Hub : Traits :

Multivitamins +/- minerals

20 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	9576675	11170131	2	1	6.7e-09	6.4e-09	1.00	100	PGD
2	10	64195778	66034105	2	1	3.0e-08	1.5e-08	0.17	94	REEP3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Blood Platelet Count	25.48	2	1	2.2	1	PGD REEP3
Vitamin and mineral supplements	15.31	2	0	0.0	1	PGD REEP3
Mineral and other dietary supplements	10.28	1	0	0.0	1	REEP3
Supplements: Glucosamine	8.11	1	0	0.0	1	REEP3
Supplements: Calcium	7.95	1	0	0.0	1	REEP3
Supplements: Fish oil (including cod liver oil)	7.85	1	0	0.0	1	REEP3
Diastolic blood pressure, automated reading	7.09	1	1	2.2	1	REEP3
Supplements: Zinc	6.95	1	0	0.0	1	REEP3
Relative age of first facial hair	6.41	1	0	0.0	1	REEP3
Blood White Count	6.09	1	1	2.2	1	REEP3
Diabetes (self-reported)	5.68	1	0	0.0	1	REEP3
Relative age voice broke	5.58	1	0	0.0	1	REEP3
Average weekly beer plus cider intake	5.42	1	0	0.0	1	REEP3
Gout (self-reported)	4.88	1	0	0.0	1	REEP3
Deep venous thrombosis (DVT) (self-reported)	4.76	1	0	0.0	1	REEP3
Height	4.68	2	2	4.4	1	PGD REEP3
Diabetes diagnosed by doctor	4.61	1	0	0.0	1	REEP3
Systolic blood pressure, automated reading	4.47	1	0	0.0	1	REEP3
Blood clot in the leg (DVT)	4.39	1	0	0.0	1	REEP3
Forced expiratory volume in 1-second (FEV1), predicted	4.17	1	0	0.0	1	PGD
Alcohol usually taken with meals	4.12	1	0	0.0	1	REEP3
Age when periods started (menarche)	4.09	1	0	0.0	1	REEP3
Maternal smoking around birth	3.99	1	0	0.0	1	PGD
High blood pressure	3.98	1	0	0.0	1	REEP3
Standing height	3.84	2	2	4.4	1	PGD REEP3
Lung FEV1/FVC ratio	3.79	2	0	0.0	1	PGD REEP3
Cardiovascular Disease	3.77	1	0	0.0	1	REEP3
Leg fat percentage (right)	3.43	1	0	0.0	1	REEP3
Leg fat percentage (left)	3.37	1	0	0.0	1	REEP3
Medication: Blood pressure	3.25	1	0	0.0	1	REEP3
Hypertension (Self-reported)	3.23	1	0	0.0	1	REEP3
Vascular/heart problems diagnosed by doctor	3.13	1	0	0.0	1	REEP3
Triglycerides	2.93	1	0	0.0	1	REEP3
BMI	2.88	1	1	2.2	1	REEP3
Systolic Blood Pressure	2.71	1	0	0.0	1	REEP3
Schizophrenia (2014)	2.70	1	0	0.0	1	REEP3
Body mass index (BMI)	2.61	1	0	0.0	1	REEP3
Arm fat percentage (left)	1.86	1	0	0.0	1	REEP3
Arm fat percentage (right)	1.73	1	0	0.0	1	REEP3
Body fat percentage	1.68	1	0	0.0	1	REEP3
Leg fat mass (right)	1.67	1	0	0.0	1	REEP3
Comparative height size at age 10	1.62	1	0	0.0	1	PGD
Sitting height	1.60	1	0	0.0	1	REEP3
Leg fat mass (left)	1.55	1	0	0.0	1	REEP3
Impedance of arm (right)	1.48	1	0	0.0	1	REEP3
Blood Red Count	1.34	1	0	0.0	1	REEP3
Heel T-Score	1.26	1	0	0.0	1	REEP3
Impedance of arm (left)	1.21	1	0	0.0	1	REEP3
Arm fat mass (left)	1.18	1	0	0.0	1	REEP3
Trunk predicted mass	1.05	1	0	0.0	1	PGD
Trunk fat-free mass	1.00	1	0	0.0	1	PGD
Whole body water mass	0.91	1	0	0.0	1	PGD
Whole body fat-free mass	0.87	1	0	0.0	1	PGD
Blood Eosinophil Count	0.79	1	0	0.0	1	REEP3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Stomach	2	0.138	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
GTEx	Adipose Subcutaneous	1	0.029	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	1	0.069	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	1	0.031	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Muscle Skeletal	1	0.035	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2