Hub : Traits :

Multivitamins +/- minerals

9 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 9576675 11170131 2 1 9e-09 6.4e-09 1.00 100 PGD
2 10 64195778 66034105 2 1 3e-08 1.5e-08 0.17 94 REEP3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Schizophrenia 2.63 1 0 0.0 0 1 REEP3
Triglycerides 2.94 1 0 0.0 0 1 REEP3
Blood Eosinophil Count 0.69 1 0 0.0 0 1 REEP3
Blood Platelet Count 24.91 1 1 3.0 0 1 REEP3
Blood Red Count 1.13 1 0 0.0 0 1 REEP3
Blood White Count 6.15 1 1 3.0 0 1 REEP3
Heel T-Score 1.63 2 0 0.0 0 1 PGD REEP3
BMI 2.79 1 1 3.0 0 1 REEP3
Height 3.98 2 2 6.1 0 1 PGD REEP3
Systolic Blood Pressure 2.88 1 0 0.0 0 1 REEP3
Cardiovascular Disease 3.43 1 0 0.0 0 1 REEP3
Type 2 Diabetes (T2D) 3.52 1 0 0.0 0 1 REEP3
Lung FEV1/FVC ratio 3.60 2 0 0.0 0 1 PGD REEP3
Number of treatments/medications taken 3.03 1 0 0.0 0 1 PGD
Relative age of first facial hair 6.12 1 0 0.0 0 1 REEP3
Systolic blood pressure, automated reading 4.51 2 0 0.0 0 1 PGD REEP3
Vitamin and mineral supplements 15.14 2 0 0.0 0 1 PGD REEP3
Supplements: Zinc 6.39 1 0 0.0 0 1 REEP3
Medication: Metformin 4.58 1 0 0.0 0 1 REEP3
Maternal smoking around birth 3.85 1 0 0.0 0 1 PGD
Relative age voice broke 5.26 1 0 0.0 0 1 REEP3
Age when periods started (menarche) 3.77 1 0 0.0 0 1 REEP3
High blood pressure 3.84 1 0 0.0 0 1 REEP3
Supplements: Glucosamine 8.01 1 0 0.0 0 1 REEP3
Sitting height 1.42 1 0 0.0 0 1 REEP3
Body mass index (BMI) 2.49 1 0 0.0 0 1 REEP3
Alcohol usually taken with meals 4.02 1 0 0.0 0 1 REEP3
Diabetes (self-reported) 5.58 1 0 0.0 0 1 REEP3
Impedance of arm (right) 1.63 1 0 0.0 0 1 REEP3
Arm fat percentage (right) 1.90 1 0 0.0 0 1 REEP3
Trunk fat-free mass 1.03 1 0 0.0 0 1 PGD
Impedance of arm (left) 1.26 1 0 0.0 0 1 REEP3
Arm fat mass (right) 1.19 1 0 0.0 0 1 REEP3
Trunk predicted mass 1.08 1 0 0.0 0 1 PGD
Standing height 3.16 2 1 3.0 0 1 PGD REEP3
Tense / 'highly strung' 2.60 1 0 0.0 0 1 REEP3
Blood clot in the leg (DVT) 4.59 1 0 0.0 0 1 REEP3
Gout (self-reported) 4.69 1 0 0.0 0 1 REEP3
Body fat percentage 1.98 1 0 0.0 0 1 REEP3
Leg fat percentage (right) 3.56 1 0 0.0 0 1 REEP3
Leg fat mass (right) 1.66 1 0 0.0 0 1 REEP3
Comparative height size at age 10 1.09 1 0 0.0 0 1 PGD
Hypertension (Self-reported) 3.11 1 0 0.0 0 1 REEP3
Forced expiratory volume in 1-second (FEV1), predicted 3.66 1 0 0.0 0 1 PGD
Whole body fat-free mass 0.86 1 0 0.0 0 1 PGD
Arm fat percentage (left) 2.01 1 0 0.0 0 1 REEP3
Diabetes diagnosed by doctor 4.70 1 0 0.0 0 1 REEP3
Mineral and other dietary supplements 10.76 1 1 3.0 0 1 REEP3
Whole body water mass 0.89 1 0 0.0 0 1 PGD
Arm fat mass (left) 1.20 1 0 0.0 0 1 REEP3
Medication: Blood pressure 3.21 1 0 0.0 0 1 REEP3
Supplements: Fish oil (including cod liver oil) 8.08 1 0 0.0 0 1 REEP3
Leg fat percentage (left) 3.50 1 0 0.0 0 1 REEP3
Average weekly beer plus cider intake 5.56 1 0 0.0 0 1 REEP3
Diastolic blood pressure, automated reading 7.13 1 1 3.0 0 1 REEP3
Vascular/heart problems diagnosed by doctor 3.09 1 0 0.0 0 1 REEP3
Supplements: Calcium 7.97 1 0 0.0 0 1 REEP3
Deep venous thrombosis (DVT) (self-reported) 4.97 1 0 0.0 0 1 REEP3
Leg fat mass (left) 1.56 1 0 0.0 0 1 REEP3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.30
GTEx Adipose Visceral Omentum 0 0.0000 1.26
GTEx Adrenal Gland 1 0.0686 1.28
GTEx Artery Aorta 0 0.0000 1.27
GTEx Artery Coronary 0 0.0000 1.30
GTEx Artery Tibial 0 0.0000 1.30
GTEx Brain Caudate basal ganglia 0 0.0000 1.25
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.26
GTEx Brain Cerebellum 0 0.0000 1.30
GTEx Brain Cortex 0 0.0000 1.30
GTEx Brain Frontal Cortex BA9 0 0.0000 1.27
GTEx Brain Hippocampus 0 0.0000 1.33
GTEx Brain Hypothalamus 0 0.0000 1.26
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.21
GTEx Brain Putamen basal ganglia 0 0.0000 1.29
GTEx Breast Mammary Tissue 0 0.0000 1.32
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.34
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.30
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.36
GTEx Cells Transformed fibroblasts 1 0.0238 1.31
GTEx Colon Sigmoid 0 0.0000 1.30
GTEx Colon Transverse 0 0.0000 1.28
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.21
GTEx Esophagus Mucosa 0 0.0000 1.33
GTEx Esophagus Muscularis 1 0.0309 1.33
GTEx Heart Atrial Appendage 0 0.0000 1.22
GTEx Heart Left Ventricle 0 0.0000 1.21
GTEx Liver 0 0.0000 1.35
GTEx Lung 1 0.0348 1.29
GTEx Muscle Skeletal 1 0.0346 1.29
GTEx Nerve Tibial 0 0.0000 1.32
GTEx Ovary 0 0.0000 1.31
GTEx Pancreas 0 0.0000 1.31
GTEx Pituitary 0 0.0000 1.34
GTEx Prostate 0 0.0000 1.32
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.33
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.31
GTEx Small Intestine Terminal Ileum 0 0.0000 1.31
GTEx Spleen 0 0.0000 1.33
GTEx Stomach 2 0.1376 1.38
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 0 0.0000 1.27
GTEx Uterus 0 0.0000 1.30
GTEx Vagina 0 0.0000 1.29
GTEx Whole Blood 0 0.0000 1.28
METSIM Adipose 0 0.0000 1.22
NTR Blood 0 0.0000 1.25
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.29
YFS Blood 0 0.0000 1.23
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.22
TCGA Breast Tumor 0 0.0000 1.29
TCGA Breast Normal 0 0.0000 1.19
TCGA Ovarian Tumor 0 0.0000 1.29
TCGA Prostate Tumor 0 0.0000 1.27