Hub : Traits :

Vitamin and mineral supplements

6 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 56838745 58303535 3 1 1.5e-10 2.1e-08 0.89 100 STAT6
2 15 63687200 65137171 2 1 6.2e-08 2.0e-07 1.00 100 SNX1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 4.78 1 0 0.0 0 1 STAT6
Depressed Affect (Nagel 2018) 3.14 1 0 0.0 0 1 STAT6
Intelligence (Savage-Jansen 2018) 1.90 1 0 0.0 0 1 STAT6
Schizophrenia (2018) 6.81 1 0 0.0 0 1 STAT6
Verbal and Numeric Reasoning (VNR) 1.69 1 0 0.0 0 1 STAT6
Breast Cancer 4.34 1 0 0.0 0 1 SNX1
Crohns Disease (2012) 3.10 1 0 0.0 0 1 STAT6
Primary Biliary Cirrhosis 4.67 1 0 0.0 0 1 STAT6
Schizophrenia (2014) 5.07 1 0 0.0 0 1 STAT6
Blood Eosinophil Count 3.29 1 1 2.2 0 1 STAT6
Blood Platelet Count 0.60 1 0 0.0 0 1 STAT6
Blood White Count 2.76 2 1 2.2 0 1 SNX1 STAT6
BMI 1.02 1 0 0.0 0 1 STAT6
Height 1.72 1 1 2.2 0 1 STAT6
Smoking Status 1.67 1 0 0.0 0 1 STAT6
Allergy or Eczema 8.90 1 1 2.2 0 1 STAT6
Respiratory disease 18.90 1 1 2.2 0 1 STAT6
Lung FEV1/FVC ratio 5.18 1 1 2.2 0 1 STAT6
Neuroticism 1.95 1 0 0.0 0 1 STAT6
Hair Pigment 0.39 2 0 0.0 0 1 SNX1 STAT6
Number of treatments/medications taken 4.45 1 0 0.0 0 1 STAT6
Supplements: Zinc 5.03 1 0 0.0 0 1 STAT6
Leg fat-free mass (left) 1.01 1 0 0.0 0 1 STAT6
Trunk fat percentage 2.91 2 0 0.0 0 1 SNX1 STAT6
Hand grip strength (right) 3.16 1 0 0.0 0 1 STAT6
Hayfever, allergic rhinitis or eczema 8.74 1 1 2.2 0 1 STAT6
Multivitamins +/- minerals 15.56 2 0 0.0 0 1 SNX1 STAT6
Sitting height 3.57 1 1 2.2 0 1 STAT6
Leg predicted mass (left) 1.03 1 0 0.0 0 1 STAT6
Trunk fat mass 1.29 1 0 0.0 0 1 SNX1
Hearing difficulty/problems with background noise 3.57 1 0 0.0 0 1 STAT6
Forced vital capacity (FVC) 1.40 1 0 0.0 0 1 STAT6
Allergy 13.02 1 1 2.2 0 1 STAT6
Hayfever/allergic rhinitis (self-reported) 7.39 1 0 0.0 0 1 STAT6
Fluid intelligence score 2.28 1 0 0.0 0 1 STAT6
Arm fat percentage (right) 2.06 2 0 0.0 0 1 SNX1 STAT6
Trunk fat-free mass 2.78 1 1 2.2 0 1 STAT6
Worrier / anxious feelings 3.84 1 0 0.0 0 1 STAT6
Asthma 16.53 1 1 2.2 0 1 STAT6
Medication: Ibuprofen (e.g. Nurofen) 23.07 1 1 2.2 0 1 STAT6
Lung cancer (father) 4.07 1 0 0.0 0 1 SNX1
Trunk predicted mass 2.79 1 1 2.2 0 1 STAT6
Standing height 1.99 1 1 2.2 0 1 STAT6
Blood clot in the leg (DVT) 5.45 1 0 0.0 0 1 SNX1
Medication: Paracetamol 13.56 1 1 2.2 0 1 STAT6
Headache pain in last month 35.53 1 1 2.2 0 1 STAT6
Gout (self-reported) 3.27 1 0 0.0 0 1 STAT6
Medication: Ventolin 100micrograms inhaler 8.92 1 0 0.0 0 1 STAT6
Birth weight 2.93 1 0 0.0 0 1 STAT6
High blood pressure (siblings) 4.03 1 0 0.0 0 1 STAT6
Forced vital capacity (FVC), Best measure 1.28 1 0 0.0 0 1 STAT6
Body fat percentage 2.63 2 0 0.0 0 1 SNX1 STAT6
Leg fat percentage (right) 2.25 1 0 0.0 0 1 STAT6
Arm fat-free mass (right) 1.47 1 0 0.0 0 1 STAT6
Comparative body size at age 10 1.47 1 0 0.0 0 1 SNX1
Reason for reducing amount of alcohol drunk: Health precaution 4.21 1 0 0.0 0 1 SNX1
Qualifications: College or University degree 1.72 1 0 0.0 0 1 SNX1
Medication for pain relief, constipation, heartburn 18.61 1 1 2.2 0 1 STAT6
Migraine (self-reported) 36.18 1 1 2.2 0 1 STAT6
Medication: Ibuprofen 18.25 1 1 2.2 0 1 STAT6
Medication: Seretide 50 evohaler 5.31 1 0 0.0 0 1 STAT6
Arm predicted mass (right) 1.48 1 0 0.0 0 1 STAT6
Alcohol intake frequency. 5.39 1 0 0.0 0 1 STAT6
Whole body fat-free mass 1.88 1 0 0.0 0 1 STAT6
Leg fat-free mass (right) 1.14 1 0 0.0 0 1 STAT6
Arm fat percentage (left) 2.36 2 0 0.0 0 1 SNX1 STAT6
Mood swings 3.18 1 0 0.0 0 1 STAT6
Back pain experienced in last month 2.73 1 0 0.0 0 1 STAT6
Mineral and other dietary supplements 9.45 2 0 0.0 0 1 SNX1 STAT6
Asthma (self-reported) 17.00 1 1 2.2 0 1 STAT6
Illnesses of father: None of the above (group 1) 3.86 1 0 0.0 0 1 SNX1
Whole body water mass 1.90 1 0 0.0 0 1 STAT6
Leg predicted mass (right) 1.13 1 0 0.0 0 1 STAT6
Miserableness 3.66 1 0 0.0 0 1 STAT6
Supplements: Fish oil (including cod liver oil) 7.59 1 0 0.0 0 1 STAT6
Medication: Paracetamol 9.51 1 1 2.2 0 1 STAT6
Ever smoked 2.24 1 0 0.0 0 1 STAT6
Basal metabolic rate 1.24 1 0 0.0 0 1 STAT6
Leg fat percentage (left) 2.29 1 0 0.0 0 1 STAT6
Arm fat-free mass (left) 1.44 1 0 0.0 0 1 STAT6
Number of operations (self-reported) 5.20 1 0 0.0 0 1 STAT6
Average weekly beer plus cider intake 4.59 1 0 0.0 0 1 STAT6
Myopia 7.53 1 0 0.0 0 1 STAT6
Pain experienced in last month 7.76 1 0 0.0 0 1 STAT6
Supplements: Calcium 10.37 2 0 0.0 0 1 SNX1 STAT6
Deep venous thrombosis (DVT) (self-reported) 5.58 1 0 0.0 0 1 SNX1
Arm predicted mass (left) 1.47 1 0 0.0 0 1 STAT6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 1 0.027 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.5
GTEx Breast Mammary Tissue (Male) 0 0.000 1.5
GTEx Breast Mammary Tissue (Female) 0 0.000 1.5
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.5
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.5
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.6
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.5
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.5
GTEx Whole Blood 1 0.050 1.4
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4