Hub : Traits :

Supplements: Fish oil (including cod liver oil)

4 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	203692179	205160074	1	1	5.8e-08	5.8e-10	0.0014	73	PIK3C2B
2	11	65636509	67294308	2	2	9.9e-08	2.0e-07	0.9650	100	C11orf80 CTSF

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Mineral and other dietary supplements	12.59	3	0	0.0	1	C11orf80 CTSF PIK3C2B
Fed-up feelings	9.52	3	0	0.0	1	C11orf80 CTSF PIK3C2B
Bipolar Disorder (2011)	8.86	1	0	0.0	1	CTSF
Alcohol usually taken with meals	8.63	3	0	0.0	1	C11orf80 CTSF PIK3C2B
Average weekly red wine intake	7.94	3	0	0.0	1	C11orf80 CTSF PIK3C2B
Pain all over the body in last month	6.62	1	0	0.0	1	C11orf80
Qualifications: College or University degree	6.10	3	1	2.2	1	C11orf80 CTSF PIK3C2B
Medication: Co-codamol	5.91	2	0	0.0	1	C11orf80 CTSF
Unable to work because of sickness or disability	5.74	2	0	0.0	1	C11orf80 CTSF
Qualifications: None of the above	5.58	2	0	0.0	1	CTSF PIK3C2B
Lung FVC	5.36	3	1	2.2	1	C11orf80 CTSF PIK3C2B
Vitamin and mineral supplements	5.34	2	0	0.0	1	CTSF PIK3C2B
Breast Cancer	5.02	2	0	0.0	1	C11orf80 CTSF
Wears glasses or contact lenses	4.76	1	0	0.0	1	PIK3C2B
Schizophrenia vs Biploar Disorder	4.62	2	0	0.0	1	C11orf80 CTSF
Health satisfaction	4.60	1	0	0.0	1	C11orf80
Depressed Affect (Nagel 2018)	4.33	2	0	0.0	1	C11orf80 PIK3C2B
Mood swings	4.27	2	0	0.0	1	C11orf80 PIK3C2B
Comparative body size at age 10	4.18	1	0	0.0	1	C11orf80
Irritability	3.76	2	0	0.0	1	CTSF PIK3C2B
Allergy or Eczema	3.63	2	0	0.0	1	C11orf80 CTSF
Frequency of unenthusiasm / disinterest in last 2 weeks	3.57	1	0	0.0	1	C11orf80
Mouth/teeth dental problems: Loose teeth	3.52	1	0	0.0	1	C11orf80
Medication: Omeprazole (e.g. Zanprol)	3.44	1	0	0.0	1	PIK3C2B
Qualifications: nursing, teaching	3.36	2	0	0.0	1	CTSF PIK3C2B
Number of full brothers	3.31	1	0	0.0	1	C11orf80
Supplements: Zinc	3.29	1	0	0.0	1	PIK3C2B
Mean time to correctly identify matches	3.27	1	0	0.0	1	CTSF
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.21	1	0	0.0	1	PIK3C2B
Chronotype (morning person)	3.10	2	0	0.0	1	C11orf80 CTSF
Frequency of tiredness / lethargy in last 2 weeks	3.09	2	0	0.0	1	C11orf80 PIK3C2B
Overall health rating	3.03	2	0	0.0	1	C11orf80 PIK3C2B
Pain experienced in last month	3.00	1	0	0.0	1	C11orf80
Supplements: Calcium	2.87	1	0	0.0	1	PIK3C2B
Hair/balding pattern: Pattern 2	2.85	1	0	0.0	1	PIK3C2B
Supplements: Glucosamine	2.76	1	0	0.0	1	PIK3C2B
Neuroticism (Nagel 2018)	2.75	2	0	0.0	1	C11orf80 PIK3C2B
Risk taking	2.74	1	0	0.0	1	CTSF
Pack years adult smoking proportion	2.73	1	0	0.0	1	PIK3C2B
Neuroticism score	2.73	1	0	0.0	1	PIK3C2B
Reaction Time	2.70	1	0	0.0	1	CTSF
Miserableness	2.69	1	0	0.0	1	PIK3C2B
Neuroticism	2.60	1	0	0.0	1	PIK3C2B
Number of operations (self-reported)	2.57	1	0	0.0	1	C11orf80
Forced expiratory volume in 1-second (FEV1), Best measure	2.55	1	0	0.0	1	PIK3C2B
Peak expiratory flow (PEF)	2.52	1	0	0.0	1	PIK3C2B
Diabetes (self-reported)	2.44	1	0	0.0	1	PIK3C2B
Seen a psychiatrist for nerves, anxiety, tension or depression	2.39	1	0	0.0	1	CTSF
Commuting to job workplace: Cycle	2.39	1	0	0.0	1	CTSF
Prostate Cancer	2.38	1	0	0.0	1	PIK3C2B
Hayfever, allergic rhinitis or eczema	2.33	1	0	0.0	1	CTSF
Forced expiratory volume in 1-second (FEV1)	2.22	1	0	0.0	1	PIK3C2B
Waist Hip Ratio (WHR)	2.06	1	0	0.0	1	PIK3C2B
Birth weight	1.99	1	0	0.0	1	PIK3C2B
Medication: Levothyroxine sodium	1.94	1	0	0.0	1	C11orf80
Forced vital capacity (FVC), Best measure	1.94	1	0	0.0	1	PIK3C2B
Pulse rate	1.91	1	0	0.0	1	PIK3C2B
Long-standing illness, disability or infirmity	1.91	1	0	0.0	1	C11orf80
Bipolar Disorder (2018)	1.86	1	0	0.0	1	CTSF
Type 2 Diabetes (T2D) (2018)	1.82	1	0	0.0	1	PIK3C2B
Waist circumference	1.79	1	0	0.0	1	PIK3C2B
Leg fat percentage (right)	1.79	2	0	0.0	1	C11orf80 PIK3C2B
Impedance of leg (right)	1.77	1	0	0.0	1	CTSF
Body fat percentage	1.71	2	0	0.0	1	C11orf80 PIK3C2B
Forced vital capacity (FVC)	1.68	1	0	0.0	1	PIK3C2B
Leg fat mass (right)	1.66	2	0	0.0	1	C11orf80 PIK3C2B
Worrier / anxious feelings	1.61	1	0	0.0	1	C11orf80
Trunk fat percentage	1.58	2	0	0.0	1	C11orf80 PIK3C2B
Diabetes diagnosed by doctor	1.56	1	0	0.0	1	PIK3C2B
Whole body fat mass	1.54	2	0	0.0	1	C11orf80 PIK3C2B
Leg fat mass (left)	1.48	2	0	0.0	1	C11orf80 PIK3C2B
Leg fat percentage (left)	1.47	2	0	0.0	1	C11orf80 PIK3C2B
Allergy	1.45	1	0	0.0	1	CTSF
Schizophrenia (2014)	1.38	1	0	0.0	1	PIK3C2B
Trunk fat mass	1.37	2	0	0.0	1	C11orf80 PIK3C2B
Schizophrenia (2018)	1.34	1	0	0.0	1	PIK3C2B
Arm fat percentage (right)	1.33	2	0	0.0	1	C11orf80 PIK3C2B
Arm fat percentage (left)	1.28	1	0	0.0	1	PIK3C2B
Arm fat mass (right)	1.26	2	0	0.0	1	C11orf80 PIK3C2B
Arm fat mass (left)	1.24	2	0	0.0	1	C11orf80 PIK3C2B
Hair/balding pattern: Pattern 4	1.23	1	0	0.0	1	C11orf80
Impedance of leg (left)	1.15	1	0	0.0	1	CTSF
Impedance of whole body	1.01	1	0	0.0	1	CTSF
Body mass index (BMI)	0.97	1	0	0.0	1	C11orf80
Intelligence (Savage-Jansen 2018)	0.91	1	0	0.0	1	PIK3C2B
Hand grip strength (right)	0.91	1	0	0.0	1	PIK3C2B
Hand grip strength (left)	0.89	1	0	0.0	1	PIK3C2B
BMI	0.72	1	0	0.0	1	C11orf80
Blood Platelet Count	0.69	1	0	0.0	1	PIK3C2B
Lung FEV1/FVC ratio	0.56	1	0	0.0	1	PIK3C2B
Blood Red Count	0.54	1	0	0.0	1	CTSF
Blood White Count	0.52	1	0	0.0	1	CTSF
Leg predicted mass (right)	0.45	1	0	0.0	1	CTSF
Leg fat-free mass (right)	0.44	1	0	0.0	1	CTSF
Blood Eosinophil Count	0.43	1	0	0.0	1	PIK3C2B
Sitting height	0.34	1	0	0.0	1	PIK3C2B

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	1	0.068	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	2	0.060	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
NTR	Blood	0	0.000	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2