Hub : Traits :

Vitamin and mineral supplements

6 significantly associated models · 5 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	12	56838745	58303535	3	1	1.5e-10	2.1e-08	0.89	100	STAT6
2	15	63687200	65137171	2	1	6.2e-08	2.0e-07	1.00	100	SNX1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Migraine (self-reported)	36.18	1	1	2.2	1	STAT6
Headache pain in last month	35.53	1	1	2.2	1	STAT6
Medication: Ibuprofen (e.g. Nurofen)	23.07	1	1	2.2	1	STAT6
Respiratory disease	18.90	1	1	2.2	1	STAT6
Medication for pain relief, constipation, heartburn	18.61	1	1	2.2	1	STAT6
Medication: Ibuprofen	18.25	1	1	2.2	1	STAT6
Asthma (self-reported)	17.00	1	1	2.2	1	STAT6
Asthma	16.53	1	1	2.2	1	STAT6
Multivitamins +/- minerals	15.56	2	0	0.0	1	SNX1 STAT6
Medication: Paracetamol	13.56	1	1	2.2	1	STAT6
Allergy	13.02	1	1	2.2	1	STAT6
Supplements: Calcium	10.37	2	0	0.0	1	SNX1 STAT6
Medication: Paracetamol	9.51	1	1	2.2	1	STAT6
Mineral and other dietary supplements	9.45	2	0	0.0	1	SNX1 STAT6
Medication: Ventolin 100micrograms inhaler	8.92	1	0	0.0	1	STAT6
Allergy or Eczema	8.90	1	1	2.2	1	STAT6
Hayfever, allergic rhinitis or eczema	8.74	1	1	2.2	1	STAT6
Pain experienced in last month	7.76	1	0	0.0	1	STAT6
Supplements: Fish oil (including cod liver oil)	7.59	1	0	0.0	1	STAT6
Myopia	7.53	1	0	0.0	1	STAT6
Hayfever/allergic rhinitis (self-reported)	7.39	1	0	0.0	1	STAT6
Schizophrenia (2018)	6.81	1	0	0.0	1	STAT6
Deep venous thrombosis (DVT) (self-reported)	5.58	1	0	0.0	1	SNX1
Blood clot in the leg (DVT)	5.45	1	0	0.0	1	SNX1
Alcohol intake frequency.	5.39	1	0	0.0	1	STAT6
Medication: Seretide 50 evohaler	5.31	1	0	0.0	1	STAT6
Number of operations (self-reported)	5.20	1	0	0.0	1	STAT6
Lung FEV1/FVC ratio	5.18	1	1	2.2	1	STAT6
Schizophrenia (2014)	5.07	1	0	0.0	1	STAT6
Supplements: Zinc	5.03	1	0	0.0	1	STAT6
Bipolar Disorder or Schizophrenia	4.78	1	0	0.0	1	STAT6
Primary Biliary Cirrhosis	4.67	1	0	0.0	1	STAT6
Average weekly beer plus cider intake	4.59	1	0	0.0	1	STAT6
Number of treatments/medications taken	4.45	1	0	0.0	1	STAT6
Breast Cancer	4.34	1	0	0.0	1	SNX1
Reason for reducing amount of alcohol drunk: Health precaution	4.21	1	0	0.0	1	SNX1
Lung cancer (father)	4.07	1	0	0.0	1	SNX1
High blood pressure (siblings)	4.03	1	0	0.0	1	STAT6
Illnesses of father: None of the above (group 1)	3.86	1	0	0.0	1	SNX1
Worrier / anxious feelings	3.84	1	0	0.0	1	STAT6
Miserableness	3.66	1	0	0.0	1	STAT6
Sitting height	3.57	1	1	2.2	1	STAT6
Hearing difficulty/problems with background noise	3.57	1	0	0.0	1	STAT6
Blood Eosinophil Count	3.29	1	1	2.2	1	STAT6
Gout (self-reported)	3.27	1	0	0.0	1	STAT6
Mood swings	3.18	1	0	0.0	1	STAT6
Hand grip strength (right)	3.16	1	0	0.0	1	STAT6
Depressed Affect (Nagel 2018)	3.14	1	0	0.0	1	STAT6
Crohns Disease (2012)	3.10	1	0	0.0	1	STAT6
Birth weight	2.93	1	0	0.0	1	STAT6
Trunk fat percentage	2.91	2	0	0.0	1	SNX1 STAT6
Trunk predicted mass	2.79	1	1	2.2	1	STAT6
Trunk fat-free mass	2.78	1	1	2.2	1	STAT6
Blood White Count	2.76	2	1	2.2	1	SNX1 STAT6
Back pain experienced in last month	2.73	1	0	0.0	1	STAT6
Body fat percentage	2.63	2	0	0.0	1	SNX1 STAT6
Arm fat percentage (left)	2.36	2	0	0.0	1	SNX1 STAT6
Leg fat percentage (left)	2.29	1	0	0.0	1	STAT6
Fluid intelligence score	2.28	1	0	0.0	1	STAT6
Leg fat percentage (right)	2.25	1	0	0.0	1	STAT6
Ever smoked	2.24	1	0	0.0	1	STAT6
Arm fat percentage (right)	2.06	2	0	0.0	1	SNX1 STAT6
Standing height	1.99	1	1	2.2	1	STAT6
Neuroticism	1.95	1	0	0.0	1	STAT6
Intelligence (Savage-Jansen 2018)	1.90	1	0	0.0	1	STAT6
Whole body water mass	1.90	1	0	0.0	1	STAT6
Whole body fat-free mass	1.88	1	0	0.0	1	STAT6
Height	1.72	1	1	2.2	1	STAT6
Qualifications: College or University degree	1.72	1	0	0.0	1	SNX1
Verbal and Numeric Reasoning (VNR)	1.69	1	0	0.0	1	STAT6
Smoking Status	1.67	1	0	0.0	1	STAT6
Arm predicted mass (right)	1.48	1	0	0.0	1	STAT6
Arm fat-free mass (right)	1.47	1	0	0.0	1	STAT6
Comparative body size at age 10	1.47	1	0	0.0	1	SNX1
Arm predicted mass (left)	1.47	1	0	0.0	1	STAT6
Arm fat-free mass (left)	1.44	1	0	0.0	1	STAT6
Forced vital capacity (FVC)	1.40	1	0	0.0	1	STAT6
Trunk fat mass	1.29	1	0	0.0	1	SNX1
Forced vital capacity (FVC), Best measure	1.28	1	0	0.0	1	STAT6
Basal metabolic rate	1.24	1	0	0.0	1	STAT6
Leg fat-free mass (right)	1.14	1	0	0.0	1	STAT6
Leg predicted mass (right)	1.13	1	0	0.0	1	STAT6
Leg predicted mass (left)	1.03	1	0	0.0	1	STAT6
BMI	1.02	1	0	0.0	1	STAT6
Leg fat-free mass (left)	1.01	1	0	0.0	1	STAT6
Blood Platelet Count	0.60	1	0	0.0	1	STAT6
Hair Pigment	0.39	2	0	0.0	1	SNX1 STAT6

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Prostate	0	0.000	1.6
GTEx	Breast Mammary Tissue	0	0.000	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Liver	0	0.000	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Uterus	0	0.000	1.5
GTEx	Vagina	0	0.000	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Artery Aorta	0	0.000	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	1	0.027	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Lung	0	0.000	1.4
GTEx	Muscle Skeletal	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Whole Blood	1	0.050	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
NTR	Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.3