Hub : Traits :

Heart disease (mother)

6 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 35908451 37310669 1 1 8.1e-08 2.9e-07 8.7e-01 100 TRAPPC3
2 6 160071844 161571560 2 2 2.1e-10 1.0e-17 1.1e-07 62 SLC22A1 SLC22A3
3 9 21303958 22705094 1 1 6.2e-10 1.6e-19 2.4e-11 45 CDKN2B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 2.17 1 0 0.0 0 1 TRAPPC3
Neuroticism (Nagel 2018) 2.27 1 0 0.0 0 1 SLC22A1
Schizophrenia (2018) 2.67 1 0 0.0 0 1 TRAPPC3
Worry (Nagel 2018) 2.36 1 0 0.0 0 1 SLC22A1
Major Depression (MDD) 3.23 1 0 0.0 0 1 TRAPPC3
Breast Cancer 3.22 1 0 0.0 0 1 CDKN2B
Coronary Artery Disease (CAD) 29.80 2 1 2.2 0 1 CDKN2B SLC22A3
Primary Biliary Cirrhosis 1.88 1 0 0.0 0 1 CDKN2B
Schizophrenia (2014) 1.93 1 0 0.0 0 1 TRAPPC3
Type 2 Diabetes (T2D) (2012) 3.56 1 0 0.0 0 1 CDKN2B
Blood Eosinophil Count 0.65 2 0 0.0 0 1 CDKN2B TRAPPC3
Blood Platelet Count 1.31 3 0 0.0 0 1 CDKN2B SLC22A3 TRAPPC3
Blood Red Count 0.38 1 0 0.0 0 1 CDKN2B
Blood White Count 0.93 2 0 0.0 0 1 CDKN2B TRAPPC3
BMI 1.51 2 0 0.0 0 1 SLC22A3 TRAPPC3
Height 0.82 2 1 2.2 0 1 SLC22A3 TRAPPC3
Waist Hip Ratio (WHR) 4.49 2 1 2.2 0 1 SLC22A3 TRAPPC3
Systolic Blood Pressure 1.72 2 0 0.0 0 1 SLC22A1 SLC22A3
Smoking Status 1.60 1 0 0.0 0 1 SLC22A1
Allergy or Eczema 1.70 1 0 0.0 0 1 SLC22A3
Cardiovascular Disease 4.31 2 1 2.2 0 1 SLC22A1 SLC22A3
Type 2 Diabetes (T2D) (2018) 3.38 2 0 0.0 0 1 CDKN2B SLC22A3
Neuroticism 1.67 1 0 0.0 0 1 SLC22A1
Hair Pigment 0.69 1 1 2.2 0 1 CDKN2B
Number of treatments/medications taken 2.31 1 0 0.0 0 1 SLC22A1
Angina 29.33 3 3 6.7 0 1 CDKN2B SLC22A1 SLC22A3
Medication: Metformin 3.26 1 0 0.0 0 1 CDKN2B
Impedance of leg (right) 2.60 1 1 2.2 0 1 TRAPPC3
Leg fat-free mass (left) 2.47 2 1 2.2 0 1 SLC22A3 TRAPPC3
Trunk fat percentage 1.56 1 0 0.0 0 1 SLC22A3
Taking other prescription medications 1.66 1 0 0.0 0 1 TRAPPC3
High blood pressure 1.22 1 0 0.0 0 1 SLC22A3
Hayfever, allergic rhinitis or eczema 1.75 1 0 0.0 0 1 SLC22A3
Multivitamins +/- minerals 2.12 1 0 0.0 0 1 SLC22A3
Medication: Atenolol 4.67 1 0 0.0 0 1 CDKN2B
Sitting height 1.00 1 0 0.0 0 1 SLC22A3
Chronic bronchitis/emphysema (father) 2.93 1 0 0.0 0 1 SLC22A3
Impedance of leg (left) 2.28 1 1 2.2 0 1 TRAPPC3
Leg predicted mass (left) 2.50 2 1 2.2 0 1 SLC22A3 TRAPPC3
Trunk fat mass 1.71 1 0 0.0 0 1 SLC22A3
Heel bone mineral density (BMD) T-score, automated (right) 1.06 1 0 0.0 0 1 CDKN2B
Mouth/teeth dental problems 2.02 1 0 0.0 0 1 CDKN2B
Heart attack 24.72 3 3 6.7 0 1 CDKN2B SLC22A1 SLC22A3
Pain all over the body in last month 2.86 1 0 0.0 0 1 TRAPPC3
Diabetes (self-reported) 1.90 1 0 0.0 0 1 SLC22A3
Medication: Ramipril 4.33 1 0 0.0 0 1 SLC22A3
Medication: Simvastatin 7.33 3 0 0.0 0 1 CDKN2B SLC22A1 SLC22A3
Illnesses of siblings 2.70 1 0 0.0 0 1 SLC22A3
Neuroticism score 1.19 1 0 0.0 0 1 SLC22A1
Weight 1.80 2 0 0.0 0 1 SLC22A3 TRAPPC3
Impedance of arm (right) 1.31 2 0 0.0 0 1 CDKN2B TRAPPC3
Arm fat percentage (right) 1.10 1 0 0.0 0 1 SLC22A3
Trunk fat-free mass 2.07 2 1 2.2 0 1 SLC22A3 TRAPPC3
Hip circumference 2.27 2 1 2.2 0 1 SLC22A3 TRAPPC3
Father's age at death 5.46 2 0 0.0 0 1 CDKN2B SLC22A1
Worrier / anxious feelings 1.42 1 0 0.0 0 1 SLC22A1
Frequency of tiredness / lethargy in last 2 weeks 1.66 1 0 0.0 0 1 TRAPPC3
Pulse rate 2.30 1 0 0.0 0 1 SLC22A1
Mouth/teeth dental problems: Dentures 2.12 1 0 0.0 0 1 CDKN2B
Medication: Ibuprofen (e.g. Nurofen) 2.55 1 0 0.0 0 1 SLC22A3
Medication: Cholesterol lowering 12.93 3 1 2.2 0 1 CDKN2B SLC22A1 SLC22A3
Medication: Lansoprazole 2.55 1 0 0.0 0 1 SLC22A3
Illnesses of mother 5.82 3 0 0.0 0 1 CDKN2B SLC22A1 TRAPPC3
Pulse wave Arterial Stiffness index 2.45 1 0 0.0 0 1 CDKN2B
Impedance of arm (left) 1.01 2 0 0.0 0 1 CDKN2B TRAPPC3
Arm fat mass (right) 1.43 1 0 0.0 0 1 SLC22A3
Trunk predicted mass 2.05 2 1 2.2 0 1 SLC22A3 TRAPPC3
Standing height 1.03 2 1 2.2 0 1 SLC22A3 TRAPPC3
Pulse wave reflection index 2.26 1 0 0.0 0 1 SLC22A3
Headache pain in last month 1.42 1 0 0.0 0 1 SLC22A3
Medication for cholesterol, blood pressure or diabetes 5.28 1 0 0.0 0 1 SLC22A1
Glaucoma (self-reported) 12.25 2 1 2.2 0 1 CDKN2B TRAPPC3
Forced vital capacity (FVC), Best measure 0.84 1 0 0.0 0 1 TRAPPC3
Body fat percentage 1.27 1 0 0.0 0 1 SLC22A3
Arm fat-free mass (right) 1.81 2 0 0.0 0 1 SLC22A3 TRAPPC3
Pulse wave peak to peak time 2.44 1 0 0.0 0 1 CDKN2B
Qualifications: College or University degree 0.96 1 0 0.0 0 1 TRAPPC3
Medication for pain relief, constipation, heartburn 3.30 1 0 0.0 0 1 SLC22A1
Medication: Blood pressure 2.97 1 0 0.0 0 1 SLC22A1
Angina (self-reported) 30.27 3 3 6.7 0 1 CDKN2B SLC22A1 SLC22A3
Medication: Ibuprofen 3.25 1 0 0.0 0 1 SLC22A3
Whole body fat mass 1.70 1 0 0.0 0 1 SLC22A3
Leg fat mass (right) 1.07 1 0 0.0 0 1 SLC22A3
Arm predicted mass (right) 1.74 2 0 0.0 0 1 SLC22A3 TRAPPC3
Comparative height size at age 10 1.46 2 0 0.0 0 1 SLC22A3 TRAPPC3
Chest pain or discomfort 3.84 1 0 0.0 0 1 CDKN2B
Medication: Aspirin 17.71 3 2 4.4 0 1 CDKN2B SLC22A1 SLC22A3
Hypertension (Self-reported) 1.59 1 0 0.0 0 1 SLC22A3
Illnesses of father: Heart disease 30.99 3 3 6.7 0 1 CDKN2B SLC22A1 SLC22A3
Smoking status: Previous 2.13 1 0 0.0 0 1 CDKN2B
Whole body fat-free mass 2.29 2 1 2.2 0 1 SLC22A3 TRAPPC3
Leg fat-free mass (right) 2.64 2 1 2.2 0 1 SLC22A3 TRAPPC3
Arm fat percentage (left) 0.92 1 0 0.0 0 1 SLC22A3
Average weekly red wine intake 2.64 1 0 0.0 0 1 SLC22A3
Loneliness, isolation 2.12 1 0 0.0 0 1 TRAPPC3
Long-standing illness, disability or infirmity 3.44 1 0 0.0 0 1 CDKN2B
Diabetes diagnosed by doctor 2.92 1 0 0.0 0 1 SLC22A3
Medication for cholesterol 7.31 2 1 2.2 0 1 CDKN2B SLC22A3
Mineral and other dietary supplements 1.91 1 0 0.0 0 1 SLC22A3
Breast cancer (self-reported) 3.02 1 0 0.0 0 1 CDKN2B
Osteoporosis (self-reported) 2.67 1 0 0.0 0 1 SLC22A3
Medication: Aspirin 18.21 3 2 4.4 0 1 CDKN2B SLC22A1 SLC22A3
Medication: Gliclazide 2.66 1 0 0.0 0 1 CDKN2B
Illnesses of father: None of the above (group 1) 11.34 3 1 2.2 0 1 CDKN2B SLC22A1 SLC22A3
Whole body water mass 2.19 2 1 2.2 0 1 SLC22A3 TRAPPC3
Leg predicted mass (right) 2.62 2 1 2.2 0 1 SLC22A3 TRAPPC3
Arm fat mass (left) 1.43 1 0 0.0 0 1 SLC22A3
Number of self-reported non-cancer illnesses 3.73 2 0 0.0 0 1 SLC22A1 SLC22A3
Ever taken oral contraceptive pill 4.48 1 0 0.0 0 1 TRAPPC3
Mother's age at death 4.05 1 0 0.0 0 1 SLC22A1
Eye problems/disorders: Glaucoma 15.64 2 1 2.2 0 1 CDKN2B TRAPPC3
Medication: Blood pressure 3.01 1 0 0.0 0 1 SLC22A3
Supplements: Fish oil (including cod liver oil) 2.59 1 0 0.0 0 1 SLC22A3
High cholesterol (Self-reported) 15.38 3 2 4.4 0 1 CDKN2B SLC22A1 SLC22A3
Medication: Atorvastatin 16.18 3 2 4.4 0 1 CDKN2B SLC22A1 SLC22A3
Ever smoked 1.41 1 0 0.0 0 1 SLC22A1
Basal metabolic rate 2.25 2 1 2.2 0 1 SLC22A3 TRAPPC3
Arm fat-free mass (left) 1.53 2 0 0.0 0 1 SLC22A3 TRAPPC3
Number of operations (self-reported) 1.84 1 0 0.0 0 1 CDKN2B
Diastolic blood pressure, automated reading 2.26 2 0 0.0 0 1 CDKN2B SLC22A3
Vascular/heart problems diagnosed by doctor 3.35 3 0 0.0 0 1 CDKN2B SLC22A1 SLC22A3
Cholesterol lowering medication 11.71 3 1 2.2 0 1 CDKN2B SLC22A1 SLC22A3
Basal cell carcinoma (self-reported) 5.98 1 0 0.0 0 1 CDKN2B
Heart attack/myocardial infarction (self-reported) 24.42 3 3 6.7 0 1 CDKN2B SLC22A1 SLC22A3
Heart disease (siblings) 11.87 3 0 0.0 0 1 CDKN2B SLC22A1 SLC22A3
Impedance of whole body 2.05 1 1 2.2 0 1 TRAPPC3
Leg fat mass (left) 1.06 1 0 0.0 0 1 SLC22A3
Arm predicted mass (left) 1.66 2 0 0.0 0 1 SLC22A3 TRAPPC3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.2
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 2 0.037 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1