Hub : Traits :

Pack years of smoking

88 significantly associated models · 20 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	10	64531160	65911294	2	1	1.2e-07	2.8e-07	2.2e-01	94	JMJD1C-AS1
2	14	103398706	104866687	1	1	8.3e-08	4.8e-07	8.8e-01	100	KLC1
3	15	77859168	79802863	14	4	7.0e-66	1.1e-65	NaN	NaN	ADAMTS7 CHRNA5 HYKK PSMA4
4	17	35152143	36441093	2	1	1.4e-07	9.4e-07	4.6e-01	98	DUSP14
5	19	41034912	41537868	1	1	1.1e-09	1.0e-09	4.4e-05	55	RAB4B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Pack years adult smoking proportion	61.50	8	8	17.8	1.00	2.4e-10	ADAMTS7 CHRNA5 DUSP14 HYKK JMJD1C-AS1 KLC1 PSMA4 RAB4B
Lung cancer (father)	12.45	2	1	2.2	0.00	1.0e+00	HYKK PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage	9.17	4	2	4.4	-0.91	9.2e-02	CHRNA5 HYKK JMJD1C-AS1 PSMA4
Chronic bronchitis/emphysema (father)	9.01	2	1	2.2	0.00	1.0e+00	HYKK PSMA4
Father's age at death	8.15	2	1	2.2	0.00	1.0e+00	HYKK PSMA4
Chronic bronchitis/emphysema (mother)	7.59	2	1	2.2	0.00	1.0e+00	HYKK PSMA4
Current tobacco smoking	6.51	3	1	2.2	0.00	1.0e+00	KLC1 PSMA4 RAB4B
Maternal smoking around birth	5.65	2	0	0.0	0.00	1.0e+00	KLC1 PSMA4
Smoking status: Current	5.51	3	0	0.0	0.00	1.0e+00	JMJD1C-AS1 KLC1 RAB4B
Emphysema/chronic bronchitis	5.28	1	0	0.0	0.00	1.0e+00	PSMA4
Smoking status: Previous	5.16	2	0	0.0	0.00	1.0e+00	HYKK RAB4B
Schizophrenia (2018)	4.71	2	2	4.4	0.00	1.0e+00	KLC1 PSMA4
Bipolar Disorder or Schizophrenia	4.53	2	2	4.4	0.00	1.0e+00	KLC1 PSMA4
Financial difficulties in last 2 years	4.26	1	0	0.0	0.00	1.0e+00	KLC1
Frequency of unenthusiasm / disinterest in last 2 weeks	4.25	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Ever smoked	4.23	2	0	0.0	0.00	1.0e+00	HYKK PSMA4
Mother's age at death	4.10	2	0	0.0	0.00	1.0e+00	KLC1 PSMA4
Risk taking	3.94	2	0	0.0	0.00	1.0e+00	KLC1 PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure	3.88	3	2	4.4	0.00	1.0e+00	CHRNA5 HYKK PSMA4
Depression (Nagel 2018)	3.85	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Schizophrenia (2014)	3.84	2	2	4.4	0.00	1.0e+00	KLC1 PSMA4
Smoking Status	3.77	3	0	0.0	0.00	1.0e+00	CHRNA5 HYKK KLC1
Heel T-Score	3.72	2	1	2.2	0.00	1.0e+00	DUSP14 KLC1
Mouth/teeth dental problems: Dentures	3.66	1	0	0.0	0.00	1.0e+00	PSMA4
Long-standing illness, disability or infirmity	3.63	1	0	0.0	0.00	1.0e+00	KLC1
Qualifications: CSEs or equivalent	3.61	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Overall health rating	3.47	2	0	0.0	0.00	1.0e+00	KLC1 PSMA4
Qualifications: None of the above	3.43	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Wheeze or whistling in the chest in last year	3.28	1	0	0.0	0.00	1.0e+00	PSMA4
Forced expiratory volume in 1-second (FEV1)	3.25	2	1	2.2	0.00	1.0e+00	HYKK PSMA4
Frequency of depressed mood in last 2 weeks	3.21	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Pain experienced in last month	3.21	2	0	0.0	0.00	1.0e+00	CHRNA5 HYKK
Past tobacco smoking	3.20	2	0	0.0	0.00	1.0e+00	KLC1 RAB4B
Number of self-reported non-cancer illnesses	3.14	1	0	0.0	0.00	1.0e+00	KLC1
Hearing difficulty/problems with background noise	3.06	1	0	0.0	0.00	1.0e+00	KLC1
Lung FEV1/FVC ratio	3.05	5	1	2.2	-0.82	8.7e-02	DUSP14 HYKK JMJD1C-AS1 PSMA4 RAB4B
Loneliness, isolation	3.00	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Reaction Time	2.85	2	0	0.0	0.00	1.0e+00	CHRNA5 HYKK
Frequency of tiredness / lethargy in last 2 weeks	2.85	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 KLC1
Falls in the last year	2.83	1	0	0.0	0.00	1.0e+00	CHRNA5
Qualifications: nursing, teaching	2.78	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Qualifications: College or University degree	2.77	2	1	2.2	0.00	1.0e+00	DUSP14 JMJD1C-AS1
Lung FVC	2.62	4	2	4.4	-0.85	1.5e-01	CHRNA5 HYKK JMJD1C-AS1 PSMA4
BMI	2.45	3	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1 RAB4B
Mouth/teeth dental problems	2.43	1	0	0.0	0.00	1.0e+00	KLC1
Medication for pain relief, constipation, heartburn	2.40	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Heel bone mineral density (BMD) T-score, automated (left)	2.27	1	1	2.2	0.00	1.0e+00	KLC1
Qualifications: A levels/AS levels or equivalent	2.23	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Exposure to tobacco smoke outside home	2.20	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Body mass index (BMI)	2.16	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1
Intelligence (Savage-Jansen 2018)	2.14	2	1	2.2	0.00	1.0e+00	DUSP14 JMJD1C-AS1
Fluid intelligence score	2.14	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Medication: Paracetamol	2.13	1	0	0.0	0.00	1.0e+00	KLC1
Verbal and Numeric Reasoning (VNR)	2.10	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Forced vital capacity (FVC), Best measure	2.10	3	0	0.0	0.00	1.0e+00	CHRNA5 HYKK PSMA4
Age at first live birth	2.01	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Frequency of tenseness / restlessness in last 2 weeks	1.90	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Blood White Count	1.82	3	1	2.2	0.00	1.0e+00	DUSP14 JMJD1C-AS1 KLC1
Waist circumference	1.82	1	1	2.2	0.00	1.0e+00	KLC1
Impedance of leg (left)	1.79	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1
Impedance of arm (left)	1.78	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Impedance of whole body	1.78	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1
Impedance of leg (right)	1.76	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1
Age when periods started (menarche)	1.76	1	0	0.0	0.00	1.0e+00	PSMA4
Depressed Affect (Nagel 2018)	1.69	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Triglycerides	1.68	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Forced vital capacity (FVC)	1.65	2	0	0.0	0.00	1.0e+00	HYKK PSMA4
Arm fat percentage (right)	1.63	1	1	2.2	0.00	1.0e+00	KLC1
Impedance of arm (right)	1.60	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 RAB4B
Blood Platelet Count	1.58	3	2	4.4	0.00	1.0e+00	ADAMTS7 DUSP14 JMJD1C-AS1
Arm fat mass (right)	1.56	1	1	2.2	0.00	1.0e+00	KLC1
Peak expiratory flow (PEF)	1.56	1	0	0.0	0.00	1.0e+00	PSMA4
Heel bone mineral density (BMD) T-score, automated (right)	1.55	1	0	0.0	0.00	1.0e+00	KLC1
Cardiovascular Disease	1.49	1	1	2.2	0.00	1.0e+00	KLC1
Arm fat mass (left)	1.46	1	1	2.2	0.00	1.0e+00	KLC1
Blood Red Count	1.45	3	1	2.2	0.00	1.0e+00	DUSP14 JMJD1C-AS1 KLC1
Arm fat percentage (left)	1.42	1	1	2.2	0.00	1.0e+00	KLC1
Diabetes diagnosed by doctor	1.36	1	0	0.0	0.00	1.0e+00	KLC1
Mood swings	1.34	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Diastolic blood pressure, automated reading	1.31	1	0	0.0	0.00	1.0e+00	KLC1
Hip circumference	1.30	1	0	0.0	0.00	1.0e+00	KLC1
Type 2 Diabetes (T2D) (2018)	1.25	1	0	0.0	0.00	1.0e+00	KLC1
Leg fat mass (left)	1.17	1	0	0.0	0.00	1.0e+00	KLC1
Leg fat mass (right)	1.12	1	0	0.0	0.00	1.0e+00	KLC1
Vascular/heart problems diagnosed by doctor	1.11	1	0	0.0	0.00	1.0e+00	KLC1
Whole body fat mass	1.10	1	0	0.0	0.00	1.0e+00	KLC1
Allergy or Eczema	1.06	1	0	0.0	0.00	1.0e+00	PSMA4
Weight	1.06	1	0	0.0	0.00	1.0e+00	KLC1
Breast Cancer	1.05	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Arm predicted mass (left)	1.02	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Hypertension (Self-reported)	1.01	1	0	0.0	0.00	1.0e+00	KLC1
Leg fat percentage (left)	0.99	1	0	0.0	0.00	1.0e+00	KLC1
Body fat percentage	0.97	1	0	0.0	0.00	1.0e+00	KLC1
Arm fat-free mass (left)	0.97	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
High blood pressure	0.96	1	0	0.0	0.00	1.0e+00	KLC1
Leg fat percentage (right)	0.95	1	0	0.0	0.00	1.0e+00	KLC1
Pulse rate, automated reading	0.95	1	0	0.0	0.00	1.0e+00	KLC1
Comparative height size at age 10	0.94	2	0	0.0	0.00	1.0e+00	DUSP14 KLC1
Leg fat-free mass (left)	0.91	1	0	0.0	0.00	1.0e+00	KLC1
Trunk fat mass	0.91	1	0	0.0	0.00	1.0e+00	KLC1
Trunk fat percentage	0.88	1	0	0.0	0.00	1.0e+00	KLC1
Leg predicted mass (right)	0.86	1	0	0.0	0.00	1.0e+00	KLC1
Waist Hip Ratio (WHR)	0.80	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Blood Eosinophil Count	0.72	1	0	0.0	0.00	1.0e+00	KLC1
Height	0.65	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1
Standing height	0.49	1	0	0.0	0.00	1.0e+00	KLC1
Hair Pigment	0.42	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.292	2.2
GTEx	Liver	1	0.139	1.8
GTEx	Brain Cortex	2	0.193	1.7
GTEx	Brain Putamen basal ganglia	2	0.321	1.7
GTEx	Brain Caudate basal ganglia	1	0.109	1.6
GTEx	Brain Frontal Cortex BA9	1	0.108	1.6
GTEx	Brain Hippocampus	1	0.191	1.6
GTEx	Brain Hypothalamus	1	0.169	1.6
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.6
GTEx	Breast Mammary Tissue	1	0.051	1.6
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.6
GTEx	Heart Left Ventricle	2	0.131	1.6
GTEx	Ovary	1	0.110	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.6
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.6
GTEx	Adipose Subcutaneous	2	0.057	1.5
GTEx	Adipose Visceral Omentum	0	0.000	1.5
GTEx	Artery Aorta	1	0.034	1.5
GTEx	Artery Coronary	1	0.085	1.5
GTEx	Artery Tibial	2	0.053	1.5
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.5
GTEx	Brain Cerebellum	1	0.050	1.5
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.5
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.5
GTEx	Cells EBV-transformed lymphocytes	2	0.141	1.5
GTEx	Colon Sigmoid	1	0.068	1.5
GTEx	Colon Transverse	1	0.048	1.5
GTEx	Esophagus Mucosa	1	0.030	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Lung	1	0.035	1.5
GTEx	Muscle Skeletal	1	0.035	1.5
GTEx	Nerve Tibial	3	0.069	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.5
GTEx	Skin Sun Exposed Lower leg	3	0.082	1.5
GTEx	Spleen	1	0.071	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Testis	2	0.063	1.5
GTEx	Thyroid	0	0.000	1.5
GTEx	Whole Blood	0	0.000	1.5
YFS	Blood	2	0.043	1.5
CommonMind	Brain Pre-frontal Cortex	4	0.074	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.065	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.5
GTEx	Adrenal Gland	1	0.069	1.4
GTEx	Cells Transformed fibroblasts	1	0.024	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
METSIM	Adipose	2	0.043	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.091	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	3	0.073	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.156	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.4
NTR	Blood	0	0.000	1.3