Hub : Traits :

Supplements: Fish oil (including cod liver oil)

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 203692179 205160074 1 1 5.8e-08 5.8e-10 0.0014 73 PIK3C2B
2 11 65636509 67294308 2 2 9.9e-08 2.0e-07 0.9650 100 C11orf80 CTSF

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 1.86 1 0 0.0 0 1 CTSF
Depressed Affect (Nagel 2018) 4.33 2 0 0.0 0 1 C11orf80 PIK3C2B
Intelligence (Savage-Jansen 2018) 0.91 1 0 0.0 0 1 PIK3C2B
Neuroticism (Nagel 2018) 2.75 2 0 0.0 0 1 C11orf80 PIK3C2B
Schizophrenia (2018) 1.34 1 0 0.0 0 1 PIK3C2B
Schizophrenia vs Biploar Disorder 4.62 2 0 0.0 0 1 C11orf80 CTSF
Reaction Time 2.70 1 0 0.0 0 1 CTSF
Breast Cancer 5.02 2 0 0.0 0 1 C11orf80 CTSF
Prostate Cancer 2.38 1 0 0.0 0 1 PIK3C2B
Bipolar Disorder (2011) 8.86 1 0 0.0 0 1 CTSF
Schizophrenia (2014) 1.38 1 0 0.0 0 1 PIK3C2B
Blood Eosinophil Count 0.43 1 0 0.0 0 1 PIK3C2B
Blood Platelet Count 0.69 1 0 0.0 0 1 PIK3C2B
Blood Red Count 0.54 1 0 0.0 0 1 CTSF
Blood White Count 0.52 1 0 0.0 0 1 CTSF
BMI 0.72 1 0 0.0 0 1 C11orf80
Waist Hip Ratio (WHR) 2.06 1 0 0.0 0 1 PIK3C2B
Allergy or Eczema 3.63 2 0 0.0 0 1 C11orf80 CTSF
Type 2 Diabetes (T2D) (2018) 1.82 1 0 0.0 0 1 PIK3C2B
Lung FEV1/FVC ratio 0.56 1 0 0.0 0 1 PIK3C2B
Lung FVC 5.36 3 1 2.2 0 1 C11orf80 CTSF PIK3C2B
Neuroticism 2.60 1 0 0.0 0 1 PIK3C2B
Chronotype (morning person) 3.10 2 0 0.0 0 1 C11orf80 CTSF
Hand grip strength (left) 0.89 1 0 0.0 0 1 PIK3C2B
Vitamin and mineral supplements 5.34 2 0 0.0 0 1 CTSF PIK3C2B
Supplements: Zinc 3.29 1 0 0.0 0 1 PIK3C2B
Medication: Co-codamol 5.91 2 0 0.0 0 1 C11orf80 CTSF
Pack years adult smoking proportion 2.73 1 0 0.0 0 1 PIK3C2B
Impedance of leg (right) 1.77 1 0 0.0 0 1 CTSF
Trunk fat percentage 1.58 2 0 0.0 0 1 C11orf80 PIK3C2B
Hand grip strength (right) 0.91 1 0 0.0 0 1 PIK3C2B
Fed-up feelings 9.52 3 0 0.0 0 1 C11orf80 CTSF PIK3C2B
Frequency of unenthusiasm / disinterest in last 2 weeks 3.57 1 0 0.0 0 1 C11orf80
Hayfever, allergic rhinitis or eczema 2.33 1 0 0.0 0 1 CTSF
Supplements: Glucosamine 2.76 1 0 0.0 0 1 PIK3C2B
Medication: Levothyroxine sodium 1.94 1 0 0.0 0 1 C11orf80
Sitting height 0.34 1 0 0.0 0 1 PIK3C2B
Body mass index (BMI) 0.97 1 0 0.0 0 1 C11orf80
Impedance of leg (left) 1.15 1 0 0.0 0 1 CTSF
Trunk fat mass 1.37 2 0 0.0 0 1 C11orf80 PIK3C2B
Waist circumference 1.79 1 0 0.0 0 1 PIK3C2B
Alcohol usually taken with meals 8.63 3 0 0.0 0 1 C11orf80 CTSF PIK3C2B
Hair/balding pattern: Pattern 2 2.85 1 0 0.0 0 1 PIK3C2B
Forced vital capacity (FVC) 1.68 1 0 0.0 0 1 PIK3C2B
Qualifications: None of the above 5.58 2 0 0.0 0 1 CTSF PIK3C2B
Allergy 1.45 1 0 0.0 0 1 CTSF
Pain all over the body in last month 6.62 1 0 0.0 0 1 C11orf80
Diabetes (self-reported) 2.44 1 0 0.0 0 1 PIK3C2B
Neuroticism score 2.73 1 0 0.0 0 1 PIK3C2B
Arm fat percentage (right) 1.33 2 0 0.0 0 1 C11orf80 PIK3C2B
Worrier / anxious feelings 1.61 1 0 0.0 0 1 C11orf80
Frequency of tiredness / lethargy in last 2 weeks 3.09 2 0 0.0 0 1 C11orf80 PIK3C2B
Forced expiratory volume in 1-second (FEV1) 2.22 1 0 0.0 0 1 PIK3C2B
Pulse rate 1.91 1 0 0.0 0 1 PIK3C2B
Forced expiratory volume in 1-second (FEV1), Best measure 2.55 1 0 0.0 0 1 PIK3C2B
Arm fat mass (right) 1.26 2 0 0.0 0 1 C11orf80 PIK3C2B
Hair/balding pattern: Pattern 4 1.23 1 0 0.0 0 1 C11orf80
Peak expiratory flow (PEF) 2.52 1 0 0.0 0 1 PIK3C2B
Birth weight 1.99 1 0 0.0 0 1 PIK3C2B
Forced vital capacity (FVC), Best measure 1.94 1 0 0.0 0 1 PIK3C2B
Body fat percentage 1.71 2 0 0.0 0 1 C11orf80 PIK3C2B
Leg fat percentage (right) 1.79 2 0 0.0 0 1 C11orf80 PIK3C2B
Comparative body size at age 10 4.18 1 0 0.0 0 1 C11orf80
Number of full brothers 3.31 1 0 0.0 0 1 C11orf80
Seen a psychiatrist for nerves, anxiety, tension or depression 2.39 1 0 0.0 0 1 CTSF
Health satisfaction 4.60 1 0 0.0 0 1 C11orf80
Qualifications: College or University degree 6.10 3 1 2.2 0 1 C11orf80 CTSF PIK3C2B
Mouth/teeth dental problems: Loose teeth 3.52 1 0 0.0 0 1 C11orf80
Mean time to correctly identify matches 3.27 1 0 0.0 0 1 CTSF
Whole body fat mass 1.54 2 0 0.0 0 1 C11orf80 PIK3C2B
Leg fat mass (right) 1.66 2 0 0.0 0 1 C11orf80 PIK3C2B
Overall health rating 3.03 2 0 0.0 0 1 C11orf80 PIK3C2B
Leg fat-free mass (right) 0.44 1 0 0.0 0 1 CTSF
Arm fat percentage (left) 1.28 1 0 0.0 0 1 PIK3C2B
Average weekly red wine intake 7.94 3 0 0.0 0 1 C11orf80 CTSF PIK3C2B
Mood swings 4.27 2 0 0.0 0 1 C11orf80 PIK3C2B
Long-standing illness, disability or infirmity 1.91 1 0 0.0 0 1 C11orf80
Diabetes diagnosed by doctor 1.56 1 0 0.0 0 1 PIK3C2B
Qualifications: nursing, teaching 3.36 2 0 0.0 0 1 CTSF PIK3C2B
Mineral and other dietary supplements 12.59 3 0 0.0 0 1 C11orf80 CTSF PIK3C2B
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.21 1 0 0.0 0 1 PIK3C2B
Leg predicted mass (right) 0.45 1 0 0.0 0 1 CTSF
Arm fat mass (left) 1.24 2 0 0.0 0 1 C11orf80 PIK3C2B
Miserableness 2.69 1 0 0.0 0 1 PIK3C2B
Wears glasses or contact lenses 4.76 1 0 0.0 0 1 PIK3C2B
Leg fat percentage (left) 1.47 2 0 0.0 0 1 C11orf80 PIK3C2B
Number of operations (self-reported) 2.57 1 0 0.0 0 1 C11orf80
Irritability 3.76 2 0 0.0 0 1 CTSF PIK3C2B
Risk taking 2.74 1 0 0.0 0 1 CTSF
Unable to work because of sickness or disability 5.74 2 0 0.0 0 1 C11orf80 CTSF
Commuting to job workplace: Cycle 2.39 1 0 0.0 0 1 CTSF
Medication: Omeprazole (e.g. Zanprol) 3.44 1 0 0.0 0 1 PIK3C2B
Pain experienced in last month 3.00 1 0 0.0 0 1 C11orf80
Supplements: Calcium 2.87 1 0 0.0 0 1 PIK3C2B
Impedance of whole body 1.01 1 0 0.0 0 1 CTSF
Leg fat mass (left) 1.48 2 0 0.0 0 1 C11orf80 PIK3C2B

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 1 0.084 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 1 0.068 1.3
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 2 0.060 1.3
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4