Hub : Traits :

Heart disease (mother)

6 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	35908451	37310669	1	1	8.1e-08	2.9e-07	8.7e-01	100	TRAPPC3
2	6	160071844	161571560	2	2	2.1e-10	1.0e-17	1.1e-07	62	SLC22A1 SLC22A3
3	9	21303958	22705094	1	1	6.2e-10	1.6e-19	2.4e-11	45	CDKN2B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Illnesses of father: Heart disease	30.99	3	3	6.7	1	CDKN2B SLC22A1 SLC22A3
Angina (self-reported)	30.27	3	3	6.7	1	CDKN2B SLC22A1 SLC22A3
Coronary Artery Disease (CAD)	29.80	2	1	2.2	1	CDKN2B SLC22A3
Angina	29.33	3	3	6.7	1	CDKN2B SLC22A1 SLC22A3
Heart attack	24.72	3	3	6.7	1	CDKN2B SLC22A1 SLC22A3
Heart attack/myocardial infarction (self-reported)	24.42	3	3	6.7	1	CDKN2B SLC22A1 SLC22A3
Medication: Aspirin	18.21	3	2	4.4	1	CDKN2B SLC22A1 SLC22A3
Medication: Aspirin	17.71	3	2	4.4	1	CDKN2B SLC22A1 SLC22A3
Medication: Atorvastatin	16.18	3	2	4.4	1	CDKN2B SLC22A1 SLC22A3
Eye problems/disorders: Glaucoma	15.64	2	1	2.2	1	CDKN2B TRAPPC3
High cholesterol (Self-reported)	15.38	3	2	4.4	1	CDKN2B SLC22A1 SLC22A3
Medication: Cholesterol lowering	12.93	3	1	2.2	1	CDKN2B SLC22A1 SLC22A3
Glaucoma (self-reported)	12.25	2	1	2.2	1	CDKN2B TRAPPC3
Heart disease (siblings)	11.87	3	0	0.0	1	CDKN2B SLC22A1 SLC22A3
Cholesterol lowering medication	11.71	3	1	2.2	1	CDKN2B SLC22A1 SLC22A3
Illnesses of father: None of the above (group 1)	11.34	3	1	2.2	1	CDKN2B SLC22A1 SLC22A3
Medication: Simvastatin	7.33	3	0	0.0	1	CDKN2B SLC22A1 SLC22A3
Medication for cholesterol	7.31	2	1	2.2	1	CDKN2B SLC22A3
Basal cell carcinoma (self-reported)	5.98	1	0	0.0	1	CDKN2B
Illnesses of mother	5.82	3	0	0.0	1	CDKN2B SLC22A1 TRAPPC3
Father's age at death	5.46	2	0	0.0	1	CDKN2B SLC22A1
Medication for cholesterol, blood pressure or diabetes	5.28	1	0	0.0	1	SLC22A1
Medication: Atenolol	4.67	1	0	0.0	1	CDKN2B
Waist Hip Ratio (WHR)	4.49	2	1	2.2	1	SLC22A3 TRAPPC3
Ever taken oral contraceptive pill	4.48	1	0	0.0	1	TRAPPC3
Medication: Ramipril	4.33	1	0	0.0	1	SLC22A3
Cardiovascular Disease	4.31	2	1	2.2	1	SLC22A1 SLC22A3
Mother's age at death	4.05	1	0	0.0	1	SLC22A1
Chest pain or discomfort	3.84	1	0	0.0	1	CDKN2B
Number of self-reported non-cancer illnesses	3.73	2	0	0.0	1	SLC22A1 SLC22A3
Type 2 Diabetes (T2D) (2012)	3.56	1	0	0.0	1	CDKN2B
Long-standing illness, disability or infirmity	3.44	1	0	0.0	1	CDKN2B
Type 2 Diabetes (T2D) (2018)	3.38	2	0	0.0	1	CDKN2B SLC22A3
Vascular/heart problems diagnosed by doctor	3.35	3	0	0.0	1	CDKN2B SLC22A1 SLC22A3
Medication for pain relief, constipation, heartburn	3.30	1	0	0.0	1	SLC22A1
Medication: Metformin	3.26	1	0	0.0	1	CDKN2B
Medication: Ibuprofen	3.25	1	0	0.0	1	SLC22A3
Major Depression (MDD)	3.23	1	0	0.0	1	TRAPPC3
Breast Cancer	3.22	1	0	0.0	1	CDKN2B
Breast cancer (self-reported)	3.02	1	0	0.0	1	CDKN2B
Medication: Blood pressure	3.01	1	0	0.0	1	SLC22A3
Medication: Blood pressure	2.97	1	0	0.0	1	SLC22A1
Chronic bronchitis/emphysema (father)	2.93	1	0	0.0	1	SLC22A3
Diabetes diagnosed by doctor	2.92	1	0	0.0	1	SLC22A3
Pain all over the body in last month	2.86	1	0	0.0	1	TRAPPC3
Illnesses of siblings	2.70	1	0	0.0	1	SLC22A3
Schizophrenia (2018)	2.67	1	0	0.0	1	TRAPPC3
Osteoporosis (self-reported)	2.67	1	0	0.0	1	SLC22A3
Medication: Gliclazide	2.66	1	0	0.0	1	CDKN2B
Leg fat-free mass (right)	2.64	2	1	2.2	1	SLC22A3 TRAPPC3
Average weekly red wine intake	2.64	1	0	0.0	1	SLC22A3
Leg predicted mass (right)	2.62	2	1	2.2	1	SLC22A3 TRAPPC3
Impedance of leg (right)	2.60	1	1	2.2	1	TRAPPC3
Supplements: Fish oil (including cod liver oil)	2.59	1	0	0.0	1	SLC22A3
Medication: Ibuprofen (e.g. Nurofen)	2.55	1	0	0.0	1	SLC22A3
Medication: Lansoprazole	2.55	1	0	0.0	1	SLC22A3
Leg predicted mass (left)	2.50	2	1	2.2	1	SLC22A3 TRAPPC3
Leg fat-free mass (left)	2.47	2	1	2.2	1	SLC22A3 TRAPPC3
Pulse wave Arterial Stiffness index	2.45	1	0	0.0	1	CDKN2B
Pulse wave peak to peak time	2.44	1	0	0.0	1	CDKN2B
Worry (Nagel 2018)	2.36	1	0	0.0	1	SLC22A1
Number of treatments/medications taken	2.31	1	0	0.0	1	SLC22A1
Pulse rate	2.30	1	0	0.0	1	SLC22A1
Whole body fat-free mass	2.29	2	1	2.2	1	SLC22A3 TRAPPC3
Impedance of leg (left)	2.28	1	1	2.2	1	TRAPPC3
Neuroticism (Nagel 2018)	2.27	1	0	0.0	1	SLC22A1
Hip circumference	2.27	2	1	2.2	1	SLC22A3 TRAPPC3
Pulse wave reflection index	2.26	1	0	0.0	1	SLC22A3
Diastolic blood pressure, automated reading	2.26	2	0	0.0	1	CDKN2B SLC22A3
Basal metabolic rate	2.25	2	1	2.2	1	SLC22A3 TRAPPC3
Whole body water mass	2.19	2	1	2.2	1	SLC22A3 TRAPPC3
Bipolar Disorder or Schizophrenia	2.17	1	0	0.0	1	TRAPPC3
Smoking status: Previous	2.13	1	0	0.0	1	CDKN2B
Multivitamins +/- minerals	2.12	1	0	0.0	1	SLC22A3
Mouth/teeth dental problems: Dentures	2.12	1	0	0.0	1	CDKN2B
Loneliness, isolation	2.12	1	0	0.0	1	TRAPPC3
Trunk fat-free mass	2.07	2	1	2.2	1	SLC22A3 TRAPPC3
Trunk predicted mass	2.05	2	1	2.2	1	SLC22A3 TRAPPC3
Impedance of whole body	2.05	1	1	2.2	1	TRAPPC3
Mouth/teeth dental problems	2.02	1	0	0.0	1	CDKN2B
Schizophrenia (2014)	1.93	1	0	0.0	1	TRAPPC3
Mineral and other dietary supplements	1.91	1	0	0.0	1	SLC22A3
Diabetes (self-reported)	1.90	1	0	0.0	1	SLC22A3
Primary Biliary Cirrhosis	1.88	1	0	0.0	1	CDKN2B
Number of operations (self-reported)	1.84	1	0	0.0	1	CDKN2B
Arm fat-free mass (right)	1.81	2	0	0.0	1	SLC22A3 TRAPPC3
Weight	1.80	2	0	0.0	1	SLC22A3 TRAPPC3
Hayfever, allergic rhinitis or eczema	1.75	1	0	0.0	1	SLC22A3
Arm predicted mass (right)	1.74	2	0	0.0	1	SLC22A3 TRAPPC3
Systolic Blood Pressure	1.72	2	0	0.0	1	SLC22A1 SLC22A3
Trunk fat mass	1.71	1	0	0.0	1	SLC22A3
Allergy or Eczema	1.70	1	0	0.0	1	SLC22A3
Whole body fat mass	1.70	1	0	0.0	1	SLC22A3
Neuroticism	1.67	1	0	0.0	1	SLC22A1
Taking other prescription medications	1.66	1	0	0.0	1	TRAPPC3
Frequency of tiredness / lethargy in last 2 weeks	1.66	1	0	0.0	1	TRAPPC3
Arm predicted mass (left)	1.66	2	0	0.0	1	SLC22A3 TRAPPC3
Smoking Status	1.60	1	0	0.0	1	SLC22A1
Hypertension (Self-reported)	1.59	1	0	0.0	1	SLC22A3
Trunk fat percentage	1.56	1	0	0.0	1	SLC22A3
Arm fat-free mass (left)	1.53	2	0	0.0	1	SLC22A3 TRAPPC3
BMI	1.51	2	0	0.0	1	SLC22A3 TRAPPC3
Comparative height size at age 10	1.46	2	0	0.0	1	SLC22A3 TRAPPC3
Arm fat mass (right)	1.43	1	0	0.0	1	SLC22A3
Arm fat mass (left)	1.43	1	0	0.0	1	SLC22A3
Worrier / anxious feelings	1.42	1	0	0.0	1	SLC22A1
Headache pain in last month	1.42	1	0	0.0	1	SLC22A3
Ever smoked	1.41	1	0	0.0	1	SLC22A1
Blood Platelet Count	1.31	3	0	0.0	1	CDKN2B SLC22A3 TRAPPC3
Impedance of arm (right)	1.31	2	0	0.0	1	CDKN2B TRAPPC3
Body fat percentage	1.27	1	0	0.0	1	SLC22A3
High blood pressure	1.22	1	0	0.0	1	SLC22A3
Neuroticism score	1.19	1	0	0.0	1	SLC22A1
Arm fat percentage (right)	1.10	1	0	0.0	1	SLC22A3
Leg fat mass (right)	1.07	1	0	0.0	1	SLC22A3
Heel bone mineral density (BMD) T-score, automated (right)	1.06	1	0	0.0	1	CDKN2B
Leg fat mass (left)	1.06	1	0	0.0	1	SLC22A3
Standing height	1.03	2	1	2.2	1	SLC22A3 TRAPPC3
Impedance of arm (left)	1.01	2	0	0.0	1	CDKN2B TRAPPC3
Sitting height	1.00	1	0	0.0	1	SLC22A3
Qualifications: College or University degree	0.96	1	0	0.0	1	TRAPPC3
Blood White Count	0.93	2	0	0.0	1	CDKN2B TRAPPC3
Arm fat percentage (left)	0.92	1	0	0.0	1	SLC22A3
Forced vital capacity (FVC), Best measure	0.84	1	0	0.0	1	TRAPPC3
Height	0.82	2	1	2.2	1	SLC22A3 TRAPPC3
Hair Pigment	0.69	1	1	2.2	1	CDKN2B
Blood Eosinophil Count	0.65	2	0	0.0	1	CDKN2B TRAPPC3
Blood Red Count	0.38	1	0	0.0	1	CDKN2B

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Thyroid	1	0.025	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1