Hub : Traits :

Chronic bronchitis/emphysema (father)

8 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 78032707 79886142 5 1 2.8e-13 3.6e-13 1 100 CHRNA3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Schizophrenia 6.9 1 0 0 0 1 CHRNA3
Blood Red Count 1.4 1 0 0 0 1 CHRNA3
Allergy or Eczema 4.4 1 0 0 0 1 CHRNA3
Lung FEV1/FVC ratio 7.6 1 1 3 0 1 CHRNA3
Lung FVC 5.3 1 1 3 0 1 CHRNA3
Angina 9.7 1 0 0 0 1 CHRNA3
Pack years adult smoking proportion 193.5 1 1 3 0 1 CHRNA3
Maternal smoking around birth 6.6 1 0 0 0 1 CHRNA3
Age when periods started (menarche) 3.3 1 0 0 0 1 CHRNA3
Bilateral oophorectomy (both ovaries removed) 8.8 1 0 0 0 1 CHRNA3
Qualifications: CSEs or equivalent 7.3 1 0 0 0 1 CHRNA3
Hayfever, allergic rhinitis or eczema 5.4 1 0 0 0 1 CHRNA3
Multivitamins +/- minerals 6.2 1 0 0 0 1 CHRNA3
Forced vital capacity (FVC) 3.3 1 0 0 0 1 CHRNA3
Father's age at death 22.5 1 1 3 0 1 CHRNA3
Number of live births 5.8 1 0 0 0 1 CHRNA3
Forced expiratory volume in 1-second (FEV1) 7.6 1 1 3 0 1 CHRNA3
Mouth/teeth dental problems: Dentures 11.4 1 0 0 0 1 CHRNA3
Lung cancer (father) 44.4 1 1 3 0 1 CHRNA3
Forced expiratory volume in 1-second (FEV1), Best measure 10.1 1 1 3 0 1 CHRNA3
Chronic bronchitis/emphysema (mother) 26.8 1 1 3 0 1 CHRNA3
Forced vital capacity (FVC), Best measure 4.6 1 0 0 0 1 CHRNA3
Wheeze or whistling in the chest in last year 8.4 1 0 0 0 1 CHRNA3
Emphysema/chronic bronchitis 19.4 1 0 0 0 1 CHRNA3
Angina (self-reported) 9.0 1 0 0 0 1 CHRNA3
Heart disease (mother) 10.1 1 0 0 0 1 CHRNA3
Overall health rating 3.5 1 0 0 0 1 CHRNA3
Knee pain experienced in last month 8.5 1 0 0 0 1 CHRNA3
Forced expiratory volume in 1-second (FEV1), predicted percentage 28.2 1 1 3 0 1 CHRNA3
Mother's age at death 7.9 1 0 0 0 1 CHRNA3
Risk taking 6.0 1 0 0 0 1 CHRNA3
Pack years of smoking 169.5 1 1 3 0 1 CHRNA3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.16
GTEx Adipose Visceral Omentum 0 0.0000 1.24
GTEx Adrenal Gland 0 0.0000 1.17
GTEx Artery Aorta 0 0.0000 1.18
GTEx Artery Coronary 0 0.0000 1.20
GTEx Artery Tibial 0 0.0000 1.17
GTEx Brain Caudate basal ganglia 0 0.0000 1.26
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.20
GTEx Brain Cerebellum 0 0.0000 1.24
GTEx Brain Cortex 0 0.0000 1.20
GTEx Brain Frontal Cortex BA9 0 0.0000 1.20
GTEx Brain Hippocampus 0 0.0000 1.29
GTEx Brain Hypothalamus 0 0.0000 1.17
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.21
GTEx Brain Putamen basal ganglia 0 0.0000 1.22
GTEx Breast Mammary Tissue 0 0.0000 1.22
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.16
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.21
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.16
GTEx Cells Transformed fibroblasts 0 0.0000 1.21
GTEx Colon Sigmoid 1 0.0684 1.27
GTEx Colon Transverse 0 0.0000 1.19
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.17
GTEx Esophagus Mucosa 0 0.0000 1.18
GTEx Esophagus Muscularis 0 0.0000 1.16
GTEx Heart Atrial Appendage 0 0.0000 1.19
GTEx Heart Left Ventricle 0 0.0000 1.21
GTEx Liver 1 0.1395 1.34
GTEx Lung 0 0.0000 1.16
GTEx Muscle Skeletal 0 0.0000 1.20
GTEx Nerve Tibial 0 0.0000 1.14
GTEx Ovary 0 0.0000 1.31
GTEx Pancreas 0 0.0000 1.17
GTEx Pituitary 0 0.0000 1.25
GTEx Prostate 0 0.0000 1.19
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.17
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.17
GTEx Small Intestine Terminal Ileum 0 0.0000 1.10
GTEx Spleen 0 0.0000 1.19
GTEx Stomach 0 0.0000 1.23
GTEx Testis 1 0.0317 1.16
GTEx Thyroid 0 0.0000 1.18
GTEx Uterus 0 0.0000 1.21
GTEx Vagina 0 0.0000 1.15
GTEx Whole Blood 0 0.0000 1.17
METSIM Adipose 0 0.0000 1.13
NTR Blood 0 0.0000 1.16
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.15
YFS Blood 2 0.0433 1.16
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.17
TCGA Breast Tumor 0 0.0000 1.28
TCGA Breast Normal 0 0.0000 1.15
TCGA Ovarian Tumor 1 0.0342 1.16
TCGA Prostate Tumor 2 0.0578 1.22