Hub : Traits :

Ever used hormone-replacement therapy (HRT)

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 180228968 181688483 2 1 2e-08 1.2e-08 1 100 STX6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 9.97 1 0 0 0 1 STX6
Lupus 6.62 1 0 0 0 1 STX6
Blood Eosinophil Count 0.97 1 0 0 0 1 STX6
Blood Red Count 0.63 1 0 0 0 1 STX6
Height 0.63 1 0 0 0 1 STX6
Lung FEV1/FVC ratio 4.37 1 0 0 0 1 STX6
Tanning 0.54 1 0 0 0 1 STX6
Other serious medical condition/disability diagnosed by doctor 8.52 1 0 0 0 1 STX6
Medication for hormone replacement therapy 5.94 1 0 0 0 1 STX6
Sitting height 1.13 1 0 0 0 1 STX6
Had menopause 11.79 1 0 0 0 1 STX6
Mouth/teeth dental problems 3.49 1 0 0 0 1 STX6
Frequency of tiredness / lethargy in last 2 weeks 4.25 1 0 0 0 1 STX6
Number of live births 6.03 1 0 0 0 1 STX6
Forced vital capacity (FVC), Best measure 2.42 1 0 0 0 1 STX6
Qualifications: College or University degree 3.02 1 0 0 0 1 STX6
Mean time to correctly identify matches 2.69 1 0 0 0 1 STX6
Overall health rating 2.86 1 0 0 0 1 STX6
Forced expiratory volume in 1-second (FEV1), predicted 3.57 1 0 0 0 1 STX6
Medication for cholesterol 4.73 1 0 0 0 1 STX6
Osteoarthritis (self-reported) 9.19 1 0 0 0 1 STX6
Pain type(s) experienced in last month: Hip pain 5.51 1 0 0 0 1 STX6
High cholesterol (Self-reported) 3.52 1 0 0 0 1 STX6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.32
GTEx Adipose Visceral Omentum 0 0.0000 1.32
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 0 0.0000 1.28
GTEx Artery Coronary 0 0.0000 1.33
GTEx Artery Tibial 0 0.0000 1.28
GTEx Brain Caudate basal ganglia 0 0.0000 1.23
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.29
GTEx Brain Cerebellum 0 0.0000 1.25
GTEx Brain Cortex 0 0.0000 1.33
GTEx Brain Frontal Cortex BA9 0 0.0000 1.23
GTEx Brain Hippocampus 0 0.0000 1.28
GTEx Brain Hypothalamus 0 0.0000 1.27
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.19
GTEx Brain Putamen basal ganglia 0 0.0000 1.22
GTEx Breast Mammary Tissue 0 0.0000 1.32
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.25
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.24
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.23
GTEx Cells Transformed fibroblasts 0 0.0000 1.27
GTEx Colon Sigmoid 0 0.0000 1.40
GTEx Colon Transverse 0 0.0000 1.31
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.34
GTEx Esophagus Mucosa 0 0.0000 1.31
GTEx Esophagus Muscularis 0 0.0000 1.31
GTEx Heart Atrial Appendage 0 0.0000 1.23
GTEx Heart Left Ventricle 0 0.0000 1.28
GTEx Liver 1 0.1395 1.38
GTEx Lung 0 0.0000 1.35
GTEx Muscle Skeletal 0 0.0000 1.35
GTEx Nerve Tibial 0 0.0000 1.30
GTEx Ovary 0 0.0000 1.32
GTEx Pancreas 0 0.0000 1.30
GTEx Pituitary 0 0.0000 1.28
GTEx Prostate 0 0.0000 1.35
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.33
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.32
GTEx Small Intestine Terminal Ileum 0 0.0000 1.37
GTEx Spleen 0 0.0000 1.30
GTEx Stomach 0 0.0000 1.28
GTEx Testis 0 0.0000 1.38
GTEx Thyroid 0 0.0000 1.34
GTEx Uterus 0 0.0000 1.26
GTEx Vagina 0 0.0000 1.27
GTEx Whole Blood 0 0.0000 1.24
METSIM Adipose 0 0.0000 1.26
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.23
YFS Blood 0 0.0000 1.25
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.27
TCGA Breast Tumor 0 0.0000 1.29
TCGA Breast Normal 0 0.0000 1.21
TCGA Ovarian Tumor 0 0.0000 1.16
TCGA Prostate Tumor 0 0.0000 1.25