Hub : Traits :

Commuting to job workplace: Car/motor vehicle

1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	179566296	180095451	1	1	5.9e-08	0.00011	0.57	98	TOR1AIP2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Chronotype (morning person)	12.49	1	1	2.2	1	TOR1AIP2
Commuting to job workplace: Walk	9.38	1	0	0.0	1	TOR1AIP2
Time employed in main current job	8.76	1	0	0.0	1	TOR1AIP2
Hearing aid user	8.02	1	0	0.0	1	TOR1AIP2
Long-standing illness, disability or infirmity	6.45	1	0	0.0	1	TOR1AIP2
Exposure to tobacco smoke at home	6.26	1	0	0.0	1	TOR1AIP2
Commuting to job workplace: Public transport	5.79	1	0	0.0	1	TOR1AIP2
Ever depressed for a whole week	5.69	1	0	0.0	1	TOR1AIP2
Major Depression (MDD)	5.62	1	0	0.0	1	TOR1AIP2
Qualifications: CSEs or equivalent	5.55	1	0	0.0	1	TOR1AIP2
Age started oral contraceptive pill	5.36	1	0	0.0	1	TOR1AIP2
Osteoporosis (self-reported)	5.25	1	0	0.0	1	TOR1AIP2
Ever had stillbirth, spontaneous miscarriage or termination	4.95	1	0	0.0	1	TOR1AIP2
Falls in the last year	4.13	1	0	0.0	1	TOR1AIP2
Heart disease (siblings)	4.02	1	0	0.0	1	TOR1AIP2
Diabetes (self-reported)	3.98	1	0	0.0	1	TOR1AIP2
Hayfever, allergic rhinitis or eczema	3.77	1	0	0.0	1	TOR1AIP2
Hair/balding pattern: Pattern 2	3.67	1	0	0.0	1	TOR1AIP2
Type 2 Diabetes (T2D) (2018)	3.61	1	0	0.0	1	TOR1AIP2
Relative age of first facial hair	3.53	1	0	0.0	1	TOR1AIP2
Illnesses of father: Heart disease	3.52	1	0	0.0	1	TOR1AIP2
Osteoarthritis (self-reported)	3.40	1	0	0.0	1	TOR1AIP2
Eye problems/disorders: Cataract	3.35	1	0	0.0	1	TOR1AIP2
Age when periods started (menarche)	3.31	1	0	0.0	1	TOR1AIP2
Breastfed as a baby	3.27	1	0	0.0	1	TOR1AIP2
Wheeze or whistling in the chest in last year	3.26	1	0	0.0	1	TOR1AIP2
Nervous feelings	3.14	1	0	0.0	1	TOR1AIP2
Schizophrenia (2018)	3.13	1	0	0.0	1	TOR1AIP2
Allergy	3.06	1	0	0.0	1	TOR1AIP2
Medication: Cholesterol lowering	3.00	1	0	0.0	1	TOR1AIP2
Comparative body size at age 10	2.88	1	0	0.0	1	TOR1AIP2
Smoking Status	2.60	1	0	0.0	1	TOR1AIP2
Fluid intelligence score	2.56	1	0	0.0	1	TOR1AIP2
Bipolar Disorder or Schizophrenia	2.25	1	0	0.0	1	TOR1AIP2
Diastolic blood pressure, automated reading	2.05	1	0	0.0	1	TOR1AIP2
Trunk fat percentage	1.85	1	0	0.0	1	TOR1AIP2
Whole body fat mass	1.71	1	0	0.0	1	TOR1AIP2
Body fat percentage	1.70	1	0	0.0	1	TOR1AIP2
Blood Red Count	1.57	1	0	0.0	1	TOR1AIP2
Trunk fat mass	1.56	1	0	0.0	1	TOR1AIP2
Arm fat percentage (left)	1.49	1	0	0.0	1	TOR1AIP2
Arm fat percentage (right)	1.41	1	0	0.0	1	TOR1AIP2
Arm fat mass (right)	1.29	1	0	0.0	1	TOR1AIP2
Arm fat mass (left)	1.27	1	0	0.0	1	TOR1AIP2
Blood Eosinophil Count	1.12	1	0	0.0	1	TOR1AIP2
Waist circumference	1.10	1	0	0.0	1	TOR1AIP2
BMI	1.09	1	0	0.0	1	TOR1AIP2
Body mass index (BMI)	1.09	1	0	0.0	1	TOR1AIP2
Lung FVC	0.77	1	0	0.0	1	TOR1AIP2
Blood Platelet Count	0.46	1	0	0.0	1	TOR1AIP2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.1
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Brain Cortex	0	0.000	1.1
GTEx	Brain Hippocampus	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Brain Putamen basal ganglia	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Cells Transformed fibroblasts	0	0.000	1.1
GTEx	Colon Transverse	0	0.000	1.1
GTEx	Muscle Skeletal	0	0.000	1.1
GTEx	Nerve Tibial	0	0.000	1.1
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.1
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.1
GTEx	Testis	0	0.000	1.1
GTEx	Thyroid	0	0.000	1.1
GTEx	Uterus	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.0
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.0
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.0