
Breast cancer (self-reported)	1.3	1.5	4.4	-0.8	0.7	-0.8	-2.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.7	0.4	-1.9	-0.5	1.0
Financial difficulties in last 2 years	1.2	1.6	3.8	1.2	0.1	2.0	1.0
Mouth/teeth dental problems	1.2	1.9	3.4	-1.0	-1.3	-1.8	-1.2
Medication: Cholesterol lowering	1.2	1.9	6.1	0.1	-2.5	-1.1	0.5
Headache pain in last month	1.2	2.0	4.0	1.9	2.0	0.5	0.5
Wears glasses or contact lenses	1.2	1.3	4.6	-2.2	-0.8	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.6	-0.2	-1.6	0.9	1.5
Systolic Blood Pressure	1.1	5.7	18.3	-4.3	-1.1	-1.7	0.3
Average weekly spirits intake	1.1	1.4	4.2	2.0	-0.1	-0.9	-0.7
Townsend deprivation index at recruitment	1.1	1.6	5.6	-0.2	-2.4	-0.6	0.6
Stomach or abdominal pain in last month	1.1	1.3	2.4	1.6	0.9	1.0	1.0
Medication: Levothyroxine sodium	1.1	1.8	4.6	0.1	-0.0	-1.6	-2.1
Fluid intelligence score	1.1	2.4	5.4	-1.1	1.4	-0.9	-2.3
Time employed in main current job	1.1	1.2	2.4	-0.9	0.0	-1.5	-1.3
Father’s age at death	1.1	1.5	5.0	-0.4	-2.2	-0.9	0.2
Breastfed as a baby	1.1	1.4	3.7	-0.3	-1.9	1.3	0.3
Medication: Ibuprofen	1.1	1.3	1.8	-0.9	-1.2	-1.3	-1.1
Osteoporosis (self-reported)	1.1	1.4	3.2	1.3	0.6	0.6	1.8
Eye problems/disorders: Glaucoma	1.1	1.4	3.3	0.9	-0.4	1.1	1.8
High cholesterol (Self-reported)	1.1	1.9	3.8	-0.8	-2.0	-1.4	-1.2
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.3	-1.3	1.8	-0.0	-2.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.8	1.7	0.2	-0.5	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.2	0.4	1.8	1.7	0.3
Number of live births	1.0	1.4	4.5	-0.4	0.8	-2.1	-0.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.1	-1.8	0.7	-1.3	-1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	4.0	-0.3	0.9	2.0	-0.4
Number of full brothers	1.0	1.2	2.7	-0.5	0.3	-1.7	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.0	0.7	0.4	0.9	1.7
Lupus	0.9	1.4	3.5	0.4	1.9	0.1	-1.4
Systolic blood pressure, automated reading	0.9	2.6	7.6	-2.8	-0.4	-1.6	-0.5
Illnesses of mother	0.9	1.2	2.6	1.0	1.6	0.8	-0.6
Hair/balding pattern: Pattern 4	0.9	2.2	4.7	-1.0	-1.7	2.2	-0.5
Medication: Seretide 50 evohaler	0.9	1.0	1.2	-1.0	-1.0	1.1	0.9
Heart disease (mother)	0.9	1.1	2.2	-1.4	-1.5	0.2	0.5
Age at last live birth	0.9	1.3	1.8	-1.0	1.0	-1.1	-1.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.0	1.3	-1.4	-0.6	-0.1
Eye problems/disorders: Cataract	0.9	1.0	1.6	-0.9	-1.3	-0.6	1.2
Number of self-reported non-cancer illnesses	0.9	1.5	2.4	1.4	-1.2	0.4	1.6
Medication: Lisinopril	0.9	1.2	2.5	0.3	-1.4	0.5	1.6
Fasting Glucose	0.8	0.9	3.3	-0.4	1.8	0.3	0.0
Neuroticism (2016)	0.8	1.1	2.8	1.2	-0.0	-0.4	1.7
High blood pressure (mother)	0.8	1.1	2.6	-1.6	-0.3	-1.3	0.2
Alcohol usually taken with meals	0.8	1.3	3.9	-2.0	-0.4	0.9	-0.4
Had other major operations	0.8	1.0	2.0	-0.9	1.4	-0.2	-1.1
Lung cancer (father)	0.8	0.9	2.9	-0.0	-0.1	1.7	-0.9
Tense / ‘highly strung’	0.8	1.3	2.3	1.5	0.8	-1.5	0.2
Gout (self-reported)	0.8	1.1	2.6	1.6	1.2	-0.1	0.6
Medication: Allopurinol	0.8	1.0	2.3	1.5	1.3	-0.6	0.1
Medication: Omeprazole	0.8	1.0	2.2	-0.3	-1.1	0.7	1.5
Number of full sisters	0.8	1.0	1.5	1.2	0.6	1.0	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.1	-1.4	0.9	0.3	-0.9
Back pain experienced in last month	0.8	1.1	2.5	-1.6	-1.3	-0.1	0.5
Miserableness	0.8	1.5	3.1	1.3	1.0	0.4	1.8
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.2	0.5	1.3	-1.2	-2.3
Prostate Cancer	0.7	0.9	1.6	-1.0	1.3	-0.3	-1.1
LDL Cholesterol	0.7	1.1	3.4	0.6	1.9	0.9	0.0
Primary Biliary Cirrhosis	0.7	1.0	1.9	1.4	0.2	0.7	1.2
Smoking Status	0.7	1.7	4.1	2.0	0.7	1.4	0.3
Multivitamins +/- minerals	0.7	0.9	1.0	0.9	1.0	0.9	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.5	0.4	1.9	0.3	0.7
Hearing difficulty/problems with background noise	0.7	1.1	3.6	1.9	0.9	0.4	-0.1
High blood pressure (siblings)	0.7	1.0	3.2	0.3	0.8	0.3	1.8
Comparative body size at age 10	0.7	1.9	4.4	2.1	1.2	1.3	-0.3
Leg pain on walking	0.7	0.9	3.3	-0.0	-0.2	-1.8	-0.5
Arm fat percentage (left)	0.7	2.7	4.3	-1.9	-0.9	-2.1	-1.5
Medication for cholesterol	0.7	1.1	1.9	-0.8	0.9	-0.9	-1.4
Myopia	0.7	1.0	3.3	-1.8	0.6	0.6	-0.1
Allergy or Eczema	0.6	1.5	4.7	-2.2	-1.1	0.1	0.2
Angina	0.6	0.8	1.4	-0.6	-1.1	-1.2	-0.0
Medication: Co-codamol	0.6	0.7	1.9	0.2	-1.4	-0.9	0.5
Hand grip strength (right)	0.6	1.5	3.1	0.2	0.2	-1.8	-1.7
Supplements: Glucosamine	0.6	0.8	1.8	-1.3	-0.6	-0.2	-1.0
Number of incorrect matches in round	0.6	1.0	2.8	-0.4	-0.4	-1.0	-1.7
Depression (self-reported)	0.6	0.7	1.2	0.7	-1.1	-1.1	0.4
Medication: Lansoprazole	0.6	0.7	1.7	0.9	-0.5	-0.1	1.3
Impedance of arm (left)	0.6	2.7	9.9	-3.1	-0.5	-0.9	-0.3
Length of working week for main job	0.6	0.6	2.1	-0.5	-0.0	-0.4	-1.5
Exposure to tobacco smoke at home	0.6	0.7	1.6	-0.4	-0.3	1.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.5	1.6	0.7	-0.6	0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.7	0.6	1.3	1.0	0.5
Medication for pain relief, constipation, heartburn	0.6	0.9	2.0	0.5	1.4	0.3	-1.2
Angina (self-reported)	0.6	0.9	1.5	-0.8	-1.1	-1.2	-0.2
Suffer from ‘nerves’	0.6	0.9	3.0	-0.0	0.2	-1.7	-0.8
Knee pain experienced in last month	0.6	1.0	3.6	0.2	1.9	0.1	-0.6
Illnesses of father: Heart disease	0.6	0.8	1.6	0.7	-1.3	-0.7	0.7
Average weekly red wine intake	0.6	0.8	3.2	0.1	0.2	1.8	-0.3
Commuting to job workplace: Walk	0.6	0.6	1.8	0.5	0.5	1.3	0.4
Commuting to job workplace: Public transport	0.6	0.8	2.4	-1.6	0.1	0.4	-0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.6	1.2	-0.9	-0.5	-0.6
Medication: Paracetamol	0.6	1.0	3.3	-1.8	0.3	-0.7	0.2
Medication: Atorvastatin	0.6	0.7	1.4	1.2	-0.6	0.4	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.1	1.0	1.8	1.4	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	-0.2	-0.6	-0.4	-1.4
Major Depression (MDD)	0.5	0.6	1.1	0.6	-0.2	-1.1	-0.9
Crohns Disease (2012)	0.5	0.7	2.5	1.6	0.6	0.3	0.0
Blood White Count	0.5	3.6	10.4	-1.9	-3.2	-0.3	-0.5
Number of treatments/medications taken	0.5	1.0	2.3	0.4	-1.2	-0.2	1.5
Sensitivity / hurt feelings	0.5	0.9	1.6	1.2	0.7	0.2	1.3
Hearing difficulty/problems: Yes	0.5	0.7	2.2	1.5	0.1	0.8	-0.0
Impedance of leg (right)	0.5	2.4	6.5	-2.6	-0.5	0.3	1.6
Trunk fat percentage	0.5	2.1	4.3	-1.7	-0.6	-2.1	-0.9
Taking other prescription medications	0.5	0.8	2.0	1.4	0.6	-0.2	0.8
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.2	-2.0	-0.0	-0.1	-0.5
Prospective memory result	0.5	0.6	1.8	0.6	-0.4	-0.1	1.3
Peak expiratory flow (PEF)	0.5	1.1	3.9	2.0	-0.8	0.0	0.1
Medication: Paracetamol	0.5	0.8	2.7	-1.6	0.5	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	1.0	-0.8	-0.6	0.8
Body fat percentage	0.5	2.1	3.8	-1.9	-0.7	-1.9	-0.9
Age at first live birth	0.5	0.8	1.5	-1.2	1.2	0.0	-0.6
Family relationship satisfaction	0.5	0.6	1.3	1.0	0.1	0.3	1.1
Ever had bowel cancer screening	0.5	0.6	1.0	1.0	1.0	-0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	0.7	-0.2	1.3	0.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.2	0.4	0.0	-0.2	-1.5
Medication: Blood pressure	0.5	1.0	2.2	-1.5	-1.0	-0.7	0.4
Medication: Bendroflumethiazide	0.5	0.8	3.0	-1.7	-0.3	-0.1	0.3
Fractured/broken bones in last 5 years	0.5	0.6	1.1	0.9	0.3	1.1	0.8
Unable to work because of sickness or disability	0.5	0.7	2.0	-1.4	-0.2	0.7	-0.4
Impedance of whole body	0.5	2.3	8.0	-2.8	-0.5	-0.5	0.9
Age at First Birth	0.4	0.5	2.0	-1.4	-0.3	-0.0	0.0
Ulcerative Colitis	0.4	0.5	1.9	1.4	-0.5	-0.1	0.0
Leg fat-free mass (left)	0.4	1.9	4.6	2.1	0.0	-1.1	-1.4
Current tobacco smoking	0.4	0.6	0.8	0.9	0.9	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.2	0.1	1.0	1.1	1.0
High blood pressure	0.4	1.2	1.7	-0.9	-1.2	-1.3	0.9
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	-0.0	-0.9	0.8	-0.8
Impedance of leg (left)	0.4	2.2	6.6	-2.6	-0.5	-0.2	1.3
Leg predicted mass (left)	0.4	2.0	4.7	2.2	0.1	-1.0	-1.4
Trunk fat mass	0.4	1.6	4.3	-0.8	-0.4	-2.1	-1.1
Nervous feelings	0.4	0.7	1.2	0.7	-0.5	-1.1	1.0
Hair/balding pattern: Pattern 2	0.4	0.6	1.2	-0.6	0.4	0.7	1.1
Impedance of arm (right)	0.4	1.7	6.7	-2.6	-0.5	-0.2	-0.0
Arm fat percentage (right)	0.4	1.7	3.2	-1.3	-0.8	-1.8	-1.2
Trunk fat-free mass	0.4	2.1	6.8	2.6	0.6	-0.6	-0.9
Falls in the last year	0.4	0.6	0.8	0.9	0.8	-0.7	0.5
Pulse rate	0.4	0.6	1.8	-1.3	-0.6	-0.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-1.6	-0.3	-0.9	-0.7
Trunk predicted mass	0.4	2.0	6.7	2.6	0.5	-0.6	-0.9
Pulse wave reflection index	0.4	0.5	1.3	0.5	1.1	0.6	0.0
Medication: Amlodipine	0.4	0.6	2.2	-0.5	-0.2	-0.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	0.7	0.2	-1.1	-0.7
Migraine (self-reported)	0.4	0.4	1.6	0.3	-1.3	-0.2	0.2
Pulse rate, automated reading	0.4	1.3	2.1	-1.3	-1.5	-0.0	1.1
Hypertension (Self-reported)	0.4	1.2	1.8	-1.1	-1.2	-1.3	0.6
Smoking status: Previous	0.4	0.6	1.9	0.5	0.3	0.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.8	1.3	1.1	-0.5	0.6
Whole body fat-free mass	0.4	2.2	6.1	2.5	0.4	-1.0	-1.2
Leg fat-free mass (right)	0.4	2.3	5.8	2.4	0.3	-1.1	-1.4
Loneliness, isolation	0.4	0.6	1.8	-0.0	-0.7	-0.3	1.3
Friendships satisfaction	0.4	0.5	1.4	-0.7	-1.2	0.0	-0.1
Qualifications: nursing, teaching	0.4	0.7	1.8	-0.8	-1.3	-0.4	-0.5
Medication: Gliclazide	0.4	0.4	1.1	0.6	-1.0	0.3	0.5
Smoking status: Current	0.4	0.6	0.8	0.6	0.7	0.8	-0.9
Whole body water mass	0.4	2.0	5.7	2.4	0.4	-0.9	-1.3
Leg predicted mass (right)	0.4	2.3	5.7	2.4	0.2	-1.1	-1.4
Arm fat mass (left)	0.4	1.5	3.8	-0.4	-0.4	-1.9	-1.4
Guilty feelings	0.4	0.5	1.1	1.1	0.9	0.4	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.4	-1.2	-0.1	-0.1	-0.9
Leg fat percentage (left)	0.4	1.3	2.4	-1.6	-1.1	-1.2	-0.4
Diastolic blood pressure, automated reading	0.4	1.2	3.1	-1.8	0.5	-1.0	-0.5
Commuting to job workplace: Cycle	0.4	0.5	1.5	1.2	-0.1	0.4	0.5
Pain experienced in last month	0.4	0.7	1.5	-1.2	-0.9	0.2	-0.4
Heart disease (siblings)	0.4	0.5	1.1	0.6	-1.0	0.2	0.6
Alcohol drinker status: Previous	0.4	0.4	1.3	0.6	-0.0	-0.1	-1.1
Neuroticism (Nagel 2018)	0.3	0.7	1.5	0.9	1.2	-0.5	0.7
Worry (Nagel 2018)	0.3	0.6	1.8	0.6	0.2	-1.3	-0.1
Ulcerative Colitis (UC)	0.3	0.5	1.1	0.9	-1.1	0.0	-0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	1.0	0.8	-0.1	0.0
HbA1C	0.3	0.3	0.5	0.6	0.6	0.7	0.0
Height	0.3	5.2	10.7	1.7	1.1	-2.5	-3.3
Waist Hip Ratio (WHR)	0.3	1.2	2.3	0.5	-1.5	-0.3	1.4
Respiratory disease	0.3	0.7	1.5	-1.2	-0.4	0.0	-1.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.2	-0.4	-0.9	-0.6
Average weekly fortified wine intake	0.3	0.3	0.8	-0.5	0.9	-0.1	-0.5
Fed-up feelings	0.3	0.5	0.6	-0.7	0.8	-0.8	0.6
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.7	0.2	1.0	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.8	0.4	-0.8	0.3
Forced vital capacity (FVC)	0.3	1.0	3.1	-0.5	-1.8	-0.7	0.4
Pain all over the body in last month	0.3	0.3	1.1	0.0	0.2	-0.5	1.0
Diabetes (self-reported)	0.3	0.5	1.3	1.1	-0.8	0.3	0.1
Neuroticism score	0.3	0.7	1.4	1.2	0.8	-0.2	0.8
Weight	0.3	1.2	2.4	0.8	0.0	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.0	-0.1	-1.7	-0.6	0.6
Happiness	0.3	0.4	0.6	-0.6	-0.7	0.1	0.8
Arm fat mass (right)	0.3	1.2	3.2	-0.1	-0.3	-1.8	-1.2
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.4	1.1	0.4	-0.1
Leg fat percentage (right)	0.3	1.2	2.4	-1.6	-1.1	-1.0	-0.1
Arm fat-free mass (right)	0.3	1.7	4.7	2.2	0.4	-1.1	-0.9
Exposure to tobacco smoke outside home	0.3	0.4	1.0	1.0	0.5	0.5	0.5
Mean time to correctly identify matches	0.3	0.5	0.8	0.7	0.8	-0.2	-0.9
Arm predicted mass (right)	0.3	1.7	4.3	2.1	0.5	-1.2	-0.9
Comparative height size at age 10	0.3	1.4	3.1	1.8	-1.0	-1.2	-0.0
Chest pain or discomfort	0.3	0.5	1.7	1.3	-0.1	0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	0.8	-0.6	0.3	0.5
Mineral and other dietary supplements	0.3	0.4	1.1	1.1	0.1	0.1	0.8
Average weekly champagne plus white wine intake	0.3	0.4	1.1	-0.0	-1.1	0.2	-0.6
Ever taken oral contraceptive pill	0.3	0.3	1.3	0.0	-1.2	-0.1	0.0
Hearing aid user	0.3	0.4	1.2	-0.2	-0.5	-0.1	1.1
Illnesses of father: High blood pressure	0.3	0.4	0.8	-0.9	-0.3	0.5	0.6
Alcohol drinker status: Never	0.3	0.4	1.0	-0.2	-0.6	-1.0	-0.2
Ever smoked	0.3	0.5	0.8	0.8	0.3	0.9	0.8
Basal metabolic rate	0.3	1.7	4.5	2.1	0.2	-1.1	-1.2
Arm fat-free mass (left)	0.3	1.6	5.2	2.3	0.5	-0.8	-0.7
Number of operations (self-reported)	0.3	0.5	1.0	0.9	1.0	0.2	0.3
Average weekly beer plus cider intake	0.3	0.4	0.8	0.9	-0.6	-0.4	0.4
Arm predicted mass (left)	0.3	1.7	5.4	2.3	0.5	-0.8	-0.8
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	-0.1	1.1	-0.5	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.3	0.7	0.3	0.3
Reaction Time	0.2	0.4	0.7	0.8	0.8	0.2	-0.3
Blood Eosinophil Count	0.2	1.3	3.0	1.1	-0.5	0.7	1.7
Blood Platelet Count	0.2	1.8	4.2	-1.1	2.1	-0.4	-1.2
Heel T-Score	0.2	1.4	2.3	-1.5	1.3	0.6	-1.0
BMI	0.2	1.4	3.1	1.3	-0.8	-1.8	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.1	0.3	-1.1	0.0	0.4
Lung FEV1/FVC ratio	0.2	0.9	2.5	1.6	-0.8	-0.1	0.7
Neuroticism	0.2	0.6	1.3	1.1	0.4	-0.6	0.7
Hand grip strength (left)	0.2	0.5	1.0	0.4	-0.6	-1.0	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	0.6	-0.5	-0.6	0.4
Relative age of first facial hair	0.2	0.3	0.7	-0.1	0.5	0.6	-0.8
Supplements: Zinc	0.2	0.2	0.6	0.1	0.8	-0.2	-0.5
Medication: Metformin	0.2	0.3	0.7	0.0	-0.5	0.8	0.3
Severe depression (siblings)	0.2	0.3	0.9	1.0	-0.3	-0.2	-0.1
Maternal smoking around birth	0.2	0.2	0.4	0.4	0.6	-0.3	-0.5
Body mass index (BMI)	0.2	0.7	1.7	0.2	-0.4	-1.3	-1.0
Waist circumference	0.2	0.7	2.4	0.7	-0.2	-1.5	-0.2
Past tobacco smoking	0.2	0.3	0.6	-0.3	-0.2	-0.8	-0.7
Qualifications: None of the above	0.2	0.5	0.9	0.9	-0.5	0.3	0.9
Allergy	0.2	0.5	1.5	1.2	-0.1	-0.2	0.6
Illnesses of siblings	0.2	0.3	0.9	-0.6	-0.1	-0.1	-0.9
Hip circumference	0.2	0.8	2.0	0.2	0.3	-1.4	-1.1
Worrier / anxious feelings	0.2	0.4	0.9	0.6	0.7	0.2	0.9
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	0.4	1.0	-0.1	0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.3	0.6	0.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	0.2	-1.1	0.1	1.2
Forced vital capacity (FVC), Best measure	0.2	0.8	1.7	0.3	-1.2	0.2	1.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.1	0.8	0.4	-0.8
Pulse wave peak to peak time	0.2	0.2	0.9	0.1	-0.9	0.0	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.7	0.2	-0.1	-0.9	-0.0
Qualifications: College or University degree	0.2	0.7	1.5	1.2	0.7	0.7	-0.7
Neck or shoulder pain in last month	0.2	0.3	0.5	0.5	0.4	-0.7	0.7
Whole body fat mass	0.2	1.0	3.2	-0.3	-0.2	-1.8	-0.9
Overall health rating	0.2	0.5	1.5	-0.3	0.2	-1.2	-0.6
Mood swings	0.2	0.4	0.6	0.7	0.5	0.4	0.8
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.2	-1.0	0.4	0.1
Asthma (self-reported)	0.2	0.4	1.5	0.0	-0.0	1.2	-0.2
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.2	0.1	-0.9	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.3	0.3	-0.5	-0.4	1.1
Irritability	0.2	0.4	0.6	0.7	0.7	0.8	-0.3
Age started oral contraceptive pill	0.2	0.2	0.5	-0.1	0.2	0.5	0.7
Ever depressed for a whole week	0.2	0.2	0.4	0.2	-0.6	-0.2	0.5
Cholesterol lowering medication	0.2	0.3	1.3	0.0	-1.1	0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.6	0.7	0.1	-0.1
Depression (Nagel 2018)	0.1	0.2	0.3	0.6	-0.3	-0.5	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	0.7	-0.1	-0.3	-0.2
Crohns Disease (2017)	0.1	0.3	0.6	0.4	0.8	-0.7	-0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.9	0.2	-0.6	-0.3
Triglycerides	0.1	0.2	0.4	0.6	-0.2	0.4	0.0
Blood Red Count	0.1	1.4	4.5	-0.5	-0.7	2.1	-0.5
Hair Pigment	0.1	1.8	3.3	-0.9	1.2	-1.8	-1.2
Tanning	0.1	1.2	1.9	-1.4	-1.2	-0.0	-1.1
Vitamin and mineral supplements	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.3	-0.6	0.3	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.7	-0.2	0.2	0.0	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.2	0.3	0.6	0.7
Alcohol intake versus 10 years previously	0.1	0.2	0.6	0.8	0.0	-0.1	0.1
Asthma	0.1	0.3	1.0	-0.0	0.1	1.0	-0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.6	-0.1	0.7	-0.1	0.1
Standing height	0.1	1.1	1.8	1.3	1.0	-0.9	-0.9
Birth weight	0.1	0.2	0.6	0.1	-0.1	-0.8	-0.3
Health satisfaction	0.1	0.1	0.3	0.3	0.3	-0.6	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.6	-0.0	0.0	-0.4
Leg fat mass (right)	0.1	0.4	1.3	-0.1	-0.4	-1.1	-0.4
Supplements: Vitamin C	0.1	0.2	0.3	-0.5	-0.1	0.3	-0.5
Supplements: Calcium	0.1	0.2	0.3	0.5	0.2	0.3	0.5
Leg fat mass (left)	0.1	0.5	1.4	-0.0	-0.3	-1.2	-0.7
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.0	-0.3	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.1	0.1	-0.1	0.2	0.4	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Relative age voice broke	0.0	0.0	0.1	-0.0	0.2	0.0	-0.2
Sitting height	0.0	0.2	0.4	-0.6	0.6	-0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.3	0.0	-0.2	0.0
Long-standing illness, disability or infirmity	0.0	0.1	0.1	0.2	-0.4	-0.0	-0.3

Hub : Genes

EIF4EBP1

Models

Trait associations