Hub : Traits :

Pack years of smoking

88 significantly associated models · 20 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 64531160 65911294 2 1 1.2e-07 2.8e-07 2.2e-01 94 JMJD1C-AS1
2 14 103398706 104866687 1 1 8.3e-08 4.8e-07 8.8e-01 100 KLC1
3 15 77859168 79802863 14 4 7.0e-66 1.1e-65 NaN NaN ADAMTS7 CHRNA5 HYKK PSMA4
4 17 35152143 36441093 2 1 1.4e-07 9.4e-07 4.6e-01 98 DUSP14
5 19 41034912 41537868 1 1 1.1e-09 1.0e-09 4.4e-05 55 RAB4B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 4.53 2 2 4.4 0.00 1.0e+00 KLC1 PSMA4
Depressed Affect (Nagel 2018) 1.69 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Depression (Nagel 2018) 3.85 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Intelligence (Savage-Jansen 2018) 2.14 2 1 2.2 0.00 1.0e+00 DUSP14 JMJD1C-AS1
Schizophrenia (2018) 4.71 2 2 4.4 0.00 1.0e+00 KLC1 PSMA4
Reaction Time 2.85 2 0 0.0 0.00 1.0e+00 CHRNA5 HYKK
Verbal and Numeric Reasoning (VNR) 2.10 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Breast Cancer 1.05 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Schizophrenia (2014) 3.84 2 2 4.4 0.00 1.0e+00 KLC1 PSMA4
Triglycerides 1.68 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Blood Eosinophil Count 0.72 1 0 0.0 0.00 1.0e+00 KLC1
Blood Platelet Count 1.58 3 2 4.4 0.00 1.0e+00 ADAMTS7 DUSP14 JMJD1C-AS1
Blood Red Count 1.45 3 1 2.2 0.00 1.0e+00 DUSP14 JMJD1C-AS1 KLC1
Blood White Count 1.82 3 1 2.2 0.00 1.0e+00 DUSP14 JMJD1C-AS1 KLC1
Heel T-Score 3.72 2 1 2.2 0.00 1.0e+00 DUSP14 KLC1
BMI 2.45 3 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1 RAB4B
Height 0.65 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1
Waist Hip Ratio (WHR) 0.80 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Smoking Status 3.77 3 0 0.0 0.00 1.0e+00 CHRNA5 HYKK KLC1
Allergy or Eczema 1.06 1 0 0.0 0.00 1.0e+00 PSMA4
Cardiovascular Disease 1.49 1 1 2.2 0.00 1.0e+00 KLC1
Type 2 Diabetes (T2D) (2018) 1.25 1 0 0.0 0.00 1.0e+00 KLC1
Lung FEV1/FVC ratio 3.05 5 1 2.2 -0.82 8.7e-02 DUSP14 HYKK JMJD1C-AS1 PSMA4 RAB4B
Lung FVC 2.62 4 2 4.4 -0.85 1.5e-01 CHRNA5 HYKK JMJD1C-AS1 PSMA4
Hair Pigment 0.42 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1
Frequency of depressed mood in last 2 weeks 3.21 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Pack years adult smoking proportion 61.50 8 8 17.8 1.00 2.4e-10 ADAMTS7 CHRNA5 DUSP14 HYKK JMJD1C-AS1 KLC1 PSMA4 RAB4B
Impedance of leg (right) 1.76 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1
Leg fat-free mass (left) 0.91 1 0 0.0 0.00 1.0e+00 KLC1
Trunk fat percentage 0.88 1 0 0.0 0.00 1.0e+00 KLC1
Current tobacco smoking 6.51 3 1 2.2 0.00 1.0e+00 KLC1 PSMA4 RAB4B
Maternal smoking around birth 5.65 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Frequency of unenthusiasm / disinterest in last 2 weeks 4.25 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Age when periods started (menarche) 1.76 1 0 0.0 0.00 1.0e+00 PSMA4
Heel bone mineral density (BMD) T-score, automated (left) 2.27 1 1 2.2 0.00 1.0e+00 KLC1
Qualifications: CSEs or equivalent 3.61 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
High blood pressure 0.96 1 0 0.0 0.00 1.0e+00 KLC1
Chronic bronchitis/emphysema (father) 9.01 2 1 2.2 0.00 1.0e+00 HYKK PSMA4
Body mass index (BMI) 2.16 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1
Impedance of leg (left) 1.79 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1
Trunk fat mass 0.91 1 0 0.0 0.00 1.0e+00 KLC1
Waist circumference 1.82 1 1 2.2 0.00 1.0e+00 KLC1
Past tobacco smoking 3.20 2 0 0.0 0.00 1.0e+00 KLC1 RAB4B
Frequency of tenseness / restlessness in last 2 weeks 1.90 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Hearing difficulty/problems with background noise 3.06 1 0 0.0 0.00 1.0e+00 KLC1
Forced vital capacity (FVC) 1.65 2 0 0.0 0.00 1.0e+00 HYKK PSMA4
Heel bone mineral density (BMD) T-score, automated (right) 1.55 1 0 0.0 0.00 1.0e+00 KLC1
Qualifications: None of the above 3.43 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Financial difficulties in last 2 years 4.26 1 0 0.0 0.00 1.0e+00 KLC1
Mouth/teeth dental problems 2.43 1 0 0.0 0.00 1.0e+00 KLC1
Fluid intelligence score 2.14 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Weight 1.06 1 0 0.0 0.00 1.0e+00 KLC1
Impedance of arm (right) 1.60 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 RAB4B
Arm fat percentage (right) 1.63 1 1 2.2 0.00 1.0e+00 KLC1
Hip circumference 1.30 1 0 0.0 0.00 1.0e+00 KLC1
Father's age at death 8.15 2 1 2.2 0.00 1.0e+00 HYKK PSMA4
Frequency of tiredness / lethargy in last 2 weeks 2.85 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 KLC1
Falls in the last year 2.83 1 0 0.0 0.00 1.0e+00 CHRNA5
Forced expiratory volume in 1-second (FEV1) 3.25 2 1 2.2 0.00 1.0e+00 HYKK PSMA4
Qualifications: A levels/AS levels or equivalent 2.23 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Mouth/teeth dental problems: Dentures 3.66 1 0 0.0 0.00 1.0e+00 PSMA4
Lung cancer (father) 12.45 2 1 2.2 0.00 1.0e+00 HYKK PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure 3.88 3 2 4.4 0.00 1.0e+00 CHRNA5 HYKK PSMA4
Impedance of arm (left) 1.78 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Arm fat mass (right) 1.56 1 1 2.2 0.00 1.0e+00 KLC1
Standing height 0.49 1 0 0.0 0.00 1.0e+00 KLC1
Peak expiratory flow (PEF) 1.56 1 0 0.0 0.00 1.0e+00 PSMA4
Medication: Paracetamol 2.13 1 0 0.0 0.00 1.0e+00 KLC1
Chronic bronchitis/emphysema (mother) 7.59 2 1 2.2 0.00 1.0e+00 HYKK PSMA4
Forced vital capacity (FVC), Best measure 2.10 3 0 0.0 0.00 1.0e+00 CHRNA5 HYKK PSMA4
Body fat percentage 0.97 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat percentage (right) 0.95 1 0 0.0 0.00 1.0e+00 KLC1
Exposure to tobacco smoke outside home 2.20 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Wheeze or whistling in the chest in last year 3.28 1 0 0.0 0.00 1.0e+00 PSMA4
Age at first live birth 2.01 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Qualifications: College or University degree 2.77 2 1 2.2 0.00 1.0e+00 DUSP14 JMJD1C-AS1
Emphysema/chronic bronchitis 5.28 1 0 0.0 0.00 1.0e+00 PSMA4
Medication for pain relief, constipation, heartburn 2.40 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Whole body fat mass 1.10 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat mass (right) 1.12 1 0 0.0 0.00 1.0e+00 KLC1
Pulse rate, automated reading 0.95 1 0 0.0 0.00 1.0e+00 KLC1
Comparative height size at age 10 0.94 2 0 0.0 0.00 1.0e+00 DUSP14 KLC1
Overall health rating 3.47 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Hypertension (Self-reported) 1.01 1 0 0.0 0.00 1.0e+00 KLC1
Smoking status: Previous 5.16 2 0 0.0 0.00 1.0e+00 HYKK RAB4B
Arm fat percentage (left) 1.42 1 1 2.2 0.00 1.0e+00 KLC1
Mood swings 1.34 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Loneliness, isolation 3.00 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Long-standing illness, disability or infirmity 3.63 1 0 0.0 0.00 1.0e+00 KLC1
Diabetes diagnosed by doctor 1.36 1 0 0.0 0.00 1.0e+00 KLC1
Qualifications: nursing, teaching 2.78 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Smoking status: Current 5.51 3 0 0.0 0.00 1.0e+00 JMJD1C-AS1 KLC1 RAB4B
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.17 4 2 4.4 -0.91 9.2e-02 CHRNA5 HYKK JMJD1C-AS1 PSMA4
Leg predicted mass (right) 0.86 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat mass (left) 1.46 1 1 2.2 0.00 1.0e+00 KLC1
Number of self-reported non-cancer illnesses 3.14 1 0 0.0 0.00 1.0e+00 KLC1
Mother's age at death 4.10 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Ever smoked 4.23 2 0 0.0 0.00 1.0e+00 HYKK PSMA4
Leg fat percentage (left) 0.99 1 0 0.0 0.00 1.0e+00 KLC1
Arm fat-free mass (left) 0.97 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Risk taking 3.94 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Diastolic blood pressure, automated reading 1.31 1 0 0.0 0.00 1.0e+00 KLC1
Vascular/heart problems diagnosed by doctor 1.11 1 0 0.0 0.00 1.0e+00 KLC1
Pain experienced in last month 3.21 2 0 0.0 0.00 1.0e+00 CHRNA5 HYKK
Impedance of whole body 1.78 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1
Leg fat mass (left) 1.17 1 0 0.0 0.00 1.0e+00 KLC1
Arm predicted mass (left) 1.02 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.057 1.5
GTEx Adipose Visceral Omentum 0 0.000 1.5
GTEx Adrenal Gland 1 0.069 1.4
GTEx Artery Aorta 1 0.034 1.5
GTEx Artery Coronary 1 0.085 1.5
GTEx Artery Tibial 2 0.053 1.5
GTEx Brain Caudate basal ganglia 1 0.109 1.6
GTEx Brain Cerebellar Hemisphere 1 0.067 1.5
GTEx Brain Cerebellum 1 0.050 1.5
GTEx Brain Cortex 2 0.193 1.7
GTEx Brain Frontal Cortex BA9 1 0.108 1.6
GTEx Brain Hippocampus 1 0.191 1.6
GTEx Brain Hypothalamus 1 0.169 1.6
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.6
GTEx Brain Putamen basal ganglia 2 0.321 1.7
GTEx Breast Mammary Tissue 1 0.051 1.6
GTEx Breast Mammary Tissue (Male) 1 0.084 1.5
GTEx Breast Mammary Tissue (Female) 1 0.061 1.5
GTEx Cells EBV-transformed lymphocytes 2 0.141 1.5
GTEx Cells Transformed fibroblasts 1 0.024 1.4
GTEx Colon Sigmoid 1 0.068 1.5
GTEx Colon Transverse 1 0.048 1.5
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.6
GTEx Esophagus Mucosa 1 0.030 1.5
GTEx Esophagus Muscularis 0 0.000 1.5
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 2 0.131 1.6
GTEx Liver 1 0.139 1.8
GTEx Lung 1 0.035 1.5
GTEx Muscle Skeletal 1 0.035 1.5
GTEx Nerve Tibial 3 0.069 1.5
GTEx Ovary 1 0.110 1.6
GTEx Pancreas 0 0.000 1.5
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.5
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.5
GTEx Skin Sun Exposed Lower leg 3 0.082 1.5
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 1 0.071 1.5
GTEx Stomach 0 0.000 1.5
GTEx Testis 2 0.063 1.5
GTEx Thyroid 0 0.000 1.5
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.5
METSIM Adipose 2 0.043 1.4
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 2 0.043 1.5
CommonMind Brain Pre-frontal Cortex 4 0.074 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 4 0.091 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 2.2
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.073 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.6
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.046 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 2 0.181 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 3 0.065 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.156 1.4
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.197 1.4